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Aliases for MDP1 Gene

Aliases for MDP1 Gene

  • Magnesium Dependent Phosphatase 1 2 3 5
  • Fructosamine-6-Phosphatase 2 3
  • MDP-1 3 4
  • Magnesium-Dependent Phosphatase 1 3
  • EC 4
  • EC 3.1.3.- 4
  • FN6PASE 3

External Ids for MDP1 Gene

Previous GeneCards Identifiers for MDP1 Gene

  • GC14M023754
  • GC14M024683
  • GC14M004798

Summaries for MDP1 Gene

GeneCards Summary for MDP1 Gene

MDP1 (Magnesium Dependent Phosphatase 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is NEDD8-MDP1.

UniProtKB/Swiss-Prot for MDP1 Gene

  • Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.

Additional gene information for MDP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MDP1 Gene

Genomics for MDP1 Gene

GeneHancer (GH) Regulatory Elements for MDP1 Gene

Promoters and enhancers for MDP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I024212 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 570.6 +1.4 1382 4.9 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MDP1 CHMP4A ENSG00000254692 ENSG00000260669 HOMEZ IPO4 RNF31 CMA1 PABPN1 RNA5SP383
GH14I024422 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.1 -211.7 -211675 10.3 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 NFYC CBLN3 KHNYN SDR39U1 NYNRIN MDP1 NGDN NFATC4 ENSG00000259321 TINF2 ADCY4
GH14I024194 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.4 +20.2 20193 3.5 HDGF PKNOX1 CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 TM9SF1 PIR45873 RNF31 TINF2 MDP1 SLC22A17 PSME2 KHNYN RNA5SP383 JPH4
GH14I024139 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.7 +75.1 75074 3.7 PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 EMC9 ENSG00000259321 NFATC4 NGDN HOMEZ IPO4 THTPA TSSK4 PABPN1 MDP1
GH14I024270 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 10.9 -56.8 -56756 5.4 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 LOC102725044 RABGGTA TSSK4 IPO4 RNF31 HOMEZ KHNYN NOP9 NGDN DHRS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MDP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MDP1 Gene

Genomic Locations for MDP1 Gene
2,134 bases
Minus strand

Genomic View for MDP1 Gene

Genes around MDP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MDP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MDP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MDP1 Gene

Proteins for MDP1 Gene

  • Protein details for MDP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Magnesium-dependent phosphatase 1
    Protein Accession:
    Secondary Accessions:
    • Q86Y84
    • Q8NAD9

    Protein attributes for MDP1 Gene

    176 amino acids
    Molecular mass:
    20109 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MDP1 Gene

    Alternative splice isoforms for MDP1 Gene


neXtProt entry for MDP1 Gene

Post-translational modifications for MDP1 Gene

No Post-translational modifications

Other Protein References for MDP1 Gene

No data available for DME Specific Peptides for MDP1 Gene

Domains & Families for MDP1 Gene

Gene Families for MDP1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MDP1 Gene

Suggested Antigen Peptide Sequences for MDP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HAD-like hydrolase superfamily.
  • Belongs to the HAD-like hydrolase superfamily.
genes like me logo Genes that share domains with MDP1: view

Function for MDP1 Gene

Molecular function for MDP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by vanadate and zinc, and slightly by calcium.
UniProtKB/Swiss-Prot Function:
Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.

Enzyme Numbers (IUBMB) for MDP1 Gene

Phenotypes From GWAS Catalog for MDP1 Gene

Gene Ontology (GO) - Molecular Function for MDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MDP1: view

Phenotypes for MDP1 Gene

MGI mutant phenotypes for MDP1:
inferred from 1 alleles
GenomeRNAi human phenotypes for MDP1:
genes like me logo Genes that share phenotypes with MDP1: view

Animal Models for MDP1 Gene

MGI Knock Outs for MDP1:
  • Mdp1 tm1.1(KOMP)Vlcg

miRNA for MDP1 Gene

miRTarBase miRNAs that target MDP1

Clone Products

  • Addgene plasmids for MDP1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MDP1 Gene

Localization for MDP1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MDP1 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with MDP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MDP1 Gene

Pathways & Interactions for MDP1 Gene

No Data Available

Interacting Proteins for MDP1 Gene

Gene Ontology (GO) - Biological Process for MDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IEA --
GO:0030389 fructosamine metabolic process IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with MDP1: view

No data available for Pathways by source and SIGNOR curated interactions for MDP1 Gene

Drugs & Compounds for MDP1 Gene

(4) Drugs for MDP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Approved Nutra 0
Magnesium Approved Nutra 0

(1) Additional Compounds for MDP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
genes like me logo Genes that share compounds with MDP1: view

Transcripts for MDP1 Gene

Unigene Clusters for MDP1 Gene

Magnesium-dependent phosphatase 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for MDP1

Alternative Splicing Database (ASD) splice patterns (SP) for MDP1 Gene

No ASD Table

Relevant External Links for MDP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MDP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MDP1 Gene

Protein differential expression in normal tissues from HIPED for MDP1 Gene

This gene is overexpressed in Serum (24.9) and Ovary (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MDP1 Gene

Protein tissue co-expression partners for MDP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MDP1 Gene:


SOURCE GeneReport for Unigene cluster for MDP1 Gene:


Evidence on tissue expression from TISSUES for MDP1 Gene

  • Intestine(4.3)
  • Nervous system(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with MDP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MDP1 Gene

Orthologs for MDP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MDP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia MDP1 33
  • 86.79 (n)
(Bos Taurus)
Mammalia MDP-1 33 34
  • 86.09 (n)
(Mus musculus)
Mammalia Mdp1 33 16 34
  • 84.66 (n)
(Rattus norvegicus)
Mammalia Mdp1 33
  • 84.66 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 65 (a)
(Danio rerio)
Actinopterygii si:dkeyp-27c8.2 33
  • 54.99 (n)
MDP1 34
  • 54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 30 (a)
-- 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G14110 33
  • 51.54 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07321 33
  • 52.48 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBP8B7.31 33
  • 49.66 (n)
Species where no ortholog for MDP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MDP1 Gene

Gene Tree for MDP1 (if available)
Gene Tree for MDP1 (if available)

Paralogs for MDP1 Gene

Paralogs for MDP1 Gene

(2) SIMAP similar genes for MDP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MDP1: view

Variants for MDP1 Gene

Sequence variations from dbSNP and Humsavar for MDP1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs193921062 uncertain-significance, Malignant tumor of prostate 24,214,313(-) G/C coding_sequence_variant, intron_variant, missense_variant
rs1000169072 -- 24,213,821(-) G/A downstream_transcript_variant
rs1000408551 -- 24,218,000(-) G/C/T upstream_transcript_variant
rs1003518970 -- 24,216,851(-) G/C upstream_transcript_variant
rs1004641002 -- 24,217,922(-) A/C upstream_transcript_variant

Variation tolerance for MDP1 Gene

Residual Variation Intolerance Score: 48.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.47; 82.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MDP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MDP1 Gene

Disorders for MDP1 Gene

Additional Disease Information for MDP1

No disorders were found for MDP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MDP1 Gene

Publications for MDP1 Gene

  1. Magnesium-dependent phosphatase-1 is a protein-fructosamine-6-phosphatase potentially involved in glycation repair. (PMID: 16670083) Fortpied J … Van Schaftingen E (The Journal of biological chemistry 2006) 2 3 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. MDP-1: A novel eukaryotic magnesium-dependent phosphatase. (PMID: 10889041) Selengut JD … Levine RL (Biochemistry 2000) 2 3 58
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58

Products for MDP1 Gene

Sources for MDP1 Gene

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