Aliases for MCOLN3 Gene
Aliases for MCOLN3 Gene
External Ids for MCOLN3 Gene
- HGNC: 13358
- Entrez Gene: 55283
- Ensembl: ENSG00000055732
- OMIM: 607400
- UniProtKB: Q8TDD5
Previous GeneCards Identifiers for MCOLN3 Gene
- GC01M085879
- GC01M084622
- GC01M084772
- GC01M084907
- GC01M084906
- GC01M085195
- GC01M085483
- GC01M083593
Summaries for MCOLN3 Gene
-
This gene encodes one of members of the mucolipin cation channel proteins. Mutation studies of the highly similar protein in mice have shown that the protein is found in cochlea hair cells, and mutant mice show early-onset hearing loss and balance problems. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for MCOLN3 Gene
MCOLN3 (Mucolipin 3) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. An important paralog of this gene is MCOLN1.
UniProtKB/Swiss-Prot for MCOLN3 Gene
-
Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:18369318, PubMed:19497048, PubMed:19522758, PubMed:19885840, PubMed:29106414). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (PubMed:21245134). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (By similarity). Involved in the regulation of autophagy (PubMed:19522758). Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (PubMed:23469151).
Additional gene information for MCOLN3 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCOLN3 Gene
Genomics for MCOLN3 Gene
GeneHancer (GH) Regulatory Elements for MCOLN3 Gene
Promoters and enhancers for MCOLN3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01I085047 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 570 | 0.0 | -47 | 3.1 | FEZF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF213 KLF7 SP3 REST TSHZ1 | MCOLN3 ENSG00000271576 MCOLN2 ZNHIT6 WDR63 MIR4423 | |
| GH01I084994 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 11.4 | +53.1 | 53054 | 3.5 | PKNOX1 BMI1 BATF IRF4 ZNF335 GLIS2 ZNF143 ZNF207 ATF7 KLF7 | MCOLN2 MCOLN3 LPAR3 | |
| GH01I084959 | Enhancer | 0.7 | ENCODE | 29 | +88.5 | 88488 | 1.1 | PKNOX1 JUN MAX SIN3A CEBPG RFX5 TEAD3 CTBP1 GATA3 RCOR1 | MCOLN2 MCOLN3 LPAR3 | |
| GH01I084968 | Enhancer | 0.7 | ENCODE | 17.2 | +79.2 | 79198 | 1.8 | SMAD1 PAX8 EBF1 BATF KLF5 IRF4 RELA ATF7 ETV6 IKZF2 | MCOLN2 MCOLN3 WDR63 LPAR3 | |
| GH01I084913 | Enhancer | 0.8 | ENCODE | 10.1 | +135.1 | 135105 | 1 | INSM2 MZF1 FEZF1 ZNF2 ZNF335 ZNF366 EGR2 ZNF362 CEBPB ZEB2 | LPAR3 MCOLN3 MCOLN2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MCOLN3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MCOLN3 gene promoter:
Regulatory Element Products
Genomic Locations for MCOLN3 Gene
Genomic Locations for MCOLN3 Gene
- chr1:85,018,082-85,048,902
- (GRCh38/hg38)
- Size:
- 30,821 bases
- Orientation:
- Minus strand
- chr1:85,483,765-85,514,182
- (GRCh37/hg19)
Genomic View for MCOLN3 Gene
Genes around MCOLN3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p22.3 by Ensembl
- 1p22.3 by Entrez Gene
- 1p22.3 by HGNC
MCOLN3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MCOLN3 Gene
Proteins for MCOLN3 Gene
-
Protein details for MCOLN3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TDD5-MCLN3_HUMAN
- Recommended name:
- Mucolipin-3
- Protein Accession:
- Q8TDD5
- Q5T4H5
- Q5T4H6
- Q9NV09
Protein attributes for MCOLN3 Gene
- Size:
- 553 amino acids
- Molecular mass:
- 64248 Da
- Quaternary structure:
-
- Homotetramer (PubMed:29106414). Can heterooligomerize with MCOLN1; heteromeric assemblies have different channel properties as compared to the respective homooligomers and may be tissue-specific (PubMed:19885840). May heterooligomerize with TRPV5 to form a functional distinct ion channel (PubMed:23469151). Interacts with GABARAPL2 (By similarity).
Protein Expression for MCOLN3 Gene
Post-translational modifications for MCOLN3 Gene
- N-glycosylated.
