Aliases for MCHR1 Gene
External Ids for MCHR1 Gene
Previous HGNC Symbols for MCHR1 Gene
Previous GeneCards Identifiers for MCHR1 Gene
The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]
GeneCards Summary for MCHR1 Gene
MCHR1 (Melanin Concentrating Hormone Receptor 1) is a Protein Coding gene. Diseases associated with MCHR1 include Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1 and Bardet-Biedl Syndrome. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and hormone binding. An important paralog of this gene is MCHR2.
UniProtKB/Swiss-Prot Summary for MCHR1 Gene
Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
Melanin-concentrating hormone (MCH) is a neuropeptide that is expressed in the central and peripheral nervous systems and plays an important role in the control of feeding behaviors and energy metabolism. MCH acts on two GPCRs: MCH1 (GPR24) and MCH2 (GPR145).