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Aliases for MCM3AP Gene

Aliases for MCM3AP Gene

  • Minichromosome Maintenance Complex Component 3 Associated Protein 2 3 5
  • Germinal-Center Associated Nuclear Protein 3 4
  • Germinal-Centre Associated Nuclear Protein 2 3
  • 80 KDa MCM3-Associated Protein 3 4
  • MCM3 Acetylating Protein 3 4
  • MCM3 Acetyltransferase 3 4
  • MAP80 3 4
  • GANP 3 4
  • MCM3 Minichromosome Maintenance Deficient 3 (S. Cerevisiae) Associated Protein 2
  • Minichromosome Maintenance Deficient (S. Cerevisiae) 3-Associated Protein 2
  • MCM3 Minichromosome Maintenance Deficient 3 Associated Protein 3
  • Germinal Center-Associated Nuclear Protein 3
  • MCM3 Import Protein 3
  • EC 2.3.1.48 4
  • EC 2.3.1.- 4
  • KIAA0572 4
  • PNRIID 3
  • SAC3 3

External Ids for MCM3AP Gene

Previous GeneCards Identifiers for MCM3AP Gene

  • GC21M044161
  • GC21M046511
  • GC21M046479
  • GC21M047655
  • GC21M033037

Summaries for MCM3AP Gene

Entrez Gene Summary for MCM3AP Gene

  • The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014]

GeneCards Summary for MCM3AP Gene

MCM3AP (Minichromosome Maintenance Complex Component 3 Associated Protein) is a Protein Coding gene. Diseases associated with MCM3AP include Peripheral Neuropathy, Autosomal Recessive, With Or Without Impaired Intellectual Development and Charcot-Marie-Tooth Disease. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is LENG8.

UniProtKB/Swiss-Prot for MCM3AP Gene

  • Isoform GANP: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:23591820, PubMed:22307388). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018).
  • Isoform MCM3AP: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (PubMed:11258703, PubMed:12226073). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018).

Gene Wiki entry for MCM3AP Gene

Additional gene information for MCM3AP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCM3AP Gene

Genomics for MCM3AP Gene

GeneHancer (GH) Regulatory Elements for MCM3AP Gene

Promoters and enhancers for MCM3AP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MCM3AP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MCM3AP gene promoter:
  • Evi-1
  • GR
  • GR-alpha
  • GR-beta
  • NF-kappaB
  • NF-kappaB1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for MCM3AP Gene

Genomic Locations for MCM3AP Gene
chr21:46,235,125-46,286,559
(GRCh38/hg38)
Size:
51,435 bases
Orientation:
Minus strand
chr21:47,655,047-47,706,211
(GRCh37/hg19)
Size:
51,165 bases
Orientation:
Minus strand

Genomic View for MCM3AP Gene

Genes around MCM3AP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCM3AP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCM3AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCM3AP Gene

Proteins for MCM3AP Gene

  • Protein details for MCM3AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60318-GANP_HUMAN
    Recommended name:
    Germinal-center associated nuclear protein
    Protein Accession:
    O60318
    Secondary Accessions:
    • C9JL56
    • Q2M3C1
    • Q6PJP6
    • Q9BSY5
    • Q9UMT4

    Protein attributes for MCM3AP Gene

    Size:
    1980 amino acids
    Molecular mass:
    218405 Da
    Quaternary structure:
    • Isoform GANP: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least GANP, 2 copies of ENY2, PCID2, SEM1/DSS1, and either centrin CETN2 or centrin CETN3. The TREX-2 complex also associates with ALYREF/ALY (PubMed:23591820, PubMed:22307388). Interacts with RNA polymerase II subunit POLR2A and with the transcription elongation factor SUPT5H/SPT5 (PubMed:23652018, PubMed:22307388). Interacts (via FG-repeats) with NXF1; this interaction is not mediated by RNA (PubMed:20005110). Isoform GANP interacts with nuclear envelope proteins NUP62, NUP153 and RANBP2/NUP358; interaction with NUP153 is required for full localization at the nuclear pore complex (PubMed:20005110, PubMed:23652018). Interacts with several RNA helicases, including DHX9, DDX21, and DDX39A/DDX39, and with DNA topoisomerase TOP2A (PubMed:23652018). Directly interacts with AICDA/AID (PubMed:20507984). Interacts with the glucocorticoid receptor NR3C1 (PubMed:16914116). Isoform MCM3AP: Interacts with the glucocorticoid receptor NR3C1 (PubMed:16914116). Interacts with MCM3; this interaction leads to MCM3 acetylation (PubMed:9712829, PubMed:11258703, PubMed:12226073).

