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This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] See more...
Aliases for MED21 Gene
Aliases for MED21 Gene
External Ids for MED21 Gene
- HGNC: 11473
- NCBI Entrez Gene: 9412
- Ensembl: ENSG00000152944
- OMIM®: 603800
- UniProtKB/Swiss-Prot: Q13503
Previous HGNC Symbols for MED21 Gene
- SURB7
Previous GeneCards Identifiers for MED21 Gene
- GC12P027067
- GC12P027175
- GC12P026945
Summaries for MED21 Gene
-
This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
GeneCards Summary for MED21 Gene
MED21 (Mediator Complex Subunit 21) is a Protein Coding gene. Diseases associated with MED21 include Temtamy Syndrome and Cantu Syndrome. Among its related pathways are Developmental Biology and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and DNA-directed 5'-3' RNA polymerase activity.
UniProtKB/Swiss-Prot Summary for MED21 Gene
-
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Additional gene information for MED21 Gene
- HGNC (11473)
- NCBI Entrez Gene (9412)
- Ensembl (ENSG00000152944)
- OMIM® (603800)
- UniProtKB/Swiss-Prot (Q13503)
- Open Targets Platform(ENSG00000152944)
- Search for MED21 at DataMed
- Search for MED21 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MED21 Gene
Genomics for MED21 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MED21 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MED21 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MED21
- Top Transcription factor binding sites by QIAGEN in the MED21 gene promoter:
-
- AhR
- AML1a
- Arnt
- C/EBPalpha
- Nkx2-5
- POU2F1
- POU2F1a
Genomic Locations for MED21 Gene
Latest Assembly
- chr12:27,022,546-27,066,343
- (GRCh38/hg38)
- Size:
- 43,798 bases
- Orientation:
- Plus strand
Previous Assembly
- chr12:27,175,491-27,183,606
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 8,116 bases
- Orientation:
- Plus strand
- chr12:27,175,479-27,219,276
- (GRCh37/hg19 by Ensembl)
- Size:
- 43,798 bases
- Orientation:
- Plus strand
Genomic View for MED21 Gene
Genes around MED21 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p11.23 by HGNC
- 12p11.23 by Entrez Gene
- 12p11.23 by Ensembl
MED21 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MED21 Gene
Proteins for MED21 Gene
-
Protein details for MED21 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13503-MED21_HUMAN
- Recommended name:
- Mediator of RNA polymerase II transcription subunit 21
- Protein Accession:
- Q13503
- B2R4I3
- Q6IB05
- Q92811
Protein attributes for MED21 Gene
- Size:
- 144 amino acids
- Molecular mass:
- 15564 Da
- Quaternary structure:
-
- Interacts with PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with THRA in a ligand-dependent fashion.
Protein Expression for MED21 Gene
Post-translational modifications for MED21 Gene
Other Protein References for MED21 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences MED21 Antibody
-
Custom Antibody ServicesOriGene Antibodies for MED21
- Novus Biologicals Antibodies for MED21
- Invitrogen Antibodies for MED21 (AFLGC-MED21)
-
Custom Antibody ServicesProSci Antibodies for MED21
-
Santa Cruz Biotechnology (SCBT) Antibodies for MED21
Protein products for research
-
OriGene Purified Proteins for MED21
- Search Origene for MassSpec and Protein Over-expression Lysates for MED21
- Origene Custom Protein Services for MED21
- ProSpec Recombinant Proteins for MED21
-
Abcam proteins for MED21
Assay products for research
No data available for DME Specific Peptides for MED21 Gene
Domains & Families for MED21 Gene
Gene Families for MED21 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MED21 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MED21 Gene
- GenScript: Design optimal peptide antigens:
-
- RNA polymerase II holoenzyme component SRB7 (MED21_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q13503- Family:
-
- Belongs to the Mediator complex subunit 21 family.
