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This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 201... See more...
Aliases for MCL1 Gene
Aliases for MCL1 Gene
- MCL1 Apoptosis Regulator, BCL2 Family Member 2 3 5
- Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 3 4
- Myeloid Cell Leukemia Sequence 1 (BCL2-Related) 2 3
- MCL1, BCL2 Family Apoptosis Regulator 2 3
- Bcl-2-Related Protein EAT/Mcl1 3 4
- Myeloid Cell Leukemia 1 2 3
- Bcl-2-Like Protein 3 3 4
- Bcl2-L-3 3 4
- Mcl1/EAT 3 4
External Ids for MCL1 Gene
- HGNC: 6943
- Entrez Gene: 4170
- Ensembl: ENSG00000143384
- OMIM: 159552
- UniProtKB: Q07820
Previous GeneCards Identifiers for MCL1 Gene
- GC01M148388
- GC01M146294
- GC01M147322
- GC01M147763
- GC01M147360
- GC01M148813
- GC01M150547
- GC01M121925
- GC01M150581
- GC01M150596
Summaries for MCL1 Gene
-
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
GeneCards Summary for MCL1 Gene
MCL1 (MCL1 Apoptosis Regulator, BCL2 Family Member) is a Protein Coding gene. Diseases associated with MCL1 include Myeloid Leukemia and Indolent B-Cell Non-Hodgkin Lymphoma. Among its related pathways are Cytokine Signaling in Immune system and Th17 cell differentiation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and BH3 domain binding. An important paralog of this gene is BAK1.
UniProtKB/Swiss-Prot Summary for MCL1 Gene
-
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Additional gene information for MCL1 Gene
- Monarch Initiative
- Search for MCL1 at DataMed
- Search for MCL1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MCL1 Gene
Genomics for MCL1 Gene
GeneHancer (GH) Regulatory Elements for MCL1 Gene
Promoters and enhancers for MCL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MCL1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MCL1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- STAT5A
Genomic Locations for MCL1 Gene
Genomic Locations for MCL1 Gene
- chr1:150,574,551-150,579,738
- (GRCh38/hg38)
- Size:
- 5,188 bases
- Orientation:
- Minus strand
- chr1:150,547,027-150,552,214
- (GRCh37/hg19)
- Size:
- 5,188 bases
- Orientation:
- Minus strand
Genomic View for MCL1 Gene
Genes around MCL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.2 by HGNC
- 1q21.2 by Entrez Gene
- 1q21.2 by Ensembl
MCL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MCL1 Gene
Proteins for MCL1 Gene
-
Protein details for MCL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q07820-MCL1_HUMAN
- Recommended name:
- Induced myeloid leukemia cell differentiation protein Mcl-1
- Protein Accession:
- Q07820
- B2R6B2
- D3DV03
- D3DV04
- Q9HD91
- Q9NRQ3
- Q9NRQ4
- Q9UHR7
- Q9UHR8
- Q9UHR9
- Q9UNJ1
Protein attributes for MCL1 Gene
- Size:
- 350 amino acids
- Molecular mass:
- 37337 Da
- Quaternary structure:
-
- Interacts with HIF3A (via C-terminus domain) (By similarity). Interacts with BAD, BOK, BIK and BMF (By similarity). Interacts with PMAIP1 (PubMed:17389404). Interacts with BBC3 (By similarity). Isoform 1 interacts with BAX, BAK1 and TPT1 (PubMed:10837489, PubMed:12149273, PubMed:15077116). Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptotic BCL2-related proteins (PubMed:10837489). Interacts with RTL10/BOP (PubMed:23055042). Interacts with BCL2L11; may sequester BCL2L11 to prevent its pro-apoptotic activity (PubMed:10837489, PubMed:27013495, PubMed:17389404, PubMed:20562877). Interacts with GIMAP5 and HSPA8/HSC70; the interaction between HSPA8 and MCL1 is impaired in the absence of GIMAP5 (By similarity).
Three dimensional structures from OCA and Proteopedia for MCL1 Gene
Protein Expression for MCL1 Gene
Post-translational modifications for MCL1 Gene
- Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
- Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.
- Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.
- Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159.
