The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TF... See more...

Aliases for MED1 Gene

Aliases for MED1 Gene

  • Mediator Complex Subunit 1 2 3 4 5
  • Thyroid Hormone Receptor-Associated Protein Complex 220 KDa Component 3 4
  • Vitamin D Receptor-Interacting Protein Complex Component DRIP205 3 4
  • Peroxisome Proliferator-Activated Receptor-Binding Protein 3 4
  • Mediator Of RNA Polymerase II Transcription Subunit 1 3 4
  • Activator-Recruited Cofactor 205 KDa Component 3 4
  • P53 Regulatory Protein RB18A 3 4
  • TR-Interacting Protein 2 3 4
  • PPAR-Binding Protein 3 4
  • PPARGBP 3 4
  • CRSP200 3 4
  • DRIP205 3 4
  • DRIP230 3 4
  • TRAP220 3 4
  • PPARBP 3 4
  • ARC205 3 4
  • TRIP-2 3 4
  • TRIP2 3 4
  • CRSP1 3 4
  • RB18A 3 4
  • PBP 3 4
  • Thyroid Hormone Receptor-Associated Protein Complex Component TRAP220 3
  • Vitamin D Receptor-Interacting Protein 230 KD 3
  • Thyroid Receptor Interacting Protein 2 3
  • Thyroid Receptor-Interacting Protein 2 4
  • PPARG Binding Protein 3
  • PPAR Binding Protein 2
  • Trap220 4

External Ids for MED1 Gene

Previous HGNC Symbols for MED1 Gene

  • TRIP2
  • PPARGBP
  • PPARBP

Previous GeneCards Identifiers for MED1 Gene

  • GC17M034815
  • GC17M037560
  • GC17M033354

Summaries for MED1 Gene

Entrez Gene Summary for MED1 Gene

  • The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED1 Gene

MED1 (Mediator Complex Subunit 1) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Glioma. Gene Ontology (GO) annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot Summary for MED1 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).

Gene Wiki entry for MED1 Gene

Additional gene information for MED1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MED1 Gene

Genomics for MED1 Gene

GeneHancer (GH) Regulatory Elements for MED1 Gene

Promoters and enhancers for MED1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MED1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MED1

Top Transcription factor binding sites by QIAGEN in the MED1 gene promoter:
  • c-Myb
  • Elk-1
  • GATA-1
  • GR
  • GR-alpha
  • MAZR
  • Meis-1
  • Meis-1a
  • Meis-1b
  • STAT3

Genomic Locations for MED1 Gene

Genomic Locations for MED1 Gene
chr17:39,404,285-39,451,280
(GRCh38/hg38)
Size:
46,996 bases
Orientation:
Minus strand
chr17:37,560,538-37,607,539
(GRCh37/hg19)
Size:
47,002 bases
Orientation:
Minus strand

Genomic View for MED1 Gene

Genes around MED1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED1 Gene

Proteins for MED1 Gene

  • Protein details for MED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15648-MED1_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 1
    Protein Accession:
    Q15648
    Secondary Accessions:
    • A2RRQ6
    • O43810
    • O75447
    • Q6P9H7
    • Q6PK58
    • Q9HD39

    Protein attributes for MED1 Gene

    Size:
    1581 amino acids
    Molecular mass:
    168478 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. This subunit specifically interacts with a number of nuclear receptors in a ligand-dependent fashion including AR, ESR1, ESR2, PPARA, PPARG, RORA, RXRA, RXRG, THRA, THRB and VDR. Interacts with CTNNB1, GABPA, GLI3, PPARGC1A and TP53. Interacts with YWHAH. Interacts with CLOCK; this interaction requires the presence of THRAP3 (By similarity). Interacts with GATA1 and CCAR1. Interacts with NR4A3 (By similarity). Interacts (via IBM motif) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (PubMed:29997176).
    SequenceCaution:
    • Sequence=AAC39854.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH06517.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAA73867.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MED1 Gene

    Alternative splice isoforms for MED1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED1 Gene

Post-translational modifications for MED1 Gene

  • Phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability and promote entry into the nucleolus (PubMed:16314496). Phosphorylation increases its interaction with PSIP1 (PubMed:29997176).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MED1 Gene

No data available for DME Specific Peptides for MED1 Gene

Domains & Families for MED1 Gene

Gene Families for MED1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MED1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED1 Gene

GenScript: Design optimal peptide antigens:
  • p53 regulatory protein RB18A (MED1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15648

UniProtKB/Swiss-Prot:

MED1_HUMAN :
  • Belongs to the Mediator complex subunit 1 family.
Family:
  • Belongs to the Mediator complex subunit 1 family.
genes like me logo Genes that share domains with MED1: view

Function for MED1 Gene

Molecular function for MED1 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).

Phenotypes From GWAS Catalog for MED1 Gene

Gene Ontology (GO) - Molecular Function for MED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA,IMP 17641689
GO:0003712 transcription coregulator activity IDA 10198638
genes like me logo Genes that share ontologies with MED1: view
genes like me logo Genes that share phenotypes with MED1: view

Animal Models for MED1 Gene

MGI Knock Outs for MED1:
  • Med1 Med1<tm1Jkr>
  • Med1 Med1<tm1Rgr>
  • Med1 Med1<tm1.1Mpk>
  • Med1 Med1<tm3b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for MED1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MED1 Gene

Localization for MED1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED1 Gene

Nucleus. Note=A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED1 gene
Compartment Confidence
nucleus 5
peroxisome 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
GO:0000785 chromatin IEA --
GO:0005634 nucleus IDA,IEA 10235267
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 16314496
genes like me logo Genes that share ontologies with MED1: view

Pathways & Interactions for MED1 Gene

genes like me logo Genes that share pathways with MED1: view

Pathways by source for MED1 Gene

2 GeneGo (Thomson Reuters) pathways for MED1 Gene
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
  • Transcription PPAR Pathway
1 Qiagen pathway for MED1 Gene
  • Estrogen Pathway
1 Cell Signaling Technology pathway for MED1 Gene

SIGNOR curated interactions for MED1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0000902 cell morphogenesis IMP 17223341
GO:0001525 angiogenesis ISS,IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001889 liver development IEA --
genes like me logo Genes that share ontologies with MED1: view

Drugs & Compounds for MED1 Gene

(6) Drugs for MED1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Becocalcidiol Investigational Pharma Target 0

(6) Additional Compounds for MED1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MED1: view

Transcripts for MED1 Gene

mRNA/cDNA for MED1 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for MED1

Alternative Splicing Database (ASD) splice patterns (SP) for MED1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2: - -
SP3: - - -
SP4:
SP5:
SP6: -
SP7:

Relevant External Links for MED1 Gene

GeneLoc Exon Structure for
MED1

Expression for MED1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MED1 Gene

This gene is overexpressed in Lung (16.8), Blymphocyte (8.6), Monocytes (6.8), and Tlymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MED1 Gene



Protein tissue co-expression partners for MED1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MED1

SOURCE GeneReport for Unigene cluster for MED1 Gene:

Hs.643754

mRNA Expression by UniProt/SwissProt for MED1 Gene:

Q15648-MED1_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for MED1 Gene

  • Liver(4.6)
  • Intestine(4.4)
  • Heart(4.3)
  • Nervous system(4.3)
  • Skin(3.3)
  • Lung(2.9)
  • Kidney(2.7)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with MED1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED1 Gene

Orthologs for MED1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED1 31 30
  • 99.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MED1 31 30
  • 95.22 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MED1 31 30
  • 94.88 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MED1 31
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med1 30
  • 90.73 (n)
mouse
(Mus musculus)
Mammalia Med1 17 31 30
  • 90.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MED1 31
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED1 31 30
  • 78.94 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED1 31
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med1 30
  • 67.85 (n)
Str.18690 30
zebrafish
(Danio rerio)
Actinopterygii med1 31
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta MED1 31
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 36 (a)
OneToOne
Species where no ortholog for MED1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED1 Gene

ENSEMBL:
Gene Tree for MED1 (if available)
TreeFam:
Gene Tree for MED1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MED1: view image

Paralogs for MED1 Gene

No data available for Paralogs for MED1 Gene

Variants for MED1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MED1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs193921049 Uncertain Significance: Malignant tumor of prostate 39,431,132(-) A/C MISSENSE_VARIANT
rs1139825 - p.Pro753Thr
rs35668211 - p.Ser1240Gly

Additional dbSNP identifiers (rs#s) for MED1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MED1 Gene

Variant ID Type Subtype PubMed ID
nsv1055612 CNV gain 25217958
nsv1063848 CNV gain 25217958
nsv1146669 OTHER inversion 26484159

Variation tolerance for MED1 Gene

Residual Variation Intolerance Score: 0.958% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MED1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED1 Gene

Disorders for MED1 Gene