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MBOAT2 Gene(Protein Coding)

Membrane Bound O-Acyltransferase Domain Containing 2

GCID:
GC02M008843
GIFtS:
42
Genes Participants
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Aliases for MBOAT2 Gene

Aliases for MBOAT2 Gene

  • Membrane Bound O-Acyltransferase Domain Containing 2 2 3 5
  • Membrane-Bound O-Acyltransferase Domain-Containing Protein 2 3 4
  • O-Acyltransferase (Membrane Bound) Domain Containing 2 2 3
  • 1-Acylglycerophosphoethanolamine O-Acyltransferase 3 4
  • Lysophosphatidylethanolamine Acyltransferase 3 4
  • 1-Acylglycerophosphate O-Acyltransferase 3 4
  • Lysophosphatidic Acid Acyltransferase 3 4
  • Lyso-PA Acyltransferase 3 4
  • Lyso-PE Acyltransferase 3 4
  • LPLAT 2 3 4
  • OACT2 3 4
  • LPAAT 3 4
  • LPEAT 3 4
  • O-Acyltransferase Domain-Containing Protein 2 4
  • Lysophospholipid Acyltransferase 2 3
  • EC 2.3.1.51 4
  • EC 2.3.1.n7 4
  • EC 2.3.1.- 4
  • LPCAT4 3

External Ids for MBOAT2 Gene

Previous HGNC Symbols for MBOAT2 Gene

  • OACT2

Previous GeneCards Identifiers for MBOAT2 Gene

  • GC02M008910
  • GC02M008996

Summaries for MBOAT2 Gene

GeneCards Summary for MBOAT2 Gene

MBOAT2 (Membrane Bound O-Acyltransferase Domain Containing 2) is a Protein Coding gene. Among its related pathways are Metabolism and triacylglycerol biosynthesis. Gene Ontology (GO) annotations related to this gene include 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is MBOAT1.

UniProtKB/Swiss-Prot for MBOAT2 Gene

  • Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.

Additional gene information for MBOAT2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBOAT2 Gene

Genomics for MBOAT2 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MBOAT2 Gene

Promoters and enhancers for MBOAT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02I009002 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.1 -119 2.9 PKNOX1 SMAD1 SIN3A FEZF1 POLR2B ZNF207 ZNF143 FOS SP3 NFYC MBOAT2 ENSG00000239300 CPSF3 TAF1B HMGB1P25
GH02I008836 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 10.8 +166.6 166593 2 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZBTB7B ZNF48 YY1 ETS1 KIDINS220 MBOAT2 LOC100216337
GH02I009142 Enhancer 1.2 Ensembl ENCODE 10.8 -139.2 -139240 1.4 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 ZNF143 FOS KLF13 ENSG00000240980 ASAP2 CPSF3 ITGB1BP1 MBOAT2 LOC105373417 LOC105373415
GH02I009099 Enhancer 1 Ensembl ENCODE 10.5 -95.7 -95659 0.9 HDGF PKNOX1 FOXA2 SAP130 BACH1 EBF1 BMI1 BATF IRF4 RELA MBOAT2 ENSG00000261104 ENSG00000242136 RPL30P3
GH02I009136 Enhancer 0.9 Ensembl ENCODE 10.5 -133.8 -133818 1.9 CTCF ESRRA KLF1 FOXA2 SAP130 ARID4B ZMYM3 CTBP1 ZNF444 GATAD2A ASAP2 CPSF3 ITGB1BP1 MBOAT2 ENSG00000240980 LOC105373417 LOC105373415
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MBOAT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MBOAT2 gene promoter:

Genomic Locations for MBOAT2 Gene

Genomic Locations for MBOAT2 Gene
chr2:8,852,690-9,003,813
(GRCh38/hg38)
Size:
151,124 bases
Orientation:
Minus strand
chr2:8,992,820-9,143,942
(GRCh37/hg19)

Genomic View for MBOAT2 Gene

Genes around MBOAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MBOAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MBOAT2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MBOAT2 Gene

Proteins for MBOAT2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MBOAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZWT7-MBOA2_HUMAN
    Recommended name:
    Lysophospholipid acyltransferase 2
    Protein Accession:
    Q6ZWT7
    Secondary Accessions:
    • A9EDR2
    • Q8NCE7
    • Q96KY4

    Protein attributes for MBOAT2 Gene

    Size:
    520 amino acids
    Molecular mass:
    59527 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11204.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MBOAT2 Gene

Protein Expression for MBOAT2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MBOAT2 Gene

No Post-translational modifications

Other Protein References for MBOAT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MBOAT2 Gene

Domains & Families for MBOAT2 Gene

Gene Families for MBOAT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for MBOAT2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MBOAT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZWT7

UniProtKB/Swiss-Prot:

MBOA2_HUMAN :
  • Belongs to the membrane-bound acyltransferase family.
Family:
  • Belongs to the membrane-bound acyltransferase family.
genes like me logo Genes that share domains with MBOAT2: view

Function for MBOAT2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MBOAT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3-phosphoethanolamine.
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Partially inhibited by thimerosal.
UniProtKB/Swiss-Prot Function:
Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.

Enzyme Numbers (IUBMB) for MBOAT2 Gene

Phenotypes From GWAS Catalog for MBOAT2 Gene

Gene Ontology (GO) - Molecular Function for MBOAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity TAS --
genes like me logo Genes that share ontologies with MBOAT2: view

Phenotypes for MBOAT2 Gene

GenomeRNAi human phenotypes for MBOAT2:
genes like me logo Genes that share phenotypes with MBOAT2: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MBOAT2 Gene

Localization for MBOAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MBOAT2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MBOAT2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MBOAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MBOAT2: view

Pathways & Interactions for MBOAT2 Gene

genes like me logo Genes that share pathways with MBOAT2: view

UniProtKB/Swiss-Prot Q6ZWT7-MBOA2_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism.

Interacting Proteins for MBOAT2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000302177%0d%0a9606.ENSP00000347581%0d%0a9606.ENSP00000284061%0d%0a9606.ENSP00000288490%0d%0a9606.ENSP00000273814%0d%0a9606.ENSP00000329697%0d%0a
Selected Interacting proteins: ENSP00000302177 Q6ZWT7-MBOA2_HUMAN for MBOAT2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for MBOAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0008654 phospholipid biosynthetic process IEA --
GO:0036151 phosphatidylcholine acyl-chain remodeling TAS --
GO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS --
genes like me logo Genes that share ontologies with MBOAT2: view

No data available for SIGNOR curated interactions for MBOAT2 Gene

Drugs & Compounds for MBOAT2 Gene

Products:

  1. Drug

(1) Drugs for MBOAT2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0
genes like me logo Genes that share compounds with MBOAT2: view

Transcripts for MBOAT2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MBOAT2 Gene

(6) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(118) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MBOAT2 Gene

Membrane bound O-acyltransferase domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MBOAT2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: - - -

Relevant External Links for MBOAT2 Gene

GeneLoc Exon Structure for
MBOAT2
ECgene alternative splicing isoforms for
MBOAT2

Expression for MBOAT2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MBOAT2 Gene

mRNA expression in normal human tissues for MBOAT2 Gene
mRNA expression by GTEx for MBOAT2 GenemRNA expression by BioGPS for MBOAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MBOAT2 Gene

This gene is overexpressed in Lung (23.7), Platelet (20.1), Peripheral blood mononuclear cells (9.8), and Breast (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MBOAT2 Gene



NURSA nuclear receptor signaling pathways regulating expression of MBOAT2 Gene:

MBOAT2

SOURCE GeneReport for Unigene cluster for MBOAT2 Gene:

Hs.467634

mRNA Expression by UniProt/SwissProt for MBOAT2 Gene:

Q6ZWT7-MBOA2_HUMAN
Tissue specificity: Expressed in neutrophils.

Evidence on tissue expression from TISSUES for MBOAT2 Gene

  • Nervous system(4.9)
  • Lung(4.6)
genes like me logo Genes that share expression patterns with MBOAT2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MBOAT2 Gene

Orthologs for MBOAT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MBOAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MBOAT2 33 34
  • 99.42 (n)
dog
(Canis familiaris)
 Mammalia MBOAT2 33 34
  • 89.47 (n)
cow
(Bos Taurus)
 Mammalia MBOAT2 33 34
  • 88.48 (n)
rat
(Rattus norvegicus)
 Mammalia Mboat2 33
  • 86.13 (n)
mouse
(Mus musculus)
 Mammalia Mboat2 33 16 34
  • 85.68 (n)
oppossum
(Monodelphis domestica)
 Mammalia MBOAT2 34
  • 85 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia MBOAT2 34
  • 82 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MBOAT2 33 34
  • 81.39 (n)
lizard
(Anolis carolinensis)
 Reptilia MBOAT2 34
  • 78 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia mboat2 33
  • 71.41 (n)
zebrafish
(Danio rerio)
 Actinopterygii mboat2b 33 34
  • 64.01 (n)
mboat2a 34
  • 64 (a)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP007567 33
  • 47.36 (n)
fruit fly
(Drosophila melanogaster)
 Insecta oys 34 33
  • 46.93 (n)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea mboa-4 33 34
  • 45.56 (n)
mboa-3 34
  • 32 (a)
 ManyToMany
mboa-5 34
  • 25 (a)
 ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes ALE1 33 34 36
  • 45.1 (n)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0F20163g 33
  • 43.73 (n)
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AGR271C 33
  • 42.13 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT1G63050 33
  • 44.62 (n)
rice
(Oryza sativa)
 Liliopsida Os02g0676000 33
  • 41.06 (n)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes SPBC16A3.10 33
  • 44.47 (n)
bread mold
(Neurospora crassa)
 Ascomycetes NCU06194 33
  • 42.29 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.10638 34
  • 32 (a)
 OneToMany
Species where no ortholog for MBOAT2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MBOAT2 Gene

ENSEMBL:
Gene Tree for MBOAT2 (if available)
TreeFam:
Gene Tree for MBOAT2 (if available)

Paralogs for MBOAT2 Gene

Paralogs for MBOAT2 Gene

(1) SIMAP similar genes for MBOAT2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MBOAT2: view

Variants for MBOAT2 Gene

Sequence variations from dbSNP and Humsavar for MBOAT2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000007777 -- 8,963,516(-) C/T intron_variant
rs1000012202 -- 8,973,423(-) CC/C intron_variant
rs1000023646 -- 8,937,513(-) G/C intron_variant
rs1000030721 -- 8,932,873(-) C/T intron_variant
rs1000062908 -- 8,861,094(-) AAAAAAAAAA/AAAAAAAAAAA genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MBOAT2 Gene

Variant ID Type Subtype PubMed ID
nsv833359 CNV loss 17160897
nsv517367 CNV gain 19592680
nsv2600 CNV insertion 18451855
nsv1112756 CNV deletion 24896259
nsv1071970 CNV deletion 25765185
esv3589761 CNV loss 21293372
esv2719616 CNV deletion 23290073

Variation tolerance for MBOAT2 Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MBOAT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MBOAT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MBOAT2 Gene

Disorders for MBOAT2 Gene

Additional Disease Information for MBOAT2

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MBOAT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MBOAT2 Gene

Publications for MBOAT2 Gene

  1. LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae. (PMID: 17890783) Tamaki H … Kumagai H (The Journal of biological chemistry 2007) 3 4 58
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58

Products for MBOAT2 Gene

Sources for MBOAT2 Gene

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