Aliases for MCUB Gene
External Ids for MCUB Gene
Previous HGNC Symbols for MCUB Gene
GeneCards Summary for MCUB Gene
MCUB (Mitochondrial Calcium Uniporter Dominant Negative Beta Subunit) is a Protein Coding gene. An important paralog of this gene is MCU.
UniProtKB/Swiss-Prot for MCUB Gene
Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.