MED26 Gene (Protein Coding)

Mediator Complex Subunit 26

GC19M016574
GIFtS:
36
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TF... See more...

Aliases for MED26 Gene

Aliases for MED26 Gene

  • Mediator Complex Subunit 26 2 3 4 5
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 7, 70kDa 2 3
  • Cofactor Required For Sp1 Transcriptional Activation Subunit 7 3 4
  • Mediator Of RNA Polymerase II Transcription Subunit 26 3 4
  • Activator-Recruited Cofactor 70 KDa Component 3 4
  • Transcriptional Coactivator CRSP70 3 4
  • CRSP Complex Subunit 7 3 4
  • CRSP7 3 4
  • ARC70 3 4
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 7 (70kD) 3
  • CRSP70 3

External Ids for MED26 Gene

Previous HGNC Symbols for MED26 Gene

  • CRSP7

Previous GeneCards Identifiers for MED26 Gene

  • GC19M016546
  • GC19M016685
  • GC19M016254

Summaries for MED26 Gene

Entrez Gene Summary for MED26 Gene

  • The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED26 Gene

MED26 (Mediator Complex Subunit 26) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Developmental Biology. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is ENSG00000141979.

UniProtKB/Swiss-Prot Summary for MED26 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED26 Gene

Additional gene information for MED26 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MED26 Gene

Genomics for MED26 Gene

GeneHancer (GH) Regulatory Elements for MED26 Gene

Promoters and enhancers for MED26 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MED26 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MED26 gene promoter:
  • c-Myc
  • GATA-6
  • GR
  • GR-alpha
  • Max1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Msx-1
  • RORalpha1

Genomic Locations for MED26 Gene

Genomic Locations for MED26 Gene
chr19:16,574,907-16,629,062
(GRCh38/hg38)
Size:
54,156 bases
Orientation:
Minus strand
chr19:16,685,718-16,739,873
(GRCh37/hg19)
Size:
54,156 bases
Orientation:
Minus strand

Genomic View for MED26 Gene

Genes around MED26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED26 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MED26 Gene

Proteins for MED26 Gene

Products:

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  • Protein details for MED26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95402-MED26_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 26
    Protein Accession:
    O95402
    Secondary Accessions:
    • A1A4S3
    • Q0VGB6

    Protein attributes for MED26 Gene

    Size:
    600 amino acids
    Molecular mass:
    65446 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CEBPB (when not methylated)(PubMed:20111005).

    Three dimensional structures from OCA and Proteopedia for MED26 Gene

    Alternative splice isoforms for MED26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED26 Gene

Protein Expression for MED26 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MED26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MED26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MED26 Gene

Domains & Families for MED26 Gene

Gene Families for MED26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MED26 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED26 Gene

GenScript: Design optimal peptide antigens:
  • Transcriptional coactivator CRSP70 (MED26_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95402

UniProtKB/Swiss-Prot:

MED26_HUMAN :
  • Belongs to the Mediator complex subunit 26 family.
Family:
  • Belongs to the Mediator complex subunit 26 family.
genes like me logo Genes that share domains with MED26: view

Function for MED26 Gene

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  2. CRISPR
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Molecular function for MED26 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.

Phenotypes From GWAS Catalog for MED26 Gene

Gene Ontology (GO) - Molecular Function for MED26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription coregulator activity IDA 15989967
GO:0003713 transcription coactivator activity TAS 9989412
GO:0005515 protein binding IPI 15175163
genes like me logo Genes that share ontologies with MED26: view
genes like me logo Genes that share phenotypes with MED26: view

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for MED26

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED26 Gene

Localization for MED26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED26 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED26 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MED26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0016592 mediator complex IDA 15989967
GO:0070847 core mediator complex IBA 21873635
genes like me logo Genes that share ontologies with MED26: view

Pathways & Interactions for MED26 Gene

genes like me logo Genes that share pathways with MED26: view

Pathways by source for MED26 Gene

1 Cell Signaling Technology pathway for MED26 Gene

Gene Ontology (GO) - Biological Process for MED26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IDA,TAS 15989967
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010628 positive regulation of gene expression IBA 21873635
GO:1903508 positive regulation of nucleic acid-templated transcription IEA --
genes like me logo Genes that share ontologies with MED26: view

No data available for SIGNOR curated interactions for MED26 Gene

Drugs & Compounds for MED26 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MED26 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MED26 Gene

(1) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(76) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for MED26

Alternative Splicing Database (ASD) splice patterns (SP) for MED26 Gene

No ASD Table

Relevant External Links for MED26 Gene

GeneLoc Exon Structure for
MED26
ECgene alternative splicing isoforms for
MED26

Expression for MED26 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MED26 Gene

mRNA expression in normal human tissues for MED26 Gene
mRNA expression by GTEx for MED26 Gene

mRNA differential expression in normal tissues according to GTEx for MED26 Gene

This gene is overexpressed in Testis (x12.1).

Protein differential expression in normal tissues from HIPED for MED26 Gene

This gene is overexpressed in Heart (42.1) and Pancreatic juice (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MED26 Gene



Protein tissue co-expression partners for MED26 Gene

NURSA nuclear receptor signaling pathways regulating expression of MED26 Gene:

MED26

SOURCE GeneReport for Unigene cluster for MED26 Gene:

Hs.715040
genes like me logo Genes that share expression patterns with MED26: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED26 Gene

Orthologs for MED26 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia -- 33
  • 97 (a)
 OneToMany
MED26 32
  • 95.44 (n)
dog
(Canis familiaris)
 Mammalia -- 33
  • 92 (a)
 OneToMany
MED26 32
  • 90.71 (n)
cow
(Bos Taurus)
 Mammalia MED26 33 32
  • 89.82 (n)
 OneToMany
rat
(Rattus norvegicus)
 Mammalia Med26 32
  • 85.03 (n)
mouse
(Mus musculus)
 Mammalia Med26 17 33 32
  • 83.79 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 33
  • 69 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 33
  • 68 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves MED26 32
  • 67.54 (n)
-- 33
  • 65 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 33
  • 55 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia med26 32
  • 62.23 (n)
Str.1314 32
African clawed frog
(Xenopus laevis)
 Amphibia Xl.12095 32
zebrafish
(Danio rerio)
 Actinopterygii crsp7 32
  • 60.17 (n)
MED26 33
  • 25 (a)
 OneToMany
Dr.11494 32
fruit fly
(Drosophila melanogaster)
 Insecta MED26 33
  • 5 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 25 (a)
 OneToMany
Species where no ortholog for MED26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED26 Gene

ENSEMBL:
Gene Tree for MED26 (if available)
TreeFam:
Gene Tree for MED26 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MED26: view image

Paralogs for MED26 Gene

Paralogs for MED26 Gene

(2) SIMAP similar genes for MED26 Gene using alignment to 5 proteins:

  • MED26_HUMAN
  • M0QXW8_HUMAN
  • M0R064_HUMAN
  • M0R2P1_HUMAN
  • M0R2Y4_HUMAN
genes like me logo Genes that share paralogs with MED26: view

Variants for MED26 Gene

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Sequence variations from dbSNP and Humsavar for MED26 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000055623 -- 16,583,098(-) T/C intron_variant
rs1000134506 -- 16,624,194(-) C/A intron_variant
rs1000141752 -- 16,609,293(-) C/G intron_variant
rs1000196851 -- 16,611,566(-) T/C intron_variant
rs1000241311 -- 16,618,170(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MED26 Gene

Variant ID Type Subtype PubMed ID
esv2674048 CNV deletion 23128226
esv2718266 CNV deletion 23290073
nsv479037 CNV novel sequence insertion 20440878
nsv510757 CNV deletion 20534489

Variation tolerance for MED26 Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MED26 Gene

Human Gene Mutation Database (HGMD)
MED26
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED26

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED26 Gene

Disorders for MED26 Gene

Additional Disease Information for MED26

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MED26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED26 Gene

Publications for MED26 Gene

  1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PMID: 9989412) Ryu S … Tjian R (Nature 1999) 2 3 4 56
  2. Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code. (PMID: 20111005) Kowenz-Leutz E … Leutz A (The EMBO journal 2010) 3 4 56
  3. MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X … Roeder RG (Molecular cell 2005) 3 4 56
  4. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S … Conaway RC (Molecular cell 2004) 3 4 56
  5. Composite co-activator ARC mediates chromatin-directed transcriptional activation. (PMID: 10235267) Näär AM … Tjian R (Nature 1999) 3 4 56

ExternalLinks

View latest publications for MED26 gene in Mastermind

Products for MED26 Gene

  • Addgene plasmids for MED26
  • Boster Bio Antibodies for MED26
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Sources for MED26 Gene