Aliases for MED12L Gene
External Ids for MED12L Gene
Previous GeneCards Identifiers for MED12L Gene
The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010]
GeneCards Summary for MED12L Gene
MED12L (Mediator Complex Subunit 12L) is a Protein Coding gene. Diseases associated with MED12L include Alacrima, Achalasia, And Mental Retardation Syndrome and Usher Syndrome. Among its related pathways are Thyroid hormone signaling pathway. Gene Ontology (GO) annotations related to this gene include transcription factor binding. An important paralog of this gene is MED12.
UniProtKB/Swiss-Prot Summary for MED12L Gene
May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).