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This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
MED21 (Mediator Complex Subunit 21) is a Protein Coding gene. Diseases associated with MED21 include Intravenous Leiomyomatosis and Cantu Syndrome. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and DNA-directed 5'-3' RNA polymerase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003712 | transcription coregulator activity | IBA | 21873635 |
GO:0003713 | transcription coactivator activity | IDA | 12037571 |
GO:0003899 | DNA-directed 5'-3' RNA polymerase activity | TAS | 8598913 |
GO:0005515 | protein binding | IPI | 14638676 |
GO:0061630 | ubiquitin protein ligase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000151 | ubiquitin ligase complex | IEA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0016592 | mediator complex | IDA | 12037571 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
2 | Metabolism |
.40
|
|
3 | Developmental Biology | ||
4 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
Transcription Ligand-Dependent Transcription of Retinoid-Target genes
.33
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001824 | blastocyst development | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | TAS,IBA | 21873635 |
GO:0016567 | protein ubiquitination | IEA | -- |
GO:0019827 | stem cell population maintenance | IEA | -- |
GO:0032774 | RNA biosynthetic process | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||
SP2: | - | ||||||||||||||||||||
SP3: | |||||||||||||||||||||
SP4: | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MED21 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MED21 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MED21 30 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | MED21 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Med21 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MED21 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Med21 30 |
|
||
Chicken (Gallus gallus) |
Aves | MED21 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MED21 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | med21 30 |
|
||
Str.17613 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | med21 30 31 |
|
OneToOne | |
wufk48d02 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1468 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | MED21 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | MED21_ANOGA 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | mdt-21 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2745664 | CNV | deletion | 23290073 |
Disorder | Aliases | PubMed IDs |
---|---|---|
intravenous leiomyomatosis |
|
|
cantu syndrome |
|
|