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Aliases for MCTS1 Gene
Aliases for MCTS1 Gene
External Ids for MCTS1 Gene
- HGNC: 23357
- Entrez Gene: 28985
- Ensembl: ENSG00000232119
- OMIM: 300587
- UniProtKB: Q9ULC4
Previous GeneCards Identifiers for MCTS1 Gene
- GC0XP118491
- GC0XP119519
- GC0XP119621
- GC0XP119727
- GC0XP109189
Summaries for MCTS1 Gene
GeneCards Summary for MCTS1 Gene
MCTS1 (MCTS1 Re-Initiation And Release Factor) is a Protein Coding gene. Diseases associated with MCTS1 include Lymphoma. Gene Ontology (GO) annotations related to this gene include RNA binding and translation initiation factor activity. An important paralog of this gene is MCTS2P.
UniProtKB/Swiss-Prot Summary for MCTS1 Gene
-
Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MCTS1 Gene
Genomics for MCTS1 Gene
GeneHancer (GH) Regulatory Elements for MCTS1 Gene
Promoters and enhancers for MCTS1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XJ120558 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 500.3 | -33.4 | -33354 | 6.9 | FOXK2 ZBTB40 ZNF217 EP300 TCF12 POLR2G USF1 PHF8 ZNF639 ZNF10 | lnc-C1GALT1C1-3 CUL4B MCTS1 C1GALT1C1 UPF3B LINC01402 RF01210-416 | |
| GH0XJ120603 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 500.4 | +10.5 | 10491 | 2.6 | ZBTB40 ZNF217 EP300 POLR2G PHF8 ZFX ZNF639 ZNF10 POLR2A CLOCK | MCTS1 C1GALT1C1 RF00017-8664 | |
| GH0XJ120618 | Enhancer | 0.4 | Ensembl | 0.4 | +24.5 | 24491 | 1 | MAFK MEF2A PKNOX1 | piR-43107-321 lnc-MCTS1-1 lnc-C1GALT1C1-1 MCTS1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MCTS1 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MCTS1
- Top Transcription factor binding sites by QIAGEN in the MCTS1 gene promoter:
-
- p53
- Sox9
- Sp1
Genomic Locations for MCTS1 Gene
Genomic Locations for MCTS1 Gene
- chrX:120,594,010-120,621,159
- (GRCh38/hg38)
- Size:
- 27,150 bases
- Orientation:
- Plus strand
- chrX:119,727,865-119,755,014
- (GRCh37/hg19)
- Size:
- 27,150 bases
- Orientation:
- Plus strand
Genomic View for MCTS1 Gene
Genes around MCTS1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq24 by HGNC
- Xq24 by Entrez Gene
- Xq24 by Ensembl
MCTS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MCTS1 Gene
Proteins for MCTS1 Gene
-
Protein details for MCTS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9ULC4-MCTS1_HUMAN
- Recommended name:
- Malignant T-cell-amplified sequence 1
- Protein Accession:
- Q9ULC4
- B4DGY2
- Q502X6
Protein attributes for MCTS1 Gene
- Size:
- 181 amino acids
- Molecular mass:
- 20555 Da
- Quaternary structure:
-
- Interacts (via PUA domain) with DENR.
Three dimensional structures from OCA and Proteopedia for MCTS1 Gene
Protein Expression for MCTS1 Gene
Post-translational modifications for MCTS1 Gene
- Phosphorylation is critical for stabilization and promotion of cell proliferation.
-
Ubiquitination at Lys87
- NX_Q9ULC4 (NX_Q9ULC4-1)
- Modification sites at PhosphoSitePlus
Other Protein References for MCTS1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-MCTS1 monoclonal antibody, clone 3G0
- Creative Biolabs Mouse Anti-MCTS1 (AA 1-500) Recombinant Antibody (CBFYM-0217)
- GeneTex Anti-MCTS1 antibody [2G2] and Anti-MCTS1 antibody [N1C3]
-
Custom Antibody ServicesOriGene Antibodies for MCTS1
- Novus Biologicals Antibodies for MCTS1
- Invitrogen Antibodies for MCTS1 (AFLGC-MCTS1)
- antibodies-online: Show 15 available MCTS1 Antibodies ranked by validation data
-
Biorbyt antibodies for MCTS1
- Sino Biological Antibodies for MCTS1
Protein Products
-
OriGene Purified Proteins for MCTS1
- Search Origene for MassSpec and Protein Over-expression Lysates for MCTS1
- Origene Custom Protein Services for MCTS1
- ProSpec Recombinant Proteins for MCTS1
- antibodies-online: Show 12 available MCTS1 Proteins ranked by validation data
- Compare Top MCTS1 Proteins
-
Quality Products:
-
Abcam proteins for MCTS1
No data available for DME Specific Peptides for MCTS1 Gene
Domains & Families for MCTS1 Gene
Gene Families for MCTS1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MCTS1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MCTS1 Gene
- GenScript: Design optimal peptide antigens:
-
- Multiple copies T-cell malignancies (MCTS1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9ULC4UniProtKB/Swiss-Prot:
MCTS1_HUMAN :- The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function. MCT1 N-terminal region is required to enhance translation possibly through interaction with other proteins.
- Belongs to the MCTS1 family.
- Domain:
-
- The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function. MCT1 N-terminal region is required to enhance translation possibly through interaction with other proteins.
- Family:
-
- Belongs to the MCTS1 family.
Function for MCTS1 Gene
Molecular function for MCTS1 Gene
- UniProtKB/Swiss-Prot Function:
- Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
- UniProtKB/Swiss-Prot Induction:
- By DNA damaging agents such as gamma irradiation, adriamycin or taxol in lymphoid cells, but not by stress stimuli such as heat shock. This induction of protein expression does not occur at the RNA level, and does not require new protein synthesis.
Phenotypes From GWAS Catalog for MCTS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0003743 | translation initiation factor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 16169070 |
Phenotypes for MCTS1 Gene
- MGI mutant phenotypes for MCTS1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MCTS1:
-
- Decreased cell number
- Decreased shRNA abundance (Z-score < -2)
- Increased homologous recombination repair frequency
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- no effect
- Decreased Aire reporter expression
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability after Maraba virus infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MCTS1 - Select products 50% OFF >
- * MCTS1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MCTS1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for MCTS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MCTS1
- genomics-online: gRNA clones - Search results for available MCTS1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for MCTS1
miRNA for MCTS1 Gene
- miRTarBase miRNAs that target MCTS1
-
- hsa-mir-652-3p (MIRT039499)
- hsa-mir-599 (MIRT445810)
- hsa-mir-578 (MIRT445811)
- hsa-mir-3161 (MIRT445812)
- hsa-mir-4709-3p (MIRT445813)
- hsa-mir-526b-5p (MIRT445814)
- hsa-mir-4635 (MIRT445815)
- hsa-mir-6079 (MIRT504139)
- hsa-mir-671-5p (MIRT504140)
- hsa-mir-6828-5p (MIRT504141)
- hsa-mir-4448 (MIRT504142)
- hsa-mir-6806-3p (MIRT504143)
- hsa-mir-3928-5p (MIRT504144)
- hsa-mir-3680-5p (MIRT504145)
- hsa-mir-4798-3p (MIRT504146)
- hsa-mir-28-3p (MIRT504147)
- hsa-mir-6776-3p (MIRT516256)
- hsa-mir-3935 (MIRT572728)
- hsa-mir-4487 (MIRT572729)
- hsa-mir-558 (MIRT572730)
- hsa-mir-3160-3p (MIRT572731)
- hsa-mir-95-5p (MIRT572732)
- hsa-mir-4461 (MIRT572733)
- hsa-mir-888-5p (MIRT572734)
- hsa-mir-7151-3p (MIRT607403)
- hsa-mir-5095 (MIRT607404)
- hsa-mir-365b-5p (MIRT607405)
- hsa-mir-365a-5p (MIRT607406)
- hsa-mir-8052 (MIRT607407)
- hsa-mir-3199 (MIRT607408)
- hsa-mir-6778-3p (MIRT607409)
- hsa-mir-4252 (MIRT607410)
- hsa-mir-6845-3p (MIRT607411)
- hsa-mir-1976 (MIRT607412)
- hsa-mir-3653-5p (MIRT607413)
- hsa-mir-6747-3p (MIRT607414)
- hsa-mir-6727-3p (MIRT607415)
- hsa-mir-4722-3p (MIRT607416)
- hsa-mir-4740-3p (MIRT607417)
- hsa-mir-6777-3p (MIRT607418)
- hsa-mir-4438 (MIRT607419)
- hsa-mir-4639-3p (MIRT607420)
- hsa-mir-3941 (MIRT607421)
- hsa-mir-4789-3p (MIRT607422)
- hsa-mir-603 (MIRT607423)
- hsa-mir-362-3p (MIRT607424)
- hsa-mir-329-3p (MIRT607425)
- hsa-mir-8485 (MIRT607426)
- hsa-mir-3065-5p (MIRT628016)
- hsa-mir-7159-5p (MIRT670311)
- hsa-mir-498 (MIRT678335)
- hsa-mir-4772-3p (MIRT678336)
- hsa-mir-4638-5p (MIRT678337)
- hsa-mir-1307-3p (MIRT678338)
- hsa-mir-1304-3p (MIRT678339)
- hsa-mir-6741-3p (MIRT678340)
- hsa-mir-1281 (MIRT678341)
- hsa-mir-4485-5p (MIRT678342)
- hsa-mir-4726-3p (MIRT678343)
- hsa-mir-6764-5p (MIRT678344)
- hsa-mir-1915-3p (MIRT678345)
- hsa-mir-6840-3p (MIRT678346)
- hsa-mir-6890-3p (MIRT678347)
- hsa-mir-4762-5p (MIRT678348)
- hsa-mir-6848-3p (MIRT679927)
- hsa-mir-6843-3p (MIRT679928)
- hsa-mir-6878-3p (MIRT679929)
- hsa-mir-378a-5p (MIRT679930)
- hsa-mir-6744-3p (MIRT679931)
- hsa-mir-4757-5p (MIRT679932)
- hsa-mir-4454 (MIRT679933)
- hsa-mir-6821-3p (MIRT679934)
- hsa-mir-6790-3p (MIRT679935)
- hsa-mir-150-5p (MIRT679936)
- hsa-mir-212-5p (MIRT679937)
- hsa-mir-1224-3p (MIRT679938)
- hsa-mir-186-3p (MIRT679939)
- hsa-mir-6813-3p (MIRT679940)
- hsa-mir-607 (MIRT684378)
- hsa-mir-7703 (MIRT684379)
- hsa-mir-6720-5p (MIRT684380)
- hsa-mir-6512-3p (MIRT684381)
- hsa-mir-661 (MIRT684382)
- hsa-mir-4696 (MIRT684383)
- hsa-mir-4725-5p (MIRT684384)
- hsa-mir-6860 (MIRT684385)
- hsa-mir-612 (MIRT684386)
- hsa-mir-5189-5p (MIRT684387)
- hsa-mir-3187-5p (MIRT684388)
- hsa-mir-1285-3p (MIRT684389)
- hsa-mir-766-3p (MIRT684390)
- hsa-mir-939-3p (MIRT684391)
- hsa-mir-6849-3p (MIRT684392)
- hsa-mir-6501-3p (MIRT684393)
- hsa-mir-3613-3p (MIRT684394)
- hsa-mir-451b (MIRT684395)
- hsa-mir-508-5p (MIRT684396)
- hsa-mir-10b-5p (MIRT684397)
- hsa-mir-10a-5p (MIRT684398)
- hsa-mir-3667-5p (MIRT684399)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MCTS1
- Browse OriGene Inhibitory RNA Products For MCTS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCTS1
- genomics-online: shRNA clones - Search results for available MCTS1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for MCTS1 - Select products 50% OFF >
- * MCTS1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MCTS1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for MCTS1
- Addgene plasmids for MCTS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MCTS1
- genomics-online: cdna clones - Search results for available MCTS1 gene related products
- orf clones - Search results for available MCTS1 gene related products
Cell Line Products
-
Horizon Cell Lines for MCTS1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCTS1 Gene
Localization for MCTS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MCTS1 Gene
- Cytoplasm. Note=Nuclear relocalization after DNA damage.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| nucleus | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Cytosol (3)
- Plasma membrane (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | IDA | -- |
| GO:0022627 | colocalizes_with cytosolic small ribosomal subunit | IBA,IDA | 20713520 |
Pathways & Interactions for MCTS1 Gene
Interacting Proteins for MCTS1 Gene
Selected Interacting proteins:
Q9ULC4-MCTS1_HUMAN
ENSP00000360365
for MCTS1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MCTS1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001731 | formation of translation preinitiation complex | IDA | 20713520 |
| GO:0002188 | translation reinitiation | IBA | 21873635 |
| GO:0006412 | translation | IEA | -- |
| GO:0006413 | translational initiation | IEA | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for MCTS1 Gene
Transcripts for MCTS1 Gene
mRNA/cDNA for MCTS1 Gene
- 2 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000371315 1130 bps (ENST00000371315.3)
- ENST00000371317 9577 bps (ENST00000371317.10)
- ENST00000484481 398 bps (ENST00000484481.1)
- ENST00000487133 766 bps (ENST00000487133.1)
- ENST00000493274 732 bps (ENST00000493274.5)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MCTS1 - Select products 50% OFF >
- * MCTS1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MCTS1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for MCTS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MCTS1
- genomics-online: gRNA clones - Search results for available MCTS1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for MCTS1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MCTS1
- Browse OriGene Inhibitory RNA Products For MCTS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCTS1
- genomics-online: shRNA clones - Search results for available MCTS1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for MCTS1 - Select products 50% OFF >
- * MCTS1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MCTS1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for MCTS1
- Addgene plasmids for MCTS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MCTS1
- genomics-online: cdna clones - Search results for available MCTS1 gene related products
- orf clones - Search results for available MCTS1 gene related products
Relevant External Links for MCTS1 Gene
- GeneLoc Exon Structure for
- MCTS1
Expression for MCTS1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
This gene is overexpressed in Skin (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MCTS1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MCTS1
SOURCE GeneReport for Unigene cluster for MCTS1 Gene:
Hs.102696mRNA Expression by UniProt/SwissProt for MCTS1 Gene:
Q9ULC4-MCTS1_HUMAN
Tissue specificity:
Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas.
