Aliases for MCRS1 Gene

Aliases for MCRS1 Gene

  • Microspherule Protein 1 2 3 4 5
  • INO80Q 2 3 4
  • MCRS2 2 3 4
  • MSP58 2 3 4
  • Cell Cycle-Regulated Factor P78 3 4
  • 58 KDa Microspherule Protein 3 4
  • INO80 Complex Subunit Q 2 3
  • INO80 Complex Subunit J 3 4
  • ICP22BP 2 3
  • P78 2 3
  • Cell Cycle-Regulated Factor (78 KDa) 3
  • MCRS1 5

External Ids for MCRS1 Gene

Previous GeneCards Identifiers for MCRS1 Gene

  • GC12M050169
  • GC12M050008
  • GC12M049668
  • GC12M048238
  • GC12M049952
  • GC12M046982

Summaries for MCRS1 Gene

GeneCards Summary for MCRS1 Gene

MCRS1 (Microspherule Protein 1) is a Protein Coding gene. Diseases associated with MCRS1 include Pigmented Basal Cell Carcinoma. Among its related pathways are Chromatin organization and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include histone acetyltransferase activity (H4-K5 specific) and histone acetyltransferase activity (H4-K16 specific).

UniProtKB/Swiss-Prot Summary for MCRS1 Gene

  • Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602).

Gene Wiki entry for MCRS1 Gene

Additional gene information for MCRS1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MCRS1 Gene

Genomics for MCRS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MCRS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MCRS1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MCRS1

Top Transcription factor binding sites by QIAGEN in the MCRS1 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • NF-kappaB1

Genomic Locations for MCRS1 Gene

Genomic Locations for MCRS1 Gene
chr12:49,556,544-49,568,233
(GRCh38/hg38)
Size:
11,690 bases
Orientation:
Minus strand
chr12:49,950,327-49,961,936
(GRCh37/hg19)
Size:
11,610 bases
Orientation:
Minus strand

Genomic View for MCRS1 Gene

Genes around MCRS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCRS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCRS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCRS1 Gene

Proteins for MCRS1 Gene

  • Protein details for MCRS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EZ8-MCRS1_HUMAN
    Recommended name:
    Microspherule protein 1
    Protein Accession:
    Q96EZ8
    Secondary Accessions:
    • O14742
    • O75497
    • Q6VN53
    • Q7Z372

    Protein attributes for MCRS1 Gene

    Size:
    462 amino acids
    Molecular mass:
    51803 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80 (PubMed:16230350, PubMed:18922472, PubMed:21303910). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (PubMed:15960975). Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (PubMed:20018852). Interacts with NOP2 (PubMed:9654073). Interacts with PINX1 (PubMed:15044100). Interacts with TERT (PubMed:15044100). Interacts with CCDC85B (PubMed:17014843). Interacts with DAXX (PubMed:11948183). Interacts (via N-terminus) with FMR1 (via phosphorylated form) (PubMed:16571602). Interacts with FXR1 AND FXR2 (PubMed:16571602).
    • (Microbial infection) Interacts with Herpes simplex virus ICP22.
    SequenceCaution:
    • Sequence=AAC68599.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 3]: May be due to intron retention.

    Alternative splice isoforms for MCRS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCRS1 Gene

Post-translational modifications for MCRS1 Gene

  • Ubiquitination at Lys186
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MCRS1 Gene

Domains & Families for MCRS1 Gene

Gene Families for MCRS1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MCRS1 Gene

InterPro:
Blocks:
  • Forkhead-associated (FHA)
ProtoNet:

Suggested Antigen Peptide Sequences for MCRS1 Gene

GenScript: Design optimal peptide antigens:
  • MCRS2 (MCRS1_HUMAN)
genes like me logo Genes that share domains with MCRS1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MCRS1 Gene

Function for MCRS1 Gene

Molecular function for MCRS1 Gene

UniProtKB/Swiss-Prot Function:
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602).
GENATLAS Biochemistry:
microspherule protein 1,nucleolar,associated with the proliferation-related nucleolar protein which is detectable early in the G1 phase of the cell cycle and peaks early in the S phase,potentially affecting the size and shape of the nucleolus

Phenotypes From GWAS Catalog for MCRS1 Gene

Gene Ontology (GO) - Molecular Function for MCRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002151 G-quadruplex RNA binding IDA 16571602
GO:0005515 protein binding IPI 11948183
GO:0008266 poly(U) RNA binding IDA 16571602
GO:0034046 poly(G) binding IDA 16571602
GO:0043995 contributes_to histone acetyltransferase activity (H4-K5 specific) IDA 20018852
genes like me logo Genes that share ontologies with MCRS1: view
genes like me logo Genes that share phenotypes with MCRS1: view

Animal Models for MCRS1 Gene

MGI Knock Outs for MCRS1:
  • Mcrs1 Mcrs1<tm1.1(KOMP)Vlcg>
  • Mcrs1 Mcrs1<tm1.2Ndj>

Animal Model Products

CRISPR Products

miRNA for MCRS1 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCRS1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MCRS1 Gene

Localization for MCRS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCRS1 Gene

Nucleus. Nucleus, nucleolus. Cytoplasm. Note=In microspherules in the nucleolus. {ECO:0000269 PubMed:9654073}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCRS1 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
endoplasmic reticulum 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MCRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 20018852
GO:0005634 nucleus IEA,IDA 16571602
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA,IDA 16571602
GO:0005737 cytoplasm TAS,IDA 16571602
genes like me logo Genes that share ontologies with MCRS1: view

Pathways & Interactions for MCRS1 Gene

genes like me logo Genes that share pathways with MCRS1: view

Pathways by source for MCRS1 Gene

Gene Ontology (GO) - Biological Process for MCRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006325 chromatin organization IEA --
GO:0006464 cellular protein modification process TAS 9765390
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with MCRS1: view

No data available for SIGNOR curated interactions for MCRS1 Gene

Drugs & Compounds for MCRS1 Gene

(4) Drugs for MCRS1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for MCRS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MCRS1: view

Transcripts for MCRS1 Gene

mRNA/cDNA for MCRS1 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCRS1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCRS1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^
SP1: - - - - - - - - -
SP2: - -
SP3: -
SP4: - - - - - - - - - -
SP5: - - - - - -
SP6:
SP7: - - - - -
SP8: - - - - - - -
SP9:
SP10: - - - - -
SP11: - - - -
SP12: - - - - -

ExUns: 14 ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b · 17c · 17d
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6: -
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for MCRS1 Gene

GeneLoc Exon Structure for
MCRS1

Expression for MCRS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MCRS1 Gene

Protein differential expression in normal tissues from HIPED for MCRS1 Gene

This gene is overexpressed in Blymphocyte (25.9), Peripheral blood mononuclear cells (13.9), Placenta (13.2), and CD8 Tcells (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MCRS1 Gene



Protein tissue co-expression partners for MCRS1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MCRS1

SOURCE GeneReport for Unigene cluster for MCRS1 Gene:

Hs.25313

mRNA Expression by UniProt/SwissProt for MCRS1 Gene:

Q96EZ8-MCRS1_HUMAN
Tissue specificity: Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.

Evidence on tissue expression from TISSUES for MCRS1 Gene

  • Liver(4.3)
  • Nervous system(4.2)
  • Lung(2.6)
  • Kidney(2.2)
  • Muscle(2.2)
  • Skin(2.2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with MCRS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCRS1 Gene

Orthologs for MCRS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MCRS1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MCRS1 30 31
  • 99.79 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MCRS1 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia MCRS1 30 31
  • 93.26 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MCRS1 30 31
  • 93.17 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mcrs1 30 17 31
  • 91.43 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mcrs1 30
  • 91.29 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia MCRS1 31
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MCRS1 30 31
  • 81.16 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 91 (a)
OneToMany
-- 31
  • 83 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mcrs1 30
  • 73.39 (n)
African clawed frog
(Xenopus laevis)
Amphibia mcrs1-prov 30
Zebrafish
(Danio rerio)
Actinopterygii mcrs1 30 31
  • 71.34 (n)
OneToOne
Dr.23962 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005560 30
  • 65.5 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Rcd5 30 31
  • 60.74 (n)
OneToOne
CG1135 32
  • 58 (a)
Worm
(Caenorhabditis elegans)
Secernentea mcrs-1 31
  • 24 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 55 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.8684 30
Species where no ortholog for MCRS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MCRS1 Gene

ENSEMBL:
Gene Tree for MCRS1 (if available)
TreeFam:
Gene Tree for MCRS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MCRS1: view image

Paralogs for MCRS1 Gene

(1) SIMAP similar genes for MCRS1 Gene using alignment to 9 proteins:

  • MCRS1_HUMAN
  • F8VP44_HUMAN
  • F8VVA6_HUMAN
  • F8VZC2_HUMAN
  • F8W0I9_HUMAN
  • F8W126_HUMAN
  • H0YI67_HUMAN
  • H0YIA0_HUMAN
  • L8E8H6_HUMAN
genes like me logo Genes that share paralogs with MCRS1: view

No data available for Paralogs for MCRS1 Gene

Variants for MCRS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MCRS1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs780785469 A colorectal cancer sample p.Val441Ile

Additional dbSNP identifiers (rs#s) for MCRS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MCRS1 Gene

Variant ID Type Subtype PubMed ID
nsv473141 CNV novel sequence insertion 20440878
nsv832406 CNV loss 17160897

Variation tolerance for MCRS1 Gene

Residual Variation Intolerance Score: 7.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MCRS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCRS1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCRS1 Gene

Disorders for MCRS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MCRS1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
pigmented basal cell carcinoma
  • skin pigmented basal cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search MCRS1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with MCRS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCRS1 Gene

Publications for MCRS1 Gene

  1. The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120. (PMID: 9654073) Ren Y … Busch H (European journal of biochemistry 1998) 2 3 4 23
  2. Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length. (PMID: 15044100) Song H … Zhao M (Biochemical and biophysical research communications 2004) 3 4 23
  3. Herpes simplex virus 1 regulatory protein ICP22 interacts with a new cell cycle-regulated factor and accumulates in a cell cycle-dependent fashion in infected cells. (PMID: 9765390) Bruni R … Roizman B (Journal of virology 1998) 2 3 4
  4. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L … Conaway RC (The Journal of biological chemistry 2011) 3 4
  5. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. (PMID: 20018852) Cai Y … Conaway RC (The Journal of biological chemistry 2010) 3 4

Products for MCRS1 Gene

  • Signalway ELISA kits for MCRS1

Sources for MCRS1 Gene