Aliases for ME3 Gene
External Ids for ME3 Gene
Previous GeneCards Identifiers for ME3 Gene
Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for ME3 Gene
ME3 (Malic Enzyme 3) is a Protein Coding gene. Diseases associated with ME3 include Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1. Among its related pathways are Carbon metabolism and PPAR signaling pathway. Gene Ontology (GO) annotations related to this gene include NAD binding and malic enzyme activity. An important paralog of this gene is ME1.