Aliases for MED25 Gene
External Ids for MED25 Gene
Previous GeneCards Identifiers for MED25 Gene
This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010]
GeneCards Summary for MED25 Gene
MED25 (Mediator Complex Subunit 25) is a Protein Coding gene. Diseases associated with MED25 include Basel-Vanagaite-Smirin-Yosef Syndrome and Charcot-Marie-Tooth Disease, Axonal, Type 2B2. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Gene Expression. Gene Ontology (GO) annotations related to this gene include transcription factor binding and retinoid X receptor binding. An important paralog of this gene is PTOV1.
UniProtKB/Swiss-Prot Summary for MED25 Gene
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription.