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Aliases for MEA1 Gene

Aliases for MEA1 Gene

  • Male-Enhanced Antigen 1 2 3 5
  • MEA 3 4
  • Male-Enhanced Antigen (H-Y Structural Gene) 3
  • Male-Enhanced Antigen 2
  • MEA-1 4
  • HYS 3

External Ids for MEA1 Gene

Previous HGNC Symbols for MEA1 Gene

  • MEA

Previous GeneCards Identifiers for MEA1 Gene

  • GC06M043088
  • GC06M042979
  • GC06M042697

Summaries for MEA1 Gene

GeneCards Summary for MEA1 Gene

MEA1 (Male-Enhanced Antigen 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MEA1 Gene

  • May play an important role in spermatogenesis and/or testis development.

Additional gene information for MEA1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEA1 Gene

Genomics for MEA1 Gene

GeneHancer (GH) Regulatory Elements for MEA1 Gene

Promoters and enhancers for MEA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I043011 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 572.9 +2.3 2264 7 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 MEA1 KLHDC3 CUL7 KLC4 RN7SL403P PTK7 RPL7L1 DNPH1 PEX6 GC06P043011
GH06I042928 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.8 +86.3 86298 5.6 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 CNPY3 GC06M042930 PIR33684 PEX6 ZNF318 POLH GTPBP2 XPO5 RRP36 CUL7
GH06I043180 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.3 -165.1 -165077 3.2 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 YBX1 POLR2B CUL9 CUL7 ZNF318 POLH GTPBP2 RPS2P29 DNPH1 ABCC10 BICRAL XPO5
GH06I042901 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.8 +114.0 114036 3.3 FOXA2 ARNT ZFP64 ARID4B DMAP1 ZNF2 ZNF48 YY1 SLC30A9 TCF12 LOC105375063 RPL7L1 PEX6 CNPY3 ENSG00000231113 PPP2R5D KLC4 RN7SL403P CUL7 KLHDC3
GH06I043141 Enhancer 1.2 Ensembl ENCODE 10.8 -126.4 -126375 3.6 HDGF ARID4B SIN3A ZNF2 E2F8 ZNF143 SP5 MXD4 REST ZNF592 CUL7 DNPH1 KLC4 RN7SL403P KLHDC3 MEA1 PPP2R5D RPL7L1 SRF PIR51341
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MEA1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MEA1 gene promoter:

Genomic Locations for MEA1 Gene

Genomic Locations for MEA1 Gene
chr6:42,980,344-43,017,087
(GRCh38/hg38)
Size:
36,744 bases
Orientation:
Minus strand
chr6:42,979,832-42,981,706
(GRCh37/hg19)

Genomic View for MEA1 Gene

Genes around MEA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEA1 Gene

Proteins for MEA1 Gene

  • Protein details for MEA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16626-MEA1_HUMAN
    Recommended name:
    Male-enhanced antigen 1
    Protein Accession:
    Q16626
    Secondary Accessions:
    • Q5TC36
    • Q9BV01

    Protein attributes for MEA1 Gene

    Size:
    185 amino acids
    Molecular mass:
    19905 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MEA1 Gene

Post-translational modifications for MEA1 Gene

Other Protein References for MEA1 Gene

No data available for DME Specific Peptides for MEA1 Gene

Domains & Families for MEA1 Gene

Gene Families for MEA1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MEA1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MEA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MEA1: view

No data available for UniProtKB/Swiss-Prot for MEA1 Gene

Function for MEA1 Gene

Molecular function for MEA1 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in spermatogenesis and/or testis development.

Phenotypes From GWAS Catalog for MEA1 Gene

Gene Ontology (GO) - Molecular Function for MEA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with MEA1: view
genes like me logo Genes that share phenotypes with MEA1: view

Animal Model Products

CRISPR Products

miRNA for MEA1 Gene

miRTarBase miRNAs that target MEA1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MEA1 Gene

Localization for MEA1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEA1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MEA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MEA1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MEA1 Gene

Pathways & Interactions for MEA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis TAS,IEA --
GO:0008584 male gonad development TAS 2813404
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with MEA1: view

No data available for Pathways by source and SIGNOR curated interactions for MEA1 Gene

Drugs & Compounds for MEA1 Gene

No Compound Related Data Available

Transcripts for MEA1 Gene

Unigene Clusters for MEA1 Gene

Male-enhanced antigen 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEA1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for MEA1 Gene

GeneLoc Exon Structure for
MEA1
ECgene alternative splicing isoforms for
MEA1

Expression for MEA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEA1 Gene

Protein differential expression in normal tissues from HIPED for MEA1 Gene

This gene is overexpressed in Adipocyte (19.2), Fetal Brain (13.4), Lung (11.3), and Bone (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MEA1 Gene



Protein tissue co-expression partners for MEA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MEA1 Gene:

MEA1

SOURCE GeneReport for Unigene cluster for MEA1 Gene:

Hs.278362

mRNA Expression by UniProt/SwissProt for MEA1 Gene:

Q16626-MEA1_HUMAN
Tissue specificity: Highly expressed in testis.

Evidence on tissue expression from TISSUES for MEA1 Gene

  • Liver(4.4)
  • Eye(4.2)
  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with MEA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEA1 Gene

Orthologs for MEA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MEA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEA1 33 34
  • 99.82 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 94 (a)
OneToMany
MEA1 33 34
  • 93.22 (n)
dog
(Canis familiaris)
Mammalia MEA1 33 34
  • 91.39 (n)
rat
(Rattus norvegicus)
Mammalia Mea1 33
  • 91.09 (n)
mouse
(Mus musculus)
Mammalia Mea1 33 16 34
  • 90.64 (n)
oppossum
(Monodelphis domestica)
Mammalia MEA1 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEA1 34
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEA1 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mea1 33
  • 64.78 (n)
Str.10548 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.18937 33
zebrafish
(Danio rerio)
Actinopterygii mea1 33 34
  • 60.34 (n)
Species where no ortholog for MEA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEA1 Gene

ENSEMBL:
Gene Tree for MEA1 (if available)
TreeFam:
Gene Tree for MEA1 (if available)

Paralogs for MEA1 Gene

No data available for Paralogs for MEA1 Gene

Variants for MEA1 Gene

Sequence variations from dbSNP and Humsavar for MEA1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs757369209 pathogenic, Mental retardation, autosomal dominant 35 43,006,514(-) C/A/T genic_downstream_transcript_variant, intron_variant
rs863225079 pathogenic, Mental retardation, autosomal dominant 35, not provided 43,007,271(-) G/A genic_downstream_transcript_variant, intron_variant
rs863225082 pathogenic, Mental retardation, autosomal dominant 35, not provided 43,007,265(-) G/A genic_downstream_transcript_variant, intron_variant
rs869320691 pathogenic, Mental retardation, autosomal dominant 35, not provided 43,007,292(-) T/A/C genic_downstream_transcript_variant, intron_variant
rs876657383 pathogenic, Mental retardation, autosomal dominant 35, not provided 43,007,275(-) C/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MEA1 Gene

Variant ID Type Subtype PubMed ID
nsv602992 CNV loss 21841781
nsv462930 CNV loss 19166990
nsv462927 CNV loss 19166990
nsv1074927 CNV deletion 25765185
nsv1017398 CNV gain 25217958
dgv10640n54 CNV loss 21841781

Variation tolerance for MEA1 Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.57; 56.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEA1 Gene

Disorders for MEA1 Gene

Additional Disease Information for MEA1

No disorders were found for MEA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEA1 Gene

Publications for MEA1 Gene

  1. Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis. (PMID: 2813404) Lau YF … Sparkes R (Proceedings of the National Academy of Sciences of the United States of America 1989) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis. (PMID: 12444059) Ohinata Y … Mitsui Y (Biology of reproduction 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for MEA1 Gene

Sources for MEA1 Gene

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