Aliases for MED26 Gene
- Mediator Complex Subunit 26 2 3 4 5
- Cofactor Required For Sp1 Transcriptional Activation, Subunit 7, 70kDa 2 3
- Cofactor Required For Sp1 Transcriptional Activation Subunit 7 3 4
- Mediator Of RNA Polymerase II Transcription Subunit 26 3 4
- Activator-Recruited Cofactor 70 KDa Component 3 4
- Transcriptional Coactivator CRSP70 3 4
External Ids for MED26 Gene
Previous HGNC Symbols for MED26 Gene
Previous GeneCards Identifiers for MED26 Gene
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]
GeneCards Summary for MED26 Gene
MED26 (Mediator Complex Subunit 26) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is ENSG00000141979.
UniProtKB/Swiss-Prot Summary for MED26 Gene
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.