This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 201... See more...

Aliases for MCL1 Gene

Aliases for MCL1 Gene

  • MCL1 Apoptosis Regulator, BCL2 Family Member 2 3 5
  • Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 3 4
  • Myeloid Cell Leukemia Sequence 1 (BCL2-Related) 2 3
  • MCL1, BCL2 Family Apoptosis Regulator 2 3
  • Bcl-2-Related Protein EAT/Mcl1 3 4
  • Myeloid Cell Leukemia 1 2 3
  • Bcl-2-Like Protein 3 3 4
  • Bcl2-L-3 3 4
  • Mcl1/EAT 3 4
  • BCL2L3 3 4
  • BCL2 Family Apoptosis Regulator 3
  • Myeloid Cell Leukemia ES 3
  • MCL1-ES 3
  • MCL1L 3
  • MCL1S 3
  • Mcl-1 3
  • EAT 3
  • TM 3

External Ids for MCL1 Gene

Previous GeneCards Identifiers for MCL1 Gene

  • GC01M148388
  • GC01M146294
  • GC01M147322
  • GC01M147763
  • GC01M147360
  • GC01M148813
  • GC01M150547
  • GC01M121925
  • GC01M150581
  • GC01M150596

Summaries for MCL1 Gene

Entrez Gene Summary for MCL1 Gene

  • This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]

GeneCards Summary for MCL1 Gene

MCL1 (MCL1 Apoptosis Regulator, BCL2 Family Member) is a Protein Coding gene. Diseases associated with MCL1 include Myeloid Leukemia and Indolent B-Cell Non-Hodgkin Lymphoma. Among its related pathways are Cytokine Signaling in Immune system and Th17 cell differentiation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and BH3 domain binding. An important paralog of this gene is BAK1.

UniProtKB/Swiss-Prot Summary for MCL1 Gene

  • Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

Gene Wiki entry for MCL1 Gene

Additional gene information for MCL1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MCL1 Gene

Genomics for MCL1 Gene

GeneHancer (GH) Regulatory Elements for MCL1 Gene

Promoters and enhancers for MCL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MCL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MCL1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • STAT5A

Genomic Locations for MCL1 Gene

Genomic Locations for MCL1 Gene
chr1:150,574,551-150,579,738
(GRCh38/hg38)
Size:
5,188 bases
Orientation:
Minus strand
chr1:150,547,027-150,552,214
(GRCh37/hg19)
Size:
5,188 bases
Orientation:
Minus strand

Genomic View for MCL1 Gene

Genes around MCL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCL1 Gene

Proteins for MCL1 Gene

  • Protein details for MCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07820-MCL1_HUMAN
    Recommended name:
    Induced myeloid leukemia cell differentiation protein Mcl-1
    Protein Accession:
    Q07820
    Secondary Accessions:
    • B2R6B2
    • D3DV03
    • D3DV04
    • Q9HD91
    • Q9NRQ3
    • Q9NRQ4
    • Q9UHR7
    • Q9UHR8
    • Q9UHR9
    • Q9UNJ1

    Protein attributes for MCL1 Gene

    Size:
    350 amino acids
    Molecular mass:
    37337 Da
    Quaternary structure:
    • Interacts with HIF3A (via C-terminus domain) (By similarity). Interacts with BAD, BOK, BIK and BMF (By similarity). Interacts with PMAIP1 (PubMed:17389404). Interacts with BBC3 (By similarity). Isoform 1 interacts with BAX, BAK1 and TPT1 (PubMed:10837489, PubMed:12149273, PubMed:15077116). Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptotic BCL2-related proteins (PubMed:10837489). Interacts with RTL10/BOP (PubMed:23055042). Interacts with BCL2L11; may sequester BCL2L11 to prevent its pro-apoptotic activity (PubMed:10837489, PubMed:27013495, PubMed:17389404, PubMed:20562877). Interacts with GIMAP5 and HSPA8/HSC70; the interaction between HSPA8 and MCL1 is impaired in the absence of GIMAP5 (By similarity).

    Three dimensional structures from OCA and Proteopedia for MCL1 Gene

    Alternative splice isoforms for MCL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MCL1 Gene

Post-translational modifications for MCL1 Gene

  • Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
  • Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.
  • Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.
  • Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159.
  • Ubiquitination at Lys5, Lys40, Lys136, Lys194, Lys197, and Lys308
  • Modification sites at PhosphoSitePlus

Other Protein References for MCL1 Gene

Antibody Products

  • Abcam antibodies for MCL1

No data available for DME Specific Peptides for MCL1 Gene

Domains & Families for MCL1 Gene

Gene Families for MCL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for MCL1 Gene

GenScript: Design optimal peptide antigens:
  • Myeloid cell leukemia ES variant (C8YZ26_HUMAN)
  • mcl1/EAT (MCL1_HUMAN)
  • Myosin light chain 1 (Q03399_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q07820

UniProtKB/Swiss-Prot:

MCL1_HUMAN :
  • Belongs to the Bcl-2 family.
Family:
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with MCL1: view

