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The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other D... See more...
Aliases for MCM3 Gene
Aliases for MCM3 Gene
- Minichromosome Maintenance Complex Component 3 2 3 5
- DNA Polymerase Alpha Holoenzyme-Associated Protein P1 3 4
- DNA Replication Licensing Factor MCM3 3 4
- RLF Subunit Beta 3 4
- P1-MCM3 3 4
- P102 3 4
- MCM3 Minichromosome Maintenance Deficient 3 (S. Cerevisiae) 2
- Minichromosome Maintenance Deficient (S. Cerevisiae) 3 2
- MCM3 Minichromosome Maintenance Deficient 3 3
External Ids for MCM3 Gene
- HGNC: 6945
- Entrez Gene: 4172
- Ensembl: ENSG00000112118
- OMIM: 602693
- UniProtKB: P25205
Previous GeneCards Identifiers for MCM3 Gene
- GC06M052130
- GC06M052175
- GC06M052236
- GC06M051960
- GC06M052128
Summaries for MCM3 Gene
-
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018]
GeneCards Summary for MCM3 Gene
MCM3 (Minichromosome Maintenance Complex Component 3) is a Protein Coding gene. Diseases associated with MCM3 include Grade Iii Astrocytoma and Lung Cancer. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and E2F transcription factor network. Gene Ontology (GO) annotations related to this gene include DNA helicase activity and magnesium chelatase activity. An important paralog of this gene is MCM2.
UniProtKB/Swiss-Prot Summary for MCM3 Gene
-
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
Additional gene information for MCM3 Gene
- HGNC(6945)
- Entrez Gene(4172)
- Ensembl(ENSG00000112118)
- OMIM(602693)
- UniProtKB(P25205)
- Open Targets Platform(ENSG00000112118)
- Monarch Initiative
- Search for MCM3 at DataMed
- Search for MCM3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MCM3 Gene
Genomics for MCM3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MCM3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MCM3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MCM3
- Top Transcription factor binding sites by QIAGEN in the MCM3 gene promoter:
-
- CBF(2)
- CBF-A
- CBF-B
- CP1A
- MyoD
- NF-Y
- NF-YA
- NF-YB
- Pax-6
- ZIC2
Genomic Locations for MCM3 Gene
Genomic Locations for MCM3 Gene
- chr6:52,264,014-52,284,881
- (GRCh38/hg38)
- Size:
- 20,868 bases
- Orientation:
- Minus strand
- chr6:52,128,807-52,149,679
- (GRCh37/hg19)
- Size:
- 20,873 bases
- Orientation:
- Minus strand
Genomic View for MCM3 Gene
Genes around MCM3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p12.2 by HGNC
- 6p12.2 by Entrez Gene
- 6p12.2 by Ensembl
MCM3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MCM3 Gene
Proteins for MCM3 Gene
-
Protein details for MCM3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P25205-MCM3_HUMAN
- Recommended name:
- DNA replication licensing factor MCM3
- Protein Accession:
- P25205
- B4DWW4
- Q92660
- Q9BTR3
- Q9NUE7
Protein attributes for MCM3 Gene
- Size:
- 808 amino acids
- Molecular mass:
- 90981 Da
- Quaternary structure:
-
- Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (Probable). Associated with the replication-specific DNA polymerase alpha. Interacts with MCMBP. Interacts with ANKRD17. Interacts with MCM3AP isoform MCM3AP; this interaction leads to MCM3 acetylation (PubMed:9712829, PubMed:11258703, PubMed:12226073).
- Miscellaneous:
-
- Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. The MCM2-7 hexamer is the proposed physiological active complex.
Protein Expression for MCM3 Gene
Post-translational modifications for MCM3 Gene
- Acetylated by MCM3AP.
