Aliases for MCL1 Gene
Aliases for MCL1 Gene
External Ids for MCL1 Gene
- HGNC: 6943
- Entrez Gene: 4170
- Ensembl: ENSG00000143384
- OMIM: 159552
- UniProtKB: Q07820
Previous GeneCards Identifiers for MCL1 Gene
- GC01M148388
- GC01M146294
- GC01M147322
- GC01M147763
- GC01M147360
- GC01M148813
- GC01M150547
- GC01M121925
- GC01M150581
Summaries for MCL1 Gene
-
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
GeneCards Summary for MCL1 Gene
MCL1 (MCL1, BCL2 Family Apoptosis Regulator) is a Protein Coding gene. Diseases associated with MCL1 include Myeloid Leukemia and Leukemia. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins and MicroRNAs in cancer. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and BH3 domain binding.
UniProtKB/Swiss-Prot for MCL1 Gene
-
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Additional gene information for MCL1 Gene
- Monarch Initiative
- Search for MCL1 at DataMed
- Search for MCL1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MCL1 Gene
Genomics for MCL1 Gene
GeneHancer (GH) Regulatory Elements for MCL1 Gene
Promoters and enhancers for MCL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MCL1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MCL1 gene promoter:
-
- AP-1
- STAT5A
- ATF-2
- c-Jun
Regulatory Element Products
Genomic Locations for MCL1 Gene
Genomic Locations for MCL1 Gene
- chr1:150,574,551-150,579,738
- (GRCh38/hg38)
- Size:
- 5,188 bases
- Orientation:
- Minus strand
- chr1:150,547,027-150,552,214
- (GRCh37/hg19)
- Size:
- 5,188 bases
- Orientation:
- Minus strand
Genomic View for MCL1 Gene
Genes around MCL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.2 by Entrez Gene
- 1q21.2 by HGNC
- 1q21.2 by Ensembl
MCL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MCL1 Gene
Proteins for MCL1 Gene
-
Protein details for MCL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q07820-MCL1_HUMAN
- Recommended name:
- Induced myeloid leukemia cell differentiation protein Mcl-1
- Protein Accession:
- Q07820
- B2R6B2
- D3DV03
- D3DV04
- Q9HD91
- Q9NRQ3
- Q9NRQ4
- Q9UHR7
- Q9UHR8
- Q9UHR9
- Q9UNJ1
Protein attributes for MCL1 Gene
- Size:
- 350 amino acids
- Molecular mass:
- 37337 Da
- Quaternary structure:
-
- Interacts with HIF3A (via C-terminus domain) (By similarity). Interacts with BAD, BOK, BIK and BMF (By similarity). Interacts with PMAIP1 (PubMed:17389404). Interacts with BBC3 (By similarity). Isoform 1 interacts with BAX, BAK1 and TPT1 (PubMed:10837489, PubMed:12149273, PubMed:15077116). Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptotic BCL2-related proteins (PubMed:10837489). Interacts with RTL10/BOP (PubMed:23055042). Interacts with BCL2L11; may sequester BCL2L11 to prevent its pro-apoptotic activity (PubMed:10837489, PubMed:27013495, PubMed:17389404, PubMed:20562877).
Three dimensional structures from OCA and Proteopedia for MCL1 Gene
Protein Expression for MCL1 Gene
Post-translational modifications for MCL1 Gene
- Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
- Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.
- Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.
- Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159.
