Aliases for MEAF6 Gene
External Ids for MEAF6 Gene
Previous HGNC Symbols for MEAF6 Gene
Previous GeneCards Identifiers for MEAF6 Gene
This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for MEAF6 Gene
MEAF6 (MYST/Esa1 Associated Factor 6) is a Protein Coding gene. Diseases associated with MEAF6 include Endometrial Stromal Nodule and Ossifying Fibromyxoid Tumor. Among its related pathways are Regulation of TP53 Activity through Acetylation and Chromatin organization.
UniProtKB/Swiss-Prot Summary for MEAF6 Gene
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A (PubMed:14966270). This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653, PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:18794358).