-
Ubiquitination at Lys5, Lys40, Lys136, Lys194, Lys197, and Lys308
- NX_Q07820 (NX_Q07820-1)
- Modification sites at PhosphoSitePlus
Other Protein References for MCL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents MCL1 Antibody
- Atlas Antibodies Anti-MCL1 Antibody (HPA008455), Anti-MCL1 Antibody (HPA031125), and Anti-MCL1 Antibody (AMAb90859)
-
Creative Diagnostics
- Anti-MCL1 monoclonal antibody, clone SD14
- Anti-MMP7 (aa 121-139) polyclonal antibody
- Anti-MCL1 monoclonal antibody, clone 3F22
- Anti-MCL1 monoclonal antibody, clone 21G7
- Anti-MCL1 monoclonal antibody, clone 21E21
- Anti-MCL1 (C-terminal) polyclonal antibody (CPBT-66209GH)
- Anti-MCL1 (C-terminal) polyclonal antibody (DPAB-L20737)
- Anti-MCL1 (aa 151-250) polyclonal antibody
- Anti-MCL1 polyclonal antibody (CABT-BL2349)
- Anti-MCL1 polyclonal antibody (CABT-BL2357)
- Anti-MCL1 monoclonal antibody, clone 9D7E5C2
- Anti-Mcl-1 monoclonal antibody, clone SD14
- Anti-MCL1 monoclonal antibody, clone cdO466M
- Anti-MCL1 monoclonal antibody, clone cdO465M
- Anti-MCL1 polyclonal antibody (CABT-BL2350)
- Anti-MCL1 polyclonal antibody (CABT-BL2358)
- Anti-MCL1 (aa 121-139) polyclonal antibody
- Anti-MCL1 monoclonal antibody, clone Bc33
- Anti-MCL1 monoclonal antibody, clone cdO467M
- Anti-MCL1 polyclonal antibody (CABT-BL2356)
- Anti-MCL1 monoclonal antibody, clone SD24
- Rabbit Anti-Human MCL-1 polyclonal antibody
- Anti-MCL1 polyclonal antibody (CABT-BL2351)
- Anti-MCL1 monoclonal antibody, clone TQN454
- Anti-MCL1 (C-terminal) polyclonal antibody (CABT-BL2352)
- Anti-MCL1 monoclonal antibody, clone MAAG3295
-
Creative Biolabs
- Recombinant Anti-Human MCL1 Antibody Fab Fragment
- Recombinant Anti-Human MCL1 Antibody
- Mouse Anti-MCL1 Recombinant Antibody (CBFYM-1877)
- Recombinant Mouse anti-Human MCL1 Monoclonal antibody (49H4)
- Mouse Anti-MCL1 Recombinant Antibody (CBFYM-1873)
- Rabbit Anti-MCL1 Recombinant Antibody (CBFYM-1883)
- Rabbit Anti-MCL1 Recombinant Antibody (CBFYM-1881)
- Rabbit Anti-MCL1 Recombinant Antibody (CBFYM-1872)
- Mouse Anti-MCL1 (C-terminus) Recombinant Antibody (22/Mcl-1)
- Mouse Anti-MCL1 (Center) Recombinant Antibody (CBFYM-1879)
- Mouse Anti-MCL1 Recombinant Antibody (CBFYM-0220)
- Rabbit Anti-MCL1 Recombinant Antibody (CBFYM-0603)
- Mouse Anti-MCL1 Recombinant Antibody (CBFYM-0341)
- Rabbit Anti-MCL1 Recombinant Antibody (CBFYM-1882)
- Mouse Anti-MCL1 (AA 1-230) Recombinant Antibody (CBFYM-1875)
- Rabbit Anti-MCL1 Recombinant Antibody (CBFYM-0449)
- Mouse Anti-MCL1 (AA 1-327) Recombinant Antibody (CBFYM-0790)
- Rat Anti-MCL1 Recombinant Antibody (CBFYM-1884)
- Mouse Anti-MCL1 Recombinant Antibody (CBFYM-1876)
- Mouse Anti-MCL1 Recombinant Antibody (CBFYM-1878)
- Mouse Anti-MCL1 (AA 231-350) Recombinant Antibody (CBFYM-1874)
- Hi-Affi™ Recombinant Rabbit Anti-MCL1 Monoclonal Antibody (DS2189AB)
- Mouse Anti-MCL1 (AA 1-327) Recombinant Antibody (CBFYM-1880)
- BioLegend Mcl-1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for MCL1
- AM06096PU-N
- AM08411PU-N
- AP00018PU-N
- AP01226PU-N
- AP06215PU-N
- AP07772PU-N
- AP11305PU-N
- AP31050PU-N
- CF500982
- CF500983
- CF500984
- CF500985
- CF500986
- CF500987
- CF500988
- CF500989
- CF500990
- CF501036
- SP2170P
- TA302945
- TA306207
- TA306208
- TA306209
- TA326250
- TA326836
- TA328034
- TA347329
- TA347425
- TA500982
- TA500983
- TA500984
- TA500985
- TA500986
- TA500986S
- TA500987
- TA500988
- TA500989
- TA500990
- TA501036
- TA350982
- Novus Biologicals Antibodies for MCL1
-
Abcam antibodies for MCL1
- Invitrogen Antibodies for MCL1 (AFLGC-MCL1)
- antibodies-online: Show 121 available MCL-1 Antibodies ranked by validation data
- Compare Top MCL-1 Antibodies
-
Recommended
- 295 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 123 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 82 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MCL1
- Sino Biological Antibodies for MCL1
Protein Products
- Atlas Antibodies PrEST Antigen MCL1 (APrEST70113) and PrEST Antigen MCL1 (APrEST70112)
-
OriGene Purified Proteins for MCL1
- Search Origene for MassSpec and Protein Over-expression Lysates for MCL1
- Origene Custom Protein Services for MCL1
- ProSpec Recombinant Proteins for MCL1
-
Abcam proteins for MCL1
Assay Products
- RayBiotech Human Mcl-1/Bcl2L3 ELISA
- Aviva Systems Biology MCL1 ELISA Kit (Human) (OKCD08205)
-
Boster Bio ELISA Kits for MCL1
No data available for DME Specific Peptides for MCL1 Gene
Domains & Families for MCL1 Gene
Gene Families for MCL1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for MCL1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MCL1 Gene
- GenScript: Design optimal peptide antigens:
-
- Myeloid cell leukemia ES variant (C8YZ26_HUMAN)
- mcl1/EAT (MCL1_HUMAN)
- Myosin light chain 1 (Q03399_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q07820- Family:
-
- Belongs to the Bcl-2 family.
Function for MCL1 Gene
Molecular function for MCL1 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
- UniProtKB/Swiss-Prot Induction:
- Expression increases early during phorbol ester-induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell line ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat shock-induced differentiation. Expression increases early during retinoic acid-induced differentiation.
- GENATLAS Biochemistry:
- myeloid cell leukemia 1,involved in programmed myeloid cell differentiation,with homology to BCL2
Phenotypes From GWAS Catalog for MCL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15901672 |
| GO:0008320 | protein transmembrane transporter activity | TAS | 10837489 |
| GO:0042803 | protein homodimerization activity | IBA | 21873635 |
| GO:0046982 | protein heterodimerization activity | IPI,IBA | 10837489 |
| GO:0051434 | BH3 domain binding | IPI | 21036904 |
Phenotypes for MCL1 Gene
- MGI mutant phenotypes for MCL1:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for MCL1:
-
- Increased number of mitotic cells
- G0/1 arrest
- Decreased cell number
- Synthetic lethal with cisplatin
- Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased shRNA abundance
- Increased gamma-H2AX phosphorylation
- Mildly decreased CFP-tsO45G cell surface transport
- shRNA abundance <= 50%
- Decreased viability with paclitaxel
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for MCL1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for MCL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MCL1
- genomics-online: gRNA clones - Search for available MCL-1 gRNA products
- Overview of 134 available MCL-1 gene related products
- Applied Biological Materials (abm): CRISPR Clones for MCL1 - Select products 50% OFF >
- * MCL1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MCL1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for MCL1
miRNA for MCL1 Gene
- miRTarBase miRNAs that target MCL1
-
- hsa-mir-16-5p (MIRT000877)
- hsa-mir-15a-5p (MIRT000878)
- hsa-mir-193a-3p (MIRT002485)
- hsa-mir-133b (MIRT003260)
- hsa-mir-29a-3p (MIRT003286)
- hsa-mir-29b-3p (MIRT003287)
- hsa-mir-29c-3p (MIRT003288)
- hsa-mir-101-3p (MIRT003921)
- hsa-mir-153-3p (MIRT004080)
- hsa-mir-512-5p (MIRT004406)
- hsa-mir-320a (MIRT004440)
- hsa-mir-193b-3p (MIRT004663)