- Ubiquitination at posLast=308308, isoforms=2197, posLast=194194, isoforms=2136, isoforms=240, and posLast=55
- Modification sites at PhosphoSitePlus
Other Protein References for MCL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for MCL1 (Mcl-1)
-
Custom Antibody ServicesOriGene Antibodies for MCL1
- AM06096PU-N
- AM08411PU-N
- AP00018PU-N
- AP01226PU-N
- AP06215PU-N
- AP07772PU-N
- AP11305PU-N
- AP31050PU-N
- CF500982
- CF500983
- CF500984
- CF500985
- CF500986
- CF500987
- CF500988
- CF500989
- CF500990
- CF501036
- SP2170P
- TA302945
- TA306207
- TA306208
- TA306209
- TA324081
- TA326250
- TA326836
- TA328034
- TA347329
- TA347425
- TA350982
- TA500982
- TA500983
- TA500984
- TA500985
- TA500986
- TA500986S
- TA500987
- TA500988
- TA500989
- TA500990
- TA501036
- Novus Biologicals Antibodies for MCL1
-
Abcam antibodies for MCL1
- Invitrogen Antibodies for MCL1 (AFLGC-MCL1)
- antibodies-online: Search results for 344 available MCL-1 Antibodies ranked by validation data
- Compare Top MCL-1 Antibodies
-
Recommended
- 89 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 56 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 275 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 15 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- GeneTex MCL1 Antibody for MCL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for MCL1
- Sino Biological Antibodies for MCL1
Protein Products
- R&D Systems Proteins and Enzymes for MCL1 (Mcl-1)
-
OriGene Purified Proteins for MCL1
- Search Origene for MassSpec and Protein Over-expression Lysates for MCL1
- Origene Custom Protein Services for MCL1
- ProSpec Recombinant Proteins for MCL1
- Search GeneTex for Proteins for MCL1
-
Abcam proteins for MCL1
Assay Products
No data available for DME Specific Peptides for MCL1 Gene
Domains & Families for MCL1 Gene
Gene Families for MCL1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for MCL1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MCL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q07820- Family:
-
- Belongs to the Bcl-2 family.
Function for MCL1 Gene
Molecular function for MCL1 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
- UniProtKB/Swiss-Prot Induction:
- Expression increases early during phorbol ester-induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell line ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat shock-induced differentiation. Expression increases early during retinoic acid-induced differentiation.
- GENATLAS Biochemistry:
- myeloid cell leukemia 1,involved in programmed myeloid cell differentiation,with homology to BCL2
Phenotypes From GWAS Catalog for MCL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15901672 |
| GO:0008320 | protein transmembrane transporter activity | TAS | 10837489 |
| GO:0042803 | protein homodimerization activity | IBA | -- |
| GO:0046982 | protein heterodimerization activity | IPI | 10837489 |
| GO:0051434 | BH3 domain binding | IPI | 21036904 |
Phenotypes for MCL1 Gene
- MGI mutant phenotypes for MCL1:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for MCL1:
-
- Increased number of mitotic cells
- G0/1 arrest
- Increased G1 DNA content
- Synthetic lethal with cisplatin
- Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased shRNA abundance
- Increased gamma-H2AX phosphorylation
- Mildly decreased CFP-tsO45G cell surface transport
- shRNA abundance <= 50%
- Decreased viability with paclitaxel
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for MCL1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MCL1
-
CRISPR Products
-
OriGene CRISPR knockouts for MCL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MCL1
- genomics-online: gRNA clones - Search results for 102 available MCL-1 gene related products
- Overview of 102 available MCL-1 gene related products
- Applied Biological Materials CRISPR for MCL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MCL1
- GenScript: Design CRISPR guide RNA sequences for MCL1
miRNA for MCL1 Gene
- miRTarBase miRNAs that target MCL1
