Aliases for MCM3AP Gene
- Minichromosome Maintenance Complex Component 3 Associated Protein 2 3 5
- Germinal-Center Associated Nuclear Protein 3 4
- Germinal-Centre Associated Nuclear Protein 2 3
- 80 KDa MCM3-Associated Protein 3 4
- MCM3 Acetylating Protein 3 4
- MCM3 Acetyltransferase 3 4
- MAP80 3 4
- GANP 3 4
- MCM3 Minichromosome Maintenance Deficient 3 (S. Cerevisiae) Associated Protein 2
- Minichromosome Maintenance Deficient (S. Cerevisiae) 3-Associated Protein 2
External Ids for MCM3AP Gene
Previous GeneCards Identifiers for MCM3AP Gene
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014]
GeneCards Summary for MCM3AP Gene
MCM3AP (Minichromosome Maintenance Complex Component 3 Associated Protein) is a Protein Coding gene. Diseases associated with MCM3AP include Peripheral Neuropathy, Autosomal Recessive, With Or Without Impaired Intellectual Development and Charcot-Marie-Tooth Disease. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is LENG8.
UniProtKB/Swiss-Prot for MCM3AP Gene
Isoform GANP: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:23591820, PubMed:22307388). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018).
Isoform MCM3AP: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (PubMed:11258703, PubMed:12226073). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018).