Aliases for MBL2 Gene
External Ids for MBL2 Gene
Previous HGNC Symbols for MBL2 Gene
Previous GeneCards Identifiers for MBL2 Gene
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes and binds to mannose and N-acetylglucosamine on many microorganisms, including bacteria, yeast, and viruses including influenza virus, HIV and SARS-CoV. This binding activates the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jun 2020]
GeneCards Summary for MBL2 Gene
MBL2 (Mannose Binding Lectin 2) is a Protein Coding gene. Diseases associated with MBL2 include Mannose-Binding Lectin Deficiency and Pulmonary Tuberculosis. Among its related pathways are Complement and coagulation cascades and Creation of C4 and C2 activators. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent protein binding.
UniProtKB/Swiss-Prot Summary for MBL2 Gene
Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.