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Aliases for MBLAC2 Gene

Aliases for MBLAC2 Gene

  • Metallo-Beta-Lactamase Domain Containing 2 2 3 5
  • EC 3.-.-.- 4

External Ids for MBLAC2 Gene

Previous GeneCards Identifiers for MBLAC2 Gene

  • GC05M089790
  • GC05M084964

Summaries for MBLAC2 Gene

GeneCards Summary for MBLAC2 Gene

MBLAC2 (Metallo-Beta-Lactamase Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity.

Additional gene information for MBLAC2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBLAC2 Gene

Genomics for MBLAC2 Gene

GeneHancer (GH) Regulatory Elements for MBLAC2 Gene

Promoters and enhancers for MBLAC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I090472 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 550.8 -0.7 -729 5.5 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B POLR3G MBLAC2 ADGRV1
GH05I091310 Enhancer 1.5 Ensembl ENCODE dbSUPER 12.5 -838.2 -838155 5.8 PKNOX1 SMAD1 FOXA2 ARNT ARID4B NEUROD1 SIN3A FEZF1 IRF4 YY1 ENSG00000271762 GC05P091311 LUCAT1 RPS18P7 ENSG00000241059 MBLAC2 ARRDC3 ENSG00000277001
GH05I090020 Enhancer 1.1 Ensembl ENCODE 11.2 +453.3 453309 1.8 PKNOX1 FOXA2 SMAD1 ZFP64 IRF4 ZNF213 ATF7 FOS RUNX3 ZNF202 MBLAC2 ENSG00000260871 LYSMD3 CETN3 MIR3660 GC05M090101
GH05I090439 Enhancer 1 Ensembl ENCODE 11.2 +34.7 34692 1 MEIS2 CTCF NFATC3 ZNF384 ZNF644 RAD21 ZBTB40 YY1 ZNF366 BRD9 LYSMD3 ADGRV1 POLR3G MBLAC2 LOC731157 CETN3
GH05I090482 Promoter 0.6 EPDnew 0.4 -7.9 -7920 0.1 ZNF316 POLR3G ADGRV1 LYSMD3 MBLAC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MBLAC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MBLAC2 gene promoter:

Genomic Locations for MBLAC2 Gene

Genomic Locations for MBLAC2 Gene
16,566 bases
Minus strand

Genomic View for MBLAC2 Gene

Genes around MBLAC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MBLAC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MBLAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBLAC2 Gene

Proteins for MBLAC2 Gene

  • Protein details for MBLAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metallo-beta-lactamase domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • D6RJI1
    • Q8IY16
    • Q8N8D8

    Protein attributes for MBLAC2 Gene

    279 amino acids
    Molecular mass:
    31372 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MBLAC2 Gene


neXtProt entry for MBLAC2 Gene

Post-translational modifications for MBLAC2 Gene

  • Ubiquitination at posLast=1010, isoforms=226, and isoforms=256
  • Modification sites at PhosphoSitePlus

Other Protein References for MBLAC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MBLAC2 Gene

Domains & Families for MBLAC2 Gene

Gene Families for MBLAC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MBLAC2 Gene

Suggested Antigen Peptide Sequences for MBLAC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
  • Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
genes like me logo Genes that share domains with MBLAC2: view

Function for MBLAC2 Gene

Enzyme Numbers (IUBMB) for MBLAC2 Gene

Gene Ontology (GO) - Molecular Function for MBLAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MBLAC2: view

Phenotypes for MBLAC2 Gene

genes like me logo Genes that share phenotypes with MBLAC2: view

miRNA for MBLAC2 Gene

Clone Products

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MBLAC2 Gene

Localization for MBLAC2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MBLAC2 gene
Compartment Confidence
extracellular 5
nucleus 3
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MBLAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA,IDA 20458337
genes like me logo Genes that share ontologies with MBLAC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MBLAC2 Gene

Pathways & Interactions for MBLAC2 Gene

SuperPathways for MBLAC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MBLAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MBLAC2: view

No data available for Pathways by source and SIGNOR curated interactions for MBLAC2 Gene

Drugs & Compounds for MBLAC2 Gene

No Compound Related Data Available

Transcripts for MBLAC2 Gene

mRNA/cDNA for MBLAC2 Gene

Unigene Clusters for MBLAC2 Gene

Metallo-beta-lactamase domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MBLAC2 Gene

No ASD Table

Relevant External Links for MBLAC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MBLAC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MBLAC2 Gene

Protein differential expression in normal tissues from HIPED for MBLAC2 Gene

This gene is overexpressed in Brain (23.5), Peripheral blood mononuclear cells (10.2), and Fetal Brain (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MBLAC2 Gene

Protein tissue co-expression partners for MBLAC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MBLAC2 Gene:


SOURCE GeneReport for Unigene cluster for MBLAC2 Gene:


Evidence on tissue expression from TISSUES for MBLAC2 Gene

  • Nervous system(4.4)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with MBLAC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MBLAC2 Gene

Orthologs for MBLAC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MBLAC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MBLAC2 33 34
  • 99.52 (n)
(Canis familiaris)
Mammalia MBLAC2 33 34
  • 94.03 (n)
(Bos Taurus)
Mammalia MBLAC2 33 34
  • 93.43 (n)
(Rattus norvegicus)
Mammalia Mblac2 33
  • 92 (n)
(Mus musculus)
Mammalia Mblac2 33 16 34
  • 91.76 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 87 (a)
-- 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia MBLAC2 34
  • 77 (a)
(Gallus gallus)
Aves MBLAC2 33 34
  • 77.21 (n)
(Anolis carolinensis)
Reptilia MBLAC2 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mblac2 33
  • 75.88 (n)
(Danio rerio)
Actinopterygii mblac2 33 34
  • 66.54 (n)
Species where no ortholog for MBLAC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MBLAC2 Gene

Gene Tree for MBLAC2 (if available)
Gene Tree for MBLAC2 (if available)

Paralogs for MBLAC2 Gene Pseudogenes for MBLAC2 Gene

genes like me logo Genes that share paralogs with MBLAC2: view

No data available for Paralogs for MBLAC2 Gene

Variants for MBLAC2 Gene

Sequence variations from dbSNP and Humsavar for MBLAC2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000426804 -- 90,458,538(-) C/T 3_prime_UTR_variant
rs1000473994 -- 90,459,673(-) T/C 3_prime_UTR_variant
rs1000833591 -- 90,467,091(-) C/G intron_variant
rs1000865865 -- 90,473,441(-) G/A intron_variant
rs1000882163 -- 90,473,685(-) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MBLAC2 Gene

Variant ID Type Subtype PubMed ID
nsv518131 CNV loss 19592680

Variation tolerance for MBLAC2 Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MBLAC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MBLAC2 Gene

Disorders for MBLAC2 Gene

Additional Disease Information for MBLAC2

No disorders were found for MBLAC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MBLAC2 Gene

Publications for MBLAC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome AS … Carapito C (Proteomics 2015) 4 58

Products for MBLAC2 Gene

Sources for MBLAC2 Gene

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