Function for MCL1 Gene

Molecular function for MCL1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
UniProtKB/Swiss-Prot Induction:
Expression increases early during phorbol ester-induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell line ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat shock-induced differentiation. Expression increases early during retinoic acid-induced differentiation.
GENATLAS Biochemistry:
myeloid cell leukemia 1,involved in programmed myeloid cell differentiation,with homology to BCL2

Phenotypes From GWAS Catalog for MCL1 Gene

Gene Ontology (GO) - Molecular Function for MCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15901672
GO:0008320 protein transmembrane transporter activity TAS 10837489
GO:0042803 protein homodimerization activity IBA 21873635
GO:0046982 protein heterodimerization activity IPI,IBA 10837489
GO:0051434 BH3 domain binding IPI 21036904
genes like me logo Genes that share ontologies with MCL1: view
genes like me logo Genes that share phenotypes with MCL1: view

Animal Models for MCL1 Gene

MGI Knock Outs for MCL1:

Animal Model Products

CRISPR Products

miRNA for MCL1 Gene

miRTarBase miRNAs that target MCL1

Clone Products

  • Addgene plasmids for MCL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MCL1 Gene

Localization for MCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCL1 Gene

Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCL1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
plasma membrane 2
endoplasmic reticulum 2
extracellular 1
cytoskeleton 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20467439
GO:0005654 nucleoplasm IEA --
GO:0005737 cytoplasm TAS 10837489
GO:0005739 mitochondrion IDA 7896880
GO:0005741 mitochondrial outer membrane IBA,TAS 10837489
genes like me logo Genes that share ontologies with MCL1: view

Pathways & Interactions for MCL1 Gene

genes like me logo Genes that share pathways with MCL1: view

SIGNOR curated interactions for MCL1 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001709 cell fate determination NAS 10837489
GO:0006915 apoptotic process IEA --
GO:0007275 multicellular organism development IEA --
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA 21873635
GO:0010507 negative regulation of autophagy IMP 24113155
genes like me logo Genes that share ontologies with MCL1: view

Drugs & Compounds for MCL1 Gene

(60) Drugs for MCL1 Gene - From: DrugBank, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AT-101 Approved, Investigational Pharma Target, inhibitor BH3-mimetic,gossypol enantiomer, BCL-2 inhibitors 74
Mitomycin Approved Pharma Inhibits DNA synthesis,antibiotic and antitumor agent 0
A-1210477 Pharma MCL-1 inhibitor 0
Marinopyrrole A Pharma Selective Mcl-1 inhibitor 0
MIM1 Pharma Mcl-1 Inhibitor 0

(34) Additional Compounds for MCL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(6) ApexBio Compounds for MCL1 Gene

Compound Action Cas Number
A-1210477 MCL-1 inhibitor 1668553-26-1
Marinopyrrole A Selective Mcl-1 inhibitor 1227962-62-0
MIM1 Mcl-1 Inhibitor
Mitomycin C Inhibits DNA synthesis,antibiotic and antitumor agent 1950-07-7
TW-37 Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1 877877-35-5
UMI-77 518303-20-3
genes like me logo Genes that share compounds with MCL1: view

Transcripts for MCL1 Gene

mRNA/cDNA for MCL1 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for MCL1

Alternative Splicing Database (ASD) splice patterns (SP) for MCL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for MCL1 Gene

GeneLoc Exon Structure for
MCL1
ECgene alternative splicing isoforms for
MCL1

Expression for MCL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MCL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MCL1 Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for MCL1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.6), Lymph node (13.2), Heart (6.6), and Liver (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MCL1 Gene



NURSA nuclear receptor signaling pathways regulating expression of MCL1 Gene:

MCL1

SOURCE GeneReport for Unigene cluster for MCL1 Gene:

Hs.632486

Evidence on tissue expression from TISSUES for MCL1 Gene

  • Nervous system(4.9)
  • Blood(4.5)
  • Lung(4.1)
  • Bone marrow(3.6)
  • Liver(3.6)
  • Intestine(3.5)
  • Pancreas(3)
  • Heart(2.9)
  • Kidney(2.9)
  • Lymph node(2.9)
  • Bone(2.6)
  • Muscle(2.6)
  • Skin(2.6)
  • Spleen(2.6)
  • Stomach(2.6)
  • Eye(2.4)
  • Gall bladder(2.4)
  • Adrenal gland(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with MCL1: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCL1 Gene

Orthologs for MCL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MCL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MCL1 33 32
  • 99.14 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MCL1 33 32
  • 88.35 (n)
OneToMany
-- 33
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MCL1 33 32
  • 88.19 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mcl1 32
  • 82.12 (n)
mouse
(Mus musculus)
Mammalia Mcl1 17 33 32
  • 81.17 (n)
oppossum
(Monodelphis domestica)
Mammalia MCL1 33
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves MCL1 33 32
  • 64.98 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MCL1 33
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mcl1a 33 32
  • 51.38 (n)
OneToMany
mcl1b 33
  • 35 (a)
OneToMany
bcl2l10 33
  • 31 (a)
OneToMany
Species where no ortholog for MCL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)