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Aliases for MBOAT4 Gene

Aliases for MBOAT4 Gene

  • Membrane Bound O-Acyltransferase Domain Containing 4 2 3 5
  • Membrane-Bound O-Acyltransferase Domain-Containing Protein 4 3 4
  • O-Acyltransferase (Membrane Bound) Domain Containing 4 2 3
  • O-Acyltransferase Domain-Containing Protein 4 3 4
  • Ghrelin O-Acyltransferase 2 3
  • OACT4 3 4
  • GOAT 3 4
  • EC 2.3.1.- 4
  • FKSG89 3

External Ids for MBOAT4 Gene

Previous HGNC Symbols for MBOAT4 Gene

  • OACT4

Previous GeneCards Identifiers for MBOAT4 Gene

  • GC08M030108
  • GC08M029989
  • GC08M028533

Summaries for MBOAT4 Gene

GeneCards Summary for MBOAT4 Gene

MBOAT4 (Membrane Bound O-Acyltransferase Domain Containing 4) is a Protein Coding gene. Among its related pathways are Peptide hormone metabolism and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include serine O-acyltransferase activity. An important paralog of this gene is MBOAT2.

UniProtKB/Swiss-Prot for MBOAT4 Gene

  • Mediates the octanoylation of ghrelin at Ser-3. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid.

Additional gene information for MBOAT4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBOAT4 Gene

Genomics for MBOAT4 Gene

GeneHancer (GH) Regulatory Elements for MBOAT4 Gene

Promoters and enhancers for MBOAT4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J030155 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +1.8 1834 3.5 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 MBOAT4 ENSG00000271869 DCTN6 LEPROTL1 WRN SARAF DUSP4
GH08J030144 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 650.4 +13.8 13801 0.5 HDAC1 MEIS2 FOXA2 SOX6 TAL1 CBFA2T3 SP1 CCNT2 CTBP1 HMBOX1 MBOAT4 SARAF ENSG00000271869 RPS15AP24 LEPROTL1
GH08J030088 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.4 +65.9 65914 9.2 HDGF PKNOX1 ARNT ARID4B SIN3A IRF4 YY1 ZNF766 FOS NFYC LEPROTL1 DCTN6 SARAF HSPA8P11 WRN GTF2E2 ENSG00000253708 MBOAT4 GC08M030097
GH08J030097 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5.3 +58.7 58687 4.6 PKNOX1 ATF1 MLX ZNF133 ARID4B DMAP1 YY1 RXRA MXD4 REST LEPROTL1 SARAF MBOAT4 GC08M030097 RPS15AP24
GH08J030075 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 5.2 +81.9 81934 1.6 ZNF362 MAFG CBFA2T3 FEZF1 DPF2 ZNF316 CBX5 SMARCA4 IKZF1 HMBOX1 LEPROTL1 SARAF MBOAT4 ENSG00000272256 RNU6-1218P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MBOAT4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MBOAT4 gene promoter:
  • GATA-6
  • FOXC1
  • AP-1
  • c-Fos
  • c-Jun
  • FosB
  • Fra-1
  • JunB
  • JunD
  • Lmo2

Genomic Locations for MBOAT4 Gene

Genomic Locations for MBOAT4 Gene
27,246 bases
Minus strand
13,016 bases
Minus strand

Genomic View for MBOAT4 Gene

Genes around MBOAT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MBOAT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MBOAT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBOAT4 Gene

Proteins for MBOAT4 Gene

  • Protein details for MBOAT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ghrelin O-acyltransferase
    Protein Accession:
    Secondary Accessions:
    • B1Q003

    Protein attributes for MBOAT4 Gene

    435 amino acids
    Molecular mass:
    49716 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MBOAT4 Gene


neXtProt entry for MBOAT4 Gene

Post-translational modifications for MBOAT4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MBOAT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MBOAT4 Gene

Domains & Families for MBOAT4 Gene

Gene Families for MBOAT4 Gene

Protein Domains for MBOAT4 Gene


Suggested Antigen Peptide Sequences for MBOAT4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the membrane-bound acyltransferase family.
  • Belongs to the membrane-bound acyltransferase family.
genes like me logo Genes that share domains with MBOAT4: view

Function for MBOAT4 Gene

Molecular function for MBOAT4 Gene

UniProtKB/Swiss-Prot Function:
Mediates the octanoylation of ghrelin at Ser-3. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid.

Enzyme Numbers (IUBMB) for MBOAT4 Gene

Phenotypes From GWAS Catalog for MBOAT4 Gene

Gene Ontology (GO) - Molecular Function for MBOAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008374 O-acyltransferase activity TAS --
GO:0016412 serine O-acyltransferase activity IDA 18443287
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with MBOAT4: view
genes like me logo Genes that share phenotypes with MBOAT4: view

Animal Models for MBOAT4 Gene

MGI Knock Outs for MBOAT4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MBOAT4

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MBOAT4 Gene

Localization for MBOAT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MBOAT4 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MBOAT4 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MBOAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane ISS,IEA --
genes like me logo Genes that share ontologies with MBOAT4: view

Pathways & Interactions for MBOAT4 Gene

genes like me logo Genes that share pathways with MBOAT4: view

Pathways by source for MBOAT4 Gene

Interacting Proteins for MBOAT4 Gene

Gene Ontology (GO) - Biological Process for MBOAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018191 peptidyl-serine octanoylation IDA 18443287
genes like me logo Genes that share ontologies with MBOAT4: view

No data available for SIGNOR curated interactions for MBOAT4 Gene

Drugs & Compounds for MBOAT4 Gene

No Compound Related Data Available

Transcripts for MBOAT4 Gene

mRNA/cDNA for MBOAT4 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MBOAT4 Gene

Membrane bound O-acyltransferase domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MBOAT4

Alternative Splicing Database (ASD) splice patterns (SP) for MBOAT4 Gene

No ASD Table

Relevant External Links for MBOAT4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MBOAT4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MBOAT4 Gene

mRNA differential expression in normal tissues according to GTEx for MBOAT4 Gene

This gene is overexpressed in Pancreas (x8.3) and Testis (x6.3).

NURSA nuclear receptor signaling pathways regulating expression of MBOAT4 Gene:


SOURCE GeneReport for Unigene cluster for MBOAT4 Gene:


mRNA Expression by UniProt/SwissProt for MBOAT4 Gene:

Tissue specificity: Expressed predominantly in stomach with moderate levels in pancreas and relatively low levels in most other tissues.

Evidence on tissue expression from TISSUES for MBOAT4 Gene

  • Stomach(2.6)
genes like me logo Genes that share expression patterns with MBOAT4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MBOAT4 Gene

Orthologs for MBOAT4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MBOAT4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MBOAT4 34 33
  • 99.08 (n)
(Canis familiaris)
Mammalia MBOAT4 34 33
  • 83.75 (n)
(Rattus norvegicus)
Mammalia Mboat4 33
  • 81.23 (n)
(Mus musculus)
Mammalia Mboat4 16 34 33
  • 80.84 (n)
(Bos Taurus)
Mammalia MBOAT4 34 33
  • 80.61 (n)
(Monodelphis domestica)
Mammalia MBOAT4 34
  • 63 (a)
(Gallus gallus)
Aves MBOAT4 34 33
  • 59.9 (n)
(Anolis carolinensis)
Reptilia MBOAT4 34
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487840 33
  • 56.34 (n)
(Danio rerio)
Actinopterygii mboat4 34 33
  • 50.42 (n)
fruit fly
(Drosophila melanogaster)
Insecta oys 34
  • 13 (a)
(Caenorhabditis elegans)
Secernentea mboa-5 34
  • 17 (a)
mboa-4 34
  • 15 (a)
mboa-3 34
  • 15 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALE1 34
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10638 34
  • 19 (a)
Species where no ortholog for MBOAT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MBOAT4 Gene

Gene Tree for MBOAT4 (if available)
Gene Tree for MBOAT4 (if available)
Evolutionary constrained regions (ECRs) for MBOAT4: view image

Paralogs for MBOAT4 Gene

Paralogs for MBOAT4 Gene

genes like me logo Genes that share paralogs with MBOAT4: view

Variants for MBOAT4 Gene

Sequence variations from dbSNP and Humsavar for MBOAT4 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000067962 -- 30,142,283(-) T/C intron_variant
rs1000236346 -- 30,135,319(-) T/C intron_variant
rs1000533422 -- 30,138,158(-) C/T intron_variant
rs1000579422 -- 30,133,400(-) A/G intron_variant
rs1000671656 -- 30,131,472(-) A/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MBOAT4 Gene

Variant ID Type Subtype PubMed ID
esv2736827 CNV deletion 23290073
esv3616784 CNV loss 21293372
nsv1124332 CNV deletion 24896259
nsv831277 CNV gain 17160897

Variation tolerance for MBOAT4 Gene

Gene Damage Index Score: 3.17; 51.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MBOAT4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MBOAT4 Gene

Disorders for MBOAT4 Gene

Additional Disease Information for MBOAT4

No disorders were found for MBOAT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MBOAT4 Gene

Publications for MBOAT4 Gene

  1. Ghrelin octanoylation mediated by an orphan lipid transferase. (PMID: 18443287) Gutierrez JA … Hale JE (Proceedings of the National Academy of Sciences of the United States of America 2008) 2 3 4 58
  2. Synthetic Triterpenoid Inhibition of Human Ghrelin O-Acyltransferase: The Involvement of a Functionally Required Cysteine Provides Mechanistic Insight into Ghrelin Acylation. (PMID: 28134508) McGovern-Gooch KR … Hougland JL (Biochemistry 2017) 3 58
  3. Ghrelin O-acyltransferase (GOAT) enzyme is overexpressed in prostate cancer, and its levels are associated with patient's metabolic status: Potential value as a non-invasive biomarker. (PMID: 27693462) Hormaechea-Agulla D … Luque RM (Cancer letters 2016) 3 58
  4. Ghrelin O-acyltransferase (GOAT), a specific enzyme that modifies ghrelin with a medium-chain fatty acid. (PMID: 27489223) Kojima M … Sato T (Journal of biochemistry 2016) 3 58
  5. Structure-activity analysis of human ghrelin O-acyltransferase reveals chemical determinants of ghrelin selectivity and acyl group recognition. (PMID: 25562443) Darling JE … Hougland JL (Biochemistry 2015) 3 58

Products for MBOAT4 Gene

Sources for MBOAT4 Gene

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