Aliases for MAZ Gene

Aliases for MAZ Gene

  • MYC Associated Zinc Finger Protein 2 3 5
  • Purine-Binding Transcription Factor 2 3 4
  • Myc-Associated Zinc Finger Protein 3 4
  • Transcription Factor Zif87 3 4
  • Zinc Finger Protein 801 3 4
  • ZNF801 3 4
  • Pur-1 3 4
  • SAF-1 3 4
  • MAZI 3 4
  • ZF87 3 4
  • MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) 2
  • Serum Amyloid A Activating Factor 1 3
  • Serum Amyloid A Activating Factor 2 3
  • Zinc-Finger Protein, 87 Kilodaltons 3
  • Serum Amyloid A-Activating Factor-1 4
  • SAF-2 3
  • SAF-3 3
  • Zif87 3
  • PUR1 3

External Ids for MAZ Gene

Previous GeneCards Identifiers for MAZ Gene

  • GC16M029338
  • GC16P030140
  • GC16P029816
  • GC16P029855
  • GC16P029725
  • GC16P029817
  • GC16P027479

Summaries for MAZ Gene

GeneCards Summary for MAZ Gene

MAZ (MYC Associated Zinc Finger Protein) is a Protein Coding gene. Diseases associated with MAZ include Amyloidosis and Alzheimer Disease. Among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is PATZ1.

UniProtKB/Swiss-Prot Summary for MAZ Gene

  • May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.

Gene Wiki entry for MAZ Gene

Additional gene information for MAZ Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAZ Gene

Genomics for MAZ Gene

GeneHancer (GH) Regulatory Elements for MAZ Gene

Promoters and enhancers for MAZ Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J029803 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +4.7 4659 14.9 RXRA EP300 FOXK2 HNRNPK ZBTB40 ZNF217 CTCF ZSCAN5C SIN3A NRF1 PRRT2 ENSG00000280893 MAZ piR-45320 piR-53734 piR-50884 piR-51020 PAGR1 SRCAP ENSG00000260853
GH16J029750 Promoter 0.6 Ensembl 12.3 -55.4 -55382 0.6 CEBPB CEBPG ATF3 FOS ATF7 piR-31470-216 MAZ QPRT SPN DOC2A KR153241-006
GH16J029845 Enhancer 0.6 FANTOM5 11.6 +39.3 39297 0.4 CEBPG ZNF189 ZNF384 CEBPB AGO2 ZNF169 CBFA2T2 CBFA2T3 IKZF1 ZNF785 SH2B1 DOC2A MAZ TMEM219 HIRIP3 INO80E C16orf92 TLCD3B TAOK2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MAZ on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAZ

Top Transcription factor binding sites by QIAGEN in the MAZ gene promoter:
  • ATF-2
  • c-Jun
  • c-Myb
  • GR
  • HSF2
  • p53
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for MAZ Gene

Genomic Locations for MAZ Gene
chr16:29,806,083-29,811,183
(GRCh38/hg38)
Size:
5,101 bases
Orientation:
Plus strand
chr16:29,817,427-29,823,649
(GRCh37/hg19)
Size:
6,223 bases
Orientation:
Plus strand

Genomic View for MAZ Gene

Genes around MAZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAZ Gene

Proteins for MAZ Gene

  • Protein details for MAZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56270-MAZ_HUMAN
    Recommended name:
    Myc-associated zinc finger protein
    Protein Accession:
    P56270
    Secondary Accessions:
    • A8QJL9
    • C6G496
    • G5E927
    • H3BQD6
    • Q15703
    • Q8NFN7
    • Q99443

    Protein attributes for MAZ Gene

    Size:
    477 amino acids
    Molecular mass:
    48608 Da
    Quaternary structure:
    • Interacts with BPTF.
    Miscellaneous:
    • [Isoform 2]: May act as a dominant negative of isoform 1. Reduced expression during inflammatory conditions.
    • [Isoform 3]: Very low expression in normal tissues, but high expression during inflammation. The transactivation potential of SAF-3 is much greater than that of the predominantly expressed form 1.
    SequenceCaution:
    • Sequence=AAB04121.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA12728.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAZ Gene

Post-translational modifications for MAZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAZ Gene

Domains & Families for MAZ Gene

Gene Families for MAZ Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MAZ Gene

Blocks:
  • C2H2-type zinc finger signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAZ Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 801 (MAZ_HUMAN)
genes like me logo Genes that share domains with MAZ: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MAZ Gene

Function for MAZ Gene

Molecular function for MAZ Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.
GENATLAS Biochemistry:
MYC-associated zinc finger gene,60kDa,housekeeping gene,involved in transcription termination and initiation,widely expressed except in kidney

Phenotypes From GWAS Catalog for MAZ Gene

Gene Ontology (GO) - Molecular Function for MAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 1502157
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IDA,NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding HDA,IEA 22658674
genes like me logo Genes that share ontologies with MAZ: view
genes like me logo Genes that share phenotypes with MAZ: view

Animal Model Products

CRISPR Products

miRNA for MAZ Gene

miRTarBase miRNAs that target MAZ
Targeted motifs for MAZ Gene
HOMER Transcription Factor Regulatory Elements motif MAZ
  • Consensus sequence: GGGGGGGG Submotif: canonical Cell Type: HepG2 GEO ID: GSE31477

