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This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p... See more...
Aliases for MDM4 Gene
Aliases for MDM4 Gene
- MDM4 Regulator Of P53 2 3 5
- Mdm2-Like P53-Binding Protein 3 4
- MDM4, P53 Regulator 2 3
- Protein Mdm4 3 4
- Protein Mdmx 3 4
- MDMX 3 4
- Mdm4, Transformed 3T3 Cell Double Minute 4, P53 Binding Protein (Mouse) 2
- Mouse Double Minute 4, Human Homolog Of; P53-Binding Protein 2
- Double Minute 4, Human Homolog Of; P53-Binding Protein 3
External Ids for MDM4 Gene
- HGNC: 6974
- Entrez Gene: 4194
- Ensembl: ENSG00000198625
- OMIM: 602704
- UniProtKB: O15151
Previous GeneCards Identifiers for MDM4 Gene
- GC01P202211
- GC01P199946
- GC01P200846
- GC01P201662
- GC01P201629
- GC01P201217
- GC01P202752
- GC01P204486
- GC01P175650
Summaries for MDM4 Gene
-
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for MDM4 Gene
MDM4 (MDM4 Regulator Of P53) is a Protein Coding gene. Diseases associated with MDM4 include Intraocular Retinoblastoma and Pancreatic Squamous Cell Carcinoma. Among its related pathways are Cellular Senescence (REACTOME) and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is MDM2.
UniProtKB/Swiss-Prot Summary for MDM4 Gene
-
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
Additional gene information for MDM4 Gene
- Monarch Initiative
- Search for MDM4 at DataMed
- Search for MDM4 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MDM4 Gene
Genomics for MDM4 Gene
GeneHancer (GH) Regulatory Elements for MDM4 Gene
Promoters and enhancers for MDM4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MDM4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MDM4 gene promoter:
-
- c-Ets-1
- Elk-1
- HEN1
- MZF-1
- NRF-2
- PPAR-alpha
- TBP
Genomic Locations for MDM4 Gene
Genomic Locations for MDM4 Gene
- chr1:204,516,379-204,581,681
- (GRCh38/hg38)
- Size:
- 65,303 bases
- Orientation:
- Plus strand
- chr1:204,485,507-204,542,871
- (GRCh37/hg19)
- Size:
- 57,365 bases
- Orientation:
- Plus strand
Genomic View for MDM4 Gene
Genes around MDM4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q32.1 by HGNC
- 1q32.1 by Entrez Gene
- 1q32.1 by Ensembl
MDM4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MDM4 Gene
Proteins for MDM4 Gene
-
Protein details for MDM4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15151-MDM4_HUMAN
- Recommended name:
- Protein Mdm4
- Protein Accession:
- O15151
- Q2M2Y2
- Q32SL2
- Q6GS18
- Q8IV83
Protein attributes for MDM4 Gene
- Size:
- 490 amino acids
- Molecular mass:
- 54864 Da
- Quaternary structure:
-
- Interacts with MDM2, TP53, TP73 and USP2. Found in a trimeric complex with USP2, MDM2 and MDM4. Interacts (phosphorylated) with YWHAG; negatively regulates MDM4 activity toward TP53.
Three dimensional structures from OCA and Proteopedia for MDM4 Gene
Protein Expression for MDM4 Gene
Post-translational modifications for MDM4 Gene
- Phosphorylated. Phosphorylation at Ser-367 promotes interaction with YWHAG and subsequent ubiquitination and degradation. Phosphorylation at Ser-342 also induces ubiquitination and degradation but to a lower extent.
- Ubiquitinated and degraded by MDM2. Deubiquitination by USP2 on the other hand stabilizes the MDM4 protein.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MDM4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ MDM4 Antibody
- NSJ Bioreagents MDM4 Antibody / MDMX
- Atlas Antibodies Anti-MDM4 Antibody (HPA018919) and Anti-MDM4 Antibody (HPA048821)
-
Creative Diagnostics
-
Creative Biolabs
- Recombinant Anti-Human MDM4 Antibody Fab Fragment
- Recombinant Anti-Human MDM4 Antibody
- Recombinant Anti-MDM4 VHH Single Domain Antibody
- Recombinant Mouse anti-Human MDM4 Monoclonal antibody (3E20G5)
- Mouse Anti-MDM4 Recombinant Antibody (CBFYM-1969)
- Mouse Anti-MDM4 Recombinant Antibody (CBFYM-1970)
- Mouse Anti-MDM4 Recombinant Antibody (CBFYM-1967)
- Mouse Anti-MDM4 Recombinant Antibody (CBFYM-1966)
- Mouse Anti-MDM4 Recombinant Antibody (CBFYM-1968)
-
Custom Antibody ServicesOriGene Antibodies for MDM4
- AM06258SU-N
- CF505706
- CF505707
- CF505712
- CF505722
- CF505723
- CF505724
- CF505725
- CF505726
- CF505727
- CF505732
- CF505733
- CF505734
- CF505735
- CF505736
- CF505749
- CF505750
- TA312001
- TA505706
- TA505707
- TA505712
- TA505722
- TA505723
- TA505724
- TA505725
- TA505726
- TA505727
- TA505732
- TA505733
- TA505734
- TA505735
- TA505736
- TA505749
- TA505750
- Novus Biologicals Antibodies for MDM4
-
Abcam antibodies for MDM4
- Invitrogen Antibodies for MDM4 (AFLGC-MDM4)
-
Boster Bio Antibodies for MDM4
-
Santa Cruz Biotechnology (SCBT) Antibodies for MDM4
- Sino Biological Antibodies for MDM4
Protein Products
- Atlas Antibodies PrEST Antigen MDM4 (APrEST74262) and PrEST Antigen MDM4 (APrEST89574)
- Creative Diagnostics Human MDM4 peptide
-
OriGene Purified Proteins for MDM4
- Search Origene for MassSpec and Protein Over-expression Lysates for MDM4
- Origene Custom Protein Services for MDM4
- Sino Biological Recombinant Proteins for MDM4
- Browse Sino Biological Cell Lysates
-
Abcam proteins for MDM4
Assay Products
- Creative Diagnostics Human MDM4 ELISA Matched Antibody Pair (ABPR-0560) and Human MDM4 ELISA Matched Antibody Pair (ABPR-0561)
- antibodies-online: Show 6 available MDM4-binding Protein Elisa Kits ranked by validation data
- Compare Top MDM4-binding Protein Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for MDM4
No data available for DME Specific Peptides for MDM4 Gene
Domains & Families for MDM4 Gene
Gene Families for MDM4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for MDM4 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MDM4 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ51436, highly similar to Mdm4 protein (B4E122_HUMAN)
- p53-binding protein Mdm4 (MDM4_HUMAN)
- Mdm4 p53 binding protein homolog (Mouse) (Q5T0Y3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O15151UniProtKB/Swiss-Prot:
MDM4_HUMAN :- Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also binds TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2.
- Belongs to the MDM2/MDM4 family.
- Domain:
-
- Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also binds TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2.
- Family:
-
- Belongs to the MDM2/MDM4 family.
Function for MDM4 Gene
Molecular function for MDM4 Gene
- UniProtKB/Swiss-Prot Function:
- Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated by cisplatin (at protein level).
- GENATLAS Biochemistry:
- murine p53 binding protein Mdmx homolog,also homolog to murine Mdm2,ubiquitously expressed with high levels in thymus
Phenotypes From GWAS Catalog for MDM4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA,IPI | 10469568 |
| GO:0008270 | zinc ion binding | TAS | 10608892 |
| GO:0019899 | enzyme binding | IPI | 19838211 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for MDM4 Gene
- MGI mutant phenotypes for MDM4:
-
inferred from 10 alleles
- cardiovascular system phenotype
- limbs/digits/tail phenotype
- pigmentation phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- craniofacial phenotype
- liver/biliary system phenotype
- embryo phenotype
- normal phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for MDM4:
-
- Decreased viability ratio
- Dynamic nuclei (hole, folded or small irregular)
- Decreased shRNA abundance (Z-score < -2)
- Reduced mammosphere formation
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Increased Nanog expression
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Models for MDM4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for MDM4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MDM4
- genomics-online: gRNA clones - Search for available MDM4-binding Protein gRNA products
- Overview of 141 available MDM4-binding Protein gene related products
- Applied Biological Materials (abm): CRISPR Clones for MDM4 - Select products 50% OFF >
- * MDM4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MDM4 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for MDM4
miRNA for MDM4 Gene
- miRTarBase miRNAs that target MDM4
-
- hsa-mir-34a-5p (MIRT004403)
- hsa-mir-191-5p (MIRT006570)
- hsa-mir-9-5p (MIRT021357)
- hsa-mir-215-5p (MIRT024671)
- hsa-mir-192-5p (MIRT026375)
- hsa-mir-21-5p (MIRT030817)
- hsa-let-7b-5p (MIRT052186)
- hsa-mir-144-5p (MIRT112224)
- hsa-mir-361-5p (MIRT112226)
- hsa-mir-3074-3p (MIRT112228)
- hsa-mir-3689a-5p (MIRT112230)
- hsa-mir-3689b-5p (MIRT112231)
- hsa-mir-3689e (MIRT112233)
- hsa-mir-3689f (MIRT112234)
- hsa-let-7a-5p (MIRT112239)
- hsa-let-7c-5p (MIRT112240)
- hsa-let-7d-5p (MIRT112241)
- hsa-let-7e-5p (MIRT112242)
- hsa-let-7f-5p (MIRT112243)
- hsa-mir-98-5p (MIRT112244)
- hsa-let-7g-5p (MIRT112245)
- hsa-let-7i-5p (MIRT112246)
- hsa-mir-331-5p (MIRT112247)
- hsa-mir-1272 (MIRT112248)
- hsa-mir-3924 (MIRT112251)
- hsa-mir-3927-3p (MIRT112252)
- hsa-mir-4458 (MIRT112253)
- hsa-mir-4500 (MIRT112254)
- hsa-mir-4650-3p (MIRT112255)
- hsa-mir-6755-5p (MIRT112256)
- hsa-mir-6831-5p (MIRT112257)
- hsa-mir-34c-5p (MIRT183692)
- hsa-mir-449a (MIRT183693)
- hsa-mir-449b-5p (MIRT183694)
- hsa-mir-485-5p (MIRT183702)
- hsa-mir-6884-5p (MIRT183711)
- hsa-mir-7-1-3p (MIRT269636)
- hsa-mir-7-2-3p (MIRT269637)
- hsa-mir-3065-5p (MIRT269639)
- hsa-mir-3529-3p (MIRT269640)
- hsa-mir-183-5p (MIRT334810)
- hsa-mir-661 (MIRT438538)
- hsa-mir-4459 (MIRT473396)
- hsa-mir-6819-5p (MIRT473397)
- hsa-mir-6812-5p (MIRT473398)
- hsa-mir-6737-5p (MIRT473399)
- hsa-mir-6747-5p (MIRT473400)
- hsa-mir-608 (MIRT473401)
- hsa-mir-4664-5p (MIRT473402)
- hsa-mir-4651 (MIRT473403)
- hsa-mir-342-5p (MIRT473404)
- hsa-mir-25-5p (MIRT473405)
- hsa-mir-658 (MIRT473406)
- hsa-mir-6087 (MIRT473407)
- hsa-mir-1247-3p (MIRT473408)
- hsa-mir-6890-5p (MIRT473409)
- hsa-mir-550b-2-5p (MIRT473410)
- hsa-mir-203b-3p (MIRT473411)
- hsa-mir-1227-3p (MIRT473412)
- hsa-mir-4445-5p (MIRT473413)
- hsa-mir-6766-3p (MIRT473414)
- hsa-mir-4782-3p (MIRT473415)
- hsa-mir-219a-5p (MIRT473416)
- hsa-mir-508-3p (MIRT473417)
- hsa-mir-4679 (MIRT473418)
- hsa-mir-17-3p (MIRT473419)
- hsa-mir-5572 (MIRT473420)
- hsa-mir-4260 (MIRT473421)
- hsa-mir-450a-2-3p (MIRT473422)
- hsa-mir-6855-5p (MIRT473423)
- hsa-mir-3170 (MIRT473424)
- hsa-mir-4709-3p (MIRT473425)
- hsa-mir-19b-2-5p (MIRT473426)
- hsa-mir-19b-1-5p (MIRT473427)
- hsa-mir-19a-5p (MIRT473428)
- hsa-mir-2052 (MIRT473429)
- hsa-mir-542-3p (MIRT473430)
- hsa-mir-486-3p (MIRT473431)
- hsa-mir-122-5p (MIRT473432)
- hsa-mir-3659 (MIRT473433)
- hsa-mir-423-5p (MIRT473434)
- hsa-mir-3184-5p (MIRT473435)
- hsa-mir-7515 (MIRT473436)
- hsa-mir-494-3p (MIRT473437)
- hsa-mir-3120-5p (MIRT473438)
- hsa-mir-6743-5p (MIRT473439)
- hsa-mir-4688 (MIRT473440)
- hsa-mir-3154 (MIRT473441)
- hsa-mir-543 (MIRT473443)
- hsa-mir-30e-3p (MIRT493254)
- hsa-mir-30d-3p (MIRT493255)
- hsa-mir-30a-3p (MIRT493256)
- hsa-mir-548au-3p (MIRT493257)
- hsa-mir-202-3p (MIRT501923)
- hsa-mir-4678 (MIRT501924)
- hsa-mir-3178 (MIRT632760)
- hsa-mir-24-3p (MIRT632761)
- hsa-mir-4284 (MIRT632762)
- hsa-mir-6499-5p (MIRT632763)
- hsa-mir-770-5p (MIRT632764)
- hsa-mir-4712-5p (MIRT632765)
- hsa-mir-1180-3p (MIRT637070)
- hsa-mir-6850-3p (MIRT637071)
- hsa-mir-887-3p (MIRT734943)
- hsa-mir-103a-3p (MIRT761085)
- hsa-mir-107 (MIRT761137)
- hsa-mir-1252-3p (MIRT761622)
- hsa-mir-141-3p (MIRT762640)
- hsa-mir-1827 (MIRT763067)
- hsa-mir-200a-3p (MIRT763654)
- hsa-mir-200a-5p (MIRT763658)
- hsa-mir-200b-5p (MIRT763667)
- hsa-mir-3148 (MIRT765012)
- hsa-mir-3529-5p (MIRT765833)
- hsa-mir-3609 (MIRT765868)
- hsa-mir-3662 (MIRT766458)
- hsa-mir-374c-3p (MIRT767337)
- hsa-mir-379-5p (MIRT767536)
- hsa-mir-3944-5p (MIRT767874)
- hsa-mir-4451 (MIRT769188)
- hsa-mir-4470 (MIRT769464)
- hsa-mir-4661-3p (MIRT770781)
- hsa-mir-4668-5p (MIRT770860)
- hsa-mir-4704-3p (MIRT771352)
- hsa-mir-4716-3p (MIRT771421)
- hsa-mir-4761-5p (MIRT772001)
- hsa-mir-499a-3p (MIRT772880)
- hsa-mir-499b-3p (MIRT772890)
- hsa-mir-545-3p (MIRT774021)
- hsa-mir-548ac (MIRT774054)
- hsa-mir-548ah-5p (MIRT774105)
- hsa-mir-548as-3p (MIRT774206)
- hsa-mir-548bb-3p (MIRT774284)
- hsa-mir-548d-3p (MIRT774362)
- hsa-mir-548h-3p (MIRT774403)
- hsa-mir-548z (MIRT774584)
- hsa-mir-625-5p (MIRT776114)
- hsa-mir-651-5p (MIRT777044)
- hsa-mir-6758-3p (MIRT778421)
- hsa-mir-6794-5p (MIRT779346)
- hsa-mir-6873-3p (MIRT780711)
- hsa-mir-876-3p (MIRT782526)
- hsa-mir-942-5p (MIRT782979)
- hsa-mir-3122 (MIRT784581)
- hsa-mir-3913-5p (MIRT785435)
- hsa-mir-433-3p (MIRT785780)
- hsa-mir-450a-1-3p (MIRT786039)
- hsa-mir-514a-3p (MIRT787160)
- hsa-mir-514b-3p (MIRT787172)
- hsa-mir-544b (MIRT787388)
- hsa-mir-6078 (MIRT787995)
- hsa-mir-6513-5p (MIRT788316)
- hsa-mir-7112-5p (MIRT789418)
- hsa-mir-7162-3p (MIRT789468)
- hsa-mir-887-5p (MIRT789897)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MDM4
- Browse OriGene Inhibitory RNA Products For MDM4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MDM4
- genomics-online: shRNA clones - Search for available MDM4-binding Protein shRNA products
- Overview of 141 available MDM4-binding Protein gene related products
Clone Products
-
- MG207830
- MR207830
- MR207830L3
- MR207830L3V
- MR207830L4
- MR207830L4V
- MR229495
- MR230179
- MR230191
- MR230192
- RC209620
- RC209620L1
- RC209620L1V
- RC209620L2
- RC209620L2V
- RC209620L3
- RC209620L3V
- RC209620L4
- RC209620L4V
- RC233334
- RC234101
- RC235731
- RC235979
- RC237048
- RC237934
- RG209620
- RG233334
- RG234101
- RR210484
- RR210484L1
- RR210484L1V
- RR210484L2
- RR210484L2V
- RR210484L3
- RR210484L3V
- RR210484L4
- RR210484L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MDM4
- Addgene plasmids for MDM4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MDM4
- Applied Biological Materials (abm): Clones for MDM4 - Select products 50% OFF >
- * MDM4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MDM4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MDM4 Gene
Localization for MDM4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MDM4 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| mitochondrion | 1 |
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | NAS,IEA | 9226370 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for MDM4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 2 | Regulation of TP53 Activity | ||
| 3 | Cellular Senescence (REACTOME) | ||
| 4 | ATM Pathway |
ATM Pathway
.45
|
|
| 5 | Deubiquitination |
.74
|
|
Pathways by source for MDM4 Gene
3 BioSystems pathways for MDM4 Gene
22 Reactome pathways for MDM4 Gene
2 KEGG pathways for MDM4 Gene
1 Qiagen pathway for MDM4 Gene
- ATM Pathway
Interacting Proteins for MDM4 Gene
Selected Interacting proteins:
O15151-MDM4_HUMAN
ENSP00000356150
for MDM4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MDM4
SIGNOR curated interactions for MDM4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 9226370 |
| GO:0003170 | heart valve development | ISS | -- |
| GO:0003181 | atrioventricular valve morphogenesis | ISS | -- |
| GO:0003203 | endocardial cushion morphogenesis | ISS | -- |
| GO:0003281 | ventricular septum development | ISS | -- |
Drugs & Compounds for MDM4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Docetaxel | Approved, Investigational | Pharma | Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes | 2231 | ||
| Epirubicin | Approved | Pharma | 457 | |||
| NSC 207895 (XI-006) | Pharma | MDMX inhibitor,anti-cancer agent | 0 | |||
| SJ 172550 | Pharma | MDMX inhibitor | 0 |
(2) ApexBio Compounds for MDM4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| NSC 207895 (XI-006) | MDMX inhibitor,anti-cancer agent | 58131-57-0 |
| SJ 172550 | MDMX inhibitor | 431979-47-4 |
Drug Products
- Atlas Antibodies PrEST Antigen MDM4 (APrEST74262) and PrEST Antigen MDM4 (APrEST89574)
- Creative Diagnostics Human MDM4 peptide
- ApexBio compounds for MDM4
Transcripts for MDM4 Gene
mRNA/cDNA for MDM4 Gene
- (7) REFSEQ mRNAs :
- (26) Additional mRNA sequences :
- (235) Selected AceView cDNA sequences:
- (17) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000470797 909 bps (ENST00000470797.5)
- ENST00000367182 10050 bps (ENST00000367182.7)
- ENST00000463049 6102 bps (ENST00000463049.5)
- ENST00000470908 884 bps (ENST00000470908.5)
- ENST00000471783 552 bps (ENST00000471783.1)
CRISPR Products
-
OriGene CRISPR knockouts for MDM4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MDM4
- genomics-online: gRNA clones - Search for available MDM4-binding Protein gRNA products
- Overview of 141 available MDM4-binding Protein gene related products
- Applied Biological Materials (abm): CRISPR Clones for MDM4 - Select products 50% OFF >
- * MDM4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MDM4 CRISPR applications: KO, Activation, Repression, and more - Browse All
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Santa Cruz Biotechnology (SCBT) CRISPR for MDM4
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MDM4
- Browse OriGene Inhibitory RNA Products For MDM4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MDM4
- genomics-online: shRNA clones - Search for available MDM4-binding Protein shRNA products
- Overview of 141 available MDM4-binding Protein gene related products
Clone Products
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- MG207830
- MR207830
- MR207830L3
- MR207830L3V
- MR207830L4
- MR207830L4V
- MR229495
- MR230179
- MR230191
- MR230192
- RC209620
- RC209620L1
- RC209620L1V
- RC209620L2
- RC209620L2V
- RC209620L3
- RC209620L3V
- RC209620L4
- RC209620L4V
- RC233334
- RC234101
- RC235731
- RC235979
- RC237048
- RC237934
- RG209620
- RG233334
- RG234101
- RR210484
- RR210484L1
- RR210484L1V
- RR210484L2
- RR210484L2V
- RR210484L3
- RR210484L3V
- RR210484L4
- RR210484L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MDM4
- Addgene plasmids for MDM4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MDM4
- Applied Biological Materials (abm): Clones for MDM4 - Select products 50% OFF >
- * MDM4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MDM4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 13d | · | 13e | · | 13f |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: |
Expression for MDM4 Gene
This gene is overexpressed in Blymphocyte (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MDM4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MDM4 Gene:
MDM4SOURCE GeneReport for Unigene cluster for MDM4 Gene:
Hs.497492mRNA Expression by UniProt/SwissProt for MDM4 Gene:
O15151-MDM4_HUMAN
Tissue specificity:
Expressed in all tissues tested with high levels in thymus.
Evidence on tissue expression from TISSUES for MDM4 Gene
- Nervous system(4.6)
- Stomach(4.2)
Primer Products
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OriGene qPCR primer pairs for MDM4
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OriGene qPCR primer pairs and template standards for MDM4
- genomics-online: primer clones - Search for available MDM4-binding Protein Primer products
- Overview of 141 available MDM4-binding Protein gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MDM4 Gene
Orthologs for MDM4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MDM4 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MDM4 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MDM4 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Mdm4 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Mdm4 17 33 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MDM4 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MDM4 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MDM4 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mdm4 32 |
|
||
| Str.9227 32 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC52974 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mdm4 33 32 |
|
OneToOne | |
| wufa09h09 32 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
- Species where no ortholog for MDM4 was found in the sources mined by GeneCards:
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- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for MDM4 Gene
- ENSEMBL:
- Gene Tree for MDM4 (if available)
- TreeFam:
- Gene Tree for MDM4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MDM4: view image
Paralogs for MDM4 Gene
(7) SIMAP similar genes for MDM4 Gene using alignment to 6 proteins:
- MDM4_HUMAN
- B4E122_HUMAN
- M9UVU3_HUMAN
- Q5T0Y2_HUMAN
- Q5T0Y3_HUMAN
- Q5T0Y4_HUMAN
Pseudogenes.org Pseudogenes for MDM4 Gene
Variants for MDM4 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs41299595 | uncertain-significance, not provided | 204,549,329(+) | A/C | 3_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs1000021179 | -- | 204,557,354(+) | T/A | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1000067274 | -- | 204,557,102(+) | A/C | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1000086224 | -- | 204,521,149(+) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000095008 | -- | 204,517,256(+) | AAAAAA/AAAAAAA | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |