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The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]
MED26 (Mediator Complex Subunit 26) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is ENSG00000141979.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003712 | transcription coregulator activity | IDA | 15989967 |
GO:0003713 | transcription coactivator activity | TAS | 9989412 |
GO:0005515 | protein binding | IPI | 15175163 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0016592 | mediator complex | IEA,IDA | 15989967 |
GO:0070847 | core mediator complex | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
2 | Gene Expression |
.48
|
|
3 | Metabolism |
.40
|
|
4 | Chromatin Regulation / Acetylation | ||
5 | Developmental Biology |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006357 | regulation of transcription by RNA polymerase II | IEA,IDA | 15989967 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
GO:0010628 | positive regulation of gene expression | IBA | 21873635 |
GO:1903508 | positive regulation of nucleic acid-templated transcription | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToMany | |
MED26 30 |
|
||||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
MED26 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | MED26 30 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Med26 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Med26 30 17 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | MED26 30 |
|
||
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | med26 30 |
|
||
Str.1314 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.12095 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | crsp7 30 |
|
||
MED26 31 |
|
OneToMany | |||
Dr.11494 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | MED26 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
780549 | Benign: not provided | 16,577,059(-) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2674048 | CNV | deletion | 23128226 |
esv2718266 | CNV | deletion | 23290073 |
nsv479037 | CNV | novel sequence insertion | 20440878 |
nsv510757 | CNV | deletion | 20534489 |
No disorders were found for MED26 Gene.