The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other D... See more...

Aliases for MCM3 Gene

Aliases for MCM3 Gene

  • Minichromosome Maintenance Complex Component 3 2 3 5
  • DNA Polymerase Alpha Holoenzyme-Associated Protein P1 3 4
  • DNA Replication Licensing Factor MCM3 3 4
  • RLF Subunit Beta 3 4
  • P1-MCM3 3 4
  • P102 3 4
  • MCM3 Minichromosome Maintenance Deficient 3 (S. Cerevisiae) 2
  • Minichromosome Maintenance Deficient (S. Cerevisiae) 3 2
  • MCM3 Minichromosome Maintenance Deficient 3 3
  • Replication Licensing Factor, Beta Subunit 3
  • Minichromosome Maintenance Deficient 3 3
  • Cervical Cancer Proto-Oncogene 5 3
  • DNA Replication Factor MCM3 3
  • HRlf Beta Subunit 3
  • EC 3.6.4.12 4
  • HCC5 3
  • P1.H 3
  • RLFB 3
  • MCM3 5

External Ids for MCM3 Gene

Previous GeneCards Identifiers for MCM3 Gene

  • GC06M052130
  • GC06M052175
  • GC06M052236
  • GC06M051960
  • GC06M052128

Summaries for MCM3 Gene

Entrez Gene Summary for MCM3 Gene

  • The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018]

GeneCards Summary for MCM3 Gene

MCM3 (Minichromosome Maintenance Complex Component 3) is a Protein Coding gene. Diseases associated with MCM3 include Grade Iii Astrocytoma and Lung Cancer. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and E2F transcription factor network. Gene Ontology (GO) annotations related to this gene include DNA helicase activity and magnesium chelatase activity. An important paralog of this gene is MCM2.

UniProtKB/Swiss-Prot Summary for MCM3 Gene

  • Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.

Gene Wiki entry for MCM3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MCM3 Gene

Genomics for MCM3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MCM3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J052283 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 620.6 +0.1 111 3.9 ZNF221 SP1 HNRNPL CREB1 CTCF PRDM10 ZNF629 TFE3 SIX5 POLR2A MCM3 NONHSAG043930.2 EFHC1 ENSG00000232702 PAQR8 IL17F
GH06J052415 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 66.6 -134.1 -134144 6.8 BRCA1 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 ZNF629 EFHC1 lnc-MCM3-3 MCM3 TRAM2 PAQR8 piR-38214
GH06J052992 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 30.1 -710.0 -710020 4.6 HNRNPL CREB1 GATAD2A CTCF PRDM10 ZNF629 LEF1 IKZF1 NFKBIZ KDM1A ENSG00000202198 GSTA4 MN298307 RN7SK X05490 EFHC1 MCM3 CILK1 GSTA3 RF00019-091
GH06J053054 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 26.3 -776.9 -776886 15.5 SP1 GATAD2A CTCF HNRNPL PRDM10 ZNF629 TFE3 RFX1 SIX5 LEF1 CILK1 FBXO9 MCM3 EFHC1 TRAM2 GSTA3 piR-38352-469
GH06J052351 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 36.2 -67.6 -67620 5 CREB1 GATAD2A ATF7 PRDM10 ZNF629 TFE3 ZNF512 RFX1 LEF1 SOX13 MCM3 PAQR8 EFHC1 piR-48759-264 lnc-MCM3-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MCM3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MCM3

Top Transcription factor binding sites by QIAGEN in the MCM3 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • MyoD
  • NF-Y
  • NF-YA
  • NF-YB
  • Pax-6
  • ZIC2

Genomic Locations for MCM3 Gene

Genomic Locations for MCM3 Gene
chr6:52,264,014-52,284,881
(GRCh38/hg38)
Size:
20,868 bases
Orientation:
Minus strand
chr6:52,128,807-52,149,679
(GRCh37/hg19)
Size:
20,873 bases
Orientation:
Minus strand

Genomic View for MCM3 Gene

Genes around MCM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCM3 Gene

Proteins for MCM3 Gene

  • Protein details for MCM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25205-MCM3_HUMAN
    Recommended name:
    DNA replication licensing factor MCM3
    Protein Accession:
    P25205
    Secondary Accessions:
    • B4DWW4
    • Q92660
    • Q9BTR3
    • Q9NUE7

    Protein attributes for MCM3 Gene

    Size:
    808 amino acids
    Molecular mass:
    90981 Da
    Quaternary structure:
    • Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (Probable). Associated with the replication-specific DNA polymerase alpha. Interacts with MCMBP. Interacts with ANKRD17. Interacts with MCM3AP isoform MCM3AP; this interaction leads to MCM3 acetylation (PubMed:9712829, PubMed:11258703, PubMed:12226073).
    Miscellaneous:
    • Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. The MCM2-7 hexamer is the proposed physiological active complex.

    Alternative splice isoforms for MCM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCM3 Gene

Post-translational modifications for MCM3 Gene

  • Acetylated by MCM3AP.
  • O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
  • Ubiquitination at Lys35, Lys266, Lys293, Lys301, Lys351, Lys463, Lys579, Lys635, and Lys748
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MCM3 Gene

Domains & Families for MCM3 Gene

Gene Families for MCM3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MCM3 Gene

InterPro:
Blocks:
  • MCM family
  • Mini-chromosome maintenance (MCM) protein 3 family signature
ProtoNet:

Suggested Antigen Peptide Sequences for MCM3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55599, highly similar to DNA replication licensing factor MCM3 (B4DWW4_HUMAN)
  • p102 (MCM3_HUMAN)
  • Minichromosome maintenance complex component 3 (Q7Z6P5_HUMAN)
  • Cervical cancer proto-oncogene 5 (Q8NHX6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P25205

UniProtKB/Swiss-Prot:

MCM3_HUMAN :
  • Belongs to the MCM family.
Family:
  • Belongs to the MCM family.
genes like me logo Genes that share domains with MCM3: view

Function for MCM3 Gene

Molecular function for MCM3 Gene

UniProtKB/Swiss-Prot Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;.
GENATLAS Biochemistry:
cell division cycle,early S-phase-like-3,participating in the cell cycle control of genome duplication

Enzyme Numbers (IUBMB) for MCM3 Gene

Phenotypes From GWAS Catalog for MCM3 Gene

Gene Ontology (GO) - Molecular Function for MCM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003677 DNA binding IEA,TAS 1549468
GO:0003678 DNA helicase activity IEA --
GO:0003688 DNA replication origin binding IBA 21873635
GO:0003697 single-stranded DNA binding IBA 21873635
genes like me logo Genes that share ontologies with MCM3: view
genes like me logo Genes that share phenotypes with MCM3: view

Animal Models for MCM3 Gene

MGI Knock Outs for MCM3:
  • Mcm3 Mcm3<tm1.2Geno>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCM3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MCM3 Gene

Localization for MCM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCM3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCM3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MCM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region HDA 19135898
GO:0005634 nucleus IBA,IDA 20531406
GO:0005654 nucleoplasm TAS --
GO:0005658 alpha DNA polymerase:primase complex TAS 1549468
GO:0005730 NOT nucleolus IDA 21383955
genes like me logo Genes that share ontologies with MCM3: view

Pathways & Interactions for MCM3 Gene

genes like me logo Genes that share pathways with MCM3: view

Pathways by source for MCM3 Gene

1 GeneGo (Thomson Reuters) pathway for MCM3 Gene
  • Cell cycle Start of DNA replication in early S phase
1 Qiagen pathway for MCM3 Gene
  • Cell Cycle Control of Chromosomal Replication
1 Cell Signaling Technology pathway for MCM3 Gene

SIGNOR curated interactions for MCM3 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for MCM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000727 double-strand break repair via break-induced replication IBA 21873635
GO:0006260 DNA replication IEA,TAS --
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication IBA 21873635
GO:0006270 DNA replication initiation IEA,TAS 1549468
genes like me logo Genes that share ontologies with MCM3: view

Drugs & Compounds for MCM3 Gene

(4) Drugs for MCM3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for MCM3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with MCM3: view

Transcripts for MCM3 Gene

mRNA/cDNA for MCM3 Gene

9 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCM3

Alternative Splicing Database (ASD) splice patterns (SP) for MCM3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a ·
SP1: - - -
SP2:
SP3: -
SP4: - - - - - - - - - - - - -
SP5: - -
SP6:
SP7: - - - - - - - - -
SP8:
SP9: - - - -
SP10: - - -
SP11: - -
SP12:
SP13:

ExUns: 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MCM3 Gene

GeneLoc Exon Structure for
MCM3

Expression for MCM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MCM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MCM3 Gene

This gene is overexpressed in Liver (47.6) and Lymph node (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MCM3 Gene



Protein tissue co-expression partners for MCM3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MCM3

SOURCE GeneReport for Unigene cluster for MCM3 Gene:

Hs.179565

Evidence on tissue expression from TISSUES for MCM3 Gene

  • Pancreas(4.3)
  • Nervous system(4.2)
  • Skin(3.4)
  • Intestine(3.2)
  • Liver(3.2)
  • Blood(2.9)
  • Heart(2.8)
  • Lung(2.8)
  • Kidney(2.7)
  • Lymph node(2.6)
  • Eye(2.5)
  • Spleen(2.3)
  • Muscle(2.1)
  • Bone marrow(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with MCM3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCM3 Gene

Orthologs for MCM3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MCM3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MCM3 30 31
  • 99.73 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MCM3 30 31
  • 92.08 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MCM3 30 31
  • 89.48 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mcm3 30 17 31
  • 88.32 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MCM3 31
  • 88 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mcm3 30
  • 87.78 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia MCM3 31
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MCM3 30 31
  • 77.1 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MCM3 31
  • 77 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia zmcm3 30
  • 73.06 (n)
African clawed frog
(Xenopus laevis)
Amphibia mcm3-prov 30
Zebrafish
(Danio rerio)
Actinopterygii mcm3 30 31 31
  • 71.76 (n)
OneToMany
mcm3l 31
  • 71 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Mcm3 30 31 32
  • 62 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001135 30
  • 61.44 (n)
Worm
(Caenorhabditis elegans)
Secernentea mcm-3 31 32
  • 45 (a)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFR355C 30
  • 56.02 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCM3 30 31 33
  • 54.69 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22243g 30
  • 53.34 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons MCM3 30
  • 54.61 (n)
Rice
(Oryza sativa)
Liliopsida Os05g0476200 30
  • 54.93 (n)
Os.23359 30
Wheat
(Triticum aestivum)
Liliopsida Ta.14537 30
Corn
(Zea mays)
Liliopsida Zm.174 30
Bread mold
(Neurospora crassa)
Ascomycetes NCU08009 30
  • 57.87 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mcm3 30
  • 55.28 (n)
Species where no ortholog for MCM3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MCM3 Gene

ENSEMBL:
Gene Tree for MCM3 (if available)
TreeFam:
Gene Tree for MCM3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MCM3: view image

Paralogs for MCM3 Gene

Paralogs for MCM3 Gene

(5) SIMAP similar genes for MCM3 Gene using alignment to 5 proteins:

  • MCM3_HUMAN
  • B4DWW4_HUMAN
  • J3KQ69_HUMAN
  • M0QYS9_HUMAN
  • Q7Z6P5_HUMAN

Pseudogenes.org Pseudogenes for MCM3 Gene

genes like me logo Genes that share paralogs with MCM3: view

Variants for MCM3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MCM3 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
783464 Benign: not provided 52,278,860(-) A/G INTRON_VARIANT
rs17240063 - p.Ile590Leu
rs2230239 - p.Arg774Trp
rs2230240 - p.Glu777Lys
rs2307328 - p.Phe287Leu

Additional dbSNP identifiers (rs#s) for MCM3 Gene

Structural Variations from Database of Genomic Variants (DGV) for MCM3 Gene

Variant ID Type Subtype PubMed ID
nsv830662 CNV gain 17160897

Variation tolerance for MCM3 Gene

Residual Variation Intolerance Score: 24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.48; 77.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MCM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCM3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCM3 Gene

Disorders for MCM3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MCM3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
grade iii astrocytoma
  • anaplastic astrocytoma
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards
Search MCM3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MCM3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MCM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCM3 Gene

Publications for MCM3 Gene

  1. Identification and characterization of a novel component of the human minichromosome maintenance complex. (PMID: 17296731) Sakwe AM … Frappier L (Molecular and cellular biology 2007) 3 4 23
  2. Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. (PMID: 15210935) Cortez D … Elledge SJ (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 23
  3. The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3. (PMID: 12226073) Takei Y … Laskey R (The Journal of biological chemistry 2002) 3 4 23
  4. Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein. (PMID: 1549468) Thömmes P … Knippers R (Nucleic acids research 1992) 2 3 4
  5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 41

Products for MCM3 Gene

  • Signalway ELISA kits for MCM3
  • Signalway Proteins for MCM3

Sources for MCM3 Gene