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAZ

Clone Products

  • Addgene plasmids for MAZ

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for MAZ Gene

Localization for MAZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAZ Gene

Nucleus. Note=In brains of Alzheimer disease patients, present in a plaque-like structures.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAZ gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MAZ: view

Pathways & Interactions for MAZ Gene

genes like me logo Genes that share pathways with MAZ: view

Pathways by source for MAZ Gene

SIGNOR curated interactions for MAZ Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter IDA 1502157
GO:0006369 termination of RNA polymerase II transcription IDA 1502157
GO:0008284 positive regulation of cell proliferation IDA 25487955
GO:0010628 positive regulation of gene expression IDA 25487955
genes like me logo Genes that share ontologies with MAZ: view

Drugs & Compounds for MAZ Gene

(6) Drugs for MAZ Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MAZ Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAZ: view

Transcripts for MAZ Gene

mRNA/cDNA for MAZ Gene

4 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAZ

Clone Products

  • Addgene plasmids for MAZ

Alternative Splicing Database (ASD) splice patterns (SP) for MAZ Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - -
SP8: - -
SP9: - - -
SP10: -

Relevant External Links for MAZ Gene

GeneLoc Exon Structure for
MAZ

Expression for MAZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAZ Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.1), NK cells (10.2), Fetal Brain (10.2), and Platelet (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAZ Gene



Protein tissue co-expression partners for MAZ Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAZ

SOURCE GeneReport for Unigene cluster for MAZ Gene:

Hs.23650

mRNA Expression by UniProt/SwissProt for MAZ Gene:

P56270-MAZ_HUMAN
Tissue specificity: Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level).

Evidence on tissue expression from TISSUES for MAZ Gene

  • Pancreas(4.4)
  • Nervous system(4.3)
  • Lung(3.5)
  • Skin(2.9)
  • Eye(2.8)
  • Kidney(2.1)
  • Blood(2)
  • Bone marrow(2)
  • Heart(2)
  • Liver(2)
genes like me logo Genes that share expression patterns with MAZ: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAZ Gene

Orthologs for MAZ Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAZ 31 30
  • 99.75 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MAZ 30
  • 97.79 (n)
dog
(Canis familiaris)
Mammalia MAZ 31 30
  • 94.83 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Maz 17 31 30
  • 93.21 (n)
rat
(Rattus norvegicus)
Mammalia Maz 30
  • 92.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 77 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia MAZ 31
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia maz 30
  • 72.63 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398491 30
zebrafish
(Danio rerio)
Actinopterygii si:ch211-166g5.4 30
  • 64.07 (n)
maza 31
  • 37 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2801 30
Species where no ortholog for MAZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAZ Gene

ENSEMBL:
Gene Tree for MAZ (if available)
TreeFam:
Gene Tree for MAZ (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MAZ: view image

Paralogs for MAZ Gene

genes like me logo Genes that share paralogs with MAZ: view

Variants for MAZ Gene

Additional dbSNP identifiers (rs#s) for MAZ Gene

Structural Variations from Database of Genomic Variants (DGV) for MAZ Gene

Variant ID Type Subtype PubMed ID
dgv34n68 CNV loss 17160897
esv22680 CNV loss 19812545
nsv1126424 CNV deletion 24896259
nsv827610 CNV gain 20364138
nsv827611 CNV gain 20364138
nsv833186 CNV loss 17160897
nsv953800 CNV deletion 24416366

Variation tolerance for MAZ Gene

Residual Variation Intolerance Score: 6.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAZ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAZ

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAZ Gene

Disorders for MAZ Gene

MalaCards: The human disease database

(3) MalaCards diseases for MAZ Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
amyloidosis
  • amyloid disease
alzheimer disease
  • ad
retinitis pigmentosa 58
  • rp58
- elite association - COSMIC cancer census association via MalaCards
Search MAZ in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MAZ

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MAZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAZ Gene

Publications for MAZ Gene

  1. Isolation of a novel cDNA encoding a zinc-finger protein that binds to two sites within the c-myc promoter. (PMID: 1567856) Pyrc JJ … Hall DJ (Biochemistry 1992) 2 3 4 23 54
  2. MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination. (PMID: 1502157) Bossone SA … Marcu KB (Proceedings of the National Academy of Sciences of the United States of America 1992) 2 3 4 23 54
  3. SAF-3, a novel splice variant of the SAF-1/MAZ/Pur-1 family, is expressed during inflammation. (PMID: 19583771) Ray A … Ray BK (The FEBS journal 2009) 3 4 23 54
  4. SAF-2, a splice variant of SAF-1, acts as a negative regulator of transcription. (PMID: 12270922) Ray BK … Ray A (The Journal of biological chemistry 2002) 3 4 23 54
  5. Genomic organization and expression of a human gene for Myc-associated zinc finger protein (MAZ). (PMID: 9685418) Song J … Yokoyama KK (The Journal of biological chemistry 1998) 3 4 23 54

Products for MAZ Gene

Sources for MAZ Gene