The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of o... See more...

Aliases for MCM7 Gene

Aliases for MCM7 Gene

  • Minichromosome Maintenance Complex Component 7 2 3 5
  • CDC47 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 104 2 3
  • DNA Replication Licensing Factor MCM7 3 4
  • CDC47 Homolog 3 4
  • P1.1-MCM3 3 4
  • PPP1R104 2 3
  • MCM2 3 4
  • MCM7 Minichromosome Maintenance Deficient 7 (S. Cerevisiae) 2
  • Minichromosome Maintenance Deficient (S. Cerevisiae) 7 2
  • Minichromosome Maintenance Deficient 7 3
  • Homolog Of S. Cerevisiae Cdc47 3
  • EC 3.6.4.12 4
  • P1CDC47 3
  • PNAS146 3
  • P85MCM 3
  • MCM7 5

External Ids for MCM7 Gene

Previous HGNC Symbols for MCM7 Gene

  • MCM2

Previous GeneCards Identifiers for MCM7 Gene

  • GC07M098224
  • GC07M099287
  • GC07M099301
  • GC07M099335
  • GC07M099528
  • GC07M099690
  • GC07M094326

Summaries for MCM7 Gene

Entrez Gene Summary for MCM7 Gene

  • The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for MCM7 Gene

MCM7 (Minichromosome Maintenance Complex Component 7) is a Protein Coding gene. Diseases associated with MCM7 include Follicular Adenoma and Retinoblastoma. Among its related pathways are Cell Cycle, Mitotic and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include ATPase activity and ATP-dependent DNA helicase activity. An important paralog of this gene is MCM4.

UniProtKB/Swiss-Prot Summary for MCM7 Gene

  • Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.

Gene Wiki entry for MCM7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MCM7 Gene

Genomics for MCM7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MCM7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MCM7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MCM7

Top Transcription factor binding sites by QIAGEN in the MCM7 gene promoter:
  • C/EBPbeta
  • E47
  • Elk-1
  • MyoD
  • Pax-4a
  • Tal-1beta

Genomic Locations for MCM7 Gene

Latest Assembly
chr7:100,092,728-100,101,940
(GRCh38/hg38)
Size:
9,213 bases
Orientation:
Minus strand

Previous Assembly
chr7:99,690,351-99,699,020
(GRCh37/hg19 by Entrez Gene)
Size:
8,670 bases
Orientation:
Minus strand

chr7:99,690,351-99,699,563
(GRCh37/hg19 by Ensembl)
Size:
9,213 bases
Orientation:
Minus strand

Genomic View for MCM7 Gene

Genes around MCM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCM7 Gene

Proteins for MCM7 Gene

  • Protein details for MCM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33993-MCM7_HUMAN
    Recommended name:
    DNA replication licensing factor MCM7
    Protein Accession:
    P33993
    Secondary Accessions:
    • A4D2A1
    • A4D2A2
    • E9PGN9
    • Q15076
    • Q96D34
    • Q96GL1

    Protein attributes for MCM7 Gene

    Size:
    719 amino acids
    Molecular mass:
    81308 Da
    Quaternary structure:
    • Component of the MCM2-7 complex (PubMed:9305914, PubMed:16899510, PubMed:17296731). The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (PubMed:9305914, PubMed:16899510, PubMed:17296731). Interacts with the ATR-ATRIP complex and with RAD17 (PubMed:15210935, PubMed:15538388). Interacts with TIPIN (PubMed:17116885). Interacts with MCMBP (PubMed:17296731). Interacts with ANKRD17 (PubMed:23711367). Component of the replisome complex composed of at least DONSON, MCM2, MCM7, PCNA and TICRR (PubMed:28191891). Component of the CMG helicase complex, composed of the MCM2-7 complex, the GINS complex and CDC45 (By similarity).
    Miscellaneous:
    • Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.

    Three dimensional structures from OCA and Proteopedia for MCM7 Gene

    Alternative splice isoforms for MCM7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCM7 Gene

Post-translational modifications for MCM7 Gene

  • O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
  • Ubiquitinated by traip when forks converge following formation of DNA interstrand cross-links. Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3. If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase.
  • Ubiquitination at Lys4, Lys10, Lys15, Lys28, Lys29, Lys32, Lys231, Lys236, Lys75, Lys89, Lys96, Lys308, Lys145, Lys335, Lys159, Lys387, Lys471, Lys557, Lys569, Lys596, Lys627, Lys641, and Lys648
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for MCM7