    Three dimensional structures from OCA and Proteopedia for MCM3AP Gene

    Alternative splice isoforms for MCM3AP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCM3AP Gene

Post-translational modifications for MCM3AP Gene

  • Ubiquitination at posLast=13861386 and posLast=18011801
  • Modification sites at PhosphoSitePlus

Other Protein References for MCM3AP Gene

No data available for DME Specific Peptides for MCM3AP Gene

Domains & Families for MCM3AP Gene

Gene Families for MCM3AP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for MCM3AP Gene

Suggested Antigen Peptide Sequences for MCM3AP Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ37862 fis, clone BRSSN2015707, highly similar to 80 kDa MCM3-ASSOCIATED PROTEIN (B3KT88_HUMAN)
  • Protein GANP (MCM3A_HUMAN)
  • MCM3AP protein (Q6PJP6_HUMAN)
  • MCM3AP protein (Q9BSY5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60318

UniProtKB/Swiss-Prot:

GANP_HUMAN :
  • Belongs to the SAC3 family.
Family:
  • Belongs to the SAC3 family.
genes like me logo Genes that share domains with MCM3AP: view

Function for MCM3AP Gene

Molecular function for MCM3AP Gene

UniProtKB/Swiss-Prot Function:
Isoform GANP: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:23591820, PubMed:22307388). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018).
UniProtKB/Swiss-Prot Function:
Isoform MCM3AP: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (PubMed:11258703, PubMed:12226073). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]; Xref=Rhea:RHEA:21992, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:11338, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21993; Evidence=. ;.
GENATLAS Biochemistry:
minichromosome maintenance deficient (S cerevisiae) 3-associated protein,80kDa,involved in the nuclear localization of MCM3

Enzyme Numbers (IUBMB) for MCM3AP Gene

Phenotypes From GWAS Catalog for MCM3AP Gene

Gene Ontology (GO) - Molecular Function for MCM3AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003682 chromatin binding IDA 23652018
GO:0004402 histone acetyltransferase activity IDA 23652018
GO:0005515 protein binding IPI 23591820
GO:0010484 H3 histone acetyltransferase activity IDA 23652018
genes like me logo Genes that share ontologies with MCM3AP: view
genes like me logo Genes that share phenotypes with MCM3AP: view

Human Phenotype Ontology for MCM3AP Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MCM3AP Gene

MGI Knock Outs for MCM3AP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCM3AP

No data available for Transcription Factor Targets and HOMER Transcription for MCM3AP Gene

Localization for MCM3AP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCM3AP Gene

Isoform GANP: Nucleus envelope. Nucleus, nuclear pore complex. Nucleus, nucleoplasm. Chromosome. Note=Predominantly located at the nuclear envelope, facing the nucleus interior (PubMed:20005110, PubMed:21195085, PubMed:23591820). Localization at the nuclear pore complex requires NUP153, TPR and ALYREF/ALY (PubMed:23591820, PubMed:22307388). Also found associated with chromatin (PubMed:23652018). In B-cells, targeted to the immunoglobulin variable region genes (PubMed:23652018). {ECO:0000269 PubMed:20005110, ECO:0000269 PubMed:21195085, ECO:0000269 PubMed:22307388, ECO:0000269 PubMed:23591820, ECO:0000269 PubMed:23652018}.
Isoform MCM3AP: Cytoplasm. Nucleus. Note=Translocates into the nucleus in the presence of MCM3 (PubMed:12226073). Associates with chromatin possibly through interaction with MCM3 (PubMed:12226073). {ECO:0000269 PubMed:12226073}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCM3AP gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear membrane (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MCM3AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS --
GO:0005635 nuclear envelope IEA --
GO:0005643 nuclear pore IEA --
GO:0005654 nucleoplasm IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with MCM3AP: view

Pathways & Interactions for MCM3AP Gene

PathCards logo

SuperPathways for MCM3AP Gene

No Data Available

Gene Ontology (GO) - Biological Process for MCM3AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006406 mRNA export from nucleus IBA 21873635
GO:0015031 protein transport IEA --
GO:0016446 somatic hypermutation of immunoglobulin genes IDA 23652018
GO:0016573 histone acetylation IEA --
GO:0016973 poly(A)+ mRNA export from nucleus IMP 23591820
genes like me logo Genes that share ontologies with MCM3AP: view

No data available for Pathways by source and SIGNOR curated interactions for MCM3AP Gene

Drugs & Compounds for MCM3AP Gene

No Compound Related Data Available

Transcripts for MCM3AP Gene

mRNA/cDNA for MCM3AP Gene

Unigene Clusters for MCM3AP Gene

Minichromosome maintenance complex component 3 associated protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCM3AP

Alternative Splicing Database (ASD) splice patterns (SP) for MCM3AP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a ·
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8: -
SP9: - - - -
SP10:
SP11: - - -
SP12:
SP13: -
SP14:
SP15:
SP16:

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for MCM3AP Gene

GeneLoc Exon Structure for
MCM3AP
ECgene alternative splicing isoforms for
MCM3AP

Expression for MCM3AP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MCM3AP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MCM3AP Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (52.5) and Nasal epithelium (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MCM3AP Gene



NURSA nuclear receptor signaling pathways regulating expression of MCM3AP Gene:

MCM3AP

SOURCE GeneReport for Unigene cluster for MCM3AP Gene:

Hs.389037

mRNA Expression by UniProt/SwissProt for MCM3AP Gene:

O60318-GANP_HUMAN
Tissue specificity: Widely expressed (PubMed:11024281). Up-regulated in germinal center B-cells in tonsils (at protein level) (PubMed:11024281).

Evidence on tissue expression from TISSUES for MCM3AP Gene

  • Nervous system(4.8)
  • Lymph node(2.5)
  • Muscle(2.5)
  • Skin(2.2)
  • Blood(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with MCM3AP: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCM3AP Gene

Orthologs for MCM3AP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MCM3AP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCM3AP 35 34
  • 99.29 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MCM3AP 35 34
  • 84.62 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MCM3AP 35 34
  • 84.53 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mcm3ap 17 35 34
  • 80.39 (n)
rat
(Rattus norvegicus)
Mammalia Mcm3ap 34
  • 79.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MCM3AP 35
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MCM3AP 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves MCM3AP 35 34
  • 63.01 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCM3AP 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mcm3ap 34
  • 53.83 (n)
zebrafish
(Danio rerio)
Actinopterygii mcm3ap 35 34
  • 51.87 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta xmas-2 35 36
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F20D12.2 35 36
  • 21 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAC3 37 35
  • 15 (a)
Species where no ortholog for MCM3AP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MCM3AP Gene

ENSEMBL:
Gene Tree for MCM3AP (if available)
TreeFam:
Gene Tree for MCM3AP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MCM3AP: view image

Paralogs for MCM3AP Gene

Paralogs for MCM3AP Gene

genes like me logo Genes that share paralogs with MCM3AP: view

Variants for MCM3AP Gene

Sequence variations from dbSNP and Humsavar for MCM3AP Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs483352869 uncertain-significance, Intellectual functioning disability, Peripheral neuropathy, autosomal recessive, with or without impaired intellectual development (PNRIID) [MIM:618124] 46,267,028(-) C/T coding_sequence_variant, missense_variant
rs773228537 A colorectal cancer sample 46,283,833(-) G/A/C coding_sequence_variant, missense_variant, synonymous_variant
rs9975588 benign, not specified, - 46,284,982(-) G/A coding_sequence_variant, missense_variant
VAR_081543 Peripheral neuropathy, autosomal recessive, with or without impaired intellectual development (PNRIID) [MIM:618124] p.Met762Thr
VAR_081544 Peripheral neuropathy, autosomal recessive, with or without impaired intellectual development (PNRIID) [MIM:618124] p.Ala867Asp

Structural Variations from Database of Genomic Variants (DGV) for MCM3AP Gene

Variant ID Type Subtype PubMed ID
dgv7926n54 CNV loss 21841781
dgv7927n54 CNV gain 21841781
dgv7928n54 CNV loss 21841781
esv22993 CNV loss 19812545
esv2393806 CNV deletion 18987734
esv2641041 CNV deletion 19546169
esv3557870 CNV deletion 23714750
esv3647165 CNV loss 21293372
esv6085 CNV gain 19470904
esv8319 CNV loss 19470904
nsv1060978 CNV gain 25217958
nsv1072612 CNV deletion 25765185
nsv3547 CNV insertion 18451855
nsv470910 CNV gain 18288195
nsv509804 CNV insertion 20534489
nsv519904 CNV loss 19592680
nsv527355 CNV gain 19592680
nsv587967 CNV loss 21841781
nsv587968 CNV gain+loss 21841781
nsv587975 CNV gain 21841781
nsv587976 CNV loss 21841781
nsv587977 CNV loss 21841781

Variation tolerance for MCM3AP Gene

Residual Variation Intolerance Score: 9.44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.35; 90.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MCM3AP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCM3AP
Human Gene Mutation Database (HGMD)
MCM3AP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCM3AP Gene

Disorders for MCM3AP Gene

MalaCards: The human disease database

(2) MalaCards diseases for MCM3AP Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

GANP_HUMAN
  • Peripheral neuropathy, autosomal recessive, with or without impaired intellectual development (PNRIID) [MIM:618124]: An autosomal recessive disorder characterized by early childhood-onset of peripheral sensorimotor neuropathy, progressive distal muscle weakness, atrophy in hands and feet, and gait difficulties, often with loss of ambulation. Most affected individuals also have impaired intellectual development, although some have normal cognition. Additional features may include eye movement abnormalities, claw hands, foot deformities, and scoliosis. {ECO:0000269 PubMed:24123876, ECO:0000269 PubMed:28633435, ECO:0000269 PubMed:28969388, ECO:0000269 PubMed:29982295}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry.

Additional Disease Information for MCM3AP

genes like me logo Genes that share disorders with MCM3AP: view

No data available for Genatlas for MCM3AP Gene

Publications for MCM3AP Gene

  1. Functional interaction between the glucocorticoid receptor and GANP/MCM3AP. (PMID: 16914116) Osman W … Zilliacus J (Biochemical and biophysical research communications 2006) 2 3 4 23 58
  2. Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization. (PMID: 9712829) Takei Y … Tsujimoto G (The Journal of biological chemistry 1998) 2 3 4 23 58
  3. MCM3AP is transcribed from a promoter within an intron of the overlapping gene for GANP. (PMID: 21195085) Wickramasinghe VO … Takei Y (Journal of molecular biology 2011) 2 3 4 58
  4. The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3. (PMID: 12226073) Takei Y … Laskey R (The Journal of biological chemistry 2002) 3 4 23 58
  5. MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3. (PMID: 11258703) Takei Y … Laskey R (EMBO reports 2001) 3 4 23 58

Products for MCM3AP Gene

  • Boster Bio Antibodies for MCM3AP
  • Boster Bio ELISA Kits for MCM3AP

Sources for MCM3AP Gene

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