Aliases for MED21 Gene
External Ids for MED21 Gene
Previous HGNC Symbols for MED21 Gene
Previous GeneCards Identifiers for MED21 Gene
This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
GeneCards Summary for MED21 Gene
MED21 (Mediator Complex Subunit 21) is a Protein Coding gene. Diseases associated with MED21 include Intravenous Leiomyomatosis and Cantu Syndrome. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and DNA-directed 5'-3' RNA polymerase activity.
UniProtKB/Swiss-Prot Summary for MED21 Gene
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.