Aliases for MECOM Gene
Aliases for MECOM Gene
- MDS1 And EVI1 Complex Locus 2 3 5
- Ecotropic Virus Integration Site 1 Protein Homolog 3 4
- Myelodysplasia Syndrome-Associated Protein 1 3 4
- PR Domain 3 2 3
- EVI1 3 4
- MDS1 3 4
- MDS1 And EVI1 Complex Locus Protein EVI1 3
- MDS1 And EVI1 Complex Locus Protein MDS1 3
- Ecotropic Viral Integration Site 1 2
- Myelodysplasia Syndrome 1 Protein 4
- Myelodysplasia Syndrome 1 2
External Ids for MECOM Gene
Previous HGNC Symbols for MECOM Gene
- MDS1
- EVI1
Previous GeneCards Identifiers for MECOM Gene
- GC03M170284
- GC03M168802
- GC03M166172
Summaries for MECOM Gene
-
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
GeneCards Summary for MECOM Gene
MECOM (MDS1 And EVI1 Complex Locus) is a Protein Coding gene. Diseases associated with MECOM include Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia 2 and Radio-Ulnar Synostosis-Amegakaryocytic Thrombocytopenia Syndrome. Among its related pathways are Chronic myeloid leukemia and PKMTs methylate histone lysines. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein homodimerization activity. An important paralog of this gene is PRDM16.
UniProtKB/Swiss-Prot for MECOM Gene
-
Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.
Additional gene information for MECOM Gene
- HGNC(3498)
- Entrez Gene(2122)
- Ensembl(ENSG00000085276)
- OMIM(165215)
- UniProtKB(Q03112)
- UniProtKB(Q13465)
- Monarch Initiative
- Search for MECOM at DataMed
- Search for MECOM at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MECOM Gene
Genomics for MECOM Gene
GeneHancer (GH) Regulatory Elements for MECOM Gene
Promoters and enhancers for MECOM Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MECOM on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MECOM Gene
Genomic Locations for MECOM Gene
- chr3:169,083,499-169,663,786
- (GRCh38/hg38)
- Size:
- 580,288 bases
- Orientation:
- Minus strand
- chr3:168,801,287-169,381,563
- (GRCh37/hg19)
Genomic View for MECOM Gene
Genes around MECOM on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q26.2 by Ensembl
- 3q26.2 by Entrez Gene
- 3q26.2 by HGNC
MECOM Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MECOM Gene
Proteins for MECOM Gene
-
Protein details for MECOM Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q03112-EVI1_HUMAN
- Recommended name:
- MDS1 and EVI1 complex locus protein EVI1
- Protein Accession:
- Q03112
- A1L4F3
- A8KA00
- B7Z8W7
- B7ZLQ3
- B7ZLQ4
- C9JAK0
- D3DNP7
- Q16122
- Q5HYI1
- Q6MZS6
- Q8NEI5
- Q99917
Protein attributes for MECOM Gene
- Size:
- 1051 amino acids
- Molecular mass:
- 118276 Da
- Quaternary structure:
-
- Homooligomer. Interacts with SUV39H1 (via SET domain); enhances MECOM transcriptional repression activity (By similarity). Interacts with CTBP1. Interacts with SMAD3 (via MH2 domain); the interaction is direct. Interacts with SMAD4; through interaction with SMAD3. Interacts with CREBBP, KAT2B and histone deacetylases. Interacts with MAPK8 and MAPK9; inhibits JNK signaling.
- SequenceCaution:
-
- Sequence=AAB29907.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAB37456.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAI30521.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAH14103.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
-
Protein details for MECOM Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13465-MDS1_HUMAN
- Recommended name:
- MDS1 and EVI1 complex locus protein MDS1
- Protein Accession:
- Q13465
- Q13466
- Q6FH90
Protein attributes for MECOM Gene
- Size:
- 169 amino acids
- Molecular mass:
- 18696 Da
- Quaternary structure:
- No Data Available
Protein Expression for MECOM Gene
Post-translational modifications for MECOM Gene
- May be acetylated by CREBBP and KAT2B.
- Phosphorylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MECOM Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001098547.3
- NP_001098548.2
- NP_001157471.1
- NP_001157472.1
- NP_001192123.1
- NP_004982.2
- NP_005232.2
- XP_005247270.1
- XP_005247271.1
- XP_005247272.1
- XP_005247276.1
- XP_005247277.1
- XP_005247278.1
- XP_005247280.1
- XP_005247281.1
- XP_005247282.1
- XP_005247283.1
- XP_011510848.1
- XP_016861363.1
- XP_016861364.1
- XP_016861365.1
- XP_016861366.1
- XP_016861367.1
Antibody Products
- R&D Systems Antibodies for MECOM (EVI-1)
-
Custom Antibody ServicesOriGene Antibodies for MECOM
- Novus Biologicals Antibodies for MECOM
-
Abcam antibodies for MECOM
- Invitrogen Antibodies for MECOM
- antibodies-online: Search results for 3 available MDS1 Antibodies ranked by validation data
- Compare Top MDS1 Antibodies
-
Quality Products:
- GeneTex MECOM antibody for MECOM
-
Santa Cruz Biotechnology (SCBT) Antibodies for MECOM
- Sino Biological Antibodies for MECOM
Protein Products
-
OriGene Purified Proteins for MECOM
- Search Origene for MassSpec and Protein Over-expression Lysates for MECOM
- Origene Custom Protein Services for MECOM
- ProSpec Recombinant Proteins for MECOM
- Search GeneTex for Proteins for MECOM
-
Abcam proteins for MECOM
Assay Products
- antibodies-online: Search results for 2 available MDS1 Elisa Kits ranked by validation data
- Compare Top MDS1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for MECOM Gene
Domains & Families for MECOM Gene
Gene Families for MECOM Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for MECOM Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MECOM Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q03112UniProtKB/Swiss-Prot:
MDS1_HUMAN :- Both zinc finger regions are required for the transcriptional activation of PBX1.
- Domain:
-
- Both zinc finger regions are required for the transcriptional activation of PBX1.
Function for MECOM Gene
Molecular function for MECOM Gene
- UniProtKB/Swiss-Prot Function:
- Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.
Phenotypes From GWAS Catalog for MECOM Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | ISS | -- |
| GO:0003700 | DNA binding transcription factor activity | IDA | 19767769 |
| GO:0005515 | protein binding | IPI | 10856240 |
| GO:0018024 | histone-lysine N-methyltransferase activity | TAS | -- |
Phenotypes for MECOM Gene
- MGI mutant phenotypes for MECOM:
-
inferred from 8 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- reproductive system phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- adipose tissue phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for MECOM:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
- Decreased viability after Maraba virus infection
- Decreased HIV-LTR-beta-galactosidase protein expression
- Weakly decreased NFAT1-GFP nuclear translocation
- Increased viability with SS1P at EC90
- Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression
- Increased Nanog expression
- Condensed cis-Golgi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MECOM
-
- Search ViGene Biosciences for MECOM
CRISPR Products
-
OriGene CRISPR knockouts for MECOM
- genomics-online: gRNA clones - Search results for available MDS1 gene related products
- Applied Biological Materials CRISPR for MECOM
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MECOM
- GenScript: Design CRISPR guide RNA sequences for MECOM
miRNA for MECOM Gene
- miRTarBase miRNAs that target MECOM
Transcription Factor Targets for MECOM Gene
miRNA Products
- Search ViGene Biosciences for MECOM
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MECOM
- Browse OriGene Inhibitory RNA Products For MECOM
- genomics-online: shRNA clones - Search results for available MDS1 gene related products
Clone Products
-
OriGene ORF clones in human for MECOM
- RG221770
- RC221770L2
- RC221770L1
- RC221770
- RG229420
- RC229420L2
- RC229420L1
- RC229420
- RG235140
- RC235140
- RG229058
- RC229058L2
- RC229058L1
- RC229058
- RG229059
- RC229059L2
- RC229059L1
- RC229059
- RG226310
- RC226310L2
- RC226310L1
- RC226310
- RG229410
- RG226334
- RC229410L2
- RC229410L1
- RC229410
- RC226334L2
- RC226334L1
- RC226334
- RC221770L2V
- RC221770L1V
- RC229420L2V
- RC229420L1V
- RC229058L2V
- RC229058L1V
- RC229059L2V
- RC229059L1V
- RC226310L2V
- RC226310L1V
- RC229410L2V
- RC229410L1V
- RC226334L2V
- RC226334L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for MECOM
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MECOM
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MECOM
- genomics-online: cdna clones - Search results for available MDS1 gene related products
- orf clones - Search results for available MDS1 gene related products
- Applied Biological Materials Clones for MECOM
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MECOM
No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for MECOM Gene
Localization for MECOM Gene
Subcellular locations from UniProtKB/Swiss-Prot for MECOM Gene
- Nucleus. Nucleus speckle.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
- Nuclear speckles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000118 | colocalizes_with histone deacetylase complex | IDA | 11568182 |
| GO:0005634 | nucleus | IDA,IEA | 15897867 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016607 | nuclear speck | IEA,IDA | 11568182 |
Pathways & Interactions for MECOM Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chromatin organization | ||
| 2 | Chronic myeloid leukemia | ||
| 3 | MAPK signaling pathway | ||
| 4 | Pathways in cancer | ||
| 5 | NF-kappaB Signaling | ||
Pathways by source for MECOM Gene
3 Reactome pathways for MECOM Gene
3 KEGG pathways for MECOM Gene
1 GeneGo (Thomson Reuters) pathway for MECOM Gene
1 Cell Signaling Technology pathway for MECOM Gene
Interacting Proteins for MECOM Gene
Selected Interacting proteins:
ENSP00000264674
Q13465-MDS1_HUMAN
Q03112-EVI1_HUMAN
for MECOM Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
Transcripts for MECOM Gene
mRNA/cDNA for MECOM Gene
- (23) REFSEQ mRNAs :
- (25) Additional mRNA sequences :
- (120) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MECOM Gene
CRISPR Products
-
OriGene CRISPR knockouts for MECOM
- genomics-online: gRNA clones - Search results for available MDS1 gene related products
- Applied Biological Materials CRISPR for MECOM
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MECOM
- GenScript: Design CRISPR guide RNA sequences for MECOM
miRNA Products
- Search ViGene Biosciences for MECOM
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MECOM
- Browse OriGene Inhibitory RNA Products For MECOM
- genomics-online: shRNA clones - Search results for available MDS1 gene related products
Clone Products
-
OriGene ORF clones in human for MECOM
- RG221770
- RC221770L2
- RC221770L1
- RC221770
- RG229420
- RC229420L2
- RC229420L1
- RC229420
- RG235140
- RC235140
- RG229058
- RC229058L2
- RC229058L1
- RC229058
- RG229059
- RC229059L2
- RC229059L1
- RC229059
- RG226310
- RC226310L2
- RC226310L1
- RC226310
- RG229410
- RG226334
- RC229410L2
- RC229410L1
- RC229410
- RC226334L2
- RC226334L1
- RC226334
- RC221770L2V
- RC221770L1V
- RC229420L2V
- RC229420L1V
- RC229058L2V
- RC229058L1V
- RC229059L2V
- RC229059L1V
- RC226310L2V
- RC226310L1V
- RC229410L2V
- RC229410L1V
- RC226334L2V
- RC226334L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for MECOM
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MECOM
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MECOM
- genomics-online: cdna clones - Search results for available MDS1 gene related products
- orf clones - Search results for available MDS1 gene related products
- Applied Biological Materials Clones for MECOM
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
| ExUns: | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | |||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
| SP8: | |||||||||
| SP9: | |||||||||
| SP10: |
Expression for MECOM Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for MECOM Gene
This gene is overexpressed in Stomach (x6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MECOM Gene
NURSA nuclear receptor signaling pathways regulating expression of MECOM Gene:
MECOMSOURCE GeneReport for Unigene cluster for MECOM Gene:
Hs.744090Evidence on tissue expression from TISSUES for MECOM Gene
- Lung(4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MECOM Gene
Germ Layers:
- mesoderm
Systems:
- cardiovascular
Regions:
General:
- blood
- bone marrow
- coagulation system
- red blood cell
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for MECOM
- genomics-online: primer clones - Search results for available MDS1 gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MECOM Gene
Orthologs for MECOM Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MECOM 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | MECOM 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | MECOM 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MECOM 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mecom 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MECOM 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MECOM 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MECOM 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100496511 33 |
|
||
| Str.12493 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | mecom 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | ham 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | egl-43 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MSN2 34 |
|
ManyToMany | |
| MSN4 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.322 33 |
|
- Species where no ortholog for MECOM was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MECOM Gene
(130) SIMAP similar genes for MECOM Gene using alignment to 10 proteins:
- EVI1
- ZFS-5
- ZIC1
- ZFS-4
- kr-znf3
- DKFZp686N0199
- ZNF55
- PRDM16
- zf30
- KLF1
- ZNF78L1
- ZNF
- DKFZp686M04222
- ZNF56
- ZFS-2
- ZNF72
- ZNF22
- ZNF75A
- DKFZp547H249
- ZFP64
- HZF40
- ZNF833P
- ZNF702P
- ZNF581
- ZNF391
- HZF16
- HZF30
- A-328A3.4
- ZNF323
- ZNF615
- smap-7
- ZNF697
- ZFS-6
- PLAGL1
- ZSCAN31
- PLZF
- ZNF808
- ZNF600
- ZNF138
- ZNF876P
- ZNF770
- ZNF570
- ZNF2
- Nbla00121
- MST154
- ZNF708
- DKFZp686O1631
- DKFZp686D2168
- ZNF710
- ZNF525
- HZF36
- ZNF664
- DKFZp313M0722
- DKFZp434J0650
- ZNF778
- ZNF558
- ZNF485
- ZNF468
- ZNF35
- ZFP41
- ZNF649
- HZF17
- ZNF844
- ZNF726P1
- ZNF728
- ZNF254
- DKFZp666C237
- ZNF137P
- ZNF566
- ZBTB17
- ZNF562
- ZNF418
- DKFZp762K012
- DKFZp570I0164
- DKFZp434G1930
- ZNF701
- ZNF345
- ZNF83
- ZNF80
- ZNF660
- ZNF589
- ZNF501
- ZNF234
- ZNF146
- ZNF140
- ZNF888
- ZNF768
- ZNF304
- ZNF160
- ZFP62
- E4F1
- OVOL3
- ZSCAN21
- RREB1
- ZNF585B
- ZNF85
- ZNFN1A2
- ZNF500
- ZNF331
- ZNF101
- ZNF852
- ZNF841
- ZNF737
- ZNF567
- ZNF544
- ZNF34
- ZNF263
- ZFP37
- GTF3A
- ZNF678
- ZNF480
- PRMD9
- ZNF625
- ZNF575
- ZSCAN5A
- ZNF850
- ZNF726
- ZNF626
- ZNF606
- ZNF564
- ZNF426
- ZNF417
- ZNF324
- ZNF26
- ZNF19
- ZNF133
- ZIK1
- ZFP1
- ZBTB47
- DKFZp666M039
Variants for MECOM Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs864309722 | pathogenic, Radioulnar synostosis with amegakaryocytic thrombocytopenia 2, Radioulnar synostosis with amegakaryocytic thrombocytopenia 2 (RUSAT2) [MIM:616738] | 169,100,904(-) | T/C | coding_sequence_variant, missense_variant | |
| rs864309723 | pathogenic, Radioulnar synostosis with amegakaryocytic thrombocytopenia 2, Radioulnar synostosis with amegakaryocytic thrombocytopenia 2 (RUSAT2) [MIM:616738] | 169,100,918(-) | T/C | coding_sequence_variant, missense_variant | |
| rs864309724 | pathogenic, Radioulnar synostosis with amegakaryocytic thrombocytopenia 2, Radioulnar synostosis with amegakaryocytic thrombocytopenia 2 (RUSAT2) [MIM:616738] | 169,100,922(-) | G/A | coding_sequence_variant, missense_variant | |
| rs386352330 | uncertain-significance, not provided | 169,090,087(-) | A/G | coding_sequence_variant, missense_variant | |
| rs1000000858 | -- | 169,119,448(-) | G/C | intron_variant |
Residual Variation Intolerance Score:
38.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.42;
77.17% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MECOM Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MECOM Gene
Disorders for MECOM Gene
(13) MalaCards diseases for MECOM Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| radioulnar synostosis with amegakaryocytic thrombocytopenia 2 |
|
|
| radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome |
|
|
| acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2) |
|
|
| radioulnar synostosis |
|
|
| myeloid leukemia |
|
Search MECOM in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MDS1_HUMAN- Note=A chromosomal aberration involving EVI1 is a cause of chronic myelogenous leukemia (CML). Translocation t(3;21)(q26;q22) with RUNX1/AML1. {ECO:0000269 PubMed:8313895}.
- Note=A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML). Translocation t(3;21) with AML1. {ECO:0000269 PubMed:8643684}.
- Radioulnar synostosis with amegakaryocytic thrombocytopenia 2 (RUSAT2) [MIM:616738]: An autosomal dominant disease characterized by proximal fusion of the radius and ulna resulting in extremely limited pronation and supination of the forearm, and congenital thrombocytopenia that progresses to pancytopenia. {ECO:0000269 PubMed:26581901}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for MECOM
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for MECOM Gene
Publications for MECOM Gene
- Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family. (PMID: 8643684) Fears S … Nucifora G (Proceedings of the National Academy of Sciences of the United States of America 1996) 2 3 4 58
- Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain LV … van Duijn CM (Nature genetics 2011) 3 44 58
- Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. (PMID: 21909115) International Consortium for Blood Pressure Genome-Wide Association Studies … Johnson T (Nature 2011) 3 44 58
- Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M … Tobin MD (Nature genetics 2011) 3 44 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
Products for MECOM Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MECOM
- antibodies-online: Search results for 3 available MECOM Antibodies ranked by validation data
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Sources for MECOM Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
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- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems