This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms... See more...

Aliases for MDK Gene

Aliases for MDK Gene

  • Midkine 2 3 4 5
  • MK 2 3 4
  • Neurite Outgrowth-Promoting Factor 2 3 4
  • Neurite Growth-Promoting Factor 2 2 3
  • Amphiregulin-Associated Protein 3 4
  • Midgestation And Kidney Protein 3 4
  • NEGF2 3 4
  • ARAP 3 4
  • Neurite Outgrowth-Promoting Protein 4
  • Retinoic Acid Inducible Factor 3
  • FLJ27379 2
  • MDK 5
  • MK1 4

External Ids for MDK Gene

Previous HGNC Symbols for MDK Gene

  • NEGF2

Previous GeneCards Identifiers for MDK Gene

  • GC11P048187
  • GC11P047092
  • GC11P046434
  • GC11P046367
  • GC11P046359
  • GC11P046109
  • GC11P046402

Summaries for MDK Gene

Entrez Gene Summary for MDK Gene

  • This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

GeneCards Summary for MDK Gene

MDK (Midkine) is a Protein Coding gene. Diseases associated with MDK include Low Grade Glioma and Childhood Malignant Schwannoma. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include growth factor activity and heparin binding.

UniProtKB/Swiss-Prot Summary for MDK Gene

  • Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:18469519, PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:24458438, PubMed:15466886, PubMed:12084985, PubMed:10772929). Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups (PubMed:12084985, PubMed:10212223). Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration (PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:10683378, PubMed:24458438, PubMed:22323540, PubMed:12084985, PubMed:15466886, PubMed:10772929). Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression (PubMed:10683378, PubMed:24458438). This inflammation can be accompanied by epithelial cell survival and smooth muscle cell migration after renal and vessel damage, respectively (PubMed:10683378). Secondly, suppresses the development of tolerogenic dendric cells thereby inhibiting the differentiation of regulatory T cells and also promote T cell expansion through NFAT signaling and Th1 cell differentiation (PubMed:22323540). Promotes tissue regeneration after injury or trauma. After heart damage negatively regulates the recruitment of inflammatory cells and mediates cell survival through activation of anti-apoptotic signaling pathways via MAPKs and AKT pathways through the activation of angiogenesis (By similarity). Also facilitates liver regeneration as well as bone repair by recruiting macrophage at trauma site and by promoting cartilage development by facilitating chondrocyte differentiation (By similarity). Plays a role in brain by promoting neural precursor cells survival and growth through interaction with heparan sulfate proteoglycans (By similarity). Binds PTPRZ1 and promotes neuronal migration and embryonic neurons survival (PubMed:10212223). Binds SDC3 or GPC2 and mediates neurite outgrowth and cell adhesion (PubMed:12084985, PubMed:1768439). Binds chondroitin sulfate E and heparin leading to inhibition of neuronal cell adhesion induced by binding with GPC2 (PubMed:12084985). Binds CSPG5 and promotes elongation of oligodendroglial precursor-like cells (By similarity). Also binds ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (PubMed:15466886, PubMed:1768439). Binds LRP1; promotes neuronal survival (PubMed:10772929). Binds ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation (PubMed:12122009). Promotes epithelial to mesenchymal transition through interaction with NOTCH2 (PubMed:18469519). During arteriogenesis, plays a role in vascular endothelial cell proliferation by inducing VEGFA expression and release which in turn induces nitric oxide synthase expression. Moreover activates vasodilation through nitric oxide synthase activation (By similarity). Negatively regulates bone formation in response to mechanical load by inhibiting Wnt/beta-catenin signaling in osteoblasts (By similarity). In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (By similarity).

Gene Wiki entry for MDK Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MDK Gene

Genomics for MDK Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MDK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MDK on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MDK

Top Transcription factor binding sites by QIAGEN in the MDK gene promoter:
  • STAT3

Genomic Locations for MDK Gene

Latest Assembly
chr11:46,380,756-46,383,837
(GRCh38/hg38)
Size:
3,082 bases
Orientation:
Plus strand

Previous Assembly
chr11:46,402,334-46,405,387
(GRCh37/hg19 by Entrez Gene)
Size:
3,054 bases
Orientation:
Plus strand

chr11:46,402,306-46,405,375
(GRCh37/hg19 by Ensembl)
Size:
3,070 bases
Orientation:
Plus strand

Genomic View for MDK Gene

Genes around MDK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MDK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MDK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MDK Gene

Proteins for MDK Gene

  • Protein details for MDK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21741-MK_HUMAN
    Recommended name:
    Midkine
    Protein Accession:
    P21741
    Secondary Accessions:
    • Q2LEK4
    • Q9UCC7

    Protein attributes for MDK Gene

    Size:
    143 amino acids
    Molecular mass:
    15585 Da
    Quaternary structure:
    • Homodimer. Interacts with ALK (PubMed:12122009). Interacts with LRP1; promotes neuronal survival (PubMed:10772929). Interacts with LRP2 (PubMed:10772929). Interacts with NCAM1 (PubMed:10772929). Interacts (via C-terminal) with PTPRZ1 (via chondroitin sulfate chains); this interaction is inhibited by PTN; this interaction promotes neuronal migration (PubMed:10212223). Interacts with NCL; this interaction promotes NCL clustering and lateral movements of this complex into lipid rafts leading to MDK internalization (PubMed:12147681). Interacts with LRP6 and LRP8: this interaction is calcium dependent (PubMed:12573468). Interacts with ITGA4 (PubMed:15466886). Interacts with ITGA6 (PubMed:15466886). Interacts with ITGB1 (PubMed:15466886). Interacts with ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). Interacts with ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (PubMed:15466886). Interacts with NOTCH2; this interaction mediates a nuclear accumulation of NOTCH2 and therefore activation of NOTCH2 signaling leading to interaction between HES1 and STAT3 (PubMed:18469519). Interacts with GPC2 (via heparan sulfate chain); this interaction is inhibited by heparin followed by chondroitin sulfate E; this interaction induces GPC2 clustering through heparan sulfate chain; this interaction induces neuronal cell adhesion and neurite outgrowth (PubMed:12084985). Interacts with SDC3; this interaction induces SDC3 clustering; this interaction induces neuronal cell adhesion and neurite outgrowth (PubMed:12084985). Interacts with SDC1 (By similarity). Interacts with CSPG5; this interaction promotes elongation of oligodendroglial precursor-like cells (By similarity).
    Miscellaneous:
    • [Isoform 2]: Found in cancer tissues with expression in the tumor bodies and surrounding normal cells.

    Three dimensional structures from OCA and Proteopedia for MDK Gene

    Alternative splice isoforms for MDK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MDK Gene

Post-translational modifications for MDK Gene

  • Glycosylation at Thr119
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MDK Gene

Domains & Families for MDK Gene

Gene Families for MDK Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for MDK Gene

Suggested Antigen Peptide Sequences for MDK Gene

GenScript: Design optimal peptide antigens:
  • Neurite outgrowth-promoting protein (MK_HUMAN)
  • Mutant truncated midkine C (Q2LEK2_HUMAN)
  • Mutant truncated midkine B (Q2LEK3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P21741

UniProtKB/Swiss-Prot:

MK_HUMAN :
  • Belongs to the pleiotrophin family.
Family:
  • Belongs to the pleiotrophin family.
genes like me logo Genes that share domains with MDK: view

Function for MDK Gene

Molecular function for MDK Gene

UniProtKB/Swiss-Prot Function:
Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:18469519, PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:24458438, PubMed:15466886, PubMed:12084985, PubMed:10772929). Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups (PubMed:12084985, PubMed:10212223). Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration (PubMed:12573468, PubMed:12122009, PubMed:10212223, PubMed:10683378, PubMed:24458438, PubMed:22323540, PubMed:12084985, PubMed:15466886, PubMed:10772929). Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression (PubMed:10683378, PubMed:24458438). This inflammation can be accompanied by epithelial cell survival and smooth muscle cell migration after renal and vessel damage, respectively (PubMed:10683378). Secondly, suppresses the development of tolerogenic dendric cells thereby inhibiting the differentiation of regulatory T cells and also promote T cell expansion through NFAT signaling and Th1 cell differentiation (PubMed:22323540). Promotes tissue regeneration after injury or trauma. After heart damage negatively regulates the recruitment of inflammatory cells and mediates cell survival through activation of anti-apoptotic signaling pathways via MAPKs and AKT pathways through the activation of angiogenesis (By similarity). Also facilitates liver regeneration as well as bone repair by recruiting macrophage at trauma site and by promoting cartilage development by facilitating chondrocyte differentiation (By similarity). Plays a role in brain by promoting neural precursor cells survival and growth through interaction with heparan sulfate proteoglycans (By similarity). Binds PTPRZ1 and promotes neuronal migration and embryonic neurons survival (PubMed:10212223). Binds SDC3 or GPC2 and mediates neurite outgrowth and cell adhesion (PubMed:12084985, PubMed:1768439). Binds chondroitin sulfate E and heparin leading to inhibition of neuronal cell adhesion induced by binding with GPC2 (PubMed:12084985). Binds CSPG5 and promotes elongation of oligodendroglial precursor-like cells (By similarity). Also binds ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (PubMed:15466886, PubMed:1768439). Binds LRP1; promotes neuronal survival (PubMed:10772929). Binds ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation (PubMed:12122009). Promotes epithelial to mesenchymal transition through interaction with NOTCH2 (PubMed:18469519). During arteriogenesis, plays a role in vascular endothelial cell proliferation by inducing VEGFA expression and release which in turn induces nitric oxide synthase expression. Moreover activates vasodilation through nitric oxide synthase activation (By similarity). Negatively regulates bone formation in response to mechanical load by inhibiting Wnt/beta-catenin signaling in osteoblasts (By similarity). In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (By similarity).
UniProtKB/Swiss-Prot Induction:
By heparin and retinoic acid.
GENATLAS Biochemistry:
neurite growth promoting factor 2,retinoic acid responsive,heparin binding cytokine family

Phenotypes From GWAS Catalog for MDK Gene

Gene Ontology (GO) - Molecular Function for MDK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10212223
GO:0008083 growth factor activity IBA,NAS 1639750
GO:0008201 heparin binding IEA,IDA 9384573
GO:0035374 chondroitin sulfate binding ISS --
GO:1904399 heparan sulfate binding IDA 12084985
genes like me logo Genes that share ontologies with MDK: view
genes like me logo Genes that share phenotypes with MDK: view

Animal Models for MDK Gene

MGI Knock Outs for MDK:
  • Mdk Mdk<tm1Tmu>
  • Mdk Mdk<tm1.1(KOMP)Mbp>

Animal Models for research

  • Taconic Biosciences Mouse Models for MDK

miRNA for MDK Gene

miRTarBase miRNAs that target MDK

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MDK

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MDK Gene

Localization for MDK Gene

Subcellular locations from UniProtKB/Swiss-Prot for MDK Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MDK gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MDK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0062023 colocalizes_with collagen-containing extracellular matrix HDA 28327460
genes like me logo Genes that share ontologies with MDK: view

Pathways & Interactions for MDK Gene

PathCards logo

SuperPathways for MDK Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
2 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
3 ERK Signaling
.61
.61
.58
.51
.49
4 Nanog in Mammalian ESC Pluripotency
.61
.61
.59
.48
5 CREB Pathway
.68
.68
.63
.50
genes like me logo Genes that share pathways with MDK: view

Pathways by source for MDK Gene

54 Qiagen pathways for MDK Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

SIGNOR curated interactions for MDK Gene

Activates:

Gene Ontology (GO) - Biological Process for MDK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002232 leukocyte chemotaxis involved in inflammatory response ISS --
GO:0002286 T cell activation involved in immune response ISS --
GO:0002690 positive regulation of leukocyte chemotaxis ISS --
GO:0007010 cytoskeleton organization ISS --
GO:0007162 negative regulation of cell adhesion ISS --
genes like me logo Genes that share ontologies with MDK: view

Drugs & Compounds for MDK Gene

(3) Drugs for MDK Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma 1160

(3) Additional Compounds for MDK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MDK: view

Transcripts for MDK Gene

mRNA/cDNA for MDK Gene

6 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MDK

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for MDK Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: - - - - -
SP6: -
SP7: - - -
SP8:
SP9: -
SP10: - - -

Relevant External Links for MDK Gene

GeneLoc Exon Structure for
MDK

Expression for MDK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MDK Gene

mRNA differential expression in normal tissues according to GTEx for MDK Gene

This gene is overexpressed in Ovary (x7.8), Pituitary (x4.7), and Cervix - Ectocervix (x4.3).

Protein differential expression in normal tissues from HIPED for MDK Gene

This gene is overexpressed in Amniocyte (47.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MDK Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MDK

SOURCE GeneReport for Unigene cluster for MDK Gene:

Hs.82045

mRNA Expression by UniProt/SwissProt for MDK Gene:

P21741-MK_HUMAN
Tissue specificity: Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions.

Evidence on tissue expression from TISSUES for MDK Gene

  • Nervous system(4.7)
  • Kidney(4.5)
  • Bone marrow(4.4)
  • Pancreas(3)
  • Stomach(2.6)
  • Intestine(2.6)
  • Spleen(2.5)
  • Heart(2.4)
  • Gall bladder(2.4)
  • Muscle(2.3)
  • Lung(2.3)
  • Lymph node(2.2)
  • Liver(2.2)
  • Adrenal gland(2.2)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with MDK: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MDK Gene

Orthologs for MDK Gene

This gene was present in the common ancestor of chordates.

Orthologs for MDK Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia BMK 30
  • 94 (a)
OneToOne
MDK 29
  • 92.45 (n)
Mouse
(Mus musculus)
Mammalia Mdk 29 16 30
  • 88.98 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mdk 29
  • 88.71 (n)
Chicken
(Gallus gallus)
Aves MDK 29 30
  • 73.05 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MDK 30
  • 61 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mdk 29
  • 69.5 (n)
MGC75716 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.899 29
Zebrafish
(Danio rerio)
Actinopterygii mdka 29 30
  • 66.67 (n)
OneToMany
mdkb 30
  • 46 (a)
OneToMany
Species where no ortholog for MDK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MDK Gene

ENSEMBL:
Gene Tree for MDK (if available)
TreeFam:
Gene Tree for MDK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MDK: view image
Alliance of Genome Resources:
Additional Orthologs for MDK

Paralogs for MDK Gene

(1) SIMAP similar genes for MDK Gene using alignment to 6 proteins:

  • MK_HUMAN
  • C9JHA4_HUMAN
  • E9PLM6_HUMAN
  • E9PPJ5_HUMAN
  • Q2LEK2_HUMAN
  • Q2LEK3_HUMAN
genes like me logo Genes that share paralogs with MDK: view

No data available for Paralogs for MDK Gene

Variants for MDK Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MDK Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MDK Gene

Variant ID Type Subtype PubMed ID
esv3626183 CNV gain 21293372
esv3626185 CNV loss 21293372
nsv309 CNV deletion 18451855
nsv554201 CNV loss 21841781
nsv554202 CNV loss 21841781
nsv554203 CNV loss 21841781
nsv825867 CNV gain 20364138
nsv951610 CNV deletion 24416366

Variation tolerance for MDK Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MDK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MDK
Leiden Open Variation Database (LOVD)
MDK

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MDK Gene

Disorders for MDK Gene

MalaCards: The human disease database

(4) MalaCards diseases for MDK Gene - From: COP and GCD

Disorder Aliases PubMed IDs
low grade glioma
  • benign glioma
childhood malignant schwannoma
  • pediatric mpnst
breast adenocarcinoma
  • adenocarcinoma of breast
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search MDK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MDK

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MDK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MDK Gene

Publications for MDK Gene

  1. The anti-HIV cytokine midkine binds the cell surface-expressed nucleolin as a low affinity receptor. (PMID: 12147681) Said EA … Hovanessian AG (The Journal of biological chemistry 2002) 3 4 22
  2. Midkine gene (MDK), a gene for prenatal differentiation and neuroregulation, maps to band 11p11.2 by fluorescence in situ hybridization. (PMID: 8406506) Kaname T … Kajii T (Genomics 1993) 2 3 22
  3. Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins. (PMID: 1768439) Kretschmer PJ … Kovesdi I (Growth factors (Chur, Switzerland) 1991) 3 4 22
  4. Amphiregulin-associated protein: complete amino acid sequence of a protein produced by the 12-0-tetradecanoylphorbol-13-acetate-treated human breast adenocarcinoma cell line MCF-7. (PMID: 1883381) Shoyab M … Plowman GD (Biochemical and biophysical research communications 1991) 3 4 22
  5. The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via β2 integrins (CD11/CD18). (PMID: 24458438) Weckbach LT … Walzog B (Blood 2014) 3 4

Products for MDK Gene

Sources for MDK Gene