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This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 201... See more...
Aliases for MCL1 Gene
Aliases for MCL1 Gene
- MCL1 Apoptosis Regulator, BCL2 Family Member 2 3 5
- BCL2L3 2 3 4
- Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 3 4
- Myeloid Cell Leukemia Sequence 1 (BCL2-Related) 2 3
- MCL1, BCL2 Family Apoptosis Regulator 2 3
- Bcl-2-Related Protein EAT/Mcl1 3 4
- Myeloid Cell Leukemia 1 2 3
- Bcl-2-Like Protein 3 3 4
- Bcl2-L-3 3 4
External Ids for MCL1 Gene
- HGNC: 6943
- NCBI Entrez Gene: 4170
- Ensembl: ENSG00000143384
- OMIM®: 159552
- UniProtKB/Swiss-Prot: Q07820
Previous GeneCards Identifiers for MCL1 Gene
- GC01M148388
- GC01M146294
- GC01M147322
- GC01M147763
- GC01M147360
- GC01M148813
- GC01M150547
- GC01M121925
- GC01M150581
- GC01M150596
- GC01M150643
- GC01M150673
- GC01M150707
Summaries for MCL1 Gene
-
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
GeneCards Summary for MCL1 Gene
MCL1 (MCL1 Apoptosis Regulator, BCL2 Family Member) is a Protein Coding gene. Diseases associated with MCL1 include Myeloid Leukemia and Chlamydia. Among its related pathways are Interleukin-4 and 13 signaling and E2F transcription factor network. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and BH3 domain binding. An important paralog of this gene is BCL2L1.
UniProtKB/Swiss-Prot Summary for MCL1 Gene
-
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Additional gene information for MCL1 Gene
- HGNC (6943)
- NCBI Entrez Gene (4170)
- Ensembl (ENSG00000143384)
- OMIM® (159552)
- UniProtKB/Swiss-Prot (Q07820)
- Open Targets Platform(ENSG00000143384)
- Monarch Initiative
- Search for MCL1 at DataMed
- Search for MCL1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MCL1 Gene
Genomics for MCL1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MCL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MCL1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MCL1
- Top Transcription factor binding sites by QIAGEN in the MCL1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- STAT5A
Genomic Locations for MCL1 Gene
Latest Assembly
- chr1:150,560,895-150,579,738
- (GRCh38/hg38)
- Size:
- 18,844 bases
- Orientation:
- Minus strand
Previous Assembly
- chr1:150,547,034-150,552,086
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 5,053 bases
- Orientation:
- Minus strand
- chr1:150,547,032-150,552,066
- (GRCh37/hg19 by Ensembl)
- Size:
- 5,035 bases
- Orientation:
- Minus strand
Genomic View for MCL1 Gene
Genes around MCL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.2 by HGNC
- 1q21.2 by Entrez Gene
- 1q21.2 by Ensembl
MCL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MCL1 Gene
Proteins for MCL1 Gene
-
Protein details for MCL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q07820-MCL1_HUMAN
- Recommended name:
- Induced myeloid leukemia cell differentiation protein Mcl-1
- Protein Accession:
- Q07820
- B2R6B2
- D3DV03
- D3DV04
- Q9HD91
- Q9NRQ3
- Q9NRQ4
- Q9UHR7
- Q9UHR8
- Q9UHR9
- Q9UNJ1
Protein attributes for MCL1 Gene
- Size:
- 350 amino acids
- Molecular mass:
- 37337 Da
- Quaternary structure:
-
- Interacts with HIF3A (via C-terminus domain) (By similarity). Interacts with BAD, BOK, BIK and BMF (By similarity). Interacts with PMAIP1 (PubMed:17389404). Interacts with BBC3 (By similarity). Isoform 1 interacts with BAX, BAK1 and TPT1 (PubMed:10837489, PubMed:12149273, PubMed:15077116). Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptotic BCL2-related proteins (PubMed:10837489). Interacts with RTL10/BOP (PubMed:23055042). Interacts with BCL2L11; may sequester BCL2L11 to prevent its pro-apoptotic activity (PubMed:10837489, PubMed:27013495, PubMed:17389404, PubMed:20562877). Interacts with GIMAP5 and HSPA8/HSC70; the interaction between HSPA8 and MCL1 is impaired in the absence of GIMAP5 (By similarity).
Three dimensional structures from OCA and Proteopedia for MCL1 Gene
Protein Expression for MCL1 Gene
Post-translational modifications for MCL1 Gene
- Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
- Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.
- Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.
- Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159.
-
Ubiquitination at Lys5, Lys40, Lys136, Lys194, Lys197, and Lys308
- NX_Q07820 (NX_Q07820-1)
- Modification sites at PhosphoSitePlus
Other Protein References for MCL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences MCL1 / MCL 1 Antibody and MCL1 / MCL 1 Monoclonal Antibody
- NSJ Bioreagents MCL1 Antibody
- BioLegend Mcl-1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for MCL1
- AM06096PU-N
- AM08411PU-N
- AP00018PU-N
- AP01226PU-N
- AP06215PU-N
- AP07772PU-N
- AP11305PU-N
- AP31050PU-N
- CF500982
- CF500983
- CF500984
- CF500985
- CF500986
- CF500987
- CF500988
- CF500989
- CF500990
- CF501036
- SP2170P
- TA302945
- TA306207
- TA306208
- TA306209
- TA326250
- TA326836
- TA347329
- TA347425
- TA350982
- TA500982
- TA500982S
- TA500983
- TA500983S
- TA500984
- TA500984S
- TA500985
- TA500985S
- TA500986
- TA500986S
- TA500987
- TA500987S
- TA500988
- TA500988S
- TA500989
- TA500989S
- TA500990
- TA500990S
- TA501036
- TA501036S
- Novus Biologicals Antibodies for MCL1
-
Abcam antibodies for MCL1
- Invitrogen Antibodies for MCL1 (AFLGC-MCL1)
- antibodies-online: Show 121 available MCL-1 Antibodies ranked by validation data
- Compare Top MCL-1 Antibodies
-
Recommended
- 295 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 123 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 82 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
-
Boster Bio Antibodies for MCL1
-
Custom Antibody ServicesProSci Antibodies for MCL1
- myeloid cell leukemia sequence 1 (BCL2-related) [3477]
- myeloid cell leukemia sequence 1 (BCL2-related) [3479]
- myeloid cell leukemia sequence 1 (BCL2-related) [3481]
- myeloid cell leukemia sequence 1 (BCL2-related) [13-878]
- myeloid cell leukemia sequence 1 (BCL2-related) [18-188]
- myeloid cell leukemia sequence 1 (BCL2-related) [48-737]
- myeloid cell leukemia sequence 1 (BCL2-related) [32-191]
- myeloid cell leukemia sequence 1 (BCL2-related) [45-872]
- myeloid cell leukemia sequence 1 (BCL2-related) [51-043]
- myeloid cell leukemia sequence 1 (BCL2-related) [70-778]
- myeloid cell leukemia sequence 1 (BCL2-related) [79-656]
-
Santa Cruz Biotechnology (SCBT) Antibodies for MCL1
- Sino Biological Antibodies for MCL1
Protein products for research
-
OriGene Purified Proteins for MCL1
- Search Origene for MassSpec and Protein Over-expression Lysates for MCL1
- Origene Custom Protein Services for MCL1
- Novus Biologicals proteins for MCL1
- ProSpec Recombinant Proteins for MCL1
-
Abcam proteins for MCL1
No data available for DME Specific Peptides for MCL1 Gene
Domains & Families for MCL1 Gene
Gene Families for MCL1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for MCL1 Gene
- InterPro:
- Blocks:
-
- Apoptosis regulator Bcl-2 protein, BH
- ProtoNet:
Suggested Antigen Peptide Sequences for MCL1 Gene
- GenScript: Design optimal peptide antigens:
-
- Myeloid cell leukemia ES variant (C8YZ26_HUMAN)
- mcl1/EAT (MCL1_HUMAN)
- Myosin light chain 1 (Q03399_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q07820- Family:
-
- Belongs to the Bcl-2 family.
Function for MCL1 Gene
Molecular function for MCL1 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
- UniProtKB/Swiss-Prot Induction:
- Expression increases early during phorbol ester-induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell line ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat shock-induced differentiation. Expression increases early during retinoic acid-induced differentiation.
- GENATLAS Biochemistry:
- myeloid cell leukemia 1,involved in programmed myeloid cell differentiation,with homology to BCL2
Phenotypes From GWAS Catalog for MCL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15901672 |
| GO:0008320 | protein transmembrane transporter activity | TAS | 10837489 |
| GO:0042803 | protein homodimerization activity | IBA | 21873635 |
| GO:0046982 | protein heterodimerization activity | IBA,IPI | 10837489 |
| GO:0051434 | BH3 domain binding | IPI | 21036904 |
Phenotypes for MCL1 Gene
- MGI mutant phenotypes for MCL1:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for MCL1:
-
- Increased gamma-H2AX phosphorylation
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- shRNA abundance <= 50%
- Decreased cell number
- No cells
- Increased number of mitotic cells
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Synthetic lethal with vaccinia virus (VACV) infection
- Increased viability with MLN4924 (a NAE inhibitor)
- Increased shRNA abundance
- G0/1 arrest
- Decreased viability with paclitaxel
- Synthetic lethal with cisplatin
- Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation
Animal Models for MCL1 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MCL1 - Starting at $85 >
- * MCL1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MCL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MCL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MCL1
miRNA for MCL1 Gene
- miRTarBase miRNAs that target MCL1
-
- hsa-miR-16-5p (MIRT000877)
- hsa-miR-15a-5p (MIRT000878)
- hsa-miR-193a-3p (MIRT002485)
- hsa-miR-133b (MIRT003260)
- hsa-miR-29a-3p (MIRT003286)
- hsa-miR-29b-3p (MIRT003287)
- hsa-miR-29c-3p (MIRT003288)
- hsa-miR-101-3p (MIRT003921)
- hsa-miR-153-3p (MIRT004080)
- hsa-miR-512-5p (MIRT004406)
- hsa-miR-320a (MIRT004440)
- rno-miR-29a-3p (MIRT004599)
- rno-miR-29c-3p (MIRT004600)
- hsa-miR-193b-3p (MIRT004663)
- hsa-miR-518a-5p (MIRT004667)
- hsa-miR-582-5p (MIRT004668)
- hsa-miR-661 (MIRT004743)
- hsa-miR-876-3p (MIRT004744)
- hsa-miR-892b (MIRT004745)
- hsa-miR-148b-5p (MIRT004746)
- hsa-miR-886-3p (MIRT006591)
- hsa-miR-125b-5p (MIRT006843)
- hsa-miR-181a-5p (MIRT006949)
- hsa-miR-181b-5p (MIRT006952)
- mmu-miR-425-5p (MIRT008467)
- mmu-miR-17-5p (MIRT009893)
- mmu-miR-340-5p (MIRT010243)
- mmu-miR-30e-5p (MIRT013264)
- mmu-miR-181a-5p (MIRT014107)
- hsa-miR-151a-3p (MIRT019504)
- hsa-miR-186-5p (MIRT021163)
- hsa-miR-26b-5p (MIRT030090)
- hsa-miR-615-3p (MIRT040421)
- hsa-miR-30d-5p (MIRT047799)
- hsa-miR-133a-3p (MIRT052648)
- hsa-miR-26a-5p (MIRT052649)
- hsa-miR-3679-3p (MIRT052877)
- hsa-miR-139-5p (MIRT053049)
- hsa-miR-761 (MIRT053078)
- hsa-miR-20a-5p (MIRT053332)
- hsa-miR-7153-3p (MIRT059414)
- hsa-miR-596 (MIRT130525)
- hsa-miR-4293 (MIRT130549)
- hsa-miR-6747-3p (MIRT130583)
- hsa-miR-4773 (MIRT130631)
- hsa-miR-7159-3p (MIRT180958)
- hsa-miR-495-3p (MIRT180983)
- hsa-miR-5688 (MIRT180988)
- mmu-miR-29b-3p (MIRT427824)
- mmu-miR-208a-3p (MIRT427825)
- mmu-miR-29a-3p (MIRT427826)
- mmu-miR-29c-3p (MIRT427827)
- mmu-miR-499-5p (MIRT427834)
- mmu-miR-208b-3p (MIRT427835)
- mmu-miR-669d-5p (MIRT427836)
- mmu-miR-767 (MIRT427837)
- mmu-miR-1251-5p (MIRT427838)
- mmu-miR-344f-3p (MIRT427839)
- hsa-miR-106b-5p (MIRT440267)
- hsa-miR-1264 (MIRT473456)
- hsa-miR-3184-3p (MIRT473457)
- hsa-miR-8080 (MIRT473458)
- hsa-miR-4452 (MIRT473459)
- hsa-miR-1469 (MIRT473460)
- hsa-miR-545-5p (MIRT473461)
- hsa-miR-144-3p (MIRT473462)
- hsa-miR-200a-3p (MIRT473463)
- hsa-miR-141-3p (MIRT473464)
- hsa-miR-7702 (MIRT501925)
- hsa-miR-5682 (MIRT501926)
- hsa-miR-767-5p (MIRT501927)
- hsa-miR-6871-3p (MIRT501928)
- mmu-miR-3102-3p (MIRT592621)
- hsa-miR-6836-3p (MIRT640050)
- hsa-miR-6829-3p (MIRT640051)
- hsa-miR-6791-3p (MIRT640052)
- hsa-miR-6778-3p (MIRT640053)
- hsa-miR-6771-3p (MIRT640054)
