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Aliases for MED15 Gene

Aliases for MED15 Gene

  • Mediator Complex Subunit 15 2 3 4 5
  • PC2 (Positive Cofactor 2, Multiprotein Complex) Glutamine/Q-Rich-Associated Protein 2 3
  • Activator-Recruited Cofactor 105 KDa Component 3 4
  • Trinucleotide Repeat-Containing Gene 7 Protein 3 4
  • PC2 Glutamine/Q-Rich-Associated Protein 3 4
  • Trinucleotide Repeat Containing 7 2 3
  • TPA-Inducible Gene 1 Protein 3 4
  • CTG Repeat Protein 7a 3 4
  • ARC105 3 4
  • PCQAP 3 4
  • TNRC7 3 4
  • CTG7A 3 4
  • TIG-1 3 4
  • TIG1 3 4
  • Positive Cofactor 2, Glutamine/Q-Rich-Associated Protein 3
  • Positive Cofactor 2 Glutamine/Q-Rich-Associated Protein 4
  • Mediator Of RNA Polymerase II Transcription Subunit 15 3
  • PC2-Glutamine-Rich-Associated Protein 3
  • Activator-Recruited Cofactor, 105-KD 3
  • TPA Inducible Protein 3
  • TPA Inducible Gene-1 3
  • CAG7A 3

External Ids for MED15 Gene

Previous HGNC Symbols for MED15 Gene

  • TNRC7
  • PCQAP

Previous GeneCards Identifiers for MED15 Gene

  • GC22P019191
  • GC22P020850
  • GC22P004129

Summaries for MED15 Gene

Entrez Gene Summary for MED15 Gene

  • The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for MED15 Gene

MED15 (Mediator Complex Subunit 15) is a Protein Coding gene. Diseases associated with MED15 include Chromosome 22Q11.2 Duplication Syndrome and Velocardiofacial Syndrome. Among its related pathways are Gene Expression and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED15 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.

Gene Wiki entry for MED15 Gene

Additional gene information for MED15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED15 Gene

Genomics for MED15 Gene

GeneHancer (GH) Regulatory Elements for MED15 Gene

Promoters and enhancers for MED15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I020494 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 655.3 -0.1 -70 2.7 CLOCK FEZF1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 MED15 KLHL22 LOC101928824 LZTR1 DGCR8 RPL7AP70 TRMT2A RPL8P5 LOC100420177 THAP7
GH22I020506 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 593.9 +13.6 13589 5.8 HDGF HNRNPUL1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 MED15 LZTR1 LOC100420177 DGCR8 TRMT2A RPL7AP70 RPL8P5 ZNF74 KLHL22 ABHD17AP4
GH22I020078 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 66.4 -414.4 -414392 5.2 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 DGCR8 LZTR1 TRMT2A MED15 RPL7AP70 RPL8P5 UFD1 ENSG00000273300 LOC100420177 RANBP1
GH22I020916 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 40.3 +423.0 422984 5.7 HNRNPUL1 PKNOX1 CLOCK MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CRKL SNAP29 MED15 LZTR1 SERPIND1 ZNF74 PPIL2 ENSG00000273343 KLHL22 ENSG00000225544
GH22I020548 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 53.4 +58.0 58001 10.5 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX ARNT ARID4B YBX1 FEZF1 YY1 MED15 LZTR1 DGCR8 TRMT2A LOC100420177 THAP7-AS1 KLHL22 THAP7 RPL7AP70 ZDHHC8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MED15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MED15 gene promoter:

Genomic Locations for MED15 Gene

Genomic Locations for MED15 Gene
chr22:20,495,913-20,587,632
(GRCh38/hg38)
Size:
91,720 bases
Orientation:
Plus strand
chr22:20,850,200-20,941,919
(GRCh37/hg19)

Genomic View for MED15 Gene

Genes around MED15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED15 Gene

Proteins for MED15 Gene

  • Protein details for MED15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RN5-MED15_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 15
    Protein Accession:
    Q96RN5
    Secondary Accessions:
    • D3DX31
    • D3DX32
    • O15413
    • Q6IC31
    • Q8NF16
    • Q96CT0
    • Q96IH7
    • Q9P1T3

    Protein attributes for MED15 Gene

    Size:
    788 amino acids
    Molecular mass:
    86753 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with SMAD2, SMAD3, SREBF1 and SREBF2. Interacts with WWTR1. Interacts with TRIM11.
    SequenceCaution:
    • Sequence=AAC12944.1; Type=Frameshift; Positions=13, 600, 749; Evidence={ECO:0000305}; Sequence=BAB85034.1; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305}; Sequence=BAC03446.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MED15 Gene

    Alternative splice isoforms for MED15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED15 Gene

Post-translational modifications for MED15 Gene

  • Ubiquitinated by TRIM11, leading to proteasomal degradation.
  • Ubiquitination at posLast=578578
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MED15 Gene

Domains & Families for MED15 Gene

Gene Families for MED15 Gene

Protein Domains for MED15 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96RN5

UniProtKB/Swiss-Prot:

MED15_HUMAN :
  • Belongs to the Mediator complex subunit 15 family.
Family:
  • Belongs to the Mediator complex subunit 15 family.
genes like me logo Genes that share domains with MED15: view

Function for MED15 Gene

Molecular function for MED15 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.
UniProtKB/Swiss-Prot Induction:
By 12-O-tetradecanoylphorbol-13-acetate (TPA).

Phenotypes From GWAS Catalog for MED15 Gene

Gene Ontology (GO) - Molecular Function for MED15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA --
GO:0005515 protein binding IPI 16799563
genes like me logo Genes that share ontologies with MED15: view
genes like me logo Genes that share phenotypes with MED15: view

Animal Model Products

miRNA for MED15 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED15 Gene

Localization for MED15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED15 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED15 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MED15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA,HDA 19946888
GO:0016592 mediator complex IEA --
genes like me logo Genes that share ontologies with MED15: view

Pathways & Interactions for MED15 Gene

genes like me logo Genes that share pathways with MED15: view

Gene Ontology (GO) - Biological Process for MED15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with MED15: view

No data available for SIGNOR curated interactions for MED15 Gene

Drugs & Compounds for MED15 Gene

(1) Drugs for MED15 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MED15: view

Transcripts for MED15 Gene

Unigene Clusters for MED15 Gene

Mediator complex subunit 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED15 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^
SP1:
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - -
SP12: - - - -
SP13: - - -
SP14: - -
SP15: -
SP16: - - - -
SP17:
SP18:
SP19:
SP20:

ExUns: 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19: - -
SP20:

Relevant External Links for MED15 Gene

GeneLoc Exon Structure for
MED15
ECgene alternative splicing isoforms for
MED15

Expression for MED15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MED15 Gene

Protein differential expression in normal tissues from HIPED for MED15 Gene

This gene is overexpressed in Placenta (19.9), Plasma (10.0), and CD8 Tcells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MED15 Gene



Protein tissue co-expression partners for MED15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MED15 Gene:

MED15

SOURCE GeneReport for Unigene cluster for MED15 Gene:

Hs.517421

mRNA Expression by UniProt/SwissProt for MED15 Gene:

Q96RN5-MED15_HUMAN
Tissue specificity: Expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood leukocyte and placenta. However, the level of expression varied, with highest expression in the placenta and peripheral blood and lowest in the pancreas and kidney.

Evidence on tissue expression from TISSUES for MED15 Gene

  • Nervous system(4.9)
  • Blood(4.4)
  • Eye(4.3)
  • Kidney(4.3)
  • Spleen(4.3)
  • Liver(4.2)
  • Pancreas(3.4)
  • Lung(3.3)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with MED15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED15 Gene

Orthologs for MED15 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED15 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED15 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED15 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med15 34
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 89 (a)
OneToMany
-- 34
  • 61 (a)
OneToMany
-- 34
  • 52 (a)
OneToMany
-- 34
  • 44 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MED15 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED15 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11806 33
African clawed frog
(Xenopus laevis)
Amphibia ARC105 33
zebrafish
(Danio rerio)
Actinopterygii med15 34
  • 59 (a)
OneToOne
Dr.7497 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.986 33
fruit fly
(Drosophila melanogaster)
Insecta MED15 34
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToOne
Species where no ortholog for MED15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED15 Gene

ENSEMBL:
Gene Tree for MED15 (if available)
TreeFam:
Gene Tree for MED15 (if available)

Paralogs for MED15 Gene

genes like me logo Genes that share paralogs with MED15: view

No data available for Paralogs for MED15 Gene

Variants for MED15 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MED15 Gene

MED15_HUMAN-Q96RN5
The poly-Gln region from amino acids 235-262 of PCQAP is polymorphic. There are from 15 to 18 repeats in the Italian population.

Sequence variations from dbSNP and Humsavar for MED15 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000017832 -- 20,575,948(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000020117 -- 20,524,701(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000079152 -- 20,543,414(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000088313 -- 20,569,028(+) G/A coding_sequence_variant, intron_variant, synonymous_variant
rs1000129895 -- 20,543,017(+) TTTTTT/TTTTT genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MED15 Gene

Variant ID Type Subtype PubMed ID
dgv4483n100 CNV gain 25217958
dgv7993n54 CNV gain 21841781
dgv7994n54 CNV gain 21841781
esv25802 CNV gain 19812545
esv2763693 CNV gain 21179565
esv3647294 CNV loss 21293372
esv3647295 CNV loss 21293372
esv3893438 CNV gain 25118596
nsv1056614 CNV loss 25217958
nsv1062650 CNV gain 25217958
nsv3561 CNV insertion 18451855
nsv3562 CNV deletion 18451855
nsv436864 CNV insertion 17901297
nsv509810 CNV insertion 20534489
nsv523162 CNV loss 19592680
nsv588293 CNV gain 21841781
nsv588298 CNV gain 21841781
nsv819580 CNV gain 19587683
nsv821342 CNV deletion 20802225
nsv828954 CNV gain 20364138
nsv828956 CNV gain 20364138
nsv834136 CNV loss 17160897
nsv834138 CNV loss 17160897
nsv834139 CNV loss 17160897
nsv953033 CNV deletion 24416366

Variation tolerance for MED15 Gene

Residual Variation Intolerance Score: 15.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MED15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED15

SNP Genotyping and Copy Number Assay Products

Disorders for MED15 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MED15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 22q11.2 duplication syndrome
  • chromosome 22q11.2 microduplication syndrome
velocardiofacial syndrome
  • chromosome 22q11.2 deletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search MED15 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MED15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MED15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MED15 Gene

Publications for MED15 Gene

  1. Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a mediator subunit. (PMID: 11414760) Berti L … Meisterernst M (Genomics 2001) 2 3 4 22 58
  2. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. (PMID: 16799563) Yang F … Näär AM (Nature 2006) 3 4 22 58
  3. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S … Conaway RC (Molecular cell 2004) 2 3 4 58
  4. Association study between CAG trinucleotide repeats in the PCQAP gene (PC2 glutamine/Q-rich-associated protein) and schizophrenia. (PMID: 12497610) De Luca A … Novelli G (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2003) 3 22 44 58
  5. A novel glutamine-rich putative transcriptional adaptor protein (TIG-1), preferentially expressed in placental and bone-marrow tissues. (PMID: 11024300) Abraham S … Solomon WB (Gene 2000) 2 3 4 58

Products for MED15 Gene

Sources for MED15 Gene