- Ubiquitination at isoforms=2536
- Modification sites at PhosphoSitePlus
Other Protein References for MCOLN3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
Abcam antibodies for MCOLN3
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- GeneTex MCOLN3 antibody for MCOLN3
Protein Products
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Assay Products
No data available for DME Specific Peptides for MCOLN3 Gene
Domains & Families for MCOLN3 Gene
Gene Families for MCOLN3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
- Voltage-gated ion channels
Protein Domains for MCOLN3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MCOLN3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8TDD5UniProtKB/Swiss-Prot:
MCLN3_HUMAN :- The most N-terminal extracellular/lumenal domain (referred to as I-II linker or polycystin-mucolipin domain) contributes to a structure with a four-fold rotational symmetry in a tetrameric assembly; the structure contains a central highly electronegative pore with a 14 A diameter. The pore is critical for Ca(2+) and pH regulation. The protruding structure formed by the I-II linkers may contain all the interaction sites with lipids and proteins in the endolysosomal lumen.
- Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN3 sub-subfamily.
- Domain:
-
- The most N-terminal extracellular/lumenal domain (referred to as I-II linker or polycystin-mucolipin domain) contributes to a structure with a four-fold rotational symmetry in a tetrameric assembly; the structure contains a central highly electronegative pore with a 14 A diameter. The pore is critical for Ca(2+) and pH regulation. The protruding structure formed by the I-II linkers may contain all the interaction sites with lipids and proteins in the endolysosomal lumen.
- Family:
-
- Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN3 sub-subfamily.
Function for MCOLN3 Gene
Molecular function for MCOLN3 Gene
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by lumenal H(+) and Na(+) (PubMed:18369318, PubMed:29106414). The channel pore shows dynamic behavior and undergoes spontaneous, Ca(2+)-dependent modulation when conducting Ca(2+) (PubMed:20378547).
- UniProtKB/Swiss-Prot Function:
- Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:18369318, PubMed:19497048, PubMed:19522758, PubMed:19885840, PubMed:29106414). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (PubMed:21245134). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (By similarity). Involved in the regulation of autophagy (PubMed:19522758). Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (PubMed:23469151).
Phenotypes From GWAS Catalog for MCOLN3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005262 | calcium channel activity | TAS | -- |
| GO:0008289 | lipid binding | IEA | -- |
Phenotypes for MCOLN3 Gene
- MGI mutant phenotypes for MCOLN3:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for MCOLN3:
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miRNA for MCOLN3 Gene
- miRTarBase miRNAs that target MCOLN3
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MCOLN3 Gene
Localization for MCOLN3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MCOLN3 Gene
- Cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane. Note=Recycles between the plasma membrane and intracellular compartments by a dynamin-dependent endocytic pathway (PubMed:19522758). Under normal conditions, only a very minor proportion is present at the cell membrane (PubMed:19522758). In the cochlea located at the base of stereocilia near the position of the ankle links (By similarity). {ECO:0000250 UniProtKB:Q8R4F0, ECO:0000269 PubMed:19522758}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| lysosome | 4 |
| endosome | 4 |
| nucleus | 2 |
| cytosol | 2 |
- Cytosol (2)
- Nucleoli (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000421 | autophagosome membrane | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005764 | lysosome | IEA | -- |
| GO:0005765 | lysosomal membrane | IEA | -- |
| GO:0005768 | endosome | IEA | -- |
Pathways & Interactions for MCOLN3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Ion channel transport | ||
| 2 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
| 3 | TRP channels | ||
Pathways by source for MCOLN3 Gene
4 Reactome pathways for MCOLN3 Gene
Interacting Proteins for MCOLN3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0007626 | locomotory behavior | IEA | -- |
| GO:0042491 | inner ear auditory receptor cell differentiation | IEA | -- |
| GO:0070588 | calcium ion transmembrane transport | TAS | -- |
No data available for SIGNOR curated interactions for MCOLN3 Gene
Drugs & Compounds for MCOLN3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| MK6-83 |
|
1062271-24-2 |
|
|
(3) Tocris Compounds for MCOLN3 Gene
Transcripts for MCOLN3 Gene
mRNA/cDNA for MCOLN3 Gene
- (8) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (52) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
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Vectors and viruses for KO, Activation, Repression, and more
-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available Mcoln3 gene related products
- orf clones - Search results for available Mcoln3 gene related products
- Applied Biological Materials Clones for MCOLN3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||
| SP5: |
Expression for MCOLN3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Pancreas (Endocrine System)
- Ovary (Reproductive System)
- NULL (Uncategorized)
-
Adrenal Gland (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for MCOLN3 Gene
This gene is overexpressed in Adrenal Gland (x10.6) and Pituitary (x6.0).
