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The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of othe... See more...
Aliases for MCM10 Gene
Aliases for MCM10 Gene
External Ids for MCM10 Gene
- HGNC: 18043
- Entrez Gene: 55388
- Ensembl: ENSG00000065328
- OMIM: 609357
- UniProtKB: Q7L590
Previous GeneCards Identifiers for MCM10 Gene
- GC10P013185
- GC10P013353
- GC10P013207
- GC10P013243
- GC10P013116
- GC10P013203
Summaries for MCM10 Gene
-
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for MCM10 Gene
MCM10 (Minichromosome Maintenance 10 Replication Initiation Factor) is a Protein Coding gene. Diseases associated with MCM10 include Baller-Gerold Syndrome and Rapadilino Syndrome. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and E2F mediated regulation of DNA replication. Gene Ontology (GO) annotations related to this gene include identical protein binding.
UniProtKB/Swiss-Prot Summary for MCM10 Gene
-
Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359).
Additional gene information for MCM10 Gene
- HGNC(18043)
- Entrez Gene(55388)
- Ensembl(ENSG00000065328)
- OMIM(609357)
- UniProtKB(Q7L590)
- Open Targets Platform(ENSG00000065328)
- Search for MCM10 at DataMed
- Search for MCM10 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MCM10 Gene
Genomics for MCM10 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MCM10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MCM10 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MCM10
- Top Transcription factor binding sites by QIAGEN in the MCM10 gene promoter:
-
- AML1a
- Cart-1
- FOXO4
- Max1
- MIF-1
- Pax-2
- Pax-4a
- SRF
- SRF (504 AA)
Genomic Locations for MCM10 Gene
Genomic Locations for MCM10 Gene
- chr10:13,161,554-13,211,110
- (GRCh38/hg38)
- Size:
- 49,557 bases
- Orientation:
- Plus strand
- chr10:13,203,554-13,253,104
- (GRCh37/hg19)
- Size:
- 49,551 bases
- Orientation:
- Plus strand
Genomic View for MCM10 Gene
Genes around MCM10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p13 by HGNC
- 10p13 by Entrez Gene
- 10p13 by Ensembl
MCM10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MCM10 Gene
Proteins for MCM10 Gene
-
Protein details for MCM10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7L590-MCM10_HUMAN
- Recommended name:
- Protein MCM10 homolog
- Protein Accession:
- Q7L590
- A8K9I6
- B7ZKZ8
- Q3MIR3
- Q7LD55
- Q96GX4
- Q96NB6
- Q9H0D7
- Q9H3P9
- Q9P177
Protein attributes for MCM10 Gene
- Size:
- 875 amino acids
- Molecular mass:
- 98183 Da
- Quaternary structure:
-
- Self-associates (By similarity). Interacts with ORC2. May interact with MCM2 and MCM6. Interacts with the DNA polymerase alpha subunit POLA1. Interacts with RECQL4; this interaction regulates RECQL4 unwinding activity. Interacts with WDHD1.
- SequenceCaution:
-
- Sequence=AAF69623.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for MCM10 Gene
Post-translational modifications for MCM10 Gene
Other Protein References for MCM10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences MCM10 Antibody
- G Biosciences Immunotag™ MCM10 Antibody
-
Custom Antibody ServicesOriGene Antibodies for MCM10
- Novus Biologicals Antibodies for MCM10
-
Abcam antibodies for MCM10
- Invitrogen Antibodies for MCM10 (AFLGC-MCM10)
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for MCM10
- Origene Custom Protein Services for MCM10
-
Signalway Proteins for MCM10
-
Abcam proteins for MCM10
No data available for DME Specific Peptides for MCM10 Gene
Domains & Families for MCM10 Gene
Gene Families for MCM10 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MCM10 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MCM10 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein MCM10 homolog (MCM10_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q7L590UniProtKB/Swiss-Prot:
MCM10_HUMAN :- Each zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the OB-fold domain.
- Belongs to the MCM10 family.
- Domain:
-
- Each zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the OB-fold domain.
- The N-terminal domain mediates homodimerization.
- Family:
-
- Belongs to the MCM10 family.
Function for MCM10 Gene
Molecular function for MCM10 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359).