- hsa-mir-518a-5p (MIRT004667)
- hsa-mir-582-5p (MIRT004668)
- hsa-mir-661 (MIRT004743)
- hsa-mir-876-3p (MIRT004744)
- hsa-mir-892b (MIRT004745)
- hsa-mir-148b-5p (MIRT004746)
- hsa-mir-886-3p (MIRT006591)
- hsa-mir-125b-5p (MIRT006843)
- hsa-mir-181a-5p (MIRT006949)
- hsa-mir-181b-5p (MIRT006952)
- hsa-mir-151a-3p (MIRT019504)
- hsa-mir-186-5p (MIRT021163)
- hsa-mir-26b-5p (MIRT030090)
- hsa-mir-615-3p (MIRT040421)
- hsa-mir-30d-5p (MIRT047799)
- hsa-mir-133a-3p (MIRT052648)
- hsa-mir-26a-5p (MIRT052649)
- hsa-mir-3679-3p (MIRT052877)
- hsa-mir-139-5p (MIRT053049)
- hsa-mir-761 (MIRT053078)
- hsa-mir-20a-5p (MIRT053332)
- hsa-mir-7153-3p (MIRT059414)
- hsa-mir-596 (MIRT130525)
- hsa-mir-4293 (MIRT130549)
- hsa-mir-6747-3p (MIRT130583)
- hsa-mir-4773 (MIRT130631)
- hsa-mir-7159-3p (MIRT180958)
- hsa-mir-495-3p (MIRT180983)
- hsa-mir-5688 (MIRT180988)
- hsa-mir-106b-5p (MIRT440267)
- hsa-mir-1264 (MIRT473456)
- hsa-mir-3184-3p (MIRT473457)
- hsa-mir-8080 (MIRT473458)
- hsa-mir-4452 (MIRT473459)
- hsa-mir-1469 (MIRT473460)
- hsa-mir-545-5p (MIRT473461)
- hsa-mir-144-3p (MIRT473462)
- hsa-mir-200a-3p (MIRT473463)
- hsa-mir-141-3p (MIRT473464)
- hsa-mir-7702 (MIRT501925)
- hsa-mir-5682 (MIRT501926)
- hsa-mir-767-5p (MIRT501927)
- hsa-mir-6871-3p (MIRT501928)
- hsa-mir-6836-3p (MIRT640050)
- hsa-mir-6829-3p (MIRT640051)
- hsa-mir-6791-3p (MIRT640052)
- hsa-mir-6778-3p (MIRT640053)
- hsa-mir-6771-3p (MIRT640054)
- hsa-mir-660-3p (MIRT640055)
- hsa-mir-6749-3p (MIRT717506)
- hsa-mir-5193 (MIRT717507)
- hsa-mir-32-5p (MIRT727230)
- hsa-mir-92b-3p (MIRT727231)
- hsa-mir-92a-3p (MIRT727232)
- hsa-mir-93-5p (MIRT727233)
- hsa-mir-519d-3p (MIRT727234)
- hsa-mir-20b-5p (MIRT727235)
- hsa-mir-17-5p (MIRT727236)
- hsa-mir-125a-5p (MIRT731779)
- hsa-mir-302b-3p (MIRT732881)
- hsa-mir-34a-5p (MIRT734023)
- hsa-mir-339-3p (MIRT734201)
- hsa-mir-30c-5p (MIRT735282)
- hsa-mir-1207-5p (MIRT736037)
- hsa-mir-1909-3p (MIRT738356)
- hsa-mir-211-3p (MIRT738934)
- hsa-mir-3127-5p (MIRT740060)
- hsa-mir-3153 (MIRT740391)
- hsa-mir-320b (MIRT741196)
- hsa-mir-320c (MIRT741200)
- hsa-mir-320d (MIRT741204)
- hsa-mir-4270 (MIRT743577)
- hsa-mir-4429 (MIRT744316)
- hsa-mir-4441 (MIRT744544)
- hsa-mir-4736 (MIRT748003)
- hsa-mir-4763-3p (MIRT748546)
- hsa-mir-5000-5p (MIRT749337)
- hsa-mir-6508-5p (MIRT752979)
- hsa-mir-6722-3p (MIRT753869)
- hsa-mir-6733-5p (MIRT754115)
- hsa-mir-6739-5p (MIRT754312)
- hsa-mir-6754-5p (MIRT754719)
- hsa-mir-6757-5p (MIRT754846)
- hsa-mir-6783-5p (MIRT755754)
- hsa-mir-7150 (MIRT759167)
- hsa-mir-8065 (MIRT760062)
- hsa-mir-8067 (MIRT760072)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MCL1
- Browse OriGene Inhibitory RNA Products For MCL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCL1
- genomics-online: shRNA clones - Search for available MCL-1 shRNA products
- Overview of 134 available MCL-1 gene related products
Clone Products
-
- MG204868
- MR204868
- MR204868L1
- MR204868L1V
- MR204868L2
- MR204868L2V
- MR204868L3
- MR204868L3V
- MR204868L4
- MR204868L4V
- RC200521
- RC200521L1
- RC200521L1V
- RC200521L2
- RC200521L2V
- RC200521L3
- RC200521L3V
- RC200521L4
- RC200521L4V
- RC217440
- RC217440L3
- RC217440L3V
- RC217440L4
- RC217440L4V
- RC231044
- RC231044L3
- RC231044L3V
- RC231044L4
- RC231044L4V
- RG200521
- RG217440
- RG231044
- RR209509
- RR209509L1
- RR209509L1V
- RR209509L2
- RR209509L2V
- RR209509L3
- RR209509L3V
- RR209509L4
- RR209509L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MCL1
- Addgene plasmids for MCL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MCL1
- genomics-online: cdna clones - Search for available MCL-1 CDNA products
- Overview of 134 available MCL-1 gene related products
- orf clones - Search for available MCL-1 ORF products
- Overview of 134 available MCL-1 gene related products
- Applied Biological Materials (abm): Clones for MCL1 - Select products 50% OFF >
- * MCL1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MCL1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MCL1 Gene
Localization for MCL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MCL1 Gene
- Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| endoplasmic reticulum | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| lysosome | 1 |
- Mitochondria (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 20467439 |
| GO:0005654 | nucleoplasm | IEA | -- |
| GO:0005737 | cytoplasm | TAS | 10837489 |
| GO:0005739 | mitochondrion | IDA | 7896880 |
| GO:0005741 | mitochondrial outer membrane | IBA,TAS | 10837489 |
Pathways & Interactions for MCL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis Modulation and Signaling |
.41
|
.31
|
| 2 | Cytokine Signaling in Immune system | ||
| 3 | Apoptosis and Autophagy | ||
| 4 | JAK-STAT signaling pathway (KEGG) | ||
| 5 | MicroRNAs in cancer | ||
Pathways by source for MCL1 Gene
11 BioSystems pathways for MCL1 Gene
4 Reactome pathways for MCL1 Gene
4 KEGG pathways for MCL1 Gene
2 GeneGo (Thomson Reuters) pathways for MCL1 Gene
1 Cell Signaling Technology pathway for MCL1 Gene
1 GeneTex pathway for MCL1 Gene
Interacting Proteins for MCL1 Gene
Selected Interacting proteins:
Q07820-MCL1_HUMAN
ENSP00000358022
for MCL1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MCL1
SIGNOR curated interactions for MCL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001709 | cell fate determination | NAS | 10837489 |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | IBA | 21873635 |
| GO:0010507 | negative regulation of autophagy | IMP | 24113155 |
Drugs & Compounds for MCL1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| AT-101 | Approved, Investigational | Pharma | Target, inhibitor | BH3-mimetic,gossypol enantiomer, BCL-2 inhibitors | 74 | |
| Mitomycin | Approved | Pharma | Inhibits DNA synthesis,antibiotic and antitumor agent | 0 | ||
| A-1210477 | Pharma | MCL-1 inhibitor | 0 | |||
| Marinopyrrole A | Pharma | Selective Mcl-1 inhibitor | 0 | |||
| MIM1 | Pharma | Mcl-1 Inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(6) ApexBio Compounds for MCL1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| A-1210477 | MCL-1 inhibitor | 1668553-26-1 |
| Marinopyrrole A | Selective Mcl-1 inhibitor | 1227962-62-0 |
| MIM1 | Mcl-1 Inhibitor | |
| Mitomycin C | Inhibits DNA synthesis,antibiotic and antitumor agent | 1950-07-7 |
| TW-37 | Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1 | 877877-35-5 |
| UMI-77 | 518303-20-3 |
Drug Products
- Atlas Antibodies PrEST Antigen MCL1 (APrEST70113) and PrEST Antigen MCL1 (APrEST70112)
- ApexBio compounds for MCL1
Transcripts for MCL1 Gene
mRNA/cDNA for MCL1 Gene
- (3) REFSEQ mRNAs :
- (19) Additional mRNA sequences :
- (849) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000369026 3950 bps (ENST00000369026.2)
- ENST00000464132 1099 bps (ENST00000464132.1)
- ENST00000307940 1110 bps (ENST00000307940.3)
- ENST00000620947 3626 bps (ENST00000620947.4)
CRISPR Products
-
OriGene CRISPR knockouts for MCL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MCL1
- genomics-online: gRNA clones - Search for available MCL-1 gRNA products
- Overview of 134 available MCL-1 gene related products