- O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
-
Ubiquitination at Lys35, Lys266, Lys293, Lys301, Lys351, Lys463, Lys579, Lys635, and Lys748
- NX_P25205 (NX_P25205-1)
- Modification sites at PhosphoSitePlus
Other Protein References for MCM3 Gene
Antibody Products
- LifeSpan BioSciences MCM3 Antibody (LS-B6802) and MCM3 Antibody (LS-B6800)
- G Biosciences Immunotag™ Phospho-MCM3 (Ser112) Antibody and Immunotag™ MCM3 Antibody
- GeneTex Anti-MCM3 antibody [C2C3], C-term and Anti-MCM3 antibody
- NSJ Bioreagents MCM3 Antibody
- Novus Biologicals Antibodies for MCM3
-
Abcam antibodies for MCM3
- Invitrogen Antibodies for MCM3 (AFLGC-MCM3)
- antibodies-online: Show 30 available MCM3 Antibodies ranked by validation data
- Compare Top MCM3 Antibodies
-
Recommended
- 104 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 30 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 37 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MCM3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for MCM3
- Origene Custom Protein Services for MCM3
-
Signalway Proteins for MCM3
Assay Products
- antibodies-online: Show 4 available MCM3 Elisa Kits ranked by validation data
- Compare Top MCM3 Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for MCM3
No data available for DME Specific Peptides for MCM3 Gene
Domains & Families for MCM3 Gene
Gene Families for MCM3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for MCM3 Gene
- InterPro:
- Blocks:
-
- MCM family
- Mini-chromosome maintenance (MCM) protein 3 family signature
- ProtoNet:
Suggested Antigen Peptide Sequences for MCM3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ55599, highly similar to DNA replication licensing factor MCM3 (B4DWW4_HUMAN)
- p102 (MCM3_HUMAN)
- Minichromosome maintenance complex component 3 (Q7Z6P5_HUMAN)
- Cervical cancer proto-oncogene 5 (Q8NHX6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P25205- Family:
-
- Belongs to the MCM family.
Function for MCM3 Gene
Molecular function for MCM3 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;.
- GENATLAS Biochemistry:
- cell division cycle,early S-phase-like-3,participating in the cell cycle control of genome duplication
Enzyme Numbers (IUBMB) for MCM3 Gene
Phenotypes From GWAS Catalog for MCM3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003677 | DNA binding | IEA,TAS | 1549468 |
| GO:0003678 | DNA helicase activity | IEA | -- |
| GO:0003688 | DNA replication origin binding | IBA | 21873635 |
| GO:0003697 | single-stranded DNA binding | IBA | 21873635 |
Phenotypes for MCM3 Gene
- MGI mutant phenotypes for MCM3:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for MCM3:
-
- no effect
- Decreased viability
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased viability in non-small-cell lung cancer (NSCLC) lineage
- shRNA abundance <= 25%
- Reduced mammosphere formation
- Decreased viability after Maraba virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased ionizing radiation sensitivity
- Increased homologous recombination repair frequency
- Decreased shRNA abundance (Z-score < -2)
- Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Decreased replication of vaccinia virus (VACV)
Animal Models for MCM3 Gene
- MGI Knock Outs for MCM3:
-
- Mcm3 Mcm3<tm1.2Geno>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MCM3 - Select products 50% OFF >
- * MCM3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MCM3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MCM3
-
Santa Cruz Biotechnology (SCBT) CRISPR for MCM3
miRNA for MCM3 Gene
- miRTarBase miRNAs that target MCM3
-
- hsa-miR-193b-3p (MIRT016314)
- hsa-miR-1-3p (MIRT023522)
- hsa-miR-215-5p (MIRT024312)
- hsa-miR-34a-5p (MIRT025232)
- hsa-miR-192-5p (MIRT026151)
- hsa-miR-26b-5p (MIRT028827)
- hsa-miR-93-3p (MIRT038726)
- hsa-miR-99b-5p (MIRT044198)
- hsa-miR-222-3p (MIRT046726)
- hsa-miR-92a-3p (MIRT049183)
- hsa-miR-1260b (MIRT052696)
- hsa-miR-210-3p (MIRT054205)
- hsa-miR-147a (MIRT054211)
- hsa-miR-147b (MIRT054215)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MCM3
- Browse OriGene Inhibitory RNA Products For MCM3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCM3
Clone Products
- Applied Biological Materials (abm): Clones for MCM3 - Select products 50% OFF >
- * MCM3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MCM3
- Addgene plasmids for MCM3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MCM3
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MCM3 Gene
Localization for MCM3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MCM3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000784 | nuclear chromosome, telomeric region | HDA | 19135898 |
| GO:0005634 | nucleus | IBA,IDA | 20531406 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005658 | alpha DNA polymerase:primase complex | TAS | 1549468 |
| GO:0005730 | NOT nucleolus | IDA | 21383955 |
Pathways & Interactions for MCM3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.93
.93
|
.80
.78
|
| 2 | E2F mediated regulation of DNA replication |
.64
|
Cell cycle Start of DNA replication in early S phase
.53
|
| 3 | Telomere C-strand (Lagging Strand) Synthesis |
.67
|
.01
|
| 4 | Mitotic G1-G1/S phases |
.83
|
|
| 5 | Cell cycle |
.58
|
.58
|
Pathways by source for MCM3 Gene
5 BioSystems pathways for MCM3 Gene
20 Reactome pathways for MCM3 Gene
2 KEGG pathways for MCM3 Gene
1 GeneGo (Thomson Reuters) pathway for MCM3 Gene
- Cell cycle Start of DNA replication in early S phase
1 Qiagen pathway for MCM3 Gene
- Cell Cycle Control of Chromosomal Replication
1 Cell Signaling Technology pathway for MCM3 Gene
Interacting Proteins for MCM3 Gene
Selected Interacting proteins:
P25205-MCM3_HUMAN
ENSP00000480987
for MCM3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MCM3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | -- |
| GO:0000727 | double-strand break repair via break-induced replication | IBA | 21873635 |
| GO:0006260 | DNA replication | IEA,TAS | -- |
| GO:0006267 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication | IBA | 21873635 |
| GO:0006270 | DNA replication initiation | IEA,TAS | 1549468 |
Drugs & Compounds for MCM3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Transcripts for MCM3 Gene
mRNA/cDNA for MCM3 Gene
- 9 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000229854 3095 nts (view in UCSC)
- ENST00000419835 2523 nts (view in UCSC)
- ENST00000421471 1030 nts (view in UCSC)
- ENST00000476448 982 nts (view in UCSC)
- ENST00000596288 3068 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MCM3 - Select products 50% OFF >
- * MCM3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MCM3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MCM3
-
Santa Cruz Biotechnology (SCBT) CRISPR for MCM3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MCM3
- Browse OriGene Inhibitory RNA Products For MCM3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCM3
Clone Products
- Applied Biological Materials (abm): Clones for MCM3 - Select products 50% OFF >
- * MCM3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MCM3
- Addgene plasmids for MCM3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MCM3
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||
| SP2: | - | ||||||||||||||||||
| SP3: | |||||||||||||||||||
| SP4: | |||||||||||||||||||
| SP5: | |||||||||||||||||||
| SP6: | |||||||||||||||||||
| SP7: | - | - | |||||||||||||||||
| SP8: | |||||||||||||||||||
| SP9: | |||||||||||||||||||
| SP10: | |||||||||||||||||||
| SP11: | |||||||||||||||||||
| SP12: | |||||||||||||||||||
| SP13: |
Relevant External Links for MCM3 Gene
- GeneLoc Exon Structure for
- MCM3
Expression for MCM3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Somite (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
- Blood (Hematopoietic System)
This gene is overexpressed in Liver (47.6) and Lymph node (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MCM3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MCM3
SOURCE GeneReport for Unigene cluster for MCM3 Gene:
Hs.179565Evidence on tissue expression from TISSUES for MCM3 Gene
- Pancreas(4.3)
- Nervous system(4.2)
- Skin(3.4)
- Intestine(3.2)
- Liver(3.2)
- Blood(2.9)
- Heart(2.8)
- Lung(2.8)
- Kidney(2.7)
- Lymph node(2.6)
- Eye(2.5)
- Spleen(2.3)
- Muscle(2.1)
- Bone marrow(2.1)
- Stomach(2.1)
Primer Products
-
OriGene qPCR primer pairs for MCM3
-
OriGene qPCR primer pairs and template standards for MCM3
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCM3 Gene
Orthologs for MCM3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MCM3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MCM3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MCM3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mcm3 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MCM3 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mcm3 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MCM3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MCM3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MCM3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | zmcm3 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | mcm3-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mcm3 30 31 31 |
|
OneToMany | |
| mcm3l 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Mcm3 30 31 32 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001135 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | mcm-3 31 32 |
|
OneToOne | |