- hsa-miR-660-3p (MIRT640055)
- hsa-miR-6749-3p (MIRT717506)
- hsa-miR-5193 (MIRT717507)
- hsa-miR-32-5p (MIRT727230)
- hsa-miR-92b-3p (MIRT727231)
- hsa-miR-92a-3p (MIRT727232)
- hsa-miR-93-5p (MIRT727233)
- hsa-miR-519d-3p (MIRT727234)
- hsa-miR-20b-5p (MIRT727235)
- hsa-miR-17-5p (MIRT727236)
- hsa-miR-125a-5p (MIRT731779)
- rno-miR-106b-5p (MIRT732673)
- mmu-miR-29a-5p (MIRT732794)
- hsa-miR-302b-3p (MIRT732881)
- hsa-miR-34a-5p (MIRT734023)
- hsa-miR-339-3p (MIRT734201)
- hsa-miR-30c-5p (MIRT735282)
- hsa-miR-1207-5p (MIRT736037)
- hsa-miR-1909-3p (MIRT738356)
- hsa-miR-211-3p (MIRT738934)
- hsa-miR-3127-5p (MIRT740060)
- hsa-miR-3153 (MIRT740391)
- hsa-miR-320b (MIRT741196)
- hsa-miR-320c (MIRT741200)
- hsa-miR-320d (MIRT741204)
- hsa-miR-4270 (MIRT743577)
- hsa-miR-4429 (MIRT744316)
- hsa-miR-4441 (MIRT744544)
- hsa-miR-4736 (MIRT748003)
- hsa-miR-4763-3p (MIRT748546)
- hsa-miR-5000-5p (MIRT749337)
- hsa-miR-6508-5p (MIRT752979)
- hsa-miR-6722-3p (MIRT753869)
- hsa-miR-6733-5p (MIRT754115)
- hsa-miR-6739-5p (MIRT754312)
- hsa-miR-6754-5p (MIRT754719)
- hsa-miR-6757-5p (MIRT754846)
- hsa-miR-6783-5p (MIRT755754)
- hsa-miR-7150 (MIRT759167)
- hsa-miR-8065 (MIRT760062)
- hsa-miR-8067 (MIRT760072)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MCL1
- Browse OriGene Inhibitory RNA Products For MCL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCL1
Clone products for research
- Applied Biological Materials (abm): Clones for MCL1 - Starting at $45 >
- * MCL1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG204868
- MR204868
- MR204868L1
- MR204868L2
- MR204868L3
- MR204868L4
- RC200521
- RC200521L1
- RC200521L2
- RC200521L3
- RC200521L4
- RC217440
- RC217440L3
- RC217440L4
- RC231044
- RC231044L3
- RC231044L4
- RG200521
- RG217440
- RG231044
- RR209509
- RR209509L3
- RR209509L4
- MR204868L1V
- MR204868L2V
- MR204868L3V
- MR204868L4V
- RC200521L1V
- RC200521L2V
- RC200521L3V
- RC200521L4V
- RC217440L3V
- RC217440L4V
- RC231044L3V
- RC231044L4V
- RR209509L3V
- RR209509L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MCL1
- Addgene plasmids for MCL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MCL1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MCL1 Gene
Localization for MCL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MCL1 Gene
- Membrane. Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 3 |
| extracellular | 3 |
| cytoskeleton | 3 |
| endoplasmic reticulum | 3 |
| peroxisome | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
- Mitochondria (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 20467439 |
| GO:0005654 | nucleoplasm | IEA | -- |
| GO:0005737 | cytoplasm | TAS | 10837489 |
| GO:0005739 | mitochondrion | IEA,IDA | 7896880 |
| GO:0005741 | mitochondrial outer membrane | IBA,TAS | 10837489 |
Pathways & Interactions for MCL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis Modulation and Signaling |
.41
|
.31
|
| 2 | JAK-STAT signaling pathway | ||
| 3 | Cytokine Signaling in Immune system | ||
| 4 | Apoptosis and Autophagy | ||
| 5 | MicroRNAs in cancer | ||
Pathways by source for MCL1 Gene
11 BioSystems pathways for MCL1 Gene
4 Reactome pathways for MCL1 Gene
4 KEGG pathways for MCL1 Gene
2 GeneGo (Thomson Reuters) pathways for MCL1 Gene
- Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins
- Immune response IL-22 signaling pathway
1 R&D Systems pathway for MCL1 Gene
1 Cell Signaling Technology pathway for MCL1 Gene
1 GeneTex pathway for MCL1 Gene
Interacting Proteins for MCL1 Gene
Selected Interacting proteins:
Q07820-MCL1_HUMAN
ENSP00000358022
for MCL1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MCL1
SIGNOR curated interactions for MCL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001709 | cell fate determination | NAS | 10837489 |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | IBA | 21873635 |
| GO:0010507 | negative regulation of autophagy | IMP | 24113155 |
Drugs & Compounds for MCL1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| AT-101 | Approved, Investigational | Pharma | Target, inhibitor | BH3-mimetic,gossypol enantiomer, BCL-2 inhibitors | 91 | |
| Dexamethasone | Approved, Investigational, Vet_approved | Pharma | Anti-inflammatory glucocorticoid | 3084 | ||
| Azacitidine | Approved, Investigational | Pharma | 597 | |||
| Dexamethasone acetate | Approved, Investigational, Vet_approved | Pharma | 3084 | |||
| Mitomycin | Approved | Pharma | Inhibits DNA synthesis,antibiotic and antitumor agent | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(6) ApexBio Compounds for MCL1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| A-1210477 | MCL-1 inhibitor | 1668553-26-1 |
| Marinopyrrole A | Selective Mcl-1 inhibitor | 1227962-62-0 |
| MIM1 | Mcl-1 Inhibitor | |
| Mitomycin C | Inhibits DNA synthesis,antibiotic and antitumor agent | 1950-07-7 |
| TW-37 | Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1 | 877877-35-5 |
| UMI-77 | 518303-20-3 |
Drug products for research
- ApexBio compounds for MCL1
Transcripts for MCL1 Gene
mRNA/cDNA for MCL1 Gene
- 3 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000307940 1110 nts (view in UCSC)
- ENST00000369026 3950 nts (view in UCSC)
- ENST00000464132 4550 nts (view in UCSC)
- ENST00000617352 1036 nts (view in UCSC)
- ENST00000620947 3626 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MCL1 - Starting at $85 >
- * MCL1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
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OriGene CRISPR knockouts for MCL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MCL1
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Santa Cruz Biotechnology (SCBT) CRISPR for MCL1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MCL1
- Browse OriGene Inhibitory RNA Products For MCL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCL1
Clone products for research
- Applied Biological Materials (abm): Clones for MCL1 - Starting at $45 >
- * MCL1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
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- MG204868
- MR204868
- MR204868L1
- MR204868L2
- MR204868L3
- MR204868L4
- RC200521
- RC200521L1
- RC200521L2
- RC200521L3
- RC200521L4
- RC217440
- RC217440L3
- RC217440L4
- RC231044
- RC231044L3
- RC231044L4
- RG200521
- RG217440
- RG231044
- RR209509
- RR209509L3
- RR209509L4
- MR204868L1V
- MR204868L2V
- MR204868L3V
- MR204868L4V
- RC200521L1V
- RC200521L2V
- RC200521L3V
- RC200521L4V
- RC217440L3V
- RC217440L4V
- RC231044L3V
- RC231044L4V
- RR209509L3V
- RR209509L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MCL1
- Addgene plasmids for MCL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MCL1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | - | |||||||||||||
| SP3: | - | - | - | ||||||||||||
| SP4: |
Relevant External Links for MCL1 Gene
- GeneLoc Exon Structure for
- MCL1
Expression for MCL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
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Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- T Helper Cells Thymus
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Thymus (Hematopoietic System)
- T Helper Cells Thymus
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
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Uterus (Reproductive System)
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Colon (Gastrointestinal Tract)
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Prostate (Endocrine System)
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Placenta (Extraembryonic Tissues)
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Spleen (Hematopoietic System)