-
- hsa-mir-16-5p (MIRT000877)
- hsa-mir-15a-5p (MIRT000878)
- hsa-mir-193a-3p (MIRT002485)
- hsa-mir-133b (MIRT003260)
- hsa-mir-29a-3p (MIRT003286)
- hsa-mir-29b-3p (MIRT003287)
- hsa-mir-29c-3p (MIRT003288)
- hsa-mir-101-3p (MIRT003921)
- hsa-mir-153-3p (MIRT004080)
- hsa-mir-512-5p (MIRT004406)
- hsa-mir-320a (MIRT004440)
- hsa-mir-193b-3p (MIRT004663)
- hsa-mir-518a-5p (MIRT004667)
- hsa-mir-582-5p (MIRT004668)
- hsa-mir-661 (MIRT004743)
- hsa-mir-876-3p (MIRT004744)
- hsa-mir-892b (MIRT004745)
- hsa-mir-148b-5p (MIRT004746)
- hsa-mir-886-3p (MIRT006591)
- hsa-mir-125b-5p (MIRT006843)
- hsa-mir-181a-5p (MIRT006949)
- hsa-mir-181b-5p (MIRT006952)
- hsa-mir-151a-3p (MIRT019504)
- hsa-mir-186-5p (MIRT021163)
- hsa-mir-26b-5p (MIRT030090)
- hsa-mir-615-3p (MIRT040421)
- hsa-mir-30d-5p (MIRT047799)
- hsa-mir-133a-3p (MIRT052648)
- hsa-mir-26a-5p (MIRT052649)
- hsa-mir-3679-3p (MIRT052877)
- hsa-mir-139-5p (MIRT053049)
- hsa-mir-761 (MIRT053078)
- hsa-mir-20a-5p (MIRT053332)
- hsa-mir-7153-3p (MIRT059414)
- hsa-mir-596 (MIRT130525)
- hsa-mir-4293 (MIRT130549)
- hsa-mir-6747-3p (MIRT130583)
- hsa-mir-4773 (MIRT130631)
- hsa-mir-7159-3p (MIRT180958)
- hsa-mir-495-3p (MIRT180983)
- hsa-mir-5688 (MIRT180988)
- hsa-mir-106b-5p (MIRT440267)
- hsa-mir-1264 (MIRT473456)
- hsa-mir-3184-3p (MIRT473457)
- hsa-mir-8080 (MIRT473458)
- hsa-mir-4452 (MIRT473459)
- hsa-mir-1469 (MIRT473460)
- hsa-mir-545-5p (MIRT473461)
- hsa-mir-144-3p (MIRT473462)
- hsa-mir-200a-3p (MIRT473463)
- hsa-mir-141-3p (MIRT473464)
- hsa-mir-7702 (MIRT501925)
- hsa-mir-5682 (MIRT501926)
- hsa-mir-767-5p (MIRT501927)
- hsa-mir-6871-3p (MIRT501928)
- hsa-mir-6836-3p (MIRT640050)
- hsa-mir-6829-3p (MIRT640051)
- hsa-mir-6791-3p (MIRT640052)
- hsa-mir-6778-3p (MIRT640053)
- hsa-mir-6771-3p (MIRT640054)
- hsa-mir-660-3p (MIRT640055)
- hsa-mir-6749-3p (MIRT717506)
- hsa-mir-5193 (MIRT717507)
- hsa-mir-32-5p (MIRT727230)
- hsa-mir-92b-3p (MIRT727231)
- hsa-mir-92a-3p (MIRT727232)
- hsa-mir-93-5p (MIRT727233)
- hsa-mir-519d-3p (MIRT727234)
- hsa-mir-20b-5p (MIRT727235)
- hsa-mir-17-5p (MIRT727236)
- hsa-mir-125a-5p (MIRT731779)
- hsa-mir-302b-3p (MIRT732881)
- hsa-mir-34a-5p (MIRT734023)
- hsa-mir-339-3p (MIRT734201)
- hsa-mir-30c-5p (MIRT735282)
- hsa-mir-1207-5p (MIRT736037)
- hsa-mir-1909-3p (MIRT738356)
- hsa-mir-211-3p (MIRT738934)
- hsa-mir-3127-5p (MIRT740060)
- hsa-mir-3153 (MIRT740391)
- hsa-mir-320b (MIRT741196)
- hsa-mir-320c (MIRT741200)
- hsa-mir-320d (MIRT741204)
- hsa-mir-4270 (MIRT743577)
- hsa-mir-4429 (MIRT744316)
- hsa-mir-4441 (MIRT744544)
- hsa-mir-4736 (MIRT748003)
- hsa-mir-4763-3p (MIRT748546)
- hsa-mir-5000-5p (MIRT749337)
- hsa-mir-6508-5p (MIRT752979)
- hsa-mir-6722-3p (MIRT753869)
- hsa-mir-6733-5p (MIRT754115)
- hsa-mir-6739-5p (MIRT754312)
- hsa-mir-6754-5p (MIRT754719)
- hsa-mir-6757-5p (MIRT754846)
- hsa-mir-6783-5p (MIRT755754)
- hsa-mir-7150 (MIRT759167)
- hsa-mir-8065 (MIRT760062)
- hsa-mir-8067 (MIRT760072)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MCL1
- Browse OriGene Inhibitory RNA Products For MCL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCL1
- genomics-online: shRNA clones - Search results for 102 available MCL-1 gene related products
- Overview of 102 available MCL-1 gene related products
Clone Products
-
OriGene ORF clones in human for MCL1
- RC200521
- RC200521L1
- RC200521L2
- RC200521L3
- RC200521L4
- RC217440
- RC217440L1
- RC217440L2
- RC217440L3
- RC217440L4
- RC231044
- RC231044L1
- RC231044L2
- RC231044L3
- RC231044L4
- RC500521
- RG200521
- RG217440
- RG231044
- RC200521L1V
- RC200521L2V
- RC200521L3V
- RC200521L4V
- RC217440L1V
- RC217440L2V
- RC217440L3V
- RC217440L4V
- RC231044L1V
- RC231044L2V
- RC231044L3V
- RC231044L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MCL1
- Addgene plasmids for MCL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MCL1
- Applied Biological Materials Clones for MCL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MCL1 Gene
Localization for MCL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MCL1 Gene
- Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| extracellular | 1 |
| peroxisome | 1 |
| lysosome | 1 |
- Mitochondria (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 20467439 |
| GO:0005654 | nucleoplasm | IEA | -- |
| GO:0005737 | cytoplasm | TAS | 10837489 |
| GO:0005739 | mitochondrion | IDA | 7896880 |
| GO:0005741 | mitochondrial outer membrane | TAS | 10837489 |
Pathways & Interactions for MCL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis Modulation and Signaling |
.41
|
.31
|
| 2 | Cytokine Signaling in Immune system | ||
| 3 | Jak-STAT signaling pathway (KEGG) | ||
| 4 | MicroRNAs in cancer | ||
| 5 | PI3K-Akt signaling pathway | ||
Pathways by source for MCL1 Gene
1 GeneTex pathway for MCL1 Gene
11 BioSystems pathways for MCL1 Gene
4 Reactome pathways for MCL1 Gene
4 KEGG pathways for MCL1 Gene
2 GeneGo (Thomson Reuters) pathways for MCL1 Gene
1 Cell Signaling Technology pathway for MCL1 Gene
Interacting Proteins for MCL1 Gene
Selected Interacting proteins:
Q07820-MCL1_HUMAN
ENSP00000358022
for MCL1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MCL1
SIGNOR curated interactions for MCL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001709 | cell fate determination | NAS | 10837489 |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | IBA | -- |
| GO:0008637 | apoptotic mitochondrial changes | IEA | -- |
Drugs & Compounds for MCL1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| AT-101 | Approved, Investigational | Pharma | inhibitor, Target | BH3-mimetic,gossypol enantiomer, BCL-2 inhibitors | 62 | |
| Mitomycin | Approved | Pharma | Inhibits DNA synthesis,antibiotic and antitumor agent | 0 | ||
| A-1210477 | Pharma | MCL-1 inhibitor | 0 | |||
| Marinopyrrole A | Pharma | Selective Mcl-1 inhibitor | 0 | |||
| MIM1 | Pharma | Mcl-1 Inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
Transcripts for MCL1 Gene
mRNA/cDNA for MCL1 Gene
- (3) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (849) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000369026 3932 bps (uc001euz.4)
- ENST00000464132 1099 bps (uc057kpe.1)
- ENST00000307940 1110 bps (uc001eva.4)
- ENST00000620947 3626 bps (uc021oyf.1)
Unigene Clusters for MCL1 Gene
- Myeloid cell leukemia sequence 1 (BCL2-related):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MCL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MCL1
- genomics-online: gRNA clones - Search results for 102 available MCL-1 gene related products
- Overview of 102 available MCL-1 gene related products
- Applied Biological Materials CRISPR for MCL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MCL1
- GenScript: Design CRISPR guide RNA sequences for MCL1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MCL1
- Browse OriGene Inhibitory RNA Products For MCL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCL1
- genomics-online: shRNA clones - Search results for 102 available MCL-1 gene related products
- Overview of 102 available MCL-1 gene related products
Clone Products
-
OriGene ORF clones in human for MCL1
- RC200521
- RC200521L1
- RC200521L2
- RC200521L3
- RC200521L4
- RC217440
- RC217440L1
- RC217440L2
- RC217440L3
- RC217440L4
- RC231044
- RC231044L1
- RC231044L2
- RC231044L3
- RC231044L4
- RC500521
- RG200521
- RG217440
- RG231044
- RC200521L1V
- RC200521L2V
- RC200521L3V
- RC200521L4V
- RC217440L1V
- RC217440L2V
- RC217440L3V
- RC217440L4V
- RC231044L1V
- RC231044L2V
- RC231044L3V
- RC231044L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MCL1
- Addgene plasmids for MCL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MCL1
- Applied Biological Materials Clones for MCL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | - | |||||||||||||
| SP3: | - | - | - | ||||||||||||
| SP4: |
Expression for MCL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- T Helper Cells Thymus
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for MCL1 Gene
This gene is overexpressed in Whole Blood (x6.1).