Function for MED21 Gene
Molecular function for MED21 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Phenotypes From GWAS Catalog for MED21 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003712 | transcription coregulator activity | IBA | 21873635 |
| GO:0003713 | transcription coactivator activity | IDA | 12037571 |
| GO:0003899 | DNA-directed 5'-3' RNA polymerase activity | TAS | 8598913 |
| GO:0005515 | protein binding | IPI | 14638676 |
| GO:0061630 | ubiquitin protein ligase activity | IEA | -- |
Phenotypes for MED21 Gene
- MGI mutant phenotypes for MED21:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MED21:
Animal Models for MED21 Gene
- MGI Knock Outs for MED21:
-
- Med21 Med21<tm1Ryng>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MED21 - Starting at $85 >
- * MED21 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MED21
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MED21
-
Santa Cruz Biotechnology (SCBT) CRISPR for MED21
miRNA for MED21 Gene
- miRTarBase miRNAs that target MED21
-
- hsa-miR-93-5p (MIRT048905)
- hsa-miR-526b-5p (MIRT447409)
- hsa-miR-889-3p (MIRT447410)
- hsa-miR-6086 (MIRT447411)
- hsa-miR-377-5p (MIRT447412)
- hsa-miR-655-5p (MIRT447413)
- hsa-miR-510-3p (MIRT447414)
- hsa-miR-215-5p (MIRT447415)
- hsa-miR-192-5p (MIRT447416)
- hsa-miR-642a-5p (MIRT447417)
- hsa-miR-664b-3p (MIRT447418)
- hsa-miR-579-3p (MIRT447419)
- hsa-miR-431-5p (MIRT447420)
- hsa-miR-6759-3p (MIRT447421)
- hsa-miR-6833-5p (MIRT447422)
- hsa-miR-3190-3p (MIRT447423)
- hsa-miR-6124 (MIRT447424)
- hsa-miR-3148 (MIRT447425)
- hsa-miR-7114-5p (MIRT447426)
- hsa-miR-4511 (MIRT447427)
- hsa-miR-4318 (MIRT447428)
- hsa-miR-548s (MIRT551760)
- hsa-miR-19b-2-5p (MIRT551761)
- hsa-miR-19b-1-5p (MIRT551762)
- hsa-miR-19a-5p (MIRT551763)
- hsa-miR-2052 (MIRT551764)
- hsa-miR-3926 (MIRT551765)
- hsa-miR-3190-5p (MIRT551766)
- hsa-miR-323b-3p (MIRT551767)
- hsa-miR-4307 (MIRT551768)
- hsa-miR-1278 (MIRT551769)
- hsa-miR-892b (MIRT551770)
- hsa-miR-193b-3p (MIRT551771)
- hsa-miR-193a-3p (MIRT551772)
- hsa-miR-8054 (MIRT551773)
- hsa-miR-548k (MIRT551774)
- hsa-miR-548av-5p (MIRT551775)
- hsa-miR-548t-5p (MIRT551776)
- hsa-miR-548az-5p (MIRT551777)
- hsa-miR-548n (MIRT551778)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MED21
- Browse OriGene Inhibitory RNA Products For MED21
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MED21
Clone products for research
- Applied Biological Materials (abm): Clones for MED21 - Starting at $45 >
- * MED21 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for MED21
- Addgene plasmids for MED21
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MED21
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MED21 Gene
Localization for MED21 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MED21 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
- Cytosol (2)
- Nucleoli (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0016592 | mediator complex | IDA | 12037571 |
Pathways & Interactions for MED21 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 2 | Metabolism |
.40
|
|
| 3 | Developmental Biology | ||
| 4 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
Transcription Ligand-Dependent Transcription of Retinoid-Target genes
.32
|
|
Pathways by source for MED21 Gene
7 Reactome pathways for MED21 Gene
1 GeneGo (Thomson Reuters) pathway for MED21 Gene
- Transcription Ligand-Dependent Transcription of Retinoid-Target genes
Interacting Proteins for MED21 Gene
Selected Interacting proteins:
Q13503-MED21_HUMAN
ENSP00000282892
for MED21 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for MED21
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001824 | blastocyst development | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS,IBA | 21873635 |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0019827 | stem cell population maintenance | IEA | -- |
| GO:0032774 | RNA biosynthetic process | IEA | -- |
No data available for SIGNOR curated interactions for MED21 Gene
Transcripts for MED21 Gene
mRNA/cDNA for MED21 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000282892 2669 nts (view in UCSC)
- ENST00000536503 1374 nts (view in UCSC)
- ENST00000536711 578 nts (view in UCSC)
- ENST00000538186 552 nts (view in UCSC)
- ENST00000544998 678 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MED21 - Starting at $85 >
- * MED21 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MED21
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MED21
-
Santa Cruz Biotechnology (SCBT) CRISPR for MED21
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MED21
- Browse OriGene Inhibitory RNA Products For MED21
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MED21
Clone products for research
- Applied Biological Materials (abm): Clones for MED21 - Starting at $45 >
- * MED21 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for MED21
- Addgene plasmids for MED21
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MED21
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | |||||||||||||||||||||
| SP4: | - | - |
Relevant External Links for MED21 Gene
- GeneLoc Exon Structure for
- MED21
Expression for MED21 Gene
This gene is overexpressed in Pancreas (35.7), Bone (14.0), and Placenta (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MED21 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MED21
SOURCE GeneReport for Unigene cluster for MED21 Gene:
Hs.286145Evidence on tissue expression from TISSUES for MED21 Gene
- Nervous system(4.8)
- Kidney(4.4)
- Liver(4.3)
Primer products for research
-
OriGene qPCR primer pairs for MED21
-
OriGene qPCR primer pairs and template standards for MED21
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED21 Gene
Orthologs for MED21 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MED21 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MED21 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MED21 30 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MED21 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Med21 30 17 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MED21 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Med21 30 |
|
||
| Chicken (Gallus gallus) |
Aves | MED21 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MED21 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | med21 30 |
|
||
| Str.17613 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | med21 30 31 |
|
OneToOne | |
| wufk48d02 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1468 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | MED21 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | MED21_ANOGA 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | mdt-21 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for MED21 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MED21 Gene
- ENSEMBL:
- Gene Tree for MED21 (if available)
- TreeFam:
- Gene Tree for MED21 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MED21: view image
Paralogs for MED21 Gene
Pseudogenes.org Pseudogenes for MED21 Gene
No data available for Paralogs for MED21 Gene
Variants for MED21 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2745664 | CNV | deletion | 23290073 |
Residual Variation Intolerance Score:
39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.02;
0.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MED21 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MED21
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MED21 Gene
Disorders for MED21 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| temtamy syndrome |
|
|
| cantu syndrome |
|
|
Search MED21 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MED21
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MED21 Gene
Publications for MED21 Gene
- NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. (PMID: 9734358) Sun X … Reinberg D (Molecular cell 1998) 3 4 23
- A mammalian SRB protein associated with an RNA polymerase II holoenzyme. (PMID: 8598913) Chao DM … Young RA (Nature 1996) 2 3 4
- MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X … Roeder RG (Molecular cell 2005) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S … Conaway RC (Molecular cell 2004) 3 4
ExternalLinks
Products for MED21 Gene
- Custom Antibody ServicesOriGene Antibodies for MED21
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MED21
- Search Origene for MassSpec and Protein Over-expression Lysates for MED21
- Origene Custom Protein Services for MED21
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MED21
- Browse OriGene Inhibitory RNA Products For MED21
- OriGene qPCR primer pairs for MED21
- OriGene qPCR primer pairs and template standards for MED21
- OriGene CRISPR knockouts for MED21
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MED21
- Sino Biological Human cDNA Clone for MED21
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MED21
- Novus Biologicals proteins and lysates for MED21
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for MED21
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for MED21 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MED21 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MED21 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MED21 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MED21
- Addgene plasmids for MED21
- antibodies-online: Show 10 available MED21 Antibodies ranked by validation data
- Compare Top MED21 Antibodies
- antibodies-online: Show 11 available MED21 Elisa Kits ranked by validation data
- Compare Top MED21 Elisa Kits
- antibodies-online: Show 20 available MED21 Proteins ranked by validation data
- Compare Top MED21 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for MED21
- Search Santa Cruz Biotechnology (SCBT) for MED21 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MED21
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MED21
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MED21
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MED21
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MED21
Sources for MED21 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
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