Aliases for MCM3 Gene
Aliases for MCM3 Gene
- Minichromosome Maintenance Complex Component 3 2 3 5
- DNA Polymerase Alpha Holoenzyme-Associated Protein P1 3 4
- RLF Subunit Beta 3 4
- P1-MCM3 3 4
- P102 3 4
- MCM3 Minichromosome Maintenance Deficient 3 (S. Cerevisiae) 2
- Minichromosome Maintenance Deficient (S. Cerevisiae) 3 2
- MCM3 Minichromosome Maintenance Deficient 3 3
- Replication Licensing Factor, Beta Subunit 3
- Minichromosome Maintenance Deficient 3 3
External Ids for MCM3 Gene
- HGNC: 6945
- Entrez Gene: 4172
- Ensembl: ENSG00000112118
- OMIM: 602693
- UniProtKB: P25205
Previous GeneCards Identifiers for MCM3 Gene
- GC06M052130
- GC06M052175
- GC06M051960
- GC06M052128
Summaries for MCM3 Gene
-
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for MCM3 Gene
MCM3 (Minichromosome Maintenance Complex Component 3) is a Protein Coding gene. Diseases associated with MCM3 include Large Intestine Adenocarcinoma and Balanitis Xerotica Obliterans. Among its related pathways are Cell Cycle, Mitotic and E2F mediated regulation of DNA replication. Gene Ontology (GO) annotations related to this gene include DNA helicase activity and magnesium chelatase activity.
UniProtKB/Swiss-Prot for MCM3 Gene
-
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
Additional gene information for MCM3 Gene
- Monarch Initiative
- Search for MCM3 at DataMed
- Search for MCM3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCM3 Gene
Genomics for MCM3 Gene
GeneHancer (GH) Regulatory Elements for MCM3 Gene
Promoters and enhancers for MCM3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MCM3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MCM3 gene promoter:
-
- CBF-B
- Pax-6
- MyoD
- CBF(2)
- CBF-A
- ZIC2
- CP1A
- NF-Y
- NF-YA
- NF-YB
Regulatory Element Products
Genomic Locations for MCM3 Gene
Genomic Locations for MCM3 Gene
- chr6:52,264,009-52,284,881
- (GRCh38/hg38)
- Size:
- 20,873 bases
- Orientation:
- Minus strand
- chr6:52,128,807-52,149,679
- (GRCh37/hg19)
- Size:
- 20,873 bases
- Orientation:
- Minus strand
Genomic View for MCM3 Gene
Genes around MCM3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p12.2 by Entrez Gene
- 6p12.2 by HGNC
- 6p12.2 by Ensembl
MCM3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MCM3 Gene
Proteins for MCM3 Gene
-
Protein details for MCM3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P25205-MCM3_HUMAN
- Recommended name:
- DNA replication licensing factor MCM3
- Protein Accession:
- P25205
- B4DWW4
- Q92660
- Q9BTR3
- Q9NUE7
Protein attributes for MCM3 Gene
- Size:
- 808 amino acids
- Molecular mass:
- 90981 Da
- Quaternary structure:
-
- Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (Probable). Associated with the replication-specific DNA polymerase alpha. Interacts with MCMBP. Interacts with ANKRD17.
- Miscellaneous:
-
- Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. The MCM2-7 hexamer is the proposed physiological active complex.
Protein Expression for MCM3 Gene
Post-translational modifications for MCM3 Gene
- O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
- Ubiquitination at isoforms=2748, posLast=635635, isoforms=2579, posLast=463463, posLast=351351, posLast=301301, posLast=293293, posLast=266266, and isoforms=235
- Modification sites at PhosphoSitePlus
Other Protein References for MCM3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for MCM3
-
Abcam antibodies for MCM3
- Invitrogen Antibodies for MCM3
- antibodies-online: Search results for 116 available MCM3 Antibodies ranked by validation data
- Compare Top MCM3 Antibodies
-
Recommended
- 98 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 23 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 25 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- GeneTex MCM3 Antibody for MCM3
-
Santa Cruz Biotechnology (SCBT) Antibodies for MCM3
Protein Products
-
OriGene Purified Proteins for MCM3
- Search Origene for MassSpec and Protein Over-expression Lysates for MCM3
- Origene Custom Protein Services for MCM3
- Search GeneTex for Proteins for MCM3
Assay Products
- antibodies-online: Search results for 2 available MCM3 Elisa Kits ranked by validation data
- Compare Top MCM3 Elisa Kits
-
Recommended
No data available for DME Specific Peptides for MCM3 Gene
Domains & Families for MCM3 Gene
Gene Families for MCM3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for MCM3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MCM3 Gene
Graphical View of Domain Structure for InterPro Entry
P25205- Family:
-
- Belongs to the MCM family.
Function for MCM3 Gene
Molecular function for MCM3 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + H(2)O = ADP + phosphate.
- GENATLAS Biochemistry:
- cell division cycle,early S-phase-like-3,participating in the cell cycle control of genome duplication
Enzyme Numbers (IUBMB) for MCM3 Gene
Phenotypes From GWAS Catalog for MCM3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003677 | DNA binding | IEA,TAS | -- |
| GO:0004386 | helicase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 12364596 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for MCM3 Gene
- MGI mutant phenotypes for MCM3:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for MCM3:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased homologous recombination repair frequency
- Negative genetic interaction between BLM-/- and BLM+/+
- Reduced mammosphere formation
- Decreased ionizing radiation sensitivity
- Decreased viability in esophageal squamous lineage
- Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased viability after Maraba virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- shRNA abundance <= 50%
- Increased viability
- Increased transferrin (TF) endocytosis
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for MCM3 Gene
- MGI Knock Outs for MCM3:
-
- Mcm3 Mcm3<tm1.2Geno>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MCM3
-
CRISPR Products
-
OriGene CRISPR knockouts for MCM3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MCM3
- genomics-online: gRNA clones - Search results for 108 available MCM3 gene related products
- Overview of 108 available MCM3 gene related products
- Applied Biological Materials CRISPR for MCM3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MCM3
miRNA for MCM3 Gene
- miRTarBase miRNAs that target MCM3
-
- hsa-mir-193b-3p (MIRT016314)
- hsa-mir-1-3p (MIRT023522)
- hsa-mir-215-5p (MIRT024312)
- hsa-mir-34a-5p (MIRT025232)
- hsa-mir-192-5p (MIRT026151)
- hsa-mir-26b-5p (MIRT028827)
- hsa-mir-93-3p (MIRT038726)
- hsa-mir-99b-5p (MIRT044198)
- hsa-mir-222-3p (MIRT046726)
- hsa-mir-92a-3p (MIRT049183)
- hsa-mir-1260b (MIRT052696)
- hsa-mir-210-3p (MIRT054205)
- hsa-mir-147a (MIRT054211)
- hsa-mir-147b (MIRT054215)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MCM3
- Browse OriGene Inhibitory RNA Products For MCM3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCM3
- genomics-online: shRNA clones - Search results for 108 available MCM3 gene related products
- Overview of 108 available MCM3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MCM3
- VectorBuilder custom plasmid, inducible vectors for MCM3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MCM3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MCM3
- Applied Biological Materials Clones for MCM3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MCM3 Gene
Localization for MCM3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MCM3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000784 | nuclear chromosome, telomeric region | HDA | 19135898 |
| GO:0005634 | nucleus | IEA,IDA | 20531406 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005658 | alpha DNA polymerase:primase complex | TAS | 1549468 |
| GO:0005730 | NOT nucleolus | IDA | 21383955 |
Pathways & Interactions for MCM3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
|
| 2 | E2F mediated regulation of DNA replication |
.64
|
|
| 3 | Telomere C-strand (Lagging Strand) Synthesis |
.67
|
.01
|
| 4 | Mitotic G1-G1/S phases |
.83
|
|
| 5 | Cell cycle |
.58
|
.58
|
Pathways by source for MCM3 Gene
5 BioSystems pathways for MCM3 Gene
20 Reactome pathways for MCM3 Gene
2 KEGG pathways for MCM3 Gene
1 GeneGo (Thomson Reuters) pathway for MCM3 Gene
1 Qiagen pathway for MCM3 Gene
1 Cell Signaling Technology pathway for MCM3 Gene
Interacting Proteins for MCM3 Gene
Selected Interacting proteins:
P25205-MCM3_HUMAN
ENSP00000229854
for MCM3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MCM3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | -- |
| GO:0006260 | DNA replication | TAS | -- |
| GO:0006270 | DNA replication initiation | TAS,IEA | -- |
| GO:0007049 | cell cycle | IEA | -- |
Drugs & Compounds for MCM3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
Drug Products
Transcripts for MCM3 Gene
mRNA/cDNA for MCM3 Gene
- (2) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (449) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000229854 3083 bps (uc063ozz.1)
- ENST00000596288 3169 bps (uc063paa.1)
- ENST00000419835 2523 bps (uc011dwu.2)
- ENST00000421471 1030 bps (uc063pab.1)
- ENST00000476448 982 bps (uc063pac.1)
Unigene Clusters for MCM3 Gene
- Minichromosome maintenance complex component 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MCM3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MCM3
- genomics-online: gRNA clones - Search results for 108 available MCM3 gene related products
- Overview of 108 available MCM3 gene related products
- Applied Biological Materials CRISPR for MCM3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MCM3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MCM3
- Browse OriGene Inhibitory RNA Products For MCM3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCM3
- genomics-online: shRNA clones - Search results for 108 available MCM3 gene related products
- Overview of 108 available MCM3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MCM3
- VectorBuilder custom plasmid, inducible vectors for MCM3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MCM3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MCM3
- Applied Biological Materials Clones for MCM3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||
| SP2: | - | ||||||||||||||||||
| SP3: | |||||||||||||||||||
| SP4: | |||||||||||||||||||
| SP5: | |||||||||||||||||||
| SP6: | |||||||||||||||||||
| SP7: | - | - | |||||||||||||||||
| SP8: | |||||||||||||||||||
| SP9: | |||||||||||||||||||
| SP10: | |||||||||||||||||||
| SP11: | |||||||||||||||||||
| SP12: | |||||||||||||||||||
| SP13: |
Expression for MCM3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Somite (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
- Blood (Hematopoietic System)
This gene is overexpressed in Liver (47.6) and Lymph node (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MCM3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MCM3 Gene:
MCM3SOURCE GeneReport for Unigene cluster for MCM3 Gene:
Hs.179565Evidence on tissue expression from TISSUES for MCM3 Gene
- Pancreas(4.1)
- Nervous system(3.8)
- Skin(2.7)
- Intestine(2.5)
- Lymph node(2.3)
- Liver(2.2)
- Blood(2.1)
- Heart(2.1)
- Kidney(2)
- Lung(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for MCM3
-
OriGene qPCR primer pairs for MCM3
- genomics-online: primer clones - Search results for 108 available MCM3 gene related products
- Overview of 108 available MCM3 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCM3 Gene
Orthologs for MCM3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MCM3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MCM3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MCM3 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mcm3 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MCM3 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Mcm3 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MCM3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MCM3 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MCM3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | zmcm3 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | mcm3-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mcm3 34 34 33 33 |
|
OneToMany | |
| mcm3l 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Mcm3 34 35 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001135 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | mcm-3 34 35 |
|
OneToOne | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR355C 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MCM3 36 34 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E22243g 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | MCM3 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os05g0476200 33 |
|
||
| Os.23359 33 |
|
||||
| corn (Zea mays) |
Liliopsida | Zm.174 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.14537 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU08009 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | mcm3 33 |
|
- Species where no ortholog for MCM3 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for MCM3 Gene
- ENSEMBL:
- Gene Tree for MCM3 (if available)
- TreeFam:
- Gene Tree for MCM3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MCM3: view image
Paralogs for MCM3 Gene
(5) SIMAP similar genes for MCM3 Gene using alignment to 5 proteins:
- MCM3_HUMAN
- B4DWW4_HUMAN
- J3KQ69_HUMAN
- M0QYS9_HUMAN
- Q7Z6P5_HUMAN
Pseudogenes.org Pseudogenes for MCM3 Gene
No data available for Paralogs for MCM3 Gene
Variants for MCM3 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000064305 | -- | 52,272,350(-) | T/C | coding_sequence_variant, missense_variant | |
| rs1000316889 | -- | 52,263,515(-) | G/A | downstream_transcript_variant | |
| rs1000335077 | -- | 52,266,622(-) | TCCTCCTC/TCCTC | coding_sequence_variant, inframe_deletion | |
| rs1000378443 | -- | 52,269,805(-) | T/C | intron_variant | |
| rs1000406926 | -- | 52,278,838(-) | A/C | coding_sequence_variant, missense_variant |
Residual Variation Intolerance Score:
24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.48;
77.51% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MCM3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MCM3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCM3 Gene
Disorders for MCM3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| large intestine adenocarcinoma |
|
|
| balanitis xerotica obliterans |
|
|
Search MCM3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MCM3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MCM3 Gene
Publications for MCM3 Gene
- Identification and characterization of a novel component of the human minichromosome maintenance complex. (PMID: 17296731) Sakwe AM … Frappier L (Molecular and cellular biology 2007) 3 4 22 58
- Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. (PMID: 15210935) Cortez D … Elledge SJ (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 22 58
- Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein. (PMID: 1549468) Thömmes P … Knippers R (Nucleic acids research 1992) 2 3 4 58
- Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 44 58
- Minichromosome maintenance protein 3 is a candidate proliferation marker in papillary thyroid carcinoma. (PMID: 19818763) Lee YS … Kim JW (Experimental and molecular pathology 2010) 3 22 58
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- antibodies-online: Search results for 116 available MCM3 Antibodies ranked by validation data
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