This gene is overexpressed in Peripheral blood mononuclear cells (15.6), Lymph node (13.2), Heart (6.6), and Liver (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MCL1 Gene
NURSA nuclear receptor signaling pathways regulating expression of MCL1 Gene:
MCL1SOURCE GeneReport for Unigene cluster for MCL1 Gene:
Hs.632486Evidence on tissue expression from TISSUES for MCL1 Gene
- Nervous system(4.9)
- Blood(4.5)
- Lung(4.1)
- Bone marrow(3.6)
- Liver(3.6)
- Intestine(3.5)
- Pancreas(3)
- Heart(2.9)
- Kidney(2.9)
- Lymph node(2.9)
- Bone(2.6)
- Muscle(2.6)
- Skin(2.6)
- Spleen(2.6)
- Stomach(2.6)
- Eye(2.4)
- Gall bladder(2.4)
- Adrenal gland(2.1)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs for MCL1
-
OriGene qPCR primer pairs and template standards for MCL1
Gene Expression Assay Products
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCL1 Gene
Orthologs for MCL1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MCL1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MCL1 34 33 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | MCL1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Mcl1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Mcl1 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MCL1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MCL1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MCL1 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | mcl1a 34 33 |
|
OneToMany | |
| mcl1b 34 |
|
OneToMany | |||
| bcl2l10 34 |
|
OneToMany |
- Species where no ortholog for MCL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for MCL1 Gene
- ENSEMBL:
- Gene Tree for MCL1 (if available)
- TreeFam:
- Gene Tree for MCL1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MCL1: view image
Paralogs for MCL1 Gene
Pseudogenes.org Pseudogenes for MCL1 Gene
No data available for Paralogs for MCL1 Gene
Variants for MCL1 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000303125 | -- | 150,578,578(-) | G/A | intron_variant | |
| rs1000824081 | -- | 150,574,082(-) | C/A | downstream_transcript_variant | |
| rs1001151771 | -- | 150,574,254(-) | AAAAAAAAAA/AAAAAAAAA/AAAAAAAAAAA | downstream_transcript_variant | |
| rs1001346754 | -- | 150,576,143(-) | ATATGCACACAGCTAAT/AT | 3_prime_UTR_variant | |
| rs1001856748 | -- | 150,578,164(-) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1006838 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
50.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.20;
24.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MCL1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCL1 Gene
Disorders for MCL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| myeloid leukemia |
|
|
| leukemia |
|
|
| chlamydia |
|
|
| alk-positive anaplastic large cell lymphoma |
|
|
| anaplastic large cell lymphoma |
|
Search MCL1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MCL1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MCL1 Gene
Publications for MCL1 Gene
- MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. (PMID: 7682708) Kozopas KM … Craig RW (Proceedings of the National Academy of Sciences of the United States of America 1993) 2 3 4 22 58
- Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. (PMID: 16543145) Maurer U … Green DR (Molecular cell 2006) 3 4 22 58
- Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage. (PMID: 15122313) Michels J … Packham G (Oncogene 2004) 3 4 22 58
- MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol. (PMID: 15241487) Domina AM … Craig RW (Oncogene 2004) 3 4 22 58
- Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and Fortilin. The potential role of MCL1 as a fortilin chaperone. (PMID: 12149273) Zhang D … Fujise K (The Journal of biological chemistry 2002) 3 4 22 58
Products for MCL1 Gene
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