Aliases for MECOM Gene
- MDS1 And EVI1 Complex Locus 2 3 5
- Ecotropic Virus Integration Site 1 Protein Homolog 3 4
- Myelodysplasia Syndrome-Associated Protein 1 3 4
- Histone-Lysine N-Methyltransferase MECOM 3 4
- PR Domain 3 2 3
- PRDM3 3 4
- EVI1 3 4
- MDS1 3 4
- MDS1 And EVI1 Complex Locus Protein EVI1 3
- MDS1 And EVI1 Complex Locus Protein MDS1 3
- MDS1 And EVI1 Complex Locus Protein 4
External Ids for MECOM Gene
Previous HGNC Symbols for MECOM Gene
Previous GeneCards Identifiers for MECOM Gene
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
GeneCards Summary for MECOM Gene
MECOM (MDS1 And EVI1 Complex Locus) is a Protein Coding gene. Diseases associated with MECOM include Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia 2 and Acute Myeloid Leukemia With Inv3(P21;Q26.2) Or T(3;3)(P21;Q26.2). Among its related pathways are PKMTs methylate histone lysines and MAPK signaling pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein homodimerization activity. An important paralog of this gene is PRDM16.
UniProtKB/Swiss-Prot Summary for MECOM Gene
Isoform 1: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.
Isoform 7: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation.