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The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018]
MCM3 (Minichromosome Maintenance Complex Component 3) is a Protein Coding gene. Diseases associated with MCM3 include Grade Iii Astrocytoma and Lung Cancer. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and E2F transcription factor network. Gene Ontology (GO) annotations related to this gene include DNA helicase activity and magnesium chelatase activity. An important paralog of this gene is MCM2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003677 | DNA binding | IEA,TAS | 1549468 |
GO:0003678 | DNA helicase activity | IEA | -- |
GO:0003688 | DNA replication origin binding | IBA | 21873635 |
GO:0003697 | single-stranded DNA binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000784 | nuclear chromosome, telomeric region | HDA | 19135898 |
GO:0005634 | nucleus | IBA,IDA | 20531406 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005658 | alpha DNA polymerase:primase complex | TAS | 1549468 |
GO:0005730 | NOT nucleolus | IDA | 21383955 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.93
.93
|
.80
.78
|
2 | E2F mediated regulation of DNA replication |
.64
|
Cell cycle Start of DNA replication in early S phase
.53
|
3 | Telomere C-strand (Lagging Strand) Synthesis |
.67
|
.01
|
4 | Mitotic G1-G1/S phases |
.83
|
|
5 | Cell cycle |
.58
|
.58
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000082 | G1/S transition of mitotic cell cycle | TAS | -- |
GO:0000727 | double-strand break repair via break-induced replication | IBA | 21873635 |
GO:0006260 | DNA replication | IEA,TAS | -- |
GO:0006267 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication | IBA | 21873635 |
GO:0006270 | DNA replication initiation | IEA,TAS | 1549468 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
ExUns: | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||
SP2: | - | ||||||||||||||||||
SP3: | |||||||||||||||||||
SP4: | |||||||||||||||||||
SP5: | |||||||||||||||||||
SP6: | |||||||||||||||||||
SP7: | - | - | |||||||||||||||||
SP8: | |||||||||||||||||||
SP9: | |||||||||||||||||||
SP10: | |||||||||||||||||||
SP11: | |||||||||||||||||||
SP12: | |||||||||||||||||||
SP13: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MCM3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MCM3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MCM3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mcm3 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MCM3 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mcm3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | MCM3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MCM3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MCM3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | zmcm3 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | mcm3-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mcm3 30 31 31 |
|
OneToMany | |
mcm3l 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Mcm3 30 31 32 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001135 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | mcm-3 31 32 |
|
OneToOne | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR355C 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MCM3 30 31 33 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E22243g 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | MCM3 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os05g0476200 30 |
|
||
Os.23359 30 |
|
||||
Wheat (Triticum aestivum) |
Liliopsida | Ta.14537 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.174 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU08009 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | mcm3 30 |
|
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
783464 | Benign: not provided | 52,278,860(-) | A/G | INTRON_VARIANT | |
rs17240063 | - | p.Ile590Leu | |||
rs2230239 | - | p.Arg774Trp | |||
rs2230240 | - | p.Glu777Lys | |||
rs2307328 | - | p.Phe287Leu |
Disorder | Aliases | PubMed IDs |
---|---|---|
grade iii astrocytoma |
|
|
lung cancer |
|
|