Aliases for MC5R Gene
External Ids for MC5R Gene
Previous GeneCards Identifiers for MC5R Gene
This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]
GeneCards Summary for MC5R Gene
MC5R (Melanocortin 5 Receptor) is a Protein Coding gene. Diseases associated with MC5R include Familial Glucocorticoid Deficiency and Autoimmune Disease Of Eyes, Ear, Nose And Throat. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and melanocortin receptor activity. An important paralog of this gene is MC4R.
UniProtKB/Swiss-Prot Summary for MC5R Gene
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.
Melanocortin receptors are activated by members of the melanocortin family: alpha-, beta- and gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The melanocortins are involved in a range of physiological functions, including pigmentation and inflammation.