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Aliases for MED18 Gene

Aliases for MED18 Gene

  • Mediator Complex Subunit 18 2 3 4 5
  • P28b 3 4
  • Mediator Of RNA Polymerase II Transcription, Subunit 18 Homolog (S. Cerevisiae) 2
  • Mediator Of RNA Polymerase II Transcription, Subunit 18 Homolog 3
  • Mediator Of RNA Polymerase II Transcription Subunit 18 3
  • TRAP/Mediator Complex Subunit P28b 3
  • SRB5 3

External Ids for MED18 Gene

Previous GeneCards Identifiers for MED18 Gene

  • GC01P028528
  • GC01P028666
  • GC01P026912

Summaries for MED18 Gene

Entrez Gene Summary for MED18 Gene

  • MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

GeneCards Summary for MED18 Gene

MED18 (Mediator Complex Subunit 18) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

UniProtKB/Swiss-Prot for MED18 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Additional gene information for MED18 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED18 Gene

Genomics for MED18 Gene

GeneHancer (GH) Regulatory Elements for MED18 Gene

Promoters and enhancers for MED18 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J028326 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 650.7 -0.4 -414 4.4 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A ZNF2 IRF4 YY1 SLC30A9 POLR2B MED18 PHACTR4 GMEB1 EYA3 SRSF4 YTHDF2 TMEM200B SNHG12 RCC1 ENSG00000237934
GH01J028295 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.9 -32.1 -32123 2.7 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 IRF4 YY1 ENSG00000270605 SESN2 MED18 PHACTR4 PTAFR DNAJC8 ATP5IF1
GH01J027871 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.4 -454.4 -454378 5.3 HDGF PKNOX1 ATF1 SMAD1 FEZF1 IRF4 GTF3C2 POLR2B ZNF207 ZNF143 THEMIS2 GMEB1 TRNAU1AP ACTG1P20 SNHG12 FGR YTHDF2 EYA3 GPN2 RPA2
GH01J028350 Enhancer 1.2 Ensembl ENCODE 12.5 +23.9 23925 4.3 HDGF PKNOX1 FOXA2 ARNT SIN3A POLR2B ZNF766 FOS SP3 SP5 PHACTR4 GMEB1 RCC1 EYA3 SNHG3 SNORA73B TRNAU1AP YTHDF2 SRSF4 SNHG12
GH01J028266 Enhancer 1.1 ENCODE dbSUPER 12.8 -61.8 -61812 0.7 HDGF ATF1 ARNT TCF12 ZNF121 GATA2 ZFP91 RXRA NCOA1 ZNF592 MED18 DNAJC8 ATP5IF1 PHACTR4 SESN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MED18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MED18 gene promoter:
  • aMEF-2
  • MEF-2
  • MEF-2A

Genomic Locations for MED18 Gene

Genomic Locations for MED18 Gene
chr1:28,329,002-28,335,967
(GRCh38/hg38)
Size:
6,966 bases
Orientation:
Plus strand
chr1:28,655,513-28,662,478
(GRCh37/hg19)
Size:
6,966 bases
Orientation:
Plus strand

Genomic View for MED18 Gene

Genes around MED18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED18 Gene

Proteins for MED18 Gene

  • Protein details for MED18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUE0-MED18_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 18
    Protein Accession:
    Q9BUE0
    Secondary Accessions:
    • D3DPM1
    • Q9NXU9

    Protein attributes for MED18 Gene

    Size:
    208 amino acids
    Molecular mass:
    23663 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

neXtProt entry for MED18 Gene

Post-translational modifications for MED18 Gene

  • Ubiquitination at isoforms=96
  • Modification sites at PhosphoSitePlus

Other Protein References for MED18 Gene

No data available for DME Specific Peptides for MED18 Gene

Domains & Families for MED18 Gene

Gene Families for MED18 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MED18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUE0

UniProtKB/Swiss-Prot:

MED18_HUMAN :
  • Belongs to the Mediator complex subunit 18 family.
Family:
  • Belongs to the Mediator complex subunit 18 family.
genes like me logo Genes that share domains with MED18: view

Function for MED18 Gene

Molecular function for MED18 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Phenotypes From GWAS Catalog for MED18 Gene

Gene Ontology (GO) - Molecular Function for MED18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12584197
GO:0061630 ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with MED18: view
genes like me logo Genes that share phenotypes with MED18: view

Animal Models for MED18 Gene

MGI Knock Outs for MED18:
  • Med18 Med18<tm1a(EUCOMM)Wtsi>

Animal Model Products

miRNA for MED18 Gene

miRTarBase miRNAs that target MED18

Clone Products

  • Addgene plasmids for MED18

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MED18 Gene

Localization for MED18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED18 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED18 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MED18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
GO:0005634 nucleus IEA --
GO:0016592 mediator complex IDA 14638676
GO:0070847 core mediator complex IBA --
genes like me logo Genes that share ontologies with MED18: view

Pathways & Interactions for MED18 Gene

genes like me logo Genes that share pathways with MED18: view

Gene Ontology (GO) - Biological Process for MED18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006369 termination of RNA polymerase II transcription IBA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MED18: view

No data available for SIGNOR curated interactions for MED18 Gene

Drugs & Compounds for MED18 Gene

No Compound Related Data Available

Transcripts for MED18 Gene

mRNA/cDNA for MED18 Gene

Unigene Clusters for MED18 Gene

Mediator complex subunit 18:
Representative Sequences:

Clone Products

  • Addgene plasmids for MED18

Alternative Splicing Database (ASD) splice patterns (SP) for MED18 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for MED18 Gene

GeneLoc Exon Structure for
MED18
ECgene alternative splicing isoforms for
MED18

Expression for MED18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MED18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MED18 Gene

This gene is overexpressed in Lymph node (16.0), Tlymphocyte (9.8), and Bone (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MED18 Gene



NURSA nuclear receptor signaling pathways regulating expression of MED18 Gene:

MED18

SOURCE GeneReport for Unigene cluster for MED18 Gene:

Hs.479911

Evidence on tissue expression from TISSUES for MED18 Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with MED18: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED18 Gene

Orthologs for MED18 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED18 34 33
  • 99.84 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MED18 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED18 34 33
  • 92.79 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MED18 34 33
  • 92.47 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC682988 33
  • 90.87 (n)
mouse
(Mus musculus)
Mammalia Med18 16 34 33
  • 90.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MED18 34
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED18 34 33
  • 78.69 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med18 33
  • 71.63 (n)
Str.6523 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.12000 33
zebrafish
(Danio rerio)
Actinopterygii med18 34 33
  • 73.08 (n)
OneToOne
zgc63855 33
fruit fly
(Drosophila melanogaster)
Insecta MED18 34 33
  • 60.57 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta MED18_ANOGA 33
  • 58.2 (n)
worm
(Caenorhabditis elegans)
Secernentea mdt-18 34 33
  • 43.64 (n)
OneToOne
Species where no ortholog for MED18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED18 Gene

ENSEMBL:
Gene Tree for MED18 (if available)
TreeFam:
Gene Tree for MED18 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MED18: view image

Paralogs for MED18 Gene

No data available for Paralogs for MED18 Gene

Variants for MED18 Gene

Sequence variations from dbSNP and Humsavar for MED18 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000090415 -- 28,335,913(+) T/A 3_prime_UTR_variant
rs1000273693 -- 28,331,028(+) T/C intron_variant
rs1001191827 -- 28,329,992(+) G/A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001328743 -- 28,330,236(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001339585 -- 28,336,375(+) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MED18 Gene

Variant ID Type Subtype PubMed ID
nsv545916 CNV gain 21841781

Variation tolerance for MED18 Gene

Residual Variation Intolerance Score: 42.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MED18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED18

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED18 Gene

Disorders for MED18 Gene

Additional Disease Information for MED18

No disorders were found for MED18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED18 Gene

Publications for MED18 Gene

  1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S … Conaway RC (Molecular cell 2004) 2 3 4 58
  2. MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X … Roeder RG (Molecular cell 2005) 3 4 58
  3. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PMID: 12584197) Sato S … Conaway JW (The Journal of biological chemistry 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert JP … Gingras AC (Journal of proteomics 2015) 3 58

Products for MED18 Gene

Sources for MED18 Gene

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