No data available for DME Specific Peptides for MCM7 Gene

Domains & Families for MCM7 Gene

Gene Families for MCM7 Gene

Protein Domains for MCM7 Gene

InterPro:
Blocks:
  • MCM family
  • Mini-chromosome maintenance (MCM) protein 7 signature

Suggested Antigen Peptide Sequences for MCM7 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ30817 fis, clone FEBRA2001581, highly similar to DNA REPLICATION LICENSING FACTOR MCM7 (A4D2A2_HUMAN)
  • P1.1-MCM3 (MCM7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P33993

UniProtKB/Swiss-Prot:

MCM7_HUMAN :
  • Belongs to the MCM family.
Family:
  • Belongs to the MCM family.
genes like me logo Genes that share domains with MCM7: view

Function for MCM7 Gene

Molecular function for MCM7 Gene

UniProtKB/Swiss-Prot Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;.
GENATLAS Biochemistry:
cell division cycle 47 (CDC47) homolog,early S-phase-like 7,participating in the cell cycle control of genome duplication

Enzyme Numbers (IUBMB) for MCM7 Gene

Phenotypes From GWAS Catalog for MCM7 Gene

Gene Ontology (GO) - Molecular Function for MCM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003677 contributes_to DNA binding IEA,TAS 15538388
GO:0003678 contributes_to DNA helicase activity IEA,IDA 9305914
GO:0003688 DNA replication origin binding IBA 21873635
GO:0003697 single-stranded DNA binding IBA 21873635
genes like me logo Genes that share ontologies with MCM7: view
genes like me logo Genes that share phenotypes with MCM7: view

miRNA for MCM7 Gene

miRTarBase miRNAs that target MCM7

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCM7

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCM7 Gene

Localization for MCM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCM7 Gene

Nucleus. Chromosome. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000250 UniProtKB:Q91876}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCM7 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MCM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region HDA 19135898
GO:0000785 chromatin TAS 8798650
GO:0005634 nucleus IEA,IDA 21383955
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with MCM7: view

Pathways & Interactions for MCM7 Gene

genes like me logo Genes that share pathways with MCM7: view

Pathways by source for MCM7 Gene

1 GeneGo (Thomson Reuters) pathway for MCM7 Gene
  • Cell cycle Start of DNA replication in early S phase
1 Qiagen pathway for MCM7 Gene
  • Cell Cycle Control of Chromosomal Replication
1 Cell Signaling Technology pathway for MCM7 Gene

SIGNOR curated interactions for MCM7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MCM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000727 double-strand break repair via break-induced replication IBA 21873635
GO:0006260 DNA replication IEA,TAS --
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication IBA 21873635
GO:0006268 DNA unwinding involved in DNA replication IBA 21873635
genes like me logo Genes that share ontologies with MCM7: view

Drugs & Compounds for MCM7 Gene

(5) Drugs for MCM7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atorvastatin Approved Pharma 928
Water Approved Pharma 0
Phosphate Experimental Pharma 0
ATP Investigational Nutra 0

(1) Additional Compounds for MCM7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with MCM7: view

Transcripts for MCM7 Gene

mRNA/cDNA for MCM7 Gene

3 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCM7

Alternative Splicing Database (ASD) splice patterns (SP) for MCM7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14 ^ 15 ^
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4: - - - - -
SP5: - -
SP6: - - - - -
SP7: -
SP8: -
SP9: - - - - -
SP10: - -
SP11: -
SP12: - - - - - - - - - - - - - - -
SP13:
SP14:

ExUns: 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b
SP1: -
SP2: -
SP3: -
SP4: - - - - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - -
SP13:
SP14:

Relevant External Links for MCM7 Gene

GeneLoc Exon Structure for
MCM7

Expression for MCM7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MCM7 Gene

Protein differential expression in normal tissues from HIPED for MCM7 Gene

This gene is overexpressed in Liver (15.2), Lymph node (14.3), and Fetal ovary (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MCM7 Gene



Protein tissue co-expression partners for MCM7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MCM7

SOURCE GeneReport for Unigene cluster for MCM7 Gene:

Hs.438720

Evidence on tissue expression from TISSUES for MCM7 Gene

  • Nervous system(5)
  • Lung(4.9)
  • Skin(4.6)
  • Intestine(4.4)
  • Blood(4.3)
  • Kidney(4.1)
  • Muscle(3.8)
  • Liver(3.8)
  • Eye(3.8)
  • Lymph node(2.8)
  • Bone marrow(2.7)
  • Stomach(2.6)
  • Spleen(2.5)
  • Pancreas(2.4)
  • Heart(2.3)
  • Thyroid gland(2.3)
genes like me logo Genes that share expression patterns with MCM7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCM7 Gene

Orthologs for MCM7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCM7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MCM7 29 30
  • 99.4 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MCM7 30
  • 92 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia MCM7 29 30
  • 89.34 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MCM7 29 30
  • 88.73 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mcm7 29
  • 87.07 (n)
Mouse
(Mus musculus)
Mammalia Mcm7 29 16 30
  • 86.93 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MCM7 30
  • 58 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mcm7 29
  • 74.12 (n)
Str.6411 29
African clawed frog
(Xenopus laevis)
Amphibia LOC397852 29
Zebrafish
(Danio rerio)
Actinopterygii mcm7 29 30
  • 73.57 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9124 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005800 29
  • 64.2 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Mcm7 29 30 31
  • 63.7 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea mcm-7 29 30 31
  • 54.57 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ADR041W 29
  • 54.01 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E23189g 29
  • 52.07 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCM7 29 30 32
  • 51.25 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons PRL 29
  • 53.7 (n)
Soybean
(Glycine max)
eudicotyledons Gma.10482 29
Rice
(Oryza sativa)
Liliopsida Os12g0560700 29
  • 53.13 (n)
Os.24951 29
Wheat
(Triticum aestivum)
Liliopsida Ta.7561 29
Corn
(Zea mays)
Liliopsida Zm.3812 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8017 30
  • 69 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU08119 29
  • 56.38 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mcm7 29
  • 51.66 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4257 29
Species where no ortholog for MCM7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MCM7 Gene

ENSEMBL:
Gene Tree for MCM7 (if available)
TreeFam:
Gene Tree for MCM7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MCM7: view image
Alliance of Genome Resources:
Additional Orthologs for MCM7

Paralogs for MCM7 Gene

Paralogs for MCM7 Gene

(7) SIMAP similar genes for MCM7 Gene using alignment to 3 proteins:

  • MCM7_HUMAN
  • C9J8M6_HUMAN
  • H0YH42_HUMAN
genes like me logo Genes that share paralogs with MCM7: view

Variants for MCM7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MCM7 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs144442526 Likely Benign: not provided 100,098,170(-) G/A
NM_005916.5(MCM7):c.841C>T (p.Leu281=)
SYNONYMOUS
rs149624106 Likely Benign: not provided 100,094,248(-) C/G
NM_005916.5(MCM7):c.1773G>C (p.Glu591Asp)
MISSENSE
rs2307347 Likely Benign: not provided 100,095,952(-) C/Tp.Gly473Ser
NM_005916.5(MCM7):c.1417G>A (p.Gly473Ser)
MISSENSE
rs2307348 Benign: not provided 100,099,339(-) C/Tp.Arg114Gln
NM_005916.5(MCM7):c.341G>A (p.Arg114Gln)
MISSENSE_VARIANT,FIVE_PRIME_UTR
rs2307349 Benign: not provided 100,093,384(-) C/T
NM_005916.5(MCM7):c.1866G>A (p.Val622=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MCM7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MCM7 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv469687 CNV loss 16826518
nsv510966 OTHER complex 20534489
nsv607931 CNV loss 21841781
nsv951384 CNV deletion 24416366

Variation tolerance for MCM7 Gene

Residual Variation Intolerance Score: 9.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.40; 81.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MCM7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCM7
Leiden Open Variation Database (LOVD)
MCM7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCM7 Gene

Disorders for MCM7 Gene

MalaCards: The human disease database

(12) MalaCards diseases for MCM7 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
follicular adenoma
  • follicular adenoma of the thyroid gland
retinoblastoma
  • rb1
benign meningioma
  • meningioma, benign
cervix endometriosis
  • cervical endometriosis
adenocarcinoma in situ
- elite association - COSMIC cancer census association via MalaCards
Search MCM7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MCM7

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MCM7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCM7 Gene

Publications for MCM7 Gene

  1. Identification and characterization of a novel component of the human minichromosome maintenance complex. (PMID: 17296731) Sakwe AM … Frappier L (Molecular and cellular biology 2007) 3 4 22
  2. Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. (PMID: 15538388) Tsao CC … Abraham RT (The EMBO journal 2004) 3 4 22
  3. Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. (PMID: 15210935) Cortez D … Elledge SJ (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 22
  4. Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication. (PMID: 7842741) Nakatsuru S … Nakamura Y (Cytogenetics and cell genetics 1995) 2 3 4
  5. Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism. (PMID: 28191891) Reynolds JJ … Stewart GS (Nature genetics 2017) 3 4

Products for MCM7 Gene

Sources for MCM7 Gene