- Applied Biological Materials (abm): CRISPR Clones for MCL1 - Select products 50% OFF >
- * MCL1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MCL1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for MCL1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MCL1
- Browse OriGene Inhibitory RNA Products For MCL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCL1
- genomics-online: shRNA clones - Search for available MCL-1 shRNA products
- Overview of 134 available MCL-1 gene related products
Clone Products
-
- MG204868
- MR204868
- MR204868L1
- MR204868L1V
- MR204868L2
- MR204868L2V
- MR204868L3
- MR204868L3V
- MR204868L4
- MR204868L4V
- RC200521
- RC200521L1
- RC200521L1V
- RC200521L2
- RC200521L2V
- RC200521L3
- RC200521L3V
- RC200521L4
- RC200521L4V
- RC217440
- RC217440L3
- RC217440L3V
- RC217440L4
- RC217440L4V
- RC231044
- RC231044L3
- RC231044L3V
- RC231044L4
- RC231044L4V
- RG200521
- RG217440
- RG231044
- RR209509
- RR209509L1
- RR209509L1V
- RR209509L2
- RR209509L2V
- RR209509L3
- RR209509L3V
- RR209509L4
- RR209509L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MCL1
- Addgene plasmids for MCL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MCL1
- genomics-online: cdna clones - Search for available MCL-1 CDNA products
- Overview of 134 available MCL-1 gene related products
- orf clones - Search for available MCL-1 ORF products
- Overview of 134 available MCL-1 gene related products
- Applied Biological Materials (abm): Clones for MCL1 - Select products 50% OFF >
- * MCL1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MCL1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | - | |||||||||||||
| SP3: | - | - | - | ||||||||||||
| SP4: |
Expression for MCL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- T Helper Cells Thymus
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for MCL1 Gene
This gene is overexpressed in Whole Blood (x6.1).
This gene is overexpressed in Peripheral blood mononuclear cells (15.6), Lymph node (13.2), Heart (6.6), and Liver (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MCL1 Gene
NURSA nuclear receptor signaling pathways regulating expression of MCL1 Gene:
MCL1SOURCE GeneReport for Unigene cluster for MCL1 Gene:
Hs.632486Evidence on tissue expression from TISSUES for MCL1 Gene
- Nervous system(4.9)
- Blood(4.5)
- Lung(4.1)
- Bone marrow(3.6)
- Liver(3.6)
- Intestine(3.5)
- Pancreas(3)
- Heart(2.9)
- Kidney(2.9)
- Lymph node(2.9)
- Bone(2.6)
- Muscle(2.6)
- Skin(2.6)
- Spleen(2.6)
- Stomach(2.6)
- Eye(2.4)
- Gall bladder(2.4)
- Adrenal gland(2.1)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs for MCL1
-
OriGene qPCR primer pairs and template standards for MCL1
- genomics-online: primer clones - Search for available MCL-1 Primer products
- Overview of 134 available MCL-1 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCL1 Gene
Orthologs for MCL1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MCL1 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MCL1 33 32 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | MCL1 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Mcl1 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Mcl1 17 33 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MCL1 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MCL1 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MCL1 33 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | mcl1a 33 32 |
|
OneToMany | |
| mcl1b 33 |
|
OneToMany | |||
| bcl2l10 33 |
|
OneToMany |
- Species where no ortholog for MCL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)