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR355C 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MCM3 30 31 33 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E22243g 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | MCM3 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os05g0476200 30 |
|
||
| Os.23359 30 |
|
||||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.14537 30 |
|
||
| Corn (Zea mays) |
Liliopsida | Zm.174 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU08009 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | mcm3 30 |
|
- Species where no ortholog for MCM3 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for MCM3 Gene
- ENSEMBL:
- Gene Tree for MCM3 (if available)
- TreeFam:
- Gene Tree for MCM3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MCM3: view image
Paralogs for MCM3 Gene
(5) SIMAP similar genes for MCM3 Gene using alignment to 5 proteins:
- MCM3_HUMAN
- B4DWW4_HUMAN
- J3KQ69_HUMAN
- M0QYS9_HUMAN
- Q7Z6P5_HUMAN
Pseudogenes.org Pseudogenes for MCM3 Gene
Variants for MCM3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MCM3 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 783464 | Benign: not provided | 52,278,860(-) | A/G | INTRON_VARIANT | |
| rs17240063 | - | p.Ile590Leu | |||
| rs2230239 | - | p.Arg774Trp | |||
| rs2230240 | - | p.Glu777Lys | |||
| rs2307328 | - | p.Phe287Leu |
Residual Variation Intolerance Score:
24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.48;
77.51% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MCM3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MCM3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCM3 Gene
Disorders for MCM3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| grade iii astrocytoma |
|
|
| lung cancer |
|
|
Search MCM3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MCM3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MCM3 Gene
Publications for MCM3 Gene
- Identification and characterization of a novel component of the human minichromosome maintenance complex. (PMID: 17296731) Sakwe AM … Frappier L (Molecular and cellular biology 2007) 3 4 23
- Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. (PMID: 15210935) Cortez D … Elledge SJ (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 23
- The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3. (PMID: 12226073) Takei Y … Laskey R (The Journal of biological chemistry 2002) 3 4 23
- Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein. (PMID: 1549468) Thömmes P … Knippers R (Nucleic acids research 1992) 2 3 4
- Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 41
ExternalLinks
Products for MCM3 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for MCM3
- Origene Custom Protein Services for MCM3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MCM3
- Browse OriGene Inhibitory RNA Products For MCM3
- OriGene qPCR primer pairs for MCM3
- OriGene qPCR primer pairs and template standards for MCM3
- OriGene CRISPR knockouts for MCM3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MCM3
- Sino Biological Human cDNA Clone for MCM3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MCM3
- Novus Biologicals proteins and lysates for MCM3
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for MCM3
- Find your target
- Browse Primary Antibodies
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- Invitrogen Antibodies for MCM3 (AFLGC-MCM3)
- VectorBuilder Custom and pre-made DNA vectors for MCM3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MCM3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MCM3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MCM3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MCM3
- Addgene plasmids for MCM3
- antibodies-online: Show 30 available MCM3 Antibodies ranked by validation data
- Compare Top MCM3 Antibodies
- Recommended
- 104 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 30 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 37 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- antibodies-online: Show 4 available MCM3 Elisa Kits ranked by validation data
- Compare Top MCM3 Elisa Kits
- Quality Products:
- antibodies-online: Show 8 available MCM3 Proteins ranked by validation data
- Compare Top MCM3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for MCM3
- Search Santa Cruz Biotechnology (SCBT) for MCM3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MCM3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MCM3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MCM3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MCM3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCM3
Sources for MCM3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95)