Phenotypes From GWAS Catalog for MCM10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003688 | DNA replication origin binding | IBA | 21873635 |
| GO:0003690 | double-stranded DNA binding | IEA,IBA | 21873635 |
| GO:0003697 | single-stranded DNA binding | IEA,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 11095689 |
Phenotypes for MCM10 Gene
- MGI mutant phenotypes for MCM10:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for MCM10:
-
- Large nuclei
- no effect
- Decreased viability
- Increased cell number in G2M, increased nuclei size in G2M
- Increased gamma-H2AX phosphorylation
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased cell number
- Inconclusive
- Decreased BBC3 mRNA expression
- Bright nuclei
- Increased S DNA content, increased G2M DNA content
Animal Models for MCM10 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MCM10 - Select products 50% OFF >
- * MCM10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MCM10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MCM10
-
Santa Cruz Biotechnology (SCBT) CRISPR for MCM10
miRNA for MCM10 Gene
- miRTarBase miRNAs that target MCM10
-
- hsa-miR-192-5p (MIRT004854)
- hsa-miR-193b-3p (MIRT016315)
- hsa-miR-148b-3p (MIRT019273)
- hsa-miR-215-5p (MIRT024276)
- hsa-miR-24-3p (MIRT030381)
- hsa-miR-296-3p (MIRT038395)
- hsa-miR-615-3p (MIRT039760)
- hsa-miR-34a-5p (MIRT047354)
- hsa-miR-185-5p (MIRT437480)
- hsa-miR-6510-3p (MIRT684106)
- hsa-miR-6888-3p (MIRT684107)
- hsa-miR-4522 (MIRT684108)
- hsa-miR-3120-5p (MIRT684109)
- hsa-miR-372-5p (MIRT684110)
- hsa-miR-371a-5p (MIRT684111)
- hsa-miR-616-5p (MIRT684112)
- hsa-miR-373-5p (MIRT684113)
- hsa-miR-371b-5p (MIRT684114)
- hsa-miR-3613-3p (MIRT684115)
- hsa-miR-3664-5p (MIRT684116)
- hsa-miR-4432 (MIRT684117)
- mmu-miR-6344 (MIRT791788)
- mmu-miR-6951-3p (MIRT791976)
- mmu-miR-7116-3p (MIRT792051)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MCM10
- Browse OriGene Inhibitory RNA Products For MCM10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCM10
Clone Products
- Applied Biological Materials (abm): Clones for MCM10 - Select products 50% OFF >
- * MCM10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MCM10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MCM10
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MCM10 Gene
Localization for MCM10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MCM10 Gene
- Nucleus. Note=Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Nucleoli (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 11095689 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0031298 | replication fork protection complex | IBA | 21873635 |
Pathways & Interactions for MCM10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.93
|
.80
|
| 2 | E2F mediated regulation of DNA replication |
.64
|
Cell cycle Start of DNA replication in early S phase
.53
|
| 3 | Cell Cycle, Mitotic |
.83
|
|
| 4 | Cell Cycle Checkpoints |
.84
|
|
| 5 | Mitotic G1-G1/S phases |
.83
|
|
Pathways by source for MCM10 Gene
2 BioSystems pathways for MCM10 Gene
13 Reactome pathways for MCM10 Gene
1 GeneGo (Thomson Reuters) pathway for MCM10 Gene
- Cell cycle Start of DNA replication in early S phase
1 Qiagen pathway for MCM10 Gene
- Cell Cycle Control of Chromosomal Replication
Interacting Proteins for MCM10 Gene
Selected Interacting proteins:
Q7L590-MCM10_HUMAN
ENSP00000418268
for MCM10 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MCM10
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | -- |
| GO:0006260 | DNA replication | IEA,TAS | -- |
| GO:0006270 | DNA replication initiation | IEA,IBA | 21873635 |
| GO:0006974 | cellular response to DNA damage stimulus | IMP | 24726359 |
| GO:0008283 | cell proliferation | IEA | -- |
Transcripts for MCM10 Gene
mRNA/cDNA for MCM10 Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000378694 4587 nts (view in UCSC)
- ENST00000378714 4547 nts (view in UCSC)
- ENST00000459751 618 nts (view in UCSC)
- ENST00000479669 469 nts (view in UCSC)
- ENST00000481292 900 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MCM10 - Select products 50% OFF >
- * MCM10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MCM10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MCM10
-
Santa Cruz Biotechnology (SCBT) CRISPR for MCM10
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MCM10
- Browse OriGene Inhibitory RNA Products For MCM10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCM10
Clone Products
- Applied Biological Materials (abm): Clones for MCM10 - Select products 50% OFF >
- * MCM10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MCM10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MCM10
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for MCM10 Gene
- GeneLoc Exon Structure for
- MCM10
Expression for MCM10 Gene
This gene is overexpressed in Cerebrospinal fluid (28.6), Kidney (13.8), Lung (10.5), Urine (6.7), and Placenta (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MCM10 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MCM10
SOURCE GeneReport for Unigene cluster for MCM10 Gene:
Hs.198363Evidence on tissue expression from TISSUES for MCM10 Gene
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for MCM10
-
OriGene qPCR primer pairs and template standards for MCM10
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCM10 Gene
Orthologs for MCM10 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MCM10 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MCM10 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MCM10 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mcm10 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mcm10 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MCM10 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MCM10 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| MCM10 30 |
|
||||
| -- 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | MCM10 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mcm10 30 |
|
||
| Str.1798 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398196 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mcm10 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2336 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Mcm10 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008723 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | mcm-10 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MCM10 31 33 33 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany |
- Species where no ortholog for MCM10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MCM10 Gene
- ENSEMBL:
- Gene Tree for MCM10 (if available)
- TreeFam:
- Gene Tree for MCM10 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MCM10: view image
Paralogs for MCM10 Gene
No data available for Paralogs for MCM10 Gene
Variants for MCM10 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MCM10 Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 709266 | Likely Benign: not provided | 13,171,247(+) | G/A | SYNONYMOUS_VARIANT | |
| 725888 | Benign: not provided | 13,195,101(+) | C/T | SYNONYMOUS_VARIANT | |
| 730168 | Benign: not provided | 13,192,328(+) | G/A | SYNONYMOUS_VARIANT | |
| 761730 | Likely Benign: not provided | 13,189,045(+) | C/T | SYNONYMOUS_VARIANT | |
| 768348 | Benign: not provided | 13,192,360(+) | C/T | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2733317 | CNV | deletion | 23290073 |
| nsv1137878 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.76;
83.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MCM10 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCM10 Gene
Disorders for MCM10 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| baller-gerold syndrome |
|
|
| rapadilino syndrome |
|
|
| fanconi anemia, complementation group a |
|
|
| rothmund-thomson syndrome, type 2 |
|
|
Search MCM10 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MCM10
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MCM10 Gene
Publications for MCM10 Gene
- Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication. (PMID: 17699597) Chattopadhyay S … Bielinsky AK (Molecular biology of the cell 2007) 2 3 4 23
- The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. (PMID: 11095689) Izumi M … Hanaoka F (Nucleic acids research 2000) 2 3 4 23
- Physical interactions between Mcm10, DNA, and DNA polymerase alpha. (PMID: 19608746) Warren EM … Eichman BF (The Journal of biological chemistry 2009) 3 4 23
- Cell cycle-dependent proteolysis and phosphorylation of human Mcm10. (PMID: 11602595) Izumi M … Hanaoka F (The Journal of biological chemistry 2001) 3 4 23
- The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability. (PMID: 24726359) Miotto B … Defossez PA (Cell reports 2014) 3 4
ExternalLinks
Products for MCM10 Gene
- Custom Antibody ServicesOriGene Antibodies for MCM10
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- Custom Assay Services
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- Browse OriGene Inhibitory RNA Products For MCM10
- OriGene qPCR primer pairs for MCM10
- OriGene qPCR primer pairs and template standards for MCM10
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- Browse OriGene miRNA Products For MCM10
- Sino Biological Human cDNA Clone for MCM10
- Browse Sino Biological Recombinant Proteins
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- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MCM10
- Novus Biologicals proteins and lysates for MCM10
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MCM10
- Abcam proteins for MCM10
- Find your target
- Browse Primary Antibodies
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- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for MCM10 (AFLGC-MCM10)
- VectorBuilder Custom and pre-made DNA vectors for MCM10 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MCM10 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MCM10 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MCM10 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MCM10
- antibodies-online: Show 11 available MCM10 Antibodies ranked by validation data
- Compare Top MCM10 Antibodies
- antibodies-online: Search results for available MCM10 related products ranked by validation data
- antibodies-online: Show 3 available MCM10 Proteins ranked by validation data
- Compare Top MCM10 Proteins
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MCM10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MCM10
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MCM10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCM10
- Signalway Proteins for MCM10
Sources for MCM10 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB