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Aliases for MDFIC Gene

Aliases for MDFIC Gene

  • MyoD Family Inhibitor Domain Containing 2 3 5
  • I-Mfa Domain-Containing Protein 3 4
  • HIC 3 4
  • MyoD Family Inhibitor Domain-Containing Protein 3
  • MDFIC1 3

External Ids for MDFIC Gene

Previous GeneCards Identifiers for MDFIC Gene

  • GC07P114157
  • GC07P114349
  • GC07P114562
  • GC07P108926

Summaries for MDFIC Gene

Entrez Gene Summary for MDFIC Gene

  • This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for MDFIC Gene

MDFIC (MyoD Family Inhibitor Domain Containing) is a Protein Coding gene. Diseases associated with MDFIC include T-Cell Leukemia and Follicular Mucinosis. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription. Gene Ontology (GO) annotations related to this gene include transcription factor binding and cyclin binding. An important paralog of this gene is MDFI.

UniProtKB/Swiss-Prot for MDFIC Gene

  • Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.

Additional gene information for MDFIC Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MDFIC Gene

Genomics for MDFIC Gene

GeneHancer (GH) Regulatory Elements for MDFIC Gene

Promoters and enhancers for MDFIC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I114921 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 560.1 +5.6 5561 12.9 HDGF SIN3A FEZF1 ZNF2 IRF4 YY1 GLIS2 ATF7 RUNX3 ZNF214 MDFIC GC07M114915 GC07P114927 LINC01393
GH07I114915 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.4 -4.6 -4586 3.4 PKNOX1 BMI1 BATF KLF5 IRF4 ZNF207 ATF7 ETV6 BCLAF1 IKZF2 MDFIC GC07M114915 GC07P114775
GH07I114818 Enhancer 1.1 FANTOM5 Ensembl ENCODE 7.8 -102.6 -102554 3.2 JUN MAX RFX5 ZNF316 RCOR1 NFE2 FOSL2 FOS MAFK NFE2L2 MDFIC GC07P114775
GH07I114889 Enhancer 1 Ensembl ENCODE 6.1 -32.4 -32352 1.2 JUN RAD21 RFX5 FOSL1 ZNF366 POLR2A ZSCAN5C SCRT2 SMC3 SMARCC2 MDFIC GC07P114775
GH07I115475 Enhancer 1.4 VISTA UCNEbase Ensembl ENCODE 4.1 +554.6 554581 2.7 CTCF MAZ ZNF777 L3MBTL2 ZSCAN4 FEZF1 RAD21 ZNF335 ZNF366 PRDM1 MDFIC GC07P115459 ENSG00000244565
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MDFIC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MDFIC gene promoter:

Genomic Locations for MDFIC Gene

Genomic Locations for MDFIC Gene
chr7:114,922,154-115,019,916
(GRCh38/hg38)
Size:
97,763 bases
Orientation:
Plus strand
chr7:114,562,209-114,659,970
(GRCh37/hg19)

Genomic View for MDFIC Gene

Genes around MDFIC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MDFIC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MDFIC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MDFIC Gene

Proteins for MDFIC Gene

  • Protein details for MDFIC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1T7-MDFIC_HUMAN
    Recommended name:
    MyoD family inhibitor domain-containing protein
    Protein Accession:
    Q9P1T7
    Secondary Accessions:
    • Q9P1T6

    Protein attributes for MDFIC Gene

    Size:
    246 amino acids
    Molecular mass:
    25788 Da
    Quaternary structure:
    • Interacts with HAND1; leading to sequester HAND1 into the nucleolus and prevent its activity. Interacts with ZIC2 (By similarity). The C-terminus interacts with HIV-1 Tat and Rev, AXIN1, the histidine-rich region of CCNT1/cyclin-T and weakly with LEF1 (PubMed:12192039, PubMed:12944466, PubMed:16260749, Ref.6). Interacts with CCNT2 (PubMed:17289077).

    Alternative splice isoforms for MDFIC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MDFIC Gene

Post-translational modifications for MDFIC Gene

No Post-translational modifications

No data available for DME Specific Peptides for MDFIC Gene

Domains & Families for MDFIC Gene

Gene Families for MDFIC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for MDFIC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MDFIC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P1T7

UniProtKB/Swiss-Prot:

MDFIC_HUMAN :
  • The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation (By similarity). The cysteine-rich C-terminus is involved in its granular distribution in the cytoplasm.
  • Belongs to the MDFI family.
Domain:
  • The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation (By similarity). The cysteine-rich C-terminus is involved in its granular distribution in the cytoplasm.
Family:
  • Belongs to the MDFI family.
genes like me logo Genes that share domains with MDFIC: view

Function for MDFIC Gene

Molecular function for MDFIC Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.

