The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin ... See more...

Aliases for MCHR1 Gene

Aliases for MCHR1 Gene

  • Melanin Concentrating Hormone Receptor 1 2 3 5
  • Melanin-Concentrating Hormone Receptor 1 2 3 4
  • MCH1R 2 3 4
  • SLC1 2 3 4
  • Somatostatin Receptor-Like Protein 3 4
  • G Protein-Coupled Receptor 24 2 3
  • MCH Receptor 1 3 4
  • MCH-1R 3 4
  • GPR24 3 4
  • SLC-1 3 4
  • G-Protein Coupled Receptor 24 4
  • MCH-R1 4
  • MCHR-1 4
  • MCHR1 5
  • MCHR 4

External Ids for MCHR1 Gene

Previous HGNC Symbols for MCHR1 Gene

  • GPR24

Previous GeneCards Identifiers for MCHR1 Gene

  • GC22P039405
  • GC22P041074
  • GC22P024040

Summaries for MCHR1 Gene

Entrez Gene Summary for MCHR1 Gene

  • The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]

GeneCards Summary for MCHR1 Gene

MCHR1 (Melanin Concentrating Hormone Receptor 1) is a Protein Coding gene. Diseases associated with MCHR1 include Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1 and Bardet-Biedl Syndrome. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and hormone binding. An important paralog of this gene is MCHR2.

UniProtKB/Swiss-Prot Summary for MCHR1 Gene

  • Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.

Tocris Summary for MCHR1 Gene

  • Melanin-concentrating hormone (MCH) is a neuropeptide that is expressed in the central and peripheral nervous systems and plays an important role in the control of feeding behaviors and energy metabolism. MCH acts on two GPCRs: MCH1 (GPR24) and MCH2 (GPR145).

Gene Wiki entry for MCHR1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MCHR1 Gene

Genomics for MCHR1 Gene

GeneHancer (GH) Regulatory Elements Pubs


GeneHancers around MCHR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MCHR1

Top Transcription factor binding sites by QIAGEN in the MCHR1 gene promoter:
  • AML1a
  • Bach1
  • Bach2
  • FOXD3
  • FOXO4
  • GATA-1
  • HEN1
  • NRSF form 2
  • p53
  • Pax-5

Genomic Locations for MCHR1 Gene

Latest Assembly
chr22:40,678,750-40,682,814
(GRCh38/hg38)
Size:
4,065 bases
Orientation:
Plus strand

Previous Assembly
chr22:41,075,488-41,078,816
(GRCh37/hg19 by Entrez Gene)
Size:
3,329 bases
Orientation:
Plus strand

chr22:41,074,754-41,078,818
(GRCh37/hg19 by Ensembl)
Size:
4,065 bases
Orientation:
Plus strand

Genomic View for MCHR1 Gene

Genes around MCHR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCHR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCHR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCHR1 Gene

Proteins for MCHR1 Gene

  • Protein details for MCHR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99705-MCHR1_HUMAN
    Recommended name:
    Melanin-concentrating hormone receptor 1
    Protein Accession:
    Q99705
    Secondary Accessions:
    • B2RBX6
    • Q5R3J1
    • Q96S47
    • Q9BV08

    Protein attributes for MCHR1 Gene

    Size:
    422 amino acids
    Molecular mass:
    45963 Da
    Quaternary structure:
    • Interacts with NCDN.
    SequenceCaution:
    • Sequence=AAC14587.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MCHR1 Gene

Post-translational modifications for MCHR1 Gene

  • Glycosylation at Asn82, Asn85, and Asn92
  • Modification sites at PhosphoSitePlus

Other Protein References for MCHR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MCHR1 Gene

Domains & Families for MCHR1 Gene

Gene Families for MCHR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for MCHR1 Gene

InterPro:
Blocks:
  • Melanin-concentrating hormone 1 receptor signature

Suggested Antigen Peptide Sequences for MCHR1 Gene

GenScript: Design optimal peptide antigens:
  • Somatostatin receptor-like protein (MCHR1_HUMAN)
  • G-protein coupled receptor 24 isoform 1 (Q5IFH6_HUMAN)
  • G-protein coupled receptor 24 isoform 2 (Q5IFI4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99705

UniProtKB/Swiss-Prot:

MCHR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with MCHR1: view

Function for MCHR1 Gene

Molecular function for MCHR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.

Phenotypes From GWAS Catalog for MCHR1 Gene

Gene Ontology (GO) - Molecular Function for MCHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA,IBA 21873635
GO:0005102 signaling receptor binding IEA --
GO:0008022 protein C-terminus binding IEA --
GO:0008188 neuropeptide receptor activity TAS 10860944
GO:0030273 melanin-concentrating hormone receptor activity IEA --
genes like me logo Genes that share ontologies with MCHR1: view
genes like me logo Genes that share phenotypes with MCHR1: view

Animal Models for MCHR1 Gene

MGI Knock Outs for MCHR1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCHR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MCHR1 Gene

Localization for MCHR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCHR1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCHR1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MCHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0005929 cilium IDA 28154160
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MCHR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MCHR1 Gene

Pathways & Interactions for MCHR1 Gene

genes like me logo Genes that share pathways with MCHR1: view

SIGNOR curated interactions for MCHR1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MCHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 10421367
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway TAS 10421367
genes like me logo Genes that share ontologies with MCHR1: view

Drugs & Compounds for MCHR1 Gene

(50) Drugs for MCHR1 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Haloperidol Approved Pharma Target Antipsychotic drug 174
[Ala17]-MCH Pharma Potent MCH receptor agonist 0
ATC 0175 hydrochloride Pharma MCH1 antagonist,potent and selective, MCH1 antagonist; also 5-HT2B antagonist and 5-HT1A partial agonist 0
MCH (human, mouse, rat) Pharma Potent endogenous MCH agonist 0
[<sup>125</sup>I](3-iodo-Tyr<sup>13</sup>)-MCH Pharma Antagonist 0

(1) Additional Compounds for MCHR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for MCHR1 Gene

Compound Action Cas Number
[Ala17]-MCH Potent MCH receptor agonist 359784-84-2
ATC 0175 hydrochloride MCH1 antagonist; also 5-HT2B antagonist and 5-HT1A partial agonist 510733-97-8
MCH (human, mouse, rat) Potent endogenous MCH agonist 128315-56-0

(6) ApexBio Compounds for MCHR1 Gene

Compound Action Cas Number
[Ala17]-MCH 359784-84-2
ATC 0175 hydrochloride MCH1 antagonist,potent and selective 510733-97-8
GW 803430 515141-51-2
MCH (human, mouse, rat) 128315-56-0
SNAP 94847 hydrochloride 487051-12-7
TC-MCH 7c 864756-35-4
genes like me logo Genes that share compounds with MCHR1: view

Drug products for research

Transcripts for MCHR1 Gene

mRNA/cDNA for MCHR1 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCHR1

Alternative Splicing Database (ASD) splice patterns (SP) for MCHR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: -
SP3: - -
SP4:

Relevant External Links for MCHR1 Gene

GeneLoc Exon Structure for
MCHR1

Expression for MCHR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MCHR1 Gene

mRNA differential expression in normal tissues according to GTEx for MCHR1 Gene

This gene is overexpressed in Brain - Cortex (x7.7), Brain - Anterior cingulate cortex (BA24) (x6.9), Brain - Frontal Cortex (BA9) (x6.7), and Brain - Hypothalamus (x6.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MCHR1

SOURCE GeneReport for Unigene cluster for MCHR1 Gene:

Hs.248122

mRNA Expression by UniProt/SwissProt for MCHR1 Gene:

Q99705-MCHR1_HUMAN
Tissue specificity: Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.

Evidence on tissue expression from TISSUES for MCHR1 Gene

  • Nervous system(4.7)
  • Skin(2.3)
  • Kidney(2.3)
  • Liver(2.2)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with MCHR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCHR1 Gene

Orthologs for MCHR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MCHR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MCHR1 29 30
  • 100 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MCHR1 29 30
  • 92.33 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MCHR1 29 30
  • 91.88 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mchr1 29
  • 90.18 (n)
Mouse
(Mus musculus)
Mammalia Mchr1 29 16 30
  • 88.95 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MCHR1 30
  • 88 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MCHR1 30
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC100859572 29
  • 66.56 (n)
MCHR1 30
  • 50 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MCHR1 30
  • 59 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mchr1.2 29
  • 64.53 (n)
Zebrafish
(Danio rerio)
Actinopterygii mchr1a 29 30
  • 60.84 (n)
OneToMany
mchr1b 30
  • 54 (a)
OneToMany
-- 29
Fruit Fly
(Drosophila melanogaster)
Insecta star1 30
  • 21 (a)
ManyToMany
AlCR2 30
  • 18 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea npr-24 30
  • 23 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 26 (a)
ManyToMany
-- 30
  • 25 (a)
ManyToMany
-- 30
  • 23 (a)
ManyToMany
-- 30
  • 22 (a)
ManyToMany
-- 30
  • 15 (a)
ManyToMany
Species where no ortholog for MCHR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MCHR1 Gene

ENSEMBL:
Gene Tree for MCHR1 (if available)
TreeFam:
Gene Tree for MCHR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MCHR1: view image
Alliance of Genome Resources:
Additional Orthologs for MCHR1

Paralogs for MCHR1 Gene

(13) SIMAP similar genes for MCHR1 Gene using alignment to 2 proteins:

  • MCHR1_HUMAN
  • A6ZJ87_HUMAN
genes like me logo Genes that share paralogs with MCHR1: view

Variants for MCHR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MCHR1 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs137903389 Benign: not provided 40,681,544(+) C/T
NM_005297.3(MCHR1):c.885C>T (p.Ala295=)
SYNONYMOUS
rs112405400 -- p.Asp28Val
rs117372135 -- p.Thr25Met
rs11914085 -- p.Gly103Arg
rs133072 -- p.Asn32Asp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MCHR1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MCHR1 Gene

Variant ID Type Subtype PubMed ID
esv3568413 CNV loss 25503493
nsv1062438 CNV gain 25217958
nsv1160763 CNV duplication 26073780
nsv589047 CNV loss 21841781
nsv834205 CNV gain+loss 17160897
nsv955161 CNV deletion 24416366

Variation tolerance for MCHR1 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MCHR1 Gene

Human Gene Mutation Database (HGMD)
MCHR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCHR1
Leiden Open Variation Database (LOVD)
MCHR1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCHR1 Gene

Disorders for MCHR1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for MCHR1 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search MCHR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MCHR1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MCHR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MCHR1 Gene

Publications for MCHR1 Gene

  1. Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans. (PMID: 18198296) Rutanen J … Laakso M (Obesity (Silver Spring, Md.) 2007) 3 22 40
  2. Association analyses suggest GPR24 as a shared susceptibility gene for bipolar affective disorder and schizophrenia. (PMID: 16741940) Severinsen JE … Børglum AD (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006) 3 22 40
  3. Mutation analysis of the MCHR1 gene in human obesity. (PMID: 15941924) Wermter AK … Hebebrand J (European journal of endocrinology 2005) 3 4 22
  4. Association of melanin-concentrating hormone receptor 1 5' polymorphism with early-onset extreme obesity. (PMID: 16186414) Bell CG … Walley AJ (Diabetes 2005) 3 22 40
  5. Melanin-concentrating hormone receptor mutations and human obesity: functional analysis. (PMID: 15166293) Gibson WT … Farooqi IS (Obesity research 2004) 3 4 40

Products for MCHR1 Gene

  • Addgene plasmids for MCHR1

Sources for MCHR1 Gene