This gene is overexpressed in Plasma (67.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MCOLN3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MCOLN3 Gene:
MCOLN3SOURCE GeneReport for Unigene cluster for MCOLN3 Gene:
Hs.535239Primer Products
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Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCOLN3 Gene
Orthologs for MCOLN3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MCOLN3 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | MCOLN3 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | MCOLN3 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Mcoln3 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mcoln3 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MCOLN3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MCOLN3 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MCOLN3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mcoln3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100001113 33 |
|
||
| MCOLN3 (1 of 2) 34 |
|
OneToMany | |||
| mcoln3a 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG42638 33 34 |
|
||
| CG8743 35 |
|
|
|||
| trpml 34 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007710 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | cup-5 35 33 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.10964 33 |
|
- Species where no ortholog for MCOLN3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MCOLN3 Gene
(2) SIMAP similar genes for MCOLN3 Gene using alignment to 4 proteins:
Variants for MCOLN3 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000164194 | -- | 85,025,385(-) | GGGG/GGG | intron_variant, non_coding_transcript_variant | |
| rs1000225711 | -- | 85,035,321(-) | C/T | intron_variant | |
| rs1000271034 | -- | 85,017,618(-) | A/G | downstream_transcript_variant | |
| rs1000460804 | -- | 85,042,687(-) | T/C | intron_variant | |
| rs1000572675 | -- | 85,036,953(-) | A/G | intron_variant |
Residual Variation Intolerance Score:
48.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.49;
29.00% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MCOLN3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MCOLN3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCOLN3 Gene
Disorders for MCOLN3 Gene
Additional Disease Information for MCOLN3
No disorders were found for MCOLN3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MCOLN3 Gene
Publications for MCOLN3 Gene
- Functional multimerization of mucolipin channel proteins. (PMID: 19885840) Curcio-Morelli C … Slaugenhaupt SA (Journal of cellular physiology 2010) 3 4 22 58
- The calcium channel mucolipin-3 is a novel regulator of trafficking along the endosomal pathway. (PMID: 19497048) Martina JA … Puertollano R (Traffic (Copenhagen, Denmark) 2009) 3 4 22 58
- A novel ion channel formed by interaction of TRPML3 with TRPV5. (PMID: 23469151) Guo Z … Heller S (PloS one 2013) 3 4 58
- Properties of the TRPML3 channel pore and its stable expansion by the Varitint-Waddler-causing mutation. (PMID: 20378547) Kim HJ … Muallem S (The Journal of biological chemistry 2010) 3 4 58
- The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy. (PMID: 19522758) Kim HJ … Muallem S (Traffic (Copenhagen, Denmark) 2009) 3 4 58
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for MCOLN3
- Novus Biologicals lysates and proteins for MCOLN3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MCOLN3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for MCOLN3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for MCOLN3
- Cyagen custom Knockout/knockin (KOKI) mouse models for MCOLN3
- VectorBuilder custom plasmid, inducible vectors for MCOLN3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MCOLN3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 48 available Mcoln3 Antibodies ranked by validation data
- Compare Top Mcoln3 Antibodies
- antibodies-online: Search results for available Mcoln3 related products ranked by validation data
- antibodies-online: Search results for available Mcoln3 related products ranked by validation data
- GeneTex MCOLN3 antibody for MCOLN3
- Search GeneTex for Proteins for MCOLN3
- ViGene Biosciences adenoviral particle packaged cDNA for MCOLN3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MCOLN3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MCOLN3 gene
- Search ViGene Biosciences for MCOLN3
- Horizon Cell Lines for MCOLN3
- genomics-online: cdna clones - Search results for available Mcoln3 gene related products
- orf clones - Search results for available Mcoln3 gene related products
- genomics-online: gRNA clones - Search results for available Mcoln3 gene related products
- genomics-online: primer clones - Search results for available Mcoln3 gene related products
- genomics-online: shRNA clones - Search results for available Mcoln3 gene related products
Sources for MCOLN3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
