Aliases for MCL1 Gene
External Ids for MCL1 Gene
Previous GeneCards Identifiers for MCL1 Gene
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
GeneCards Summary for MCL1 Gene
MCL1 (MCL1, BCL2 Family Apoptosis Regulator) is a Protein Coding gene. Diseases associated with MCL1 include Myeloid Leukemia and Leukemia. Among its related pathways are Apoptosis Modulation and Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and BH3 domain binding.
UniProtKB/Swiss-Prot for MCL1 Gene
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.