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DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA.... See more...
Aliases for MBD2 Gene
Aliases for MBD2 Gene
External Ids for MBD2 Gene
- HGNC: 6917
- NCBI Entrez Gene: 8932
- Ensembl: ENSG00000134046
- OMIM®: 603547
- UniProtKB/Swiss-Prot: Q9UBB5
Previous GeneCards Identifiers for MBD2 Gene
- GC18M051851
- GC18M051615
- GC18M049932
- GC18M049934
- GC18M048535
Summaries for MBD2 Gene
-
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for MBD2 Gene
MBD2 (Methyl-CpG Binding Domain Protein 2) is a Protein Coding gene. Diseases associated with MBD2 include Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant and Klatskin's Tumor. Among its related pathways are Macrophage Differentiation and Growth Inhibition by METS and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include chromatin binding and protein domain specific binding. An important paralog of this gene is MBD3.
UniProtKB/Swiss-Prot Summary for MBD2 Gene
-
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
Additional gene information for MBD2 Gene
- HGNC (6917)
- NCBI Entrez Gene (8932)
- Ensembl (ENSG00000134046)
- OMIM® (603547)
- UniProtKB/Swiss-Prot (Q9UBB5)
- Open Targets Platform(ENSG00000134046)
- Search for MBD2 at DataMed
- Search for MBD2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MBD2 Gene
Genomics for MBD2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MBD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MBD2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MBD2
- Top Transcription factor binding sites by QIAGEN in the MBD2 gene promoter:
-
- AP-1
- c-Myb
- GATA-3
- p53
- Pax-2
- Pax-2a
- S8
- Sp1
- YY1
Genomic Locations for MBD2 Gene
Latest Assembly
- chr18:54,151,606-54,224,669
- (GRCh38/hg38)
- Size:
- 73,064 bases
- Orientation:
- Minus strand
Previous Assembly
- chr18:51,677,976-51,751,039
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 73,064 bases
- Orientation:
- Minus strand
- chr18:51,679,079-51,751,158
- (GRCh37/hg19 by Ensembl)
- Size:
- 72,080 bases
- Orientation:
- Minus strand
Genomic View for MBD2 Gene
Genes around MBD2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q21.2 by HGNC
- 18q21.2 by Entrez Gene
- 18q21.2 by Ensembl
MBD2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MBD2 Gene
Proteins for MBD2 Gene
-
Protein details for MBD2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBB5-MBD2_HUMAN
- Recommended name:
- Methyl-CpG-binding domain protein 2
- Protein Accession:
- Q9UBB5
- O95242
- Q9UIS8
Protein attributes for MBD2 Gene
- Size:
- 411 amino acids
- Molecular mass:
- 43255 Da
- Quaternary structure:
-
- Heterodimer with MBD3. Component of the MeCP1 complex that contains HDAC1 and HDAC2. Binds DNMT1, MIZF, GPN1, SIN3A, GATAD2A/p66-alpha and GATAD2B/p66-beta. Interacts with DHX9. Interacts with SPHK2 (PubMed:19729656).
- Miscellaneous:
-
- [Isoform 3]: Incomplete sequence.
Three dimensional structures from OCA and Proteopedia for MBD2 Gene
Protein Expression for MBD2 Gene
Post-translational modifications for MBD2 Gene
Other Protein References for MBD2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences MBD2 Antibody (LS-B3603) and MBD2 Antibody (LS-B7531)
- G Biosciences Immunotag™ MBD2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for MBD2
- Novus Biologicals Antibodies for MBD2
-
Abcam antibodies for MBD2
- Invitrogen Antibodies for MBD2 (AFLGC-Mbd2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MBD2
- Sino Biological Antibodies for MBD2
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MBD2
- Origene Custom Protein Services for MBD2
- Novus Biologicals proteins for MBD2
Assay products for research
- antibodies-online: Search results for available MBD2 related products ranked by validation data
No data available for DME Specific Peptides for MBD2 Gene
Domains & Families for MBD2 Gene
Gene Families for MBD2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for MBD2 Gene
- InterPro:
- Blocks:
-
- Methyl-CpG binding
- ProtoNet:
Suggested Antigen Peptide Sequences for MBD2 Gene
- GenScript: Design optimal peptide antigens:
-
- Methyl-CpG-binding protein MBD2 (MBD2_HUMAN)
- Antigen NY-CO-41 (O60535_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MBD2 Gene
Function for MBD2 Gene
Molecular function for MBD2 Gene
- UniProtKB/Swiss-Prot Function:
- Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
- GENATLAS Biochemistry:
- methyl-CpG binding protein 2,demethylase,40kDa,binding methylated DNA,histone deacetylase complex,widely expressed,underexpressed at the early stage of colorectal and stomach carcinogenesis
Phenotypes From GWAS Catalog for MBD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0003696 | satellite DNA binding | TAS | 9774669 |
| GO:0003729 | mRNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 12183469 |
Phenotypes for MBD2 Gene
- MGI mutant phenotypes for MBD2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for MBD2:
