Aliases for MDH2 Gene
External Ids for MDH2 Gene
Previous GeneCards Identifiers for MDH2 Gene
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
GeneCards Summary for MDH2 Gene
MDH2 (Malate Dehydrogenase 2) is a Protein Coding gene. Diseases associated with MDH2 include Epileptic Encephalopathy, Early Infantile, 51 and Hereditary Paraganglioma-Pheochromocytoma Syndromes. Among its related pathways are Glycosaminoglycan metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor.