Aliases for MCRIP1 Gene

Aliases for MCRIP1 Gene

  • MAPK Regulated Corepressor Interacting Protein 1 2 3 5
  • Granulin-2 2 3 4
  • Mapk-Regulated Corepressor-Interacting Protein 1 3 4
  • Family With Sequence Similarity 195, Member B 2 3
  • Protein FAM195B 3 4
  • FAM195B 3 4
  • GRAN2 3 4
  • MAPK-Regulated Co-Repressor Interacting Protein 1 3
  • Family With Sequence Similarity 195 Member B 2
  • MCRIP1 Protein 3
  • MCRIP 3

External Ids for MCRIP1 Gene

Previous HGNC Symbols for MCRIP1 Gene

  • FAM195B

Summaries for MCRIP1 Gene

GeneCards Summary for MCRIP1 Gene

MCRIP1 (MAPK Regulated Corepressor Interacting Protein 1) is a Protein Coding gene. Among its related pathways are MAP Kinase Signaling. An important paralog of this gene is MCRIP2.

UniProtKB/Swiss-Prot Summary for MCRIP1 Gene

  • The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771).

Additional gene information for MCRIP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MCRIP1 Gene

Genomics for MCRIP1 Gene

GeneHancer (GH) Regulatory Elements for MCRIP1 Gene

Promoters and enhancers for MCRIP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J081831 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 -0.1 -134 4.2 SIN3A SP1 ZBTB40 MLX RBPJ SMARCE1 POLR2A USF2 NR2F1 NR2F6 MCRIP1 PPP1R27 lnc-PPP1R27-2 lnc-MCRIP1-3 SIRT7 TBCD ENSG00000262049 NPLOC4 FAAP100 OGFOD3
GH17J081700 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 22.4 +130.5 130512 4.2 ZNF785 ZNF24 ZBTB40 SP1 SREBF1 ZBTB6 MLX RBPJ POLR2A NR2F1 ENSG00000262049 ENSG00000262660 NONHSAG023019.2 MRPL12 ARL16 HGS FAAP100 CEP131 ENSG00000265678 ENSG00000260563
GH17J081864 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -35.6 -35641 8.9 ZNF785 SIN3A ZNF24 ZBTB40 SP1 CTCF SREBF1 FOXA1 MLX RBPJ ARHGDIA ENSG00000262413 lnc-ARHGDIA-1 ENSG00000262049 TBCD CEP131 HGS NARF-IT1 ENSG00000260563 ENSG00000265678
GH17J082211 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 -382.6 -382636 8.7 GTF3C2 SIN3A ZNF24 SP1 ZBTB40 SIX5 ZBTB6 LCORL MLX RBPJ CCDC57 ENSG00000264548 lnc-CCDC57-1 SLC16A3 ENSG00000262049 ENSG00000260563 ENSG00000262652 ARL2BPP9 ALYREF NARF-IT1
GH17J081384 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 +437.2 437242 22.5 FOXK2 ZNF785 SIN3A ZBTB40 SP1 CTCF ZBTB6 LCORL FOXA1 MLX BAHCC1 ENSG00000279692 lnc-BAHCC1-3 lnc-TMEM105-4 ENSG00000262877 ENSG00000262049 ENSG00000260563 TEPSIN ENDOV ARL16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MCRIP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MCRIP1 Gene

Genomic Locations for MCRIP1 Gene
chr17:81,822,361-81,833,302
(GRCh38/hg38)
Size:
10,942 bases
Orientation:
Minus strand
chr17:79,780,287-79,791,178
(GRCh37/hg19)
Size:
10,892 bases
Orientation:
Minus strand

Genomic View for MCRIP1 Gene

Genes around MCRIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCRIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCRIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCRIP1 Gene

Proteins for MCRIP1 Gene

  • Protein details for MCRIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JLW8-MCRI1_HUMAN
    Recommended name:
    Mapk-regulated corepressor-interacting protein 1
    Protein Accession:
    C9JLW8
    Secondary Accessions:
    • Q6ZUL0

    Protein attributes for MCRIP1 Gene

    Size:
    97 amino acids
    Molecular mass:
    10920 Da
    Quaternary structure:
    • Interacts (unphosphorylated form, via the PXDLS motif) with CTBP1, competitively inhibiting CTBP-ZEB1 interaction (PubMed:25728771). Interacts with CTBP2 (PubMed:25728771). Interacts with MCRIP2 (PubMed:26184334). Interacts with DDX6 (PubMed:26184334).
    SequenceCaution:
    • Sequence=BAC86211.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

neXtProt entry for MCRIP1 Gene

Post-translational modifications for MCRIP1 Gene

  • Phosphorylation by MAPK3/1 (ERK1/2) regulates MCRIP1 binding to CTBP(s) (PubMed:25728771).
  • Ubiquitination at Lys76
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MCRIP1 Gene

Domains & Families for MCRIP1 Gene

Gene Families for MCRIP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MCRIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MCRIP1 Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM195B (F195B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

C9JLW8

UniProtKB/Swiss-Prot:

MCRI1_HUMAN :
  • Belongs to the MCRIP family.
Family:
  • Belongs to the MCRIP family.
genes like me logo Genes that share domains with MCRIP1: view

Function for MCRIP1 Gene

Molecular function for MCRIP1 Gene

UniProtKB/Swiss-Prot Function:
The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771).

Phenotypes From GWAS Catalog for MCRIP1 Gene

Gene Ontology (GO) - Molecular Function for MCRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25728771
genes like me logo Genes that share ontologies with MCRIP1: view
genes like me logo Genes that share phenotypes with MCRIP1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCRIP1 Gene

Localization for MCRIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCRIP1 Gene

Nucleus. Cytoplasm, Stress granule.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCRIP1 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MCRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 25728771
GO:0005737 cytoplasm IDA,IEA 26184334
GO:0010494 cytoplasmic stress granule IDA,IEA 26184334
genes like me logo Genes that share ontologies with MCRIP1: view

Pathways & Interactions for MCRIP1 Gene

PathCards logo

SuperPathways for MCRIP1 Gene

SuperPathway Contained pathways
1 MAP Kinase Signaling
genes like me logo Genes that share pathways with MCRIP1: view

Pathways by source for MCRIP1 Gene

1 Cell Signaling Technology pathway for MCRIP1 Gene

Interacting Proteins for MCRIP1 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000461433 C9JLW8-MCRI1_HUMAN for MCRIP1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for MCRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010717 regulation of epithelial to mesenchymal transition IDA 25728771
genes like me logo Genes that share ontologies with MCRIP1: view

No data available for SIGNOR curated interactions for MCRIP1 Gene

Drugs & Compounds for MCRIP1 Gene

No Compound Related Data Available

Transcripts for MCRIP1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MCRIP1 Gene

No ASD Table

Relevant External Links for MCRIP1 Gene

GeneLoc Exon Structure for
MCRIP1
ECgene alternative splicing isoforms for
MCRIP1

Expression for MCRIP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MCRIP1 Gene:

MCRIP1

Evidence on tissue expression from TISSUES for MCRIP1 Gene

  • Intestine(4.3)
  • Liver(4.2)
  • Nervous system(2.4)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCRIP1 Gene

Orthologs for MCRIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MCRIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM195B 33 32
  • 99.72 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM195B 33 32
  • 91.41 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM195B 33 32
  • 88.89 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fam195b 33 32
  • 88.66 (n)
OneToOne
Mcrip1 17
rat
(Rattus norvegicus)
Mammalia Fam195b 32
  • 87.29 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM195B 33
  • 37 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM195B 32
  • 81.56 (n)
lizard
(Anolis carolinensis)
Reptilia FAM195B 33
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam195b 32
  • 70.1 (n)
Str.12007 32
zebrafish
(Danio rerio)
Actinopterygii fam195b 33 32
  • 63.51 (n)
OneToOne
Species where no ortholog for MCRIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MCRIP1 Gene

ENSEMBL:
Gene Tree for MCRIP1 (if available)
TreeFam:
Gene Tree for MCRIP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MCRIP1: view image

Paralogs for MCRIP1 Gene

Paralogs for MCRIP1 Gene

genes like me logo Genes that share paralogs with MCRIP1: view

Variants for MCRIP1 Gene

Sequence variations from dbSNP and Humsavar for MCRIP1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000001219 -- 81,831,512(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000269938 -- 81,829,120(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000404663 -- 81,825,216(-) G/C intron_variant
rs1000434018 -- 81,825,395(-) C/T intron_variant
rs1000452669 -- 81,834,405(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MCRIP1 Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv3641406 CNV loss 21293372
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv952390 CNV deletion 24416366

Variation tolerance for MCRIP1 Gene

Gene Damage Index Score: 0.28; 6.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MCRIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCRIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCRIP1 Gene

Disorders for MCRIP1 Gene

Additional Disease Information for MCRIP1

No disorders were found for MCRIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MCRIP1 Gene

Publications for MCRIP1 Gene

  1. MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP. (PMID: 25728771) Ichikawa K … Takekawa M (Molecular cell 2015) 2 3 4 56
  2. Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. (PMID: 26184334) Bish R … Vogel C (Biomolecules 2015) 2 3 4 56
  3. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. (PMID: 28330616) Yadav L … Varjosalo M (Cell systems 2017) 3 56
  4. Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways. (PMID: 26972000) Rodriguez J … von Kriegsheim A (Cell reports 2016) 3 56
  5. KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II. (PMID: 26725010) McNamara RP … D'Orso I (Molecular cell 2016) 3 56

Products for MCRIP1 Gene

Sources for MCRIP1 Gene