Animal Models for MBD2 Gene
- MGI Knock Outs for MBD2:
-
- Mbd2 Mbd2<tm1Bh>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MBD2 - Starting at $85 >
- * MBD2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MBD2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MBD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MBD2
miRNA for MBD2 Gene
- miRTarBase miRNAs that target MBD2
-
- hsa-miR-373-3p (MIRT006021)
- mmu-miR-7b-5p (MIRT009502)
- mmu-miR-340-5p (MIRT010674)
- hsa-miR-375 (MIRT019870)
- hsa-miR-221-5p (MIRT437392)
- hsa-miR-224-5p (MIRT437393)
- hsa-miR-302a-3p (MIRT437510)
- hsa-miR-202-5p (MIRT501929)
- hsa-miR-337-3p (MIRT501930)
- hsa-miR-4795-3p (MIRT501931)
- hsa-miR-331-5p (MIRT501932)
- hsa-miR-202-3p (MIRT501933)
- hsa-miR-4678 (MIRT501934)
- hsa-miR-126-5p (MIRT501935)
- hsa-miR-618 (MIRT501936)
- hsa-miR-4458 (MIRT501937)
- hsa-miR-98-5p (MIRT501938)
- hsa-miR-4500 (MIRT501939)
- hsa-let-7b-5p (MIRT501940)
- hsa-let-7d-5p (MIRT501941)
- hsa-let-7a-5p (MIRT501942)
- hsa-let-7e-5p (MIRT501943)
- hsa-let-7i-5p (MIRT501944)
- hsa-let-7f-5p (MIRT501945)
- hsa-let-7c-5p (MIRT501946)
- hsa-let-7g-5p (MIRT501947)
- hsa-miR-32-5p (MIRT727239)
- hsa-miR-92b-3p (MIRT727240)
- hsa-miR-92a-3p (MIRT727241)
- hsa-miR-221-3p (MIRT735381)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MBD2
- Browse OriGene Inhibitory RNA Products For MBD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MBD2
Clone products for research
- Applied Biological Materials (abm): Clones for MBD2 - Starting at $45 >
- * MBD2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Addgene plasmids for MBD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MBD2
Cell Lines for research
-
Horizon Cell Lines for MBD2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MBD2 Gene
Localization for MBD2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MBD2 Gene
- Nucleus. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Nucleoplasm (4)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000118 | histone deacetylase complex | IEA | -- |
| GO:0000785 | chromatin | HDA,IDA | 23770133 |
| GO:0000792 | heterochromatin | IEA | -- |
| GO:0005634 | nucleus | TAS,NAS | 10441743 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for MBD2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 2 | Macrophage Differentiation and Growth Inhibition by METS |
DNA Methylation and Transcriptional Repression
.31
|
|
| 3 | Gene Expression |
.48
|
|
| 4 | Development NOTCH1-mediated pathway for NF-KB activity modulation |
Transcription Sin3 and NuRD in transcription regulation
.31
|
|
| 5 | Signaling events mediated by HDAC Class I | ||
Pathways by source for MBD2 Gene
1 BioSystems pathway for MBD2 Gene
1 GeneGo (Thomson Reuters) pathway for MBD2 Gene
- Transcription Sin3 and NuRD in transcription regulation
1 Qiagen pathway for MBD2 Gene
- DNA Methylation and Transcriptional Repression
Interacting Proteins for MBD2 Gene
Selected Interacting proteins:
Q9UBB5-MBD2_HUMAN
ENSP00000256429
for MBD2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for MBD2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IGI | 23770133 |
| GO:0000183 | chromatin silencing at rDNA | TAS | -- |
| GO:0006346 | methylation-dependent chromatin silencing | IGI | 23770133 |
| GO:0007507 | heart development | IEA | -- |
| GO:0007568 | aging | IEA | -- |
Drugs & Compounds for MBD2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| cyclic amp | Experimental | Pharma | 0 |
Transcripts for MBD2 Gene
mRNA/cDNA for MBD2 Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000256429 5064 nts (view in UCSC)
- ENST00000398398 1237 nts (view in UCSC)
- ENST00000578272 701 nts (view in UCSC)
- ENST00000579025 241 nts (view in UCSC)
- ENST00000583046 1182 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MBD2 - Starting at $85 >
- * MBD2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MBD2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MBD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for MBD2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MBD2
- Browse OriGene Inhibitory RNA Products For MBD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MBD2
Clone products for research
- Applied Biological Materials (abm): Clones for MBD2 - Starting at $45 >
- * MBD2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Addgene plasmids for MBD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MBD2
Relevant External Links for MBD2 Gene
- GeneLoc Exon Structure for
- MBD2
Expression for MBD2 Gene
This gene is overexpressed in Brain (48.0) and Peripheral blood mononuclear cells (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MBD2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MBD2
SOURCE GeneReport for Unigene cluster for MBD2 Gene:
Hs.25674mRNA Expression by UniProt/SwissProt for MBD2 Gene:
Q9UBB5-MBD2_HUMAN
Tissue specificity:
Highly expressed in brain, heart, kidney, stomach, testis and placenta.
Evidence on tissue expression from TISSUES for MBD2 Gene
- Liver(4.4)
- Skin(2.4)
- Intestine(2.3)
- Lymph node(2.3)
- Blood(2.2)
- Nervous system(2.2)
- Kidney(2.1)
- Spleen(2)
Primer products for research
-
OriGene qPCR primer pairs for MBD2
-
OriGene qPCR primer pairs and template standards for MBD2
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MBD2 Gene
Orthologs for MBD2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MBD2 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MBD2 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MBD2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MBD2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mbd2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mbd2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | MBD2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MBD2 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | MBD2 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.21615 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mbd2 30 31 |
|
ManyToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | MBD-like 30 31 32 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003982 30 |
|
- Species where no ortholog for MBD2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MBD2 Gene
- ENSEMBL:
- Gene Tree for MBD2 (if available)
- TreeFam:
- Gene Tree for MBD2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MBD2: view image
Paralogs for MBD2 Gene
Variants for MBD2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MBD2 Gene
| SNP ID | Clinical significance and condition | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs61753467 | Benign: not provided | 54,164,588(-) |
A/G NM_003927.5(MBD2):c.1044T>C (p.Pro348=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3422299 | CNV | insertion | 20981092 |
| esv993042 | CNV | deletion | 20482838 |
| nsv1072267 | CNV | deletion | 25765185 |
| nsv1121952 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.90;
18.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MBD2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MBD2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MBD2 Gene
Disorders for MBD2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cerebellar ataxia, deafness, and narcolepsy, autosomal dominant |
|
|
| klatskin's tumor |
|
|
| rett syndrome |
|
|
| tetralogy of fallot |
|
|
| exudative vitreoretinopathy 1 |
|
|
Search MBD2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MBD2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MBD2 Gene
Publications for MBD2 Gene
- Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes. (PMID: 10441743) Hendrich B … Bird A (Mammalian genome : official journal of the International Mammalian Genome Society 1999) 2 3 4 23
- Identification and characterization of a family of mammalian methyl-CpG binding proteins. (PMID: 9774669) Hendrich B … Bird A (Molecular and cellular biology 1998) 2 3 4 23
- p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction. (PMID: 16415179) Brackertz M … Renkawitz R (Nucleic acids research 2006) 3 4 23
- Genotypes and haplotypes of the methyl-CpG-binding domain 2 modify breast cancer risk dependent upon menopausal status. (PMID: 16168120) Zhu Y … Zheng T (Breast cancer research : BCR 2005) 3 23 41
- Antithetic effects of MBD2a on gene regulation. (PMID: 12665568) Fujita H … Nakajima T (Molecular and cellular biology 2003) 3 4 23
ExternalLinks
Products for MBD2 Gene
- Custom Antibody ServicesOriGene Antibodies for MBD2
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals proteins for MBD2
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- Browse Peptides and Proteins
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- Abcam antibodies for MBD2
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- Browse Primary Antibodies
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- antibodies-online: Show 44 available MBD2 Antibodies ranked by validation data
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- antibodies-online: Show 3 available MBD2 Proteins ranked by validation data
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- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MBD2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MBD2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MBD2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MBD2
Sources for MBD2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (13) UniProtKB/TrEMBL
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- (25) DrugBank
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- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB