Aliases for MC3R Gene
External Ids for MC3R Gene
Previous GeneCards Identifiers for MC3R Gene
This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008]
GeneCards Summary for MC3R Gene
MC3R (Melanocortin 3 Receptor) is a Protein Coding gene. Diseases associated with MC3R include Body Mass Index Quantitative Trait Locus 9 and Tricuspid Valve Insufficiency. Among its related pathways are Peptide ligand-binding receptors and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and neuropeptide binding. An important paralog of this gene is MC5R.
UniProtKB/Swiss-Prot for MC3R Gene
Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.
Melanocortin receptors are activated by members of the melanocortin family: alpha-, beta- and gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The melanocortins are involved in a range of physiological functions, including pigmentation and inflammation.