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The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [pr... See more...
Aliases for MED15 Gene
Aliases for MED15 Gene
- Mediator Complex Subunit 15 2 3 4 5
- TIG-1 2 3 4
- PC2 (Positive Cofactor 2, Multiprotein Complex) Glutamine/Q-Rich-Associated Protein 2 3
- Mediator Of RNA Polymerase II Transcription Subunit 15 3 4
- Activator-Recruited Cofactor 105 KDa Component 3 4
- Trinucleotide Repeat-Containing Gene 7 Protein 3 4
- PC2 Glutamine/Q-Rich-Associated Protein 3 4
- Trinucleotide Repeat Containing 7 2 3
- TPA-Inducible Gene 1 Protein 3 4
- CTG Repeat Protein 7a 3 4
- ARC105 3 4
- CAG7A 2 3
External Ids for MED15 Gene
- HGNC: 14248
- Entrez Gene: 51586
- Ensembl: ENSG00000099917
- OMIM: 607372
- UniProtKB: Q96RN5
Previous HGNC Symbols for MED15 Gene
- TNRC7
- PCQAP
Previous GeneCards Identifiers for MED15 Gene
- GC22P019191
- GC22P020850
- GC22P004129
Summaries for MED15 Gene
-
The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
GeneCards Summary for MED15 Gene
MED15 (Mediator Complex Subunit 15) is a Protein Coding gene. Diseases associated with MED15 include Digeorge Syndrome and Noonan Syndrome 5. Among its related pathways are Sterol Regulatory Element-Binding Proteins (SREBP) signalling and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
UniProtKB/Swiss-Prot Summary for MED15 Gene
-
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.
Additional gene information for MED15 Gene
- HGNC(14248)
- Entrez Gene(51586)
- Ensembl(ENSG00000099917)
- OMIM(607372)
- UniProtKB(Q96RN5)
- Open Targets Platform(ENSG00000099917)
- Search for MED15 at DataMed
- Search for MED15 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MED15 Gene
Genomics for MED15 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MED15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MED15 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MED15
- Top Transcription factor binding sites by QIAGEN in the MED15 gene promoter:
-
- FOXO4
- Ik-3
- Lmo2
- NRF-2
- POU2F1
- POU2F1a
- SRF
- SRF (504 AA)
- STAT3
Genomic Locations for MED15 Gene
Genomic Locations for MED15 Gene
- chr22:20,495,913-20,587,632
- (GRCh38/hg38)
- Size:
- 91,720 bases
- Orientation:
- Plus strand
- chr22:20,850,200-20,941,919
- (GRCh37/hg19)
- Size:
- 91,720 bases
- Orientation:
- Plus strand
Genomic View for MED15 Gene
Genes around MED15 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.21 by HGNC
- 22q11.21 by Entrez Gene
- 22q11.21 by Ensembl
MED15 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MED15 Gene
Proteins for MED15 Gene
-
Protein details for MED15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96RN5-MED15_HUMAN
- Recommended name:
- Mediator of RNA polymerase II transcription subunit 15
- Protein Accession:
- Q96RN5
- D3DX31
- D3DX32
- O15413
- Q6IC31
- Q8NF16
- Q96CT0
- Q96IH7
- Q9P1T3
Protein attributes for MED15 Gene
- Size:
- 788 amino acids
- Molecular mass:
- 86753 Da
- Quaternary structure:
-
- Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with SMAD2, SMAD3, SREBF1 and SREBF2. Interacts with WWTR1. Interacts with TRIM11.
- SequenceCaution:
-
- Sequence=AAC12944.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAB85034.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305}; Sequence=BAC03446.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for MED15 Gene
Post-translational modifications for MED15 Gene
- Ubiquitinated by TRIM11, leading to proteasomal degradation.
-
Ubiquitination at Lys578
- NX_Q96RN5 (NX_Q96RN5-1)
- Modification sites at PhosphoSitePlus
Other Protein References for MED15 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ MED15 Antibody
- NSJ Bioreagents MED15 Antibody / PCQAP
-
Custom Antibody ServicesOriGene Antibodies for MED15
- Novus Biologicals Antibodies for MED15
-
Abcam antibodies for MED15
- Invitrogen Antibodies for MED15 (AFLGC-MED15)
-
Biorbyt antibodies for MED15
-
Santa Cruz Biotechnology (SCBT) Antibodies for MED15
Protein Products
-
OriGene Purified Proteins for MED15
- Search Origene for MassSpec and Protein Over-expression Lysates for MED15
- Origene Custom Protein Services for MED15
-
Signalway Proteins for MED15
-
Abcam proteins for MED15
Assay Products
- antibodies-online: Show 12 available MED15 Elisa Kits ranked by validation data
- Compare Top MED15 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for MED15 Gene
Domains & Families for MED15 Gene
Gene Families for MED15 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MED15 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MED15 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58080, highly similar to Positive cofactor 2glutamine/Q-rich-associated protein (B4DGD6_HUMAN)
- cDNA FLJ59342, highly similar to Positive cofactor 2glutamine/Q-rich-associated protein (B4DM43_HUMAN)
- Trinucleotide repeat-containing gene 7 protein (MED15_HUMAN)
- MED15 protein (Q6PKB8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96RN5- Family:
-
- Belongs to the Mediator complex subunit 15 family.
