Aliases for MCHR2 Gene

Aliases for MCHR2 Gene

  • Melanin Concentrating Hormone Receptor 2 2 3 5
  • Melanin-Concentrating Hormone Receptor 2 2 3 4
  • MCH2R 2 3 4
  • MCH2 2 3 4
  • SLT 2 3 4
  • G-Protein Coupled Receptor 145 3 4
  • MCH Receptor 2 3 4
  • GPR145 3 4
  • GPRv17 3 4
  • MCH-2R 3 4
  • MCH-R2 3 4
  • MCHR-2 3 4
  • Melanin-Concentrating Hormone 2 3
  • G Protein-Coupled Receptor 145 2
  • G Protein-Coupled Receptor Slt 3
  • MCHR2 5

External Ids for MCHR2 Gene

Previous HGNC Symbols for MCHR2 Gene

  • GPR145

Previous GeneCards Identifiers for MCHR2 Gene

  • GC06M100476
  • GC06M100367
  • GC06M097807

Summaries for MCHR2 Gene

GeneCards Summary for MCHR2 Gene

MCHR2 (Melanin Concentrating Hormone Receptor 2) is a Protein Coding gene. Diseases associated with MCHR2 include Peach Allergy and Localized Chondrosarcoma. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is MCHR1.

UniProtKB/Swiss-Prot Summary for MCHR2 Gene

  • Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.

Tocris Summary for MCHR2 Gene

  • Melanin-concentrating hormone (MCH) is a neuropeptide that is expressed in the central and peripheral nervous systems and plays an important role in the control of feeding behaviors and energy metabolism. MCH acts on two GPCRs: MCH1 (GPR24) and MCH2 (GPR145).

Gene Wiki entry for MCHR2 Gene

Additional gene information for MCHR2 Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MCHR2 Gene

Genomics for MCHR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MCHR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J099994 Promoter 0.8 EPDnew Ensembl 600.7 +0.3 346 1 EZH2 ZBTB11 MCHR2 MCHR2-AS1 piR-31199-312 PRDM13
GH06J100087 Enhancer 0.9 Ensembl ENCODE 0.2 -94.1 -94059 1.2 PRDM10 ZNF692 CEBPB OSR2 JUN FOS ZBTB17 ATF2 JUND EP300 PNISR ENSG00000275716 piR-33598-014 MCHR2 MCHR2-AS1 SIM1
GH06J100209 Enhancer 1.5 VISTA UCNEbase FANTOM5 Ensembl 0.1 -216.0 -216011 2.5 FOXA1 HMBOX1 EZH2 NFE2 FOXA2 ZNF316 MAFG POLR2A FOXM1 MEIS2 piR-38051-245 HSALNG0052223 MCHR2 SIM1
GH06J100009 Enhancer 0.3 Ensembl 0.4 -16.2 -16154 0.8 CEBPB piR-50444-399 MCHR2 MCHR2-AS1 SIM1
GH06J100084 Enhancer 0.6 Ensembl ENCODE 0.2 -90.5 -90503 1.3 CEBPB JUND EP300 ZFHX2 PRDM1 ENSG00000275716 piR-33598-014 MCHR2 MCHR2-AS1 SIM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MCHR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MCHR2

Top Transcription factor binding sites by QIAGEN in the MCHR2 gene promoter:
  • Chx10

Genomic Locations for MCHR2 Gene

Genomic Locations for MCHR2 Gene
chr6:99,918,519-99,994,247
(GRCh38/hg38)
Size:
75,729 bases
Orientation:
Minus strand
chr6:100,367,786-100,442,123
(GRCh37/hg19)
Size:
74,338 bases
Orientation:
Minus strand

Genomic View for MCHR2 Gene

Genes around MCHR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCHR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCHR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCHR2 Gene

Proteins for MCHR2 Gene

  • Protein details for MCHR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969V1-MCHR2_HUMAN
    Recommended name:
    Melanin-concentrating hormone receptor 2
    Protein Accession:
    Q969V1
    Secondary Accessions:
    • B3KVW4
    • E1P5D7
    • Q5VTV7
    • Q6Q377
    • Q9BXA8

    Protein attributes for MCHR2 Gene

    Size:
    340 amino acids
    Molecular mass:
    38849 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MCHR2 Gene

Post-translational modifications for MCHR2 Gene

  • Glycosylation at Asn10 and Asn17

Other Protein References for MCHR2 Gene

No data available for DME Specific Peptides for MCHR2 Gene

Domains & Families for MCHR2 Gene

Gene Families for MCHR2 Gene

Protein Domains for MCHR2 Gene

Suggested Antigen Peptide Sequences for MCHR2 Gene

GenScript: Design optimal peptide antigens:
  • MCH-2R (MCHR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q969V1

UniProtKB/Swiss-Prot:

MCHR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with MCHR2: view

Function for MCHR2 Gene

Molecular function for MCHR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.

Phenotypes From GWAS Catalog for MCHR2 Gene

Gene Ontology (GO) - Molecular Function for MCHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0008528 G protein-coupled peptide receptor activity IBA 21873635
genes like me logo Genes that share ontologies with MCHR2: view
genes like me logo Genes that share phenotypes with MCHR2: view

Animal Model Products

CRISPR Products

miRNA for MCHR2 Gene

miRTarBase miRNAs that target MCHR2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCHR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MCHR2 Gene

Localization for MCHR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCHR2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCHR2 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MCHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MCHR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MCHR2 Gene

Pathways & Interactions for MCHR2 Gene

genes like me logo Genes that share pathways with MCHR2: view

SIGNOR curated interactions for MCHR2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MCHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007218 neuropeptide signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with MCHR2: view

Drugs & Compounds for MCHR2 Gene

(15) Drugs for MCHR2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2R,3S,5S)-2-(Hydroxymethyl)-5-[(2-sulfoethyl)carbamoyl]-3-pyrrolidiniumyl 2-acetamido-2-deoxy-4-O-sulfo-beta-D-glucopyranoside Experimental Pharma Target 0
[Ala17]-MCH Pharma Potent MCH receptor agonist 0
MCH (human, mouse, rat) Pharma Potent endogenous MCH agonist 0
[Ava<sup>9,10</sup>,Ava<sup>14,15</sup>]-Ac-hMCH<sub>6-16</sub>-NH2 Pharma Antagonist 0
[Phe<sup>13</sup>,Tyr<sup>19</sup>]MCH Pharma Agonist, Full agonist 0

(3) Tocris Compounds for MCHR2 Gene

Compound Action Cas Number
[Ala17]-MCH Potent MCH receptor agonist 359784-84-2
ATC 0175 hydrochloride MCH1 antagonist; also 5-HT2B antagonist and 5-HT1A partial agonist 510733-97-8
MCH (human, mouse, rat) Potent endogenous MCH agonist 128315-56-0

(5) ApexBio Compounds for MCHR2 Gene

Compound Action Cas Number
[Ala17]-MCH 359784-84-2
GW 803430 515141-51-2
MCH (human, mouse, rat) 128315-56-0
SNAP 94847 hydrochloride 487051-12-7
TC-MCH 7c 864756-35-4
genes like me logo Genes that share compounds with MCHR2: view

Drug Products

Transcripts for MCHR2 Gene

mRNA/cDNA for MCHR2 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCHR2

Alternative Splicing Database (ASD) splice patterns (SP) for MCHR2 Gene

No ASD Table

Relevant External Links for MCHR2 Gene

GeneLoc Exon Structure for
MCHR2

Expression for MCHR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MCHR2 Gene

mRNA differential expression in normal tissues according to GTEx for MCHR2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x17.7), Brain - Cortex (x12.9), and Brain - Anterior cingulate cortex (BA24) (x11.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MCHR2

SOURCE GeneReport for Unigene cluster for MCHR2 Gene:

Hs.591342

mRNA Expression by UniProt/SwissProt for MCHR2 Gene:

Q969V1-MCHR2_HUMAN
Tissue specificity: Specifically expressed in the brain, with highest levels in cerebral cortex, hippocampus and amygdala. No expression detected in the cerebellum, thalamus or hypothalamus.