Phenotypes From GWAS Catalog for MDFIC Gene

Gene Ontology (GO) - Molecular Function for MDFIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12192039
GO:0008134 transcription factor binding IPI 12192039
GO:0030332 cyclin binding IPI 12944466
GO:0030957 Tat protein binding IDA 12944466
genes like me logo Genes that share ontologies with MDFIC: view
genes like me logo Genes that share phenotypes with MDFIC: view

Animal Model Products

Clone Products

  • Addgene plasmids for MDFIC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MDFIC Gene

Localization for MDFIC Gene

Subcellular locations from UniProtKB/Swiss-Prot for MDFIC Gene

Isoform 1: Nucleus, nucleolus. Note=Also shows a granular distribution in the cytoplasm.
Isoform 2: Cytoplasm. Note=Weak expression in the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MDFIC gene
Compartment Confidence
nucleus 5
extracellular 3
golgi apparatus 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MDFIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with MDFIC: view

Pathways & Interactions for MDFIC Gene

genes like me logo Genes that share pathways with MDFIC: view

Pathways by source for MDFIC Gene

Gene Ontology (GO) - Biological Process for MDFIC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007257 activation of JUN kinase activity IDA 12192039
GO:0016032 viral process IEA --
GO:0030111 regulation of Wnt signaling pathway IDA 12192039
genes like me logo Genes that share ontologies with MDFIC: view

No data available for SIGNOR curated interactions for MDFIC Gene

Drugs & Compounds for MDFIC Gene

No Compound Related Data Available

Transcripts for MDFIC Gene

Unigene Clusters for MDFIC Gene

MyoD family inhibitor domain containing:
Representative Sequences:

Clone Products

  • Addgene plasmids for MDFIC

Alternative Splicing Database (ASD) splice patterns (SP) for MDFIC Gene

No ASD Table

Relevant External Links for MDFIC Gene

GeneLoc Exon Structure for
MDFIC
ECgene alternative splicing isoforms for
MDFIC

Expression for MDFIC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MDFIC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MDFIC Gene

This gene is overexpressed in Breast (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MDFIC Gene



Protein tissue co-expression partners for MDFIC Gene

NURSA nuclear receptor signaling pathways regulating expression of MDFIC Gene:

MDFIC

SOURCE GeneReport for Unigene cluster for MDFIC Gene:

Hs.741413

mRNA Expression by UniProt/SwissProt for MDFIC Gene:

Q9P1T7-MDFIC_HUMAN
Tissue specificity: Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as prostate, uterus and small intestine.

Evidence on tissue expression from TISSUES for MDFIC Gene

  • Blood(2)
genes like me logo Genes that share expression patterns with MDFIC: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MDFIC Gene

Orthologs for MDFIC Gene

This gene was present in the common ancestor of chordates.

Orthologs for MDFIC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MDFIC 33 34
  • 99.19 (n)
dog
(Canis familiaris)
Mammalia LOC612042 33
  • 90.26 (n)
MDFIC 34
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MDFIC 33 34
  • 90.08 (n)
mouse
(Mus musculus)
Mammalia Mdfic 33 16 34
  • 83.88 (n)
rat
(Rattus norvegicus)
Mammalia Mdfic 33
  • 83.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MDFIC 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MDFIC 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves MDFIC 33 34
  • 76.82 (n)
lizard
(Anolis carolinensis)
Reptilia MDFIC 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mdfic 33
  • 71.14 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398213 33
zebrafish
(Danio rerio)
Actinopterygii si:ch73-156e19.1 33
  • 68.95 (n)
MDFIC (2 of 2) 34
  • 64 (a)
OneToMany
MDFIC (1 of 2) 34
  • 51 (a)
OneToMany
Species where no ortholog for MDFIC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MDFIC Gene

ENSEMBL:
Gene Tree for MDFIC (if available)
TreeFam:
Gene Tree for MDFIC (if available)

Paralogs for MDFIC Gene

Paralogs for MDFIC Gene

(1) SIMAP similar genes for MDFIC Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MDFIC: view

Variants for MDFIC Gene

Sequence variations from dbSNP and Humsavar for MDFIC Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000027299 -- 114,970,678(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000065749 -- 114,926,378(+) T/A genic_downstream_transcript_variant, intron_variant
rs1000076731 -- 114,999,949(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000085112 -- 114,945,655(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000097352 -- 114,964,544(+) C/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MDFIC Gene

Variant ID Type Subtype PubMed ID
nsv819577 CNV loss 19587683
nsv7405 OTHER inversion 18451855
nsv608238 CNV gain 21841781
nsv526154 CNV loss 19592680
esv3572085 CNV loss 25503493

Variation tolerance for MDFIC Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MDFIC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MDFIC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MDFIC Gene

Disorders for MDFIC Gene

MalaCards: The human disease database

(2) MalaCards diseases for MDFIC Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
follicular mucinosis
  • alopecia mucinosa
- elite association - COSMIC cancer census association via MalaCards
Search MDFIC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MDFIC

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MDFIC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MDFIC Gene

Publications for MDFIC Gene

  1. Molecular cloning of a novel human I-mfa domain-containing protein that differently regulates human T-cell leukemia virus type I and HIV-1 expression. (PMID: 10671520) Thébault S … Mesnard JM (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription. (PMID: 17289077) Wang Q … Pe'ery T (Journal of molecular biology 2007) 3 4 22 58
  3. Direct interaction of the human I-mfa domain-containing protein, HIC, with HIV-1 Tat results in cytoplasmic sequestration and control of Tat activity. (PMID: 16260749) Gautier VW … Hall WW (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 22 58
  4. The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription. (PMID: 12944466) Young TM … Mathews MB (Molecular and cellular biology 2003) 3 4 22 58
  5. I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways. (PMID: 12192039) Kusano S … Raab-Traub N (Molecular and cellular biology 2002) 3 4 22 58

Products for MDFIC Gene

  • Addgene plasmids for MDFIC

Sources for MDFIC Gene

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