Aliases for MCTS1 Gene

Aliases for MCTS1 Gene

  • MCTS1 Re-Initiation And Release Factor 2 3 5
  • MCT-1 2 3 4
  • Malignant T-Cell Amplified Sequence 1 2 3
  • Malignant T-Cell-Amplified Sequence 1 3 4
  • Multiple Copies In T-Cell Lymphoma-1 2 3
  • Multiple Copies T-Cell Malignancies 3 4
  • MCT1 3 4
  • MCTS1, Re-Initiation And Release Factor 2
  • MCTS1 5

External Ids for MCTS1 Gene

Previous GeneCards Identifiers for MCTS1 Gene

  • GC0XP118491
  • GC0XP119519
  • GC0XP119621
  • GC0XP119727
  • GC0XP109189

Summaries for MCTS1 Gene

GeneCards Summary for MCTS1 Gene

MCTS1 (MCTS1 Re-Initiation And Release Factor) is a Protein Coding gene. Diseases associated with MCTS1 include Lymphoma. Gene Ontology (GO) annotations related to this gene include RNA binding and translation initiation factor activity. An important paralog of this gene is MCTS2P.

UniProtKB/Swiss-Prot Summary for MCTS1 Gene

  • Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

Additional gene information for MCTS1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MCTS1 Gene

Genomics for MCTS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MCTS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ120558 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.3 -33.4 -33354 6.9 BRCA1 PRDM10 ZNF629 TFE3 IKZF1 FOXA1 GABPA PRDM1 ZIC2 RBFOX2 lnc-C1GALT1C1-3 CUL4B MCTS1 C1GALT1C1 UPF3B LINC01402 SNODB1682 LAMP2
GH0XJ120603 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.4 +10.5 10491 2.6 CREB1 PRDM10 ZNF629 ZNF692 POLR2A JUND GABPA RBFOX2 PKNOX1 ZNF24 MCTS1 C1GALT1C1 RF00017-8666
GH0XJ120628 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.3 +35.8 35791 2.8 SP1 CREB1 PRDM10 ZNF692 POLR2A DDX20 PRDM1 MTA2 ZNF143 PHF21A C1GALT1C1 lnc-C1GALT1C1-1 lnc-MCTS1-3 piR-35674-567 LAMP2 CUL4B EEF1A1P30 NKAPP1 UPF3B piR-35674-566
GH0XJ120578 Enhancer 0.7 Ensembl 0.4 -14.8 -14809 2 ZNF629 ZNF140 ZNF639 ZXDB ZNF580 ZNF266 ZNF623 ZBTB11 OVOL3 ZNF189 EEF1A1P30 NKAPP1 C1GALT1C1 CUL4B NKAP MCTS1 SNODB1744
GH0XJ120582 Enhancer 0.4 Ensembl 0.4 -11.9 -11909 0.2 ZNF512 ZNF513 ZNF680 CUL4B SNODB1744 MCTS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MCTS1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MCTS1

Top Transcription factor binding sites by QIAGEN in the MCTS1 gene promoter:
  • p53
  • Sox9
  • Sp1

Genomic Locations for MCTS1 Gene

Genomic Locations for MCTS1 Gene
chrX:120,594,010-120,621,159
(GRCh38/hg38)
Size:
27,150 bases
Orientation:
Plus strand
chrX:119,727,865-119,755,014
(GRCh37/hg19)
Size:
27,150 bases
Orientation:
Plus strand

Genomic View for MCTS1 Gene

Genes around MCTS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCTS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCTS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCTS1 Gene

Proteins for MCTS1 Gene

  • Protein details for MCTS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULC4-MCTS1_HUMAN
    Recommended name:
    Malignant T-cell-amplified sequence 1
    Protein Accession:
    Q9ULC4
    Secondary Accessions:
    • B4DGY2
    • Q502X6

    Protein attributes for MCTS1 Gene

    Size:
    181 amino acids
    Molecular mass:
    20555 Da
    Quaternary structure:
    • Interacts (via PUA domain) with DENR.

    Three dimensional structures from OCA and Proteopedia for MCTS1 Gene

    Alternative splice isoforms for MCTS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCTS1 Gene

Post-translational modifications for MCTS1 Gene

  • Phosphorylation is critical for stabilization and promotion of cell proliferation.
  • Ubiquitination at Lys87
  • Modification sites at PhosphoSitePlus

Other Protein References for MCTS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MCTS1 Gene

Domains & Families for MCTS1 Gene

Gene Families for MCTS1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MCTS1 Gene

Suggested Antigen Peptide Sequences for MCTS1 Gene

GenScript: Design optimal peptide antigens:
  • Multiple copies T-cell malignancies (MCTS1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9ULC4

UniProtKB/Swiss-Prot:

MCTS1_HUMAN :
  • The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function. MCT1 N-terminal region is required to enhance translation possibly through interaction with other proteins.
  • Belongs to the MCTS1 family.
Domain:
  • The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function. MCT1 N-terminal region is required to enhance translation possibly through interaction with other proteins.
Family:
  • Belongs to the MCTS1 family.
genes like me logo Genes that share domains with MCTS1: view

Function for MCTS1 Gene

Molecular function for MCTS1 Gene

UniProtKB/Swiss-Prot Function:
Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
UniProtKB/Swiss-Prot Induction:
By DNA damaging agents such as gamma irradiation, adriamycin or taxol in lymphoid cells, but not by stress stimuli such as heat shock. This induction of protein expression does not occur at the RNA level, and does not require new protein synthesis.

Phenotypes From GWAS Catalog for MCTS1 Gene

Gene Ontology (GO) - Molecular Function for MCTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003743 translation initiation factor activity IEA --
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with MCTS1: view
genes like me logo Genes that share phenotypes with MCTS1: view

Animal Model Products

CRISPR Products

miRNA for MCTS1 Gene

miRTarBase miRNAs that target MCTS1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCTS1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCTS1 Gene

Localization for MCTS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCTS1 Gene

Cytoplasm. Note=Nuclear relocalization after DNA damage.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCTS1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MCTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0022627 colocalizes_with cytosolic small ribosomal subunit IDA 20713520
genes like me logo Genes that share ontologies with MCTS1: view

Pathways & Interactions for MCTS1 Gene

PathCards logo

SuperPathways for MCTS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MCTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IBA,IDA 20713520
GO:0002188 translation reinitiation IBA 21873635
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with MCTS1: view

No data available for Pathways by source and SIGNOR curated interactions for MCTS1 Gene

Drugs & Compounds for MCTS1 Gene

No Compound Related Data Available

Transcripts for MCTS1 Gene

mRNA/cDNA for MCTS1 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCTS1

Alternative Splicing Database (ASD) splice patterns (SP) for MCTS1 Gene

No ASD Table

Relevant External Links for MCTS1 Gene

GeneLoc Exon Structure for
MCTS1

Expression for MCTS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MCTS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MCTS1 Gene

This gene is overexpressed in Skin (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MCTS1 Gene



Protein tissue co-expression partners for MCTS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MCTS1

SOURCE GeneReport for Unigene cluster for MCTS1 Gene:

Hs.102696

mRNA Expression by UniProt/SwissProt for MCTS1 Gene:

Q9ULC4-MCTS1_HUMAN
Tissue specificity: Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas.

Evidence on tissue expression from TISSUES for MCTS1 Gene

  • Nervous system(4.6)
  • Eye(4.4)
  • Thyroid gland(2.3)
  • Intestine(2.2)
  • Liver(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with MCTS1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCTS1 Gene

Orthologs for MCTS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCTS1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MCTS1 30 31
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MCTS1 30 31
  • 97.24 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MCTS1 30 31
  • 96.5 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MCTS1 31
  • 96 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mcts1 30
  • 95.32 (n)
Mouse
(Mus musculus)
Mammalia Mcts1 30 17 31
  • 95.03 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MCTS1 31
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MCTS1 30 31
  • 87.11 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MCTS1 31
  • 96 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mcts1 30
  • 80.66 (n)
Str.11037 30
Zebrafish
(Danio rerio)
Actinopterygii mcts1 30 31
  • 79.93 (n)
OneToOne
zgc56242 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6712 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003344 30
  • 58.15 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG5941 30 31
  • 57.83 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea C11D2.7 30 31
  • 63.65 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMA20 30 31 33
  • 58.1 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13574g 30
  • 57.42 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ADR010C 30
  • 55.05 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3319 30
Barley
(Hordeum vulgare)
Liliopsida Hv.3374 30
Rice
(Oryza sativa)
Liliopsida Os.18476 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 62 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC31F10.12 30
  • 53.45 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU08678 30
  • 43 (n)
Species where no ortholog for MCTS1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MCTS1 Gene

ENSEMBL:
Gene Tree for MCTS1 (if available)
TreeFam:
Gene Tree for MCTS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MCTS1: view image

Paralogs for MCTS1 Gene

Paralogs for MCTS1 Gene

Pseudogenes.org Pseudogenes for MCTS1 Gene

genes like me logo Genes that share paralogs with MCTS1: view

Variants for MCTS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MCTS1 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
713851 Benign: not provided 120,606,129(+) G/A MISSENSE_VARIANT
rs2233110 - p.Leu106His

Additional dbSNP identifiers (rs#s) for MCTS1 Gene

Variation tolerance for MCTS1 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MCTS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCTS1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MCTS1 Gene

Disorders for MCTS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MCTS1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
- elite association - COSMIC cancer census association via MalaCards
Search MCTS1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with MCTS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCTS1 Gene

Publications for MCTS1 Gene

  1. MCT-1 protein interacts with the cap complex and modulates messenger RNA translational profiles. (PMID: 16982740) Reinert LS … Gartenhaus RB (Cancer research 2006) 2 3 4
  2. A novel candidate oncogene, MCT-1, is involved in cell cycle progression. (PMID: 9766643) Prosniak M … Gartenhaus RB (Cancer research 1998) 2 3 4
  3. DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth. (PMID: 25043021) Schleich S … Teleman AA (Nature 2014) 2 3
  4. Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling. (PMID: 20713520) Skabkin MA … Pestova TV (Genes & development 2010) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for MCTS1 Gene

Sources for MCTS1 Gene