Evidence on tissue expression from TISSUES for MCHR2 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with MCHR2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCHR2 Gene

Orthologs for MCHR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MCHR2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MCHR2 30 31
  • 99.51 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MCHR2 30 31
  • 90.24 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MCHR2 30 31
  • 87.52 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MCHR2 31
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MCHR2 31
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GPR151 31
  • 21 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 24 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mchr2 30
  • 70.99 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100150764 30
  • 65.21 (n)
MCHR2 (1 of 3) 31
  • 63 (a)
OneToMany
MCHR2 (3 of 3) 31
  • 59 (a)
OneToMany
mchr2 31
  • 33 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta star1 31
  • 18 (a)
ManyToMany
AlCR2 31
  • 17 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea npr-24 31
  • 20 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 27 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 16 (a)
ManyToMany
Species where no ortholog for MCHR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MCHR2 Gene

ENSEMBL:
Gene Tree for MCHR2 (if available)
TreeFam:
Gene Tree for MCHR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MCHR2: view image

Paralogs for MCHR2 Gene

(13) SIMAP similar genes for MCHR2 Gene using alignment to 1 proteins:

  • MCHR2_HUMAN
genes like me logo Genes that share paralogs with MCHR2: view

Variants for MCHR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MCHR2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
737754 Benign: not provided 99,921,048(-) G/T SYNONYMOUS_VARIANT
739340 Likely Benign: not provided 99,943,131(-) G/A SYNONYMOUS_VARIANT
786094 Benign: not provided 99,942,999(-) G/A SYNONYMOUS_VARIANT
rs147988902 - p.Arg63Lys
rs62434070 - p.Arg152Gln

Additional dbSNP identifiers (rs#s) for MCHR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MCHR2 Gene

Variant ID Type Subtype PubMed ID
dgv6112n100 CNV gain 25217958
esv1423203 CNV insertion 17803354
esv2659885 CNV deletion 23128226
esv2752086 CNV gain 17911159
esv3304861 CNV mobile element insertion 20981092
esv3372400 CNV insertion 20981092
esv3373841 CNV insertion 20981092
esv3406523 CNV insertion 20981092
esv3411423 CNV insertion 20981092
esv3576203 CNV gain 25503493
esv3610130 CNV gain 21293372
esv3610132 CNV loss 21293372
esv3610133 CNV loss 21293372
nsv1024904 CNV loss 25217958
nsv604259 CNV gain 21841781

Variation tolerance for MCHR2 Gene

Residual Variation Intolerance Score: 18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MCHR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCHR2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCHR2 Gene

Disorders for MCHR2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MCHR2 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
peach allergy
  • prunus persica fruit allergy
localized chondrosarcoma
body mass index quantitative trait locus 11
  • bmiq11
- elite association - COSMIC cancer census association via MalaCards
Search MCHR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MCHR2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MCHR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCHR2 Gene

Publications for MCHR2 Gene

  1. Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor. (PMID: 11355873) Mori M … Fujino M (Biochemical and biophysical research communications 2001) 2 3 4 23
  2. A systematic association mapping on chromosome 6q in bipolar affective disorder--evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorder. (PMID: 19927306) Abou Jamra R … Schumacher J (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 23 41
  3. Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity. (PMID: 17698913) Ghoussaini M … Meyre D (The Journal of clinical endocrinology and metabolism 2007) 3 23 41
  4. Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2. (PMID: 15340116) Hawes BE … Simon JS (Obesity research 2004) 3 4 23
  5. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. (PMID: 11404457) Sailer AW … Liu Q (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 4 23

Products for MCHR2 Gene

  • Signalway Proteins for MCHR2

Sources for MCHR2 Gene