Aliases for MCM5 Gene
External Ids for MCM5 Gene
Previous HGNC Symbols for MCM5 Gene
Previous GeneCards Identifiers for MCM5 Gene
The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008]
GeneCards Summary for MCM5 Gene
MCM5 (Minichromosome Maintenance Complex Component 5) is a Protein Coding gene. Diseases associated with MCM5 include Meier-Gorlin Syndrome 8 and Genitourinary Tract Anomalies. Among its related pathways are Cell Cycle, Mitotic and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include chromatin binding and DNA replication origin binding. An important paralog of this gene is MCM6.
UniProtKB/Swiss-Prot Summary for MCM5 Gene
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.