Aliases for MCAM Gene
External Ids for MCAM Gene
Previous GeneCards Identifiers for MCAM Gene
GeneCards Summary for MCAM Gene
MCAM (Melanoma Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with MCAM include Noonan Syndrome-Like Disorder With Or Without Juvenile Myelomonocytic Leukemia and Melanoma. Among its related pathways are Mesenchymal Stem Cells and Lineage-specific Markers and Adhesion. An important paralog of this gene is BCAM.
UniProtKB/Swiss-Prot Summary for MCAM Gene
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.