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Aliases for MED31 Gene

Aliases for MED31 Gene

  • Mediator Complex Subunit 31 2 3 4 5
  • Mediator Complex Subunit SOH1 3 4
  • HSOH1 3 4
  • Soh1 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 31 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 31 Homolog 3
  • Mediator Of RNA Polymerase II Transcription Subunit 31 3
  • 3110004H13Rik 3
  • CGI-125 3

External Ids for MED31 Gene

Previous GeneCards Identifiers for MED31 Gene

  • GC17M006488
  • GC17M006489
  • GC17M006546
  • GC17M006441

Summaries for MED31 Gene

GeneCards Summary for MED31 Gene

MED31 (Mediator Complex Subunit 31) is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include protein complex binding and RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED31 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED31 Gene

Additional gene information for MED31 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED31 Gene

Genomics for MED31 Gene

GeneHancer (GH) Regulatory Elements for MED31 Gene

Promoters and enhancers for MED31 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I006649 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 129 3.1 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 C17orf100 PIR47256 MED31 DVL2 ENSG00000261996 SENP3 NEURL4 SNORD10 SNORA48 ALOX12-AS1
GH17I006699 Enhancer 0.9 ENCODE 10.8 -48.9 -48934 1.8 FOXA2 MLX ARID4B ZNF48 ETS1 YY1 TCF12 SLC30A9 RXRA SP5 XAF1 C17orf100 MED31 FBXO39 GC17M006685 SLC13A5
GH17I006913 Enhancer 0.9 Ensembl ENCODE 10.3 -262.5 -262507 0.9 CTCF RB1 RAD21 CC2D1A POLR2A BRD9 ARID2 SMC3 ZNF143 CREM ALOX12 ALOX12-AS1 RNASEK RNASEK-C17orf49 MIR195 BCL6B SLC16A11 C17orf100 MED31 SLC13A5
GH17I006599 Enhancer 0.8 Ensembl ENCODE 10.6 +52.0 52013 1.2 L3MBTL2 MAX MAFG MNT ZNF316 FOXK2 SMARCA4 IKZF1 NFE2 MAFK GC17M006601 RNA5SP435 KIAA0753 PITPNM3 TXNDC17 C17orf100 MED31 SLC13A5 GC17M006460
GH17I006843 Enhancer 0.6 ENCODE 10.2 -191.8 -191823 0.2 CTCF ZNF654 RFX1 REST RAD21 SMC3 ZNF143 ZNF24 ALOX12 ALOX12-AS1 RNASEK RNASEK-C17orf49 SLC13A5 MED31 C17orf100 XAF1 SLC16A11 ALOX12P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MED31 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MED31 gene promoter:

Genomic Locations for MED31 Gene

Genomic Locations for MED31 Gene
chr17:6,643,313-6,651,634
(GRCh38/hg38)
Size:
8,322 bases
Orientation:
Minus strand
chr17:6,546,633-6,554,954
(GRCh37/hg19)

Genomic View for MED31 Gene

Genes around MED31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED31 Gene

Proteins for MED31 Gene

  • Protein details for MED31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3C7-MED31_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 31
    Protein Accession:
    Q9Y3C7
    Secondary Accessions:
    • B2R4L9

    Protein attributes for MED31 Gene

    Size:
    131 amino acids
    Molecular mass:
    15805 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

neXtProt entry for MED31 Gene

Post-translational modifications for MED31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MED31 Gene

No data available for DME Specific Peptides for MED31 Gene

Domains & Families for MED31 Gene

Gene Families for MED31 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MED31 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MED31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3C7

UniProtKB/Swiss-Prot:

MED31_HUMAN :
  • Belongs to the Mediator complex subunit 31 family.
Family:
  • Belongs to the Mediator complex subunit 31 family.
genes like me logo Genes that share domains with MED31: view

Function for MED31 Gene

Molecular function for MED31 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA --
GO:0003713 transcription coactivator activity IBA --
GO:0005515 protein binding IPI 15383276
GO:0061630 ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with MED31: view
genes like me logo Genes that share phenotypes with MED31: view

miRNA for MED31 Gene

miRTarBase miRNAs that target MED31

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED31 Gene

Localization for MED31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED31 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED31 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MED31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0016592 mediator complex IEA,IBA --
GO:0070847 core mediator complex IBA --
genes like me logo Genes that share ontologies with MED31: view

Pathways & Interactions for MED31 Gene

genes like me logo Genes that share pathways with MED31: view

Gene Ontology (GO) - Biological Process for MED31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA,IBA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MED31: view

No data available for SIGNOR curated interactions for MED31 Gene

Drugs & Compounds for MED31 Gene

No Compound Related Data Available

Transcripts for MED31 Gene

Unigene Clusters for MED31 Gene

Mediator complex subunit 31:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED31 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: - -
SP3:

Relevant External Links for MED31 Gene

GeneLoc Exon Structure for
MED31
ECgene alternative splicing isoforms for
MED31

Expression for MED31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MED31 Gene

Protein differential expression in normal tissues from HIPED for MED31 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.3), NK cells (8.0), and Fetal testis (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MED31 Gene



Protein tissue co-expression partners for MED31 Gene

NURSA nuclear receptor signaling pathways regulating expression of MED31 Gene:

MED31

SOURCE GeneReport for Unigene cluster for MED31 Gene:

Hs.567493
genes like me logo Genes that share expression patterns with MED31: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED31 Gene

Orthologs for MED31 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MED31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED31 33 34
  • 98.98 (n)
cow
(Bos Taurus)
Mammalia MED31 33 34
  • 93.64 (n)
rat
(Rattus norvegicus)
Mammalia Med31 33
  • 93.64 (n)
mouse
(Mus musculus)
Mammalia Med31 33 16 34
  • 91.6 (n)
dog
(Canis familiaris)
Mammalia MED31 33 34
  • 85.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MED31 34
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED31 33 34
  • 85.19 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia med31 33
  • 81.89 (n)
Str.4402 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8668 33
zebrafish
(Danio rerio)
Actinopterygii med31 33 34
  • 76.97 (n)
wufa04d01 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.47 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002258 33
  • 68.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta MED31 34
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mdt-31 33 34
  • 63.4 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOH1 34 36
  • 31 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons MED31 33
  • 54.6 (n)
rice
(Oryza sativa)
Liliopsida Os10g0564100 33
  • 54.74 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 56 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5791 33
Species where no ortholog for MED31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED31 Gene

ENSEMBL:
Gene Tree for MED31 (if available)
TreeFam:
Gene Tree for MED31 (if available)

Paralogs for MED31 Gene

No data available for Paralogs for MED31 Gene

Variants for MED31 Gene

Sequence variations from dbSNP and Humsavar for MED31 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000365108 -- 6,644,143(-) G/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000372565 -- 6,650,580(-) G/T intron_variant
rs1000404808 -- 6,649,447(-) A/T intron_variant
rs1000438972 -- 6,649,232(-) T/G intron_variant
rs1000769204 -- 6,650,698(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MED31 Gene

Variant ID Type Subtype PubMed ID
nsv574278 CNV gain 21841781

Variation tolerance for MED31 Gene

Residual Variation Intolerance Score: 45.3% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MED31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED31

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED31 Gene

Disorders for MED31 Gene

Additional Disease Information for MED31

No disorders were found for MED31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED31 Gene

Publications for MED31 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  2. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. (PMID: 10024883) Gu W … Roeder RG (Molecular cell 1999) 3 4 22 58
  3. MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X … Roeder RG (Molecular cell 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S … Conaway RC (Molecular cell 2004) 3 4 58

Products for MED31 Gene

Sources for MED31 Gene

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