This gene encodes a single-pass transmembrane protein. Based on its expression pattern, it is speculated to be involved in regulating mast cell differentiation or immune responses. [provided by RefSeq, Jul 2008] See more...

Aliases for MCEMP1 Gene

Aliases for MCEMP1 Gene

  • Mast Cell Expressed Membrane Protein 1 2 3 5
  • Mast Cell-Expressed Membrane Protein 1 3 4
  • C19orf59 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • Chromosome 19 Open Reading Frame 59 2
  • MGC132456 2
  • MCEMP1 5

External Ids for MCEMP1 Gene

Previous HGNC Symbols for MCEMP1 Gene

  • C19orf59

Previous GeneCards Identifiers for MCEMP1 Gene

  • GC19P007648

Summaries for MCEMP1 Gene

Entrez Gene Summary for MCEMP1 Gene

  • This gene encodes a single-pass transmembrane protein. Based on its expression pattern, it is speculated to be involved in regulating mast cell differentiation or immune responses. [provided by RefSeq, Jul 2008]

GeneCards Summary for MCEMP1 Gene

MCEMP1 (Mast Cell Expressed Membrane Protein 1) is a Protein Coding gene. Among its related pathways are Innate Immune System.

Additional gene information for MCEMP1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MCEMP1 Gene

Genomics for MCEMP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MCEMP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J007678 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 609.6 +4.1 4067 3.6 CEBPG HNRNPL CREB1 GATAD2A CTCF ZNF692 BACH1 TARDBP FOXA1 LARP7 MCEMP1 TRAPPC5 HNRNPM ELAVL1 XAB2 ZNF557 MAP2K7 STXBP2 ZNF414 PEX11G
GH19J007677 Promoter 0.7 Ensembl 600.7 +0.5 473 0.6 ETV6 EGR1 GABPA ZFHX2 ETV1 IKZF1 EGR2 ELF1 ENSG00000269711 MCEMP1
GH19J007679 Promoter 0.6 Ensembl 600.7 +1.6 1573 0.4 CREB1 CTBP1 CREM RAD21 CTCF ESRRA ENSG00000269711 MCEMP1
GH19J007676 Enhancer 0.4 ENCODE 600.7 0.0 -38 0.2 GABPA IKZF1 KLF1 ENSG00000269711 MCEMP1 RETN
GH19J007673 Promoter/Enhancer 1.2 FANTOM5 Ensembl ENCODE 17.7 -2.1 -2137 1.2 ZNF512 DDX20 PKNOX1 PBX2 ZBTB20 SP2 CBX3 CEBPB NFYA NFYB MCEMP1 XAB2 HNRNPM ZNF414 ZNF557 ELAVL1 SNAPC2 MCOLN1 STXBP2 PEX11G
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MCEMP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MCEMP1

Genomic Locations for MCEMP1 Gene

Genomic Locations for MCEMP1 Gene
chr19:7,676,628-7,679,833
(GRCh38/hg38)
Size:
3,206 bases
Orientation:
Plus strand
chr19:7,741,514-7,744,719
(GRCh37/hg19)
Size:
3,206 bases
Orientation:
Plus strand

Genomic View for MCEMP1 Gene

Genes around MCEMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MCEMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MCEMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MCEMP1 Gene

Proteins for MCEMP1 Gene

  • Protein details for MCEMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX19-MCEM1_HUMAN
    Recommended name:
    Mast cell-expressed membrane protein 1
    Protein Accession:
    Q8IX19
    Secondary Accessions:
    • Q8IX20

    Protein attributes for MCEMP1 Gene

    Size:
    187 amino acids
    Molecular mass:
    21229 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MCEMP1 Gene

Post-translational modifications for MCEMP1 Gene

  • Glycosylation at Asn124
  • Modification sites at PhosphoSitePlus

Other Protein References for MCEMP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MCEMP1 Gene

Domains & Families for MCEMP1 Gene

Gene Families for MCEMP1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MCEMP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MCEMP1 Gene

GenScript: Design optimal peptide antigens:
  • Mast cell-expressed membrane protein 1 (MCEM1_HUMAN)
genes like me logo Genes that share domains with MCEMP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MCEMP1 Gene

Function for MCEMP1 Gene

Phenotypes From GWAS Catalog for MCEMP1 Gene

genes like me logo Genes that share phenotypes with MCEMP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCEMP1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MCEMP1 Gene

Localization for MCEMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MCEMP1 Gene

Membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MCEMP1 gene
Compartment Confidence
plasma membrane 4
peroxisome 0
nucleus 0
cytosol 0

Gene Ontology (GO) - Cellular Components for MCEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0035579 specific granule membrane TAS --
GO:0070821 tertiary granule membrane TAS --
genes like me logo Genes that share ontologies with MCEMP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MCEMP1 Gene

Pathways & Interactions for MCEMP1 Gene

PathCards logo

SuperPathways for MCEMP1 Gene

genes like me logo Genes that share pathways with MCEMP1: view

Pathways by source for MCEMP1 Gene

3 Reactome pathways for MCEMP1 Gene

Gene Ontology (GO) - Biological Process for MCEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with MCEMP1: view

No data available for SIGNOR curated interactions for MCEMP1 Gene

Drugs & Compounds for MCEMP1 Gene

No Compound Related Data Available

Transcripts for MCEMP1 Gene

mRNA/cDNA for MCEMP1 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MCEMP1

Alternative Splicing Database (ASD) splice patterns (SP) for MCEMP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: - -
SP3:

Relevant External Links for MCEMP1 Gene

GeneLoc Exon Structure for
MCEMP1

Expression for MCEMP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MCEMP1 Gene

Protein differential expression in normal tissues from HIPED for MCEMP1 Gene

This gene is overexpressed in Monocytes (28.0), Blymphocyte (11.4), Neutrophil (10.7), and Peripheral blood mononuclear cells (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MCEMP1 Gene



Protein tissue co-expression partners for MCEMP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MCEMP1

mRNA Expression by UniProt/SwissProt for MCEMP1 Gene:

Q8IX19-MCEM1_HUMAN
Tissue specificity: Expressed specifically in mast cells. Found primarily in lung.

Evidence on tissue expression from TISSUES for MCEMP1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with MCEMP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MCEMP1 Gene

Orthologs for MCEMP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MCEMP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C19H19orf59 30 31
  • 98.75 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia C20H19orf59 30
  • 73.3 (n)
C19orf59 31
  • 47 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia C7H19orf59 30
  • 65.2 (n)
C19orf59 31
  • 45 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1565374 30
  • 63.92 (n)
Mouse
(Mus musculus)
Mammalia 1810033B17Rik 30 31
  • 63.67 (n)
OneToOne
Mcemp1 17
Species where no ortholog for MCEMP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MCEMP1 Gene

ENSEMBL:
Gene Tree for MCEMP1 (if available)
TreeFam:
Gene Tree for MCEMP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MCEMP1: view image

Paralogs for MCEMP1 Gene

(1) SIMAP similar genes for MCEMP1 Gene using alignment to 1 proteins:

  • MCEM1_HUMAN
genes like me logo Genes that share paralogs with MCEMP1: view

No data available for Paralogs for MCEMP1 Gene

Variants for MCEMP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MCEMP1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
712410 Benign: not provided 7,678,983(+) C/T NONSENSE
rs10409343 - p.Leu175Val
rs72996468 - p.Ile167Val
rs8111596 - p.Val129Ile

Additional dbSNP identifiers (rs#s) for MCEMP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MCEMP1 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV gain 17911159
nsv1060887 CNV gain 25217958
nsv1061452 CNV gain 25217958
nsv833731 CNV loss 17160897
nsv833732 CNV gain 17160897
nsv953959 CNV deletion 24416366

Variation tolerance for MCEMP1 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MCEMP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MCEMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MCEMP1 Gene

Disorders for MCEMP1 Gene

No disorders were found for MCEMP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MCEMP1 Gene

Publications for MCEMP1 Gene

  1. Identification and expression of a new type II transmembrane protein in human mast cells. (PMID: 15953541) Li K … Yao Z (Genomics 2005) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis. (PMID: 26846866) Raman K … Paré G (Stroke 2016) 3

Products for MCEMP1 Gene

Sources for MCEMP1 Gene