Aliases for MCRS1 Gene
External Ids for MCRS1 Gene
Previous GeneCards Identifiers for MCRS1 Gene
GeneCards Summary for MCRS1 Gene
MCRS1 (Microspherule Protein 1) is a Protein Coding gene. Diseases associated with MCRS1 include Pigmented Basal Cell Carcinoma. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Chromatin organization. Gene Ontology (GO) annotations related to this gene include histone acetyltransferase activity (H4-K5 specific) and histone acetyltransferase activity (H4-K16 specific).
UniProtKB/Swiss-Prot Summary for MCRS1 Gene
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602).