Evidence on tissue expression from TISSUES for MCTS1 Gene
- Nervous system(4.5)
- Eye(4.2)
- Thyroid gland(2.1)
Primer Products
-
OriGene qPCR primer pairs for MCTS1
- genomics-online: primer clones - Search results for available MCTS1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCTS1 Gene
Orthologs for MCTS1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MCTS1 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MCTS1 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MCTS1 31 30 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MCTS1 31 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Mcts1 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Mcts1 17 31 30 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MCTS1 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MCTS1 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MCTS1 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mcts1 30 |
|
||
| Str.11037 30 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | mcts1 31 30 |
|
OneToOne | |
| zgc56242 30 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6712 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003344 30 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG5941 31 30 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | C11D2.7 31 30 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TMA20 33 31 30 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D13574g 30 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADR010C 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3319 30 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os.18476 30 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.3374 30 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPBC31F10.12 30 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU08678 30 |
|
- Species where no ortholog for MCTS1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for MCTS1 Gene
- ENSEMBL:
- Gene Tree for MCTS1 (if available)
- TreeFam:
- Gene Tree for MCTS1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MCTS1: view image
Paralogs for MCTS1 Gene
Pseudogenes.org Pseudogenes for MCTS1 Gene
Variants for MCTS1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MCTS1 Gene
| SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2233110 | - | p.Leu106His |
Residual Variation Intolerance Score:
71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.63;
13.45% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MCTS1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MCTS1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MCTS1 Gene
Disorders for MCTS1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lymphoma |
|
|
Search MCTS1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MCTS1
No data available for UniProtKB/Swiss-Prot and Genatlas for MCTS1 Gene
Publications for MCTS1 Gene
- MCT-1 protein interacts with the cap complex and modulates messenger RNA translational profiles. (PMID: 16982740) Reinert LS … Gartenhaus RB (Cancer research 2006) 2 3 4 54
- A novel candidate oncogene, MCT-1, is involved in cell cycle progression. (PMID: 9766643) Prosniak M … Gartenhaus RB (Cancer research 1998) 2 3 4 54
- DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth. (PMID: 25043021) Schleich S … Teleman AA (Nature 2014) 2 3 54
- Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling. (PMID: 20713520) Skabkin MA … Pestova TV (Genes & development 2010) 3 4 54
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
ExternalLinks
Products for MCTS1 Gene
- Custom Antibody ServicesOriGene Antibodies for MCTS1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MCTS1
- Search Origene for MassSpec and Protein Over-expression Lysates for MCTS1
- Origene Custom Protein Services for MCTS1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MCTS1
- Browse OriGene Inhibitory RNA Products For MCTS1
- OriGene qPCR primer pairs for MCTS1
- OriGene CRISPR knockouts for MCTS1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MCTS1
- Sino Biological Human cDNA Clone for MCTS1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for MCTS1
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MCTS1
- Novus Biologicals proteins and lysates for MCTS1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for MCTS1
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- Addgene plasmids for MCTS1
- antibodies-online: Show 15 available MCTS1 Antibodies ranked by validation data
- antibodies-online: Search results for available MCTS1 related products ranked by validation data
- antibodies-online: Show 12 available MCTS1 Proteins ranked by validation data
- Compare Top MCTS1 Proteins
- Quality Products:
- Horizon Cell Lines for MCTS1
- genomics-online: cdna clones - Search results for available MCTS1 gene related products
- orf clones - Search results for available MCTS1 gene related products
- genomics-online: gRNA clones - Search results for available MCTS1 gene related products
- genomics-online: primer clones - Search results for available MCTS1 gene related products
- genomics-online: shRNA clones - Search results for available MCTS1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MCTS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MCTS1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MCTS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCTS1
- Biorbyt antibodies for MCTS1
Sources for MCTS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource