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Aliases for MBIP Gene

Aliases for MBIP Gene

  • MAP3K12 Binding Inhibitory Protein 1 2 3 5
  • MAPK Upstream Kinase-Binding Inhibitory Protein 4
  • MUK-Binding Inhibitory Protein 4

External Ids for MBIP Gene

Previous GeneCards Identifiers for MBIP Gene

  • GC14M034147
  • GC14M030625
  • GC14M034757
  • GC14M035837
  • GC14M036767
  • GC14M016882

Summaries for MBIP Gene

GeneCards Summary for MBIP Gene

MBIP (MAP3K12 Binding Inhibitory Protein 1) is a Protein Coding gene. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase inhibitor activity.

UniProtKB/Swiss-Prot for MBIP Gene

  • Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Additional gene information for MBIP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MBIP Gene

Genomics for MBIP Gene

GeneHancer (GH) Regulatory Elements for MBIP Gene

Promoters and enhancers for MBIP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I036318 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 561.5 +0.7 738 2.7 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B MBIP ENSG00000283098 LOC644584 RALGAPA1 RN7SKP21
GH14I036272 Enhancer 1.1 UCNEbase Ensembl 17.4 +48.2 48213 0.5 PKNOX1 ZSCAN4 MZF1 ZNF384 FEZF1 ZIC2 ZNF2 ZNF324 ZNF335 CTBP1 MBIP RPL29P3 NKX2-8 RN7SKP21
GH14I036345 Enhancer 1 VISTA UCNEbase 17.3 -25.2 -25238 1.6 FOXA2 POLR2A MBIP RPL29P3 NKX2-8 ENSG00000283098 DPPA3P2
GH14I037167 Enhancer 1.2 Ensembl ENCODE 10.7 -847.6 -847633 2.1 PKNOX1 SMAD1 ATF1 TCF12 POLR2B ZNF766 GATA2 ATF7 KDM4B CAVIN1 MBIP SLC25A21 SLC25A21-AS1 GC14P037106
GH14I036504 Enhancer 1.1 VISTA ENCODE dbSUPER 10.6 -184.3 -184299 0.8 RING1 SP1 SUZ12 POU5F1 CTBP2 EZH2 RALGAPA1 RPL29P3 NKX2-8 MBIP SFTA3 ENSG00000257520 GC14P036424 ENSG00000283098
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MBIP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MBIP gene promoter:

Genomic Locations for MBIP Gene

Genomic Locations for MBIP Gene
22,119 bases
Minus strand

Genomic View for MBIP Gene

Genes around MBIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MBIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MBIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MBIP Gene

Proteins for MBIP Gene

  • Protein details for MBIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MAP3K12-binding inhibitory protein 1
    Protein Accession:
    Secondary Accessions:
    • Q86TZ2
    • Q96AS5
    • Q9BS93
    • Q9NZE1

    Protein attributes for MBIP Gene

    344 amino acids
    Molecular mass:
    39281 Da
    Quaternary structure:
    • Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, KAT14 and WDR5.
    • Sequence=CAD62615.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MBIP Gene


neXtProt entry for MBIP Gene

Post-translational modifications for MBIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MBIP Gene

Domains & Families for MBIP Gene

Gene Families for MBIP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MBIP Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MBIP: view

No data available for UniProtKB/Swiss-Prot for MBIP Gene

Function for MBIP Gene

Molecular function for MBIP Gene

UniProtKB/Swiss-Prot Function:
Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Phenotypes From GWAS Catalog for MBIP Gene

Gene Ontology (GO) - Molecular Function for MBIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity TAS 10801814
GO:0005515 protein binding IPI 16189514
GO:0030366 molybdopterin synthase activity IBA --
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with MBIP: view

Phenotypes for MBIP Gene

genes like me logo Genes that share phenotypes with MBIP: view

Animal Model Products

miRNA for MBIP Gene

miRTarBase miRNAs that target MBIP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MBIP Gene

Localization for MBIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MBIP Gene

Nucleus. Cytoplasm. Note=Shows a cytoplasmic localization when coexpressed with MAP3K12.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MBIP gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MBIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MBIP: view

Pathways & Interactions for MBIP Gene

genes like me logo Genes that share pathways with MBIP: view

Pathways by source for MBIP Gene

Gene Ontology (GO) - Biological Process for MBIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000173 inactivation of MAPK activity involved in osmosensory signaling pathway TAS 10801814
GO:0032324 molybdopterin cofactor biosynthetic process IBA --
GO:0043966 histone H3 acetylation IDA 18838386
genes like me logo Genes that share ontologies with MBIP: view

No data available for SIGNOR curated interactions for MBIP Gene

Drugs & Compounds for MBIP Gene

No Compound Related Data Available

Transcripts for MBIP Gene

Unigene Clusters for MBIP Gene

MAP3K12 binding inhibitory protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MBIP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - - -
SP3: - -
SP5: - -

Relevant External Links for MBIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MBIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MBIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MBIP Gene

This gene is overexpressed in Seminal vesicle (47.2) and Blymphocyte (17.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MBIP Gene

Protein tissue co-expression partners for MBIP Gene

NURSA nuclear receptor signaling pathways regulating expression of MBIP Gene:


SOURCE GeneReport for Unigene cluster for MBIP Gene:


mRNA Expression by UniProt/SwissProt for MBIP Gene:

Tissue specificity: Ubiquitous. High expression seen in the heart and lung.

Evidence on tissue expression from TISSUES for MBIP Gene

  • Kidney(4.3)
  • Bone marrow(4.2)
  • Thyroid gland(2.4)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with MBIP: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MBIP Gene

Orthologs for MBIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MBIP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MBIP 33 34
  • 99.61 (n)
(Bos Taurus)
Mammalia MBIP 33 34
  • 92.34 (n)
(Canis familiaris)
Mammalia MBIP 33 34
  • 92.25 (n)
(Rattus norvegicus)
Mammalia Mbip 33
  • 87.59 (n)
(Mus musculus)
Mammalia Mbip 33 16 34
  • 86.82 (n)
(Ornithorhynchus anatinus)
Mammalia MBIP 34
  • 81 (a)
(Monodelphis domestica)
Mammalia MBIP 34
  • 76 (a)
(Gallus gallus)
Aves MBIP 33 34
  • 72.47 (n)
(Anolis carolinensis)
Reptilia MBIP 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mbip 33
  • 63.78 (n)
Str.1990 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6450 33
(Danio rerio)
Actinopterygii mbip 33 34
  • 57 (n)
Dr.28396 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10182 34
  • 30 (a)
Species where no ortholog for MBIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MBIP Gene

Gene Tree for MBIP (if available)
Gene Tree for MBIP (if available)

Paralogs for MBIP Gene

No data available for Paralogs for MBIP Gene

Variants for MBIP Gene

Sequence variations from dbSNP and Humsavar for MBIP Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000066679 -- 36,310,592(-) G/A intron_variant
rs1000234271 -- 36,304,957(-) A/G intron_variant
rs1000357909 -- 36,306,694(-) A/T intron_variant
rs1000538148 -- 36,312,360(-) A/C intron_variant
rs1000610255 -- 36,320,193(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MBIP Gene

Variant ID Type Subtype PubMed ID
dgv83e55 CNV gain 17911159
nsv1040487 CNV gain 25217958
nsv1054427 CNV gain 25217958
nsv518747 CNV loss 19592680
nsv832771 CNV loss 17160897

Variation tolerance for MBIP Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MBIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MBIP Gene

Disorders for MBIP Gene

Additional Disease Information for MBIP

No disorders were found for MBIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MBIP Gene

Publications for MBIP Gene

  1. MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper protein kinase. (PMID: 10801814) Fukuyama K … Ohno S (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for MBIP Gene

Sources for MBIP Gene

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