MED29 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al., 2003 [PubMed 14576168]).[supplied by OMIM, Aug 2009] See more...

Aliases for MED29 Gene

Aliases for MED29 Gene

  • Mediator Complex Subunit 29 2 3 4 5
  • Mediator Of RNA Polymerase II Transcription Subunit 29 3 4
  • Intersex-Like Protein 3 4
  • IXL 3 4
  • Intersex-Like (Drosophila) 2
  • MED2 3

External Ids for MED29 Gene

Previous HGNC Symbols for MED29 Gene

  • IXL

Previous GeneCards Identifiers for MED29 Gene

  • GC19P044577
  • GC19P039881
  • GC19P036328

Summaries for MED29 Gene

Entrez Gene Summary for MED29 Gene

  • MED29 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al., 2003 [PubMed 14576168]).[supplied by OMIM, Aug 2009]

GeneCards Summary for MED29 Gene

MED29 (Mediator Complex Subunit 29) is a Protein Coding gene. Diseases associated with MED29 include Horner's Syndrome and Enophthalmos. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism.

UniProtKB/Swiss-Prot Summary for MED29 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Additional gene information for MED29 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MED29 Gene

Genomics for MED29 Gene

GeneHancer (GH) Regulatory Elements for MED29 Gene

Promoters and enhancers for MED29 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MED29 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MED29

Top Transcription factor binding sites by QIAGEN in the MED29 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • CUTL1
  • p53

Genomic Locations for MED29 Gene

Genomic Locations for MED29 Gene
chr19:39,391,303-39,400,641
(GRCh38/hg38)
Size:
9,339 bases
Orientation:
Plus strand
chr19:39,881,943-39,891,277
(GRCh37/hg19)
Size:
9,335 bases
Orientation:
Plus strand

Genomic View for MED29 Gene

Genes around MED29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED29 Gene

Proteins for MED29 Gene

  • Protein details for MED29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX70-MED29_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 29
    Protein Accession:
    Q9NX70
    Secondary Accessions:
    • B4DNQ6
    • M0R2E4
    • Q5XX09
    • Q9NTF4

    Protein attributes for MED29 Gene

    Size:
    200 amino acids
    Molecular mass:
    21073 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Associates with the MED18/MED20 heteromer.
    SequenceCaution:
    • Sequence=AAU43732.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MED29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED29 Gene

Post-translational modifications for MED29 Gene

  • Ubiquitination at Lys76
  • Modification sites at PhosphoSitePlus

Other Protein References for MED29 Gene

No data available for DME Specific Peptides for MED29 Gene

Domains & Families for MED29 Gene

Gene Families for MED29 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MED29 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED29 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61114, highly similar to Homo sapiens intersex-lik (IXL), mRNA (B4DGM4_HUMAN)
  • cDNA FLJ54860, highly similar to Homo sapiens intersex-lik (IXL), mRNA (B4DUA7_HUMAN)
  • Mediator complex subunit 29 (MED29_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NX70

UniProtKB/Swiss-Prot:

MED29_HUMAN :
  • Belongs to the Mediator complex subunit 29 family.
Family:
  • Belongs to the Mediator complex subunit 29 family.
genes like me logo Genes that share domains with MED29: view

Function for MED29 Gene

Molecular function for MED29 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Phenotypes From GWAS Catalog for MED29 Gene

Gene Ontology (GO) - Molecular Function for MED29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14576168
genes like me logo Genes that share ontologies with MED29: view
genes like me logo Genes that share phenotypes with MED29: view

Animal Model Products

CRISPR Products

miRNA for MED29 Gene

miRTarBase miRNAs that target MED29

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MED29

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED29 Gene

Localization for MED29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED29 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED29 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MED29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0016592 mediator complex IDA,IEA 14638676
genes like me logo Genes that share ontologies with MED29: view

Pathways & Interactions for MED29 Gene

genes like me logo Genes that share pathways with MED29: view

Gene Ontology (GO) - Biological Process for MED29 Gene

None

No data available for SIGNOR curated interactions for MED29 Gene

Drugs & Compounds for MED29 Gene

No Compound Related Data Available

Transcripts for MED29 Gene

mRNA/cDNA for MED29 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MED29

Alternative Splicing Database (ASD) splice patterns (SP) for MED29 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2:
SP3: - -

Relevant External Links for MED29 Gene

GeneLoc Exon Structure for
MED29

Expression for MED29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MED29 Gene

Protein differential expression in normal tissues from HIPED for MED29 Gene

This gene is overexpressed in Fetal Brain (17.5), Fetal ovary (15.3), and Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MED29 Gene



Protein tissue co-expression partners for MED29 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MED29

SOURCE GeneReport for Unigene cluster for MED29 Gene:

Hs.611541

mRNA Expression by UniProt/SwissProt for MED29 Gene:

Q9NX70-MED29_HUMAN
Tissue specificity: Widely expressed in embryo and adult.

Evidence on tissue expression from TISSUES for MED29 Gene

  • Nervous system(5)
  • Lung(4.3)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with MED29: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED29 Gene

Orthologs for MED29 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED29 31 30
  • 95.51 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MED29 31 30
  • 91.96 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MED29 31 30
  • 90.17 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med29 30
  • 86.59 (n)
mouse
(Mus musculus)
Mammalia Med29 17 31 30
  • 85.87 (n)
oppossum
(Monodelphis domestica)
Mammalia MED29 31
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED29 31
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med29 30
  • 73.43 (n)
Str.7460 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.24074 30
zebrafish
(Danio rerio)
Actinopterygii med29 31 30
  • 70.1 (n)
OneToOne
dkfzp434h247 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13786 30
fruit fly
(Drosophila melanogaster)
Insecta ix 31
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2417 31
  • 32 (a)
OneToOne
Species where no ortholog for MED29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED29 Gene

ENSEMBL:
Gene Tree for MED29 (if available)
TreeFam:
Gene Tree for MED29 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MED29: view image

Paralogs for MED29 Gene

(1) SIMAP similar genes for MED29 Gene using alignment to 5 proteins:

  • MED29_HUMAN
  • B4DNQ6_HUMAN
  • M0R0A0_HUMAN
  • M0R0U2_HUMAN
  • M0R3F3_HUMAN
genes like me logo Genes that share paralogs with MED29: view

No data available for Paralogs for MED29 Gene

Variants for MED29 Gene

Additional dbSNP identifiers (rs#s) for MED29 Gene

Structural Variations from Database of Genomic Variants (DGV) for MED29 Gene

Variant ID Type Subtype PubMed ID
esv25791 CNV gain 19812545

Variation tolerance for MED29 Gene

Residual Variation Intolerance Score: 59.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MED29 Gene

Human Gene Mutation Database (HGMD)
MED29
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED29

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MED29 Gene

Disorders for MED29 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MED29 Gene - From: DISEASES

Disorder Aliases PubMed IDs
horner's syndrome
  • bernard horner syndrome
enophthalmos
hemophagocytic lymphohistiocytosis, familial, 1
  • fhl1
- elite association - COSMIC cancer census association via MalaCards
Search MED29 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MED29

genes like me logo Genes that share disorders with MED29: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MED29 Gene

Publications for MED29 Gene

  1. IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor. (PMID: 15555573) Wang Y … Wu X (Biochemical and biophysical research communications 2004) 2 3 4 54
  2. MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X … Roeder RG (Molecular cell 2005) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. (PMID: 14638676) Tomomori-Sato C … Conaway JW (The Journal of biological chemistry 2004) 3 4 54
  5. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S … Conaway RC (Molecular cell 2004) 3 4 54

Products for MED29 Gene

Sources for MED29 Gene