Aliases for MCRIP2 Gene

Aliases for MCRIP2 Gene

  • MAPK Regulated Corepressor Interacting Protein 2 2 3 4 5
  • Family With Sequence Similarity 195, Member A 2 3
  • Protein FAM195A 3 4
  • C16orf14 3 4
  • FAM195A 3 4
  • MAPK Regulated Co-Repressor Interacting Protein 2 3
  • Family With Sequence Similarity 195 Member A 2
  • Chromosome 16 Open Reading Frame 14 2
  • C349E10.1 3

External Ids for MCRIP2 Gene

Previous HGNC Symbols for MCRIP2 Gene

  • C16orf14
  • FAM195A

Summaries for MCRIP2 Gene

GeneCards Summary for MCRIP2 Gene

MCRIP2 (MAPK Regulated Corepressor Interacting Protein 2) is a Protein Coding gene. An important paralog of this gene is FGFRL1.

Additional gene information for MCRIP2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MCRIP2 Gene

Genomics for MCRIP2 Gene

GeneHancer (GH) Regulatory Elements for MCRIP2 Gene

Promoters and enhancers for MCRIP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J000635 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +0.4 401 4.4 HNRNPK ZBTB40 ZNF217 SIN3A NRF1 TCF12 POLR2G USF1 SP1 NCOR1 METTL26 AE006464 LOC100287175 MCRIP2 MK671732-001 TRG-CCC2-2 lnc-JMJD8-2 CRAMP1 WDR90 WDR24
GH16J000640 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.4 +8.8 8784 10.4 RXRA EP300 ZBTB40 CTCF SIN3A NRF1 TCF12 MYC POLR2G USF1 WDR90 MCRIP2 ENSG00000261505 JMJD8 ENSG00000260954 IFT140 WFIKKN1 ENSG00000260051 LUC7L TELO2
GH16J001081 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 1.2 +446.3 446256 2.8 POLR2G NCOR1 ZFX ZIC2 KDM6A ZBTB25 TGIF2 ZBTB7A SKI TEAD1 SSTR5-AS1 ENSG00000228201 SSTR5 WDR90 CACNA1H RAB40C MCRIP2 piR-32214-228
GH16J000639 Promoter 0.6 Ensembl 0.7 +3.1 3084 0.6 ZNF362 ZNF770 ZNF121 ZNF394 NONHSAG018194.2 lnc-METTL26-1 MCRIP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MCRIP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MCRIP2

Genomic Locations for MCRIP2 Gene

Genomic Locations for MCRIP2 Gene
chr16:636,817-648,474
(GRCh38/hg38)
Size:
11,658 bases
Orientation:
Plus strand
chr16:691,813-698,474
(GRCh37/hg19)
Size:
6,662 bases
Orientation:
Plus strand

Genomic View for MCRIP2 Gene

Genes around MCRIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCRIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCRIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCRIP2 Gene

Proteins for MCRIP2 Gene

  • Protein details for MCRIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUT9-MCRI2_HUMAN
    Recommended name:
    MAPK regulated corepressor interacting protein 2
    Protein Accession:
    Q9BUT9
    Secondary Accessions:
    • Q969E9
    • Q96KV8

    Protein attributes for MCRIP2 Gene

    Size:
    160 amino acids
    Molecular mass:
    17828 Da
    Quaternary structure:
    • Interacts with DDX6. Interacts with MCRIP1.
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for MCRIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCRIP2 Gene

Post-translational modifications for MCRIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MCRIP2 Gene

No data available for DME Specific Peptides for MCRIP2 Gene

Domains & Families for MCRIP2 Gene

Gene Families for MCRIP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MCRIP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MCRIP2 Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM195A (F195A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BUT9

UniProtKB/Swiss-Prot:

MCRI2_HUMAN :
  • Belongs to the MCRIP family.
Family:
  • Belongs to the MCRIP family.
genes like me logo Genes that share domains with MCRIP2: view

Function for MCRIP2 Gene

Phenotypes From GWAS Catalog for MCRIP2 Gene

Gene Ontology (GO) - Molecular Function for MCRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26184334
genes like me logo Genes that share ontologies with MCRIP2: view
genes like me logo Genes that share phenotypes with MCRIP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCRIP2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCRIP2 Gene

Localization for MCRIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCRIP2 Gene

Cytoplasm, Stress granule. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCRIP2 gene
Compartment Confidence
nucleus 5
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MCRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 26184334
GO:0005737 cytoplasm IEA,IDA 26184334
GO:0010494 cytoplasmic stress granule IDA,IEA 26184334
genes like me logo Genes that share ontologies with MCRIP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MCRIP2 Gene

Pathways & Interactions for MCRIP2 Gene

PathCards logo

SuperPathways for MCRIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MCRIP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MCRIP2 Gene

Drugs & Compounds for MCRIP2 Gene

No Compound Related Data Available

Transcripts for MCRIP2 Gene

mRNA/cDNA for MCRIP2 Gene

4 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCRIP2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCRIP2 Gene

No ASD Table

Relevant External Links for MCRIP2 Gene

GeneLoc Exon Structure for
MCRIP2

Expression for MCRIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MCRIP2

Evidence on tissue expression from TISSUES for MCRIP2 Gene

  • Liver(4.7)
  • Pancreas(4.6)
  • Skin(4.4)
  • Nervous system(4.3)
  • Lung(3.7)
  • Intestine(3.3)
  • Kidney(3)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with MCRIP2: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCRIP2 Gene

Orthologs for MCRIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MCRIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM195A 31 30
  • 99.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM195A 31 30
  • 91.18 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam195a 30
  • 87.5 (n)
dog
(Canis familiaris)
Mammalia FAM195A 31
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam195a 31 30
  • 85.83 (n)
OneToOne
Mcrip2 17
oppossum
(Monodelphis domestica)
Mammalia FAM195A 31
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM195A 31 30
  • 73.43 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam195a 30
  • 57.41 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-44g23.5 30
  • 67.38 (n)
FAM195A 31
  • 60 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10574 30
Species where no ortholog for MCRIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCRIP2 Gene

ENSEMBL:
Gene Tree for MCRIP2 (if available)
TreeFam:
Gene Tree for MCRIP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MCRIP2: view image

Paralogs for MCRIP2 Gene

Paralogs for MCRIP2 Gene

Pseudogenes.org Pseudogenes for MCRIP2 Gene

genes like me logo Genes that share paralogs with MCRIP2: view

Variants for MCRIP2 Gene

Additional dbSNP identifiers (rs#s) for MCRIP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MCRIP2 Gene

Variant ID Type Subtype PubMed ID
dgv334n27 CNV loss 19166990
dgv4823n54 CNV loss 21841781
dgv4824n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
esv2663331 CNV deletion 23128226
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv471063 CNV loss 18288195
nsv471065 CNV gain 18288195
nsv516590 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571012 CNV loss 21841781
nsv571015 CNV loss 21841781
nsv833114 CNV gain+loss 17160897
nsv9321 CNV gain+loss 18304495
nsv952898 CNV deletion 24416366

Variation tolerance for MCRIP2 Gene

Gene Damage Index Score: 0.32; 7.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MCRIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCRIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MCRIP2 Gene

Disorders for MCRIP2 Gene

Additional Disease Information for MCRIP2

No disorders were found for MCRIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MCRIP2 Gene

Publications for MCRIP2 Gene

  1. Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. (PMID: 26184334) Bish R … Vogel C (Biomolecules 2015) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 54
  4. PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation. (PMID: 30209976) Choi J … Busino L (Cell cycle (Georgetown, Tex.) 2018) 3 54
  5. Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2. (PMID: 29453251) Wang Y … Kong W (Circulation 2018) 3 54

Products for MCRIP2 Gene

Sources for MCRIP2 Gene