Aliases for MED16 Gene
External Ids for MED16 Gene
Previous HGNC Symbols for MED16 Gene
Previous GeneCards Identifiers for MED16 Gene
GeneCards Summary for MED16 Gene
MED16 (Mediator Complex Subunit 16) is a Protein Coding gene. Diseases associated with MED16 include Retinitis Pigmentosa 20 and Mixed Fibrolamellar Hepatocellular Carcinoma. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Gene Expression. Gene Ontology (GO) annotations related to this gene include transcription coregulator activity.
UniProtKB/Swiss-Prot Summary for MED16 Gene
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.