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Thyroid (Endocrine System)
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Gall Bladder (Hepatobiliary System)
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Lung (Respiratory System)
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Kidney (Urinary System)
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Testis (Reproductive System)
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Adrenal Gland (Endocrine System)
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Esophagus (Gastrointestinal Tract)
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Stomach (Gastrointestinal Tract)
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Liver (Hepatobiliary System)
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Pancreas (Endocrine System)
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Ovary (Reproductive System)
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Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for MCL1 Gene
This gene is overexpressed in Whole Blood (x6.1).
This gene is overexpressed in Peripheral blood mononuclear cells (15.6), Lymph node (13.2), Heart (6.6), and Liver (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MCL1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MCL1
SOURCE GeneReport for Unigene cluster for MCL1 Gene:
Hs.632486Evidence on tissue expression from TISSUES for MCL1 Gene
- Nervous system(4.9)
- Blood(4.5)
- Lung(4.2)
- Liver(3.8)
- Intestine(3.7)
- Bone marrow(3.7)
- Kidney(3.5)
- Lymph node(3.4)
- Heart(3.4)
- Pancreas(3.4)
- Spleen(3.3)
- Bone(3.2)
- Muscle(3.2)
- Stomach(3.1)
- Skin(3.1)
- Eye(3.1)
- Thyroid gland(3)
- Gall bladder(3)
- Adrenal gland(2.9)
Primer products for research
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OriGene qPCR primer pairs for MCL1
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OriGene qPCR primer pairs and template standards for MCL1
Gene Expression Assays for research
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCL1 Gene
Orthologs for MCL1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MCL1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MCL1 30 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | MCL1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mcl1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mcl1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MCL1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MCL1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MCL1 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | mcl1a 30 31 |
|
OneToMany | |
| mcl1b 31 |
|
OneToMany | |||
| bcl2l10 31 |
|
OneToMany |
- Species where no ortholog for MCL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MCL1 Gene
- ENSEMBL:
- Gene Tree for MCL1 (if available)
- TreeFam:
- Gene Tree for MCL1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MCL1: view image
Paralogs for MCL1 Gene
Variants for MCL1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MCL1 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1186393634 | Uncertain Significance: Severe Myopia | 150,577,397(-) |
C/A NM_021960.5(MCL1):c.1031G>T (p.Gly344Val) |
MISSENSE | |
| rs151065075 | Benign: not provided | 150,579,173(-) |
T/C NM_021960.5(MCL1):c.358A>G (p.Met120Val) |
MISSENSE_VARIANT,INTRON | |
| rs199766529 | Benign: not provided | 150,578,834(-) |
C/A NM_021960.5(MCL1):c.688+9G>T |
INTRON | |
| rs34645101 | Benign: not provided | 150,578,448(-) |
T/C NM_021960.5(MCL1):c.732A>G (p.Lys244=) |
SYNONYMOUS_VARIANT,INTRON | |
| rs11580946 | - |
p.Ala227Val |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1006838 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
50.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.20;
24.12% of all genes are more intolerant (likely to be disease-causing)