Function for MED15 Gene
Molecular function for MED15 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.
- UniProtKB/Swiss-Prot Induction:
- By 12-O-tetradecanoylphorbol-13-acetate (TPA).
Phenotypes From GWAS Catalog for MED15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003712 | transcription coregulator activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 16799563 |
Phenotypes for MED15 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MED15 - Select products 50% OFF >
- * MED15 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MED15
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MED15
-
Santa Cruz Biotechnology (SCBT) CRISPR for MED15
miRNA for MED15 Gene
- miRTarBase miRNAs that target MED15
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MED15
- Browse OriGene Inhibitory RNA Products For MED15
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MED15
Clone Products
- Applied Biological Materials (abm): Clones for MED15 - Select products 50% OFF >
- * MED15 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MED15
- Addgene plasmids for MED15
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MED15
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED15 Gene
Localization for MED15 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MED15 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0016020 | membrane | HDA | 19946888 |
| GO:0016592 | mediator complex | IEA | -- |
Pathways & Interactions for MED15 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 2 | Gene Expression |
.48
|
|
| 3 | Metabolism |
.40
|
|
| 4 | Developmental Biology | ||
| 5 | DNA Damage/Telomere Stress Induced Senescence |
Signal transduction Activin A signaling regulation
.38
|
|
Pathways by source for MED15 Gene
3 BioSystems pathways for MED15 Gene
9 Reactome pathways for MED15 Gene
1 GeneGo (Thomson Reuters) pathway for MED15 Gene
- Signal transduction Activin A signaling regulation
Interacting Proteins for MED15 Gene
Selected Interacting proteins:
Q96RN5-MED15_HUMAN
ENSP00000263205
for MED15 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MED15
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
| GO:0019827 | stem cell population maintenance | IEA | -- |
No data available for SIGNOR curated interactions for MED15 Gene
Transcripts for MED15 Gene
mRNA/cDNA for MED15 Gene
- 6 REFSEQ mRNAs :
- 30 NCBI additional mRNA sequence :
- 31 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000263205 3351 nts (view in UCSC)
- ENST00000292733 3252 nts (view in UCSC)
- ENST00000382974 2235 nts (view in UCSC)
- ENST00000406969 3210 nts (view in UCSC)
- ENST00000414658 717 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MED15 - Select products 50% OFF >
- * MED15 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MED15
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MED15
-
Santa Cruz Biotechnology (SCBT) CRISPR for MED15
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MED15
- Browse OriGene Inhibitory RNA Products For MED15
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MED15
Clone Products
- Applied Biological Materials (abm): Clones for MED15 - Select products 50% OFF >
- * MED15 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MED15
- Addgene plasmids for MED15
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MED15
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: |
| ExUns: | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · | 18c | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||
| SP16: | - | ||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||
| SP19: | - | - | |||||||||||||||||||||||||
| SP20: |
Relevant External Links for MED15 Gene
- GeneLoc Exon Structure for
- MED15
Expression for MED15 Gene
This gene is overexpressed in Placenta (19.9), Plasma (10.0), and CD8 Tcells (8.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MED15 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MED15
SOURCE GeneReport for Unigene cluster for MED15 Gene:
Hs.517421mRNA Expression by UniProt/SwissProt for MED15 Gene:
Q96RN5-MED15_HUMAN
Tissue specificity:
Expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood leukocyte and placenta. However, the level of expression varied, with highest expression in the placenta and peripheral blood and lowest in the pancreas and kidney.
Evidence on tissue expression from TISSUES for MED15 Gene
- Nervous system(4.9)
- Blood(4.5)
- Kidney(4.5)
- Liver(4.4)
- Spleen(4.3)
- Eye(4.3)
- Pancreas(3.7)
- Lung(3.5)
- Intestine(2.6)
- Skin(2.5)
- Muscle(2.5)
Primer Products
-
OriGene qPCR primer pairs for MED15
-
OriGene qPCR primer pairs and template standards for MED15
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED15 Gene
Orthologs for MED15 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MED15 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MED15 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MED15 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Med15 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | MED15 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MED15 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | ARC105 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.11806 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | med15 31 |
|
OneToOne | |
| Dr.7497 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.986 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | MED15 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for MED15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MED15 Gene
- ENSEMBL:
- Gene Tree for MED15 (if available)
- TreeFam:
- Gene Tree for MED15 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MED15: view image
Paralogs for MED15 Gene
(41) SIMAP similar genes for MED15 Gene using alignment to 19 proteins:
- MED15_HUMAN
- B4DM43_HUMAN
- C9J1I1_HUMAN
- C9JCQ3_HUMAN
- C9JEM1_HUMAN
- C9JGN2_HUMAN
- C9JJ12_HUMAN
- C9JLN7_HUMAN
- C9JM58_HUMAN
- C9JWK5_HUMAN
- C9JZV5_HUMAN
- F2Z2B7_HUMAN
- F5GZU5_HUMAN
- F8WCS1_HUMAN
- F8WDM6_HUMAN
- F8WEJ4_HUMAN
- G3V1P5_HUMAN
- H7C308_HUMAN
- Q6PKB8_HUMAN
Pseudogenes.org Pseudogenes for MED15 Gene
No data available for Paralogs for MED15 Gene
Variants for MED15 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for MED15 Gene
- MED15_HUMAN-Q96RN5
- The poly-Gln region from amino acids 235-262 of PCQAP is polymorphic. There are from 15 to 18 repeats in the Italian population.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MED15 Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 691392 | Uncertain Significance: Hirschsprung disease | 20,566,719(+) | C/A | MISSENSE_VARIANT | |
| 711359 | Likely Benign: not provided | 20,566,679(+) | G/A | SYNONYMOUS_VARIANT | |
| 770675 | Benign: not provided | 20,537,211(+) | C/CCCTA | INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4483n100 | CNV | gain | 25217958 |
| dgv7993n54 | CNV | gain | 21841781 |
| dgv7994n54 | CNV | gain | 21841781 |
| esv25802 | CNV | gain | 19812545 |
| esv2763693 | CNV | gain | 21179565 |
| esv3647294 | CNV | loss | 21293372 |
| esv3647295 | CNV | loss | 21293372 |
| esv3893438 | CNV | gain | 25118596 |
| nsv1056614 | CNV | loss | 25217958 |
| nsv1062650 | CNV | gain | 25217958 |
| nsv3561 | CNV | insertion | 18451855 |
| nsv3562 | CNV | deletion | 18451855 |
| nsv436864 | CNV | insertion | 17901297 |
| nsv509810 | CNV | insertion | 20534489 |
| nsv523162 | CNV | loss | 19592680 |
| nsv588293 | CNV | gain | 21841781 |
| nsv588298 | CNV | gain | 21841781 |
| nsv819580 | CNV | gain | 19587683 |
| nsv821342 | CNV | deletion | 20802225 |
| nsv828954 | CNV | gain | 20364138 |
| nsv828956 | CNV | gain | 20364138 |
| nsv834136 | CNV | loss | 17160897 |
| nsv834138 | CNV | loss | 17160897 |
| nsv834139 | CNV | loss | 17160897 |
| nsv953033 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
15.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.14;
38.87% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MED15 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MED15
SNP Genotyping and Copy Number Assay Products
Disorders for MED15 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| digeorge syndrome |
|
|
| noonan syndrome 5 |
|
|
| velocardiofacial syndrome |
|
|
| tetralogy of fallot |
|
|
Search MED15 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MED15
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MED15 Gene
Publications for MED15 Gene
- Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a mediator subunit. (PMID: 11414760) Berti L … Meisterernst M (Genomics 2001) 2 3 4 23
- An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. (PMID: 16799563) Yang F … Näär AM (Nature 2006) 3 4 23
- A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S … Conaway RC (Molecular cell 2004) 2 3 4
- Association study between CAG trinucleotide repeats in the PCQAP gene (PC2 glutamine/Q-rich-associated protein) and schizophrenia. (PMID: 12497610) De Luca A … Novelli G (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2003) 3 23 41
- A novel glutamine-rich putative transcriptional adaptor protein (TIG-1), preferentially expressed in placental and bone-marrow tissues. (PMID: 11024300) Abraham S … Solomon WB (Gene 2000) 2 3 4
ExternalLinks
Products for MED15 Gene
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- VectorBuilder Stable cell line generation for MED15
- Addgene plasmids for MED15
- antibodies-online: Show 17 available MED15 Antibodies ranked by validation data
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- antibodies-online: Show 12 available MED15 Elisa Kits ranked by validation data
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- antibodies-online: Show 5 available MED15 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for MED15
- Search Santa Cruz Biotechnology (SCBT) for MED15 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MED15
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MED15
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MED15
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MED15
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MED15
- Biorbyt antibodies for MED15
- Signalway Proteins for MED15
Sources for MED15 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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- (43) HuGE
- (44) Atlas
- (45) GenBank
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- (48) IMGT
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- (50) miRBase
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- (55) TGDB
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- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106)