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The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DN... See more...
Aliases for MAX Gene
Aliases for MAX Gene
External Ids for MAX Gene
- HGNC: 6913
- Entrez Gene: 4149
- Ensembl: ENSG00000125952
- OMIM: 154950
- UniProtKB: P61244
Previous GeneCards Identifiers for MAX Gene
- GC14M062799
- GC14M059335
- GC14M063462
- GC14M063531
- GC14M064542
- GC14M065472
- GC14M045642
Summaries for MAX Gene
-
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for MAX Gene
MAX (MYC Associated Factor X) is a Protein Coding gene. Diseases associated with MAX include Pheochromocytoma and Hereditary Paraganglioma-Pheochromocytoma Syndromes. Among its related pathways are Transcriptional misregulation in cancer and Validated targets of C-MYC transcriptional repression. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding.
UniProtKB/Swiss-Prot Summary for MAX Gene
-
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements.
Additional gene information for MAX Gene
- HGNC(6913)
- Entrez Gene(4149)
- Ensembl(ENSG00000125952)
- OMIM(154950)
- UniProtKB(P61244)
- Open Targets Platform(ENSG00000125952)
- Monarch Initiative
- Search for MAX at DataMed
- Search for MAX at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MAX Gene
Genomics for MAX Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MAX Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MAX on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MAX
- Top Transcription factor binding sites by QIAGEN in the MAX gene promoter:
-
- C/EBPalpha
Genomic Locations for MAX Gene
Genomic Locations for MAX Gene
- chr14:65,006,101-65,102,695
- (GRCh38/hg38)
- Size:
- 96,595 bases
- Orientation:
- Minus strand
- chr14:65,472,892-65,569,413
- (GRCh37/hg19)
- Size:
- 96,522 bases
- Orientation:
- Minus strand
Genomic View for MAX Gene
Genes around MAX on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q23.3 by HGNC
- 14q23.3 by Entrez Gene
- 14q23.3 by Ensembl
MAX Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAX Gene
Proteins for MAX Gene
-
Protein details for MAX Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P61244-MAX_HUMAN
- Recommended name:
- Protein max
- Protein Accession:
- P61244
- A6NH73
- A8K265
- A8K4G4
- A8K824
- P25912
- P52163
- Q14803
- Q96CY8
Protein attributes for MAX Gene
- Size:
- 160 amino acids
- Molecular mass:
- 18275 Da
- Quaternary structure:
-
- Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with SPAG9. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity.
- Miscellaneous:
-
- [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Three dimensional structures from OCA and Proteopedia for MAX Gene
Alternative splice isoforms for MAX Gene
- UniProtKB/Swiss-Prot:
Protein Expression for MAX Gene
Post-translational modifications for MAX Gene
- Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes.
-
Ubiquitination at Lys66
- NX_P61244 (NX_P61244-1)
- Modification sites at PhosphoSitePlus
Other Protein References for MAX Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences MAX Antibody (LS-B14086) and MAX Antibody (LS-B15935)
- G Biosciences Immunotag™ Max Antibody and Immunotag™ MAX Antibody
- NSJ Bioreagents MAX Antibody / MYC associated factor X
- Creative Diagnostics Anti-MAX (C-terminal) polyclonal antibody
- Novus Biologicals Antibodies for MAX
-
Abcam antibodies for MAX
- Invitrogen Antibodies for MAX (AFLGC-MAX)
- antibodies-online: Show 163 available MAX Antibodies ranked by validation data
- Compare Top MAX Antibodies
-
Recommended
- 49 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 99 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 DB Antibody (anti-human)
- 47 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 5 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Boster Bio Antibodies for MAX
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAX
- Sino Biological Antibodies for MAX
Protein Products
- G Biosciences Human Max, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for MAX
- Origene Custom Protein Services for MAX
- Sino Biological Recombinant Proteins for MAX
- Sino Biological Cell Lysates for MAX
- ProSpec Recombinant Proteins for MAX
- antibodies-online: Show 21 available MAX Proteins ranked by validation data
- Compare Top MAX Proteins
-
ProSci Proteins for MAX
-
Abcam proteins for MAX
Assay Products
- G Biosciences Immunotag™ Human MAX (Protein max) ELISA and Immunotag™ Protein max ELISA Kit
No data available for DME Specific Peptides for MAX Gene
Domains & Families for MAX Gene
Gene Families for MAX Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for MAX Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MAX Gene
- GenScript: Design optimal peptide antigens:
-
- Myc-associated factor X (MAX_HUMAN)
- cDNA FLJ76576, highly similar to Homo sapiens MYC associated factor X (MAX), transcript variant 5, mRNA (Q14803_HUMAN)
- MAX protein (Q6V3B1_HUMAN)
- MAX protein (Q8IYC6_HUMAN)
- MYC associated factor X (Q8TAX8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P61244- Family:
-
- Belongs to the MAX family.
Function for MAX Gene
Molecular function for MAX Gene
- UniProtKB/Swiss-Prot Function:
- Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements.
- GENATLAS Biochemistry:
- Max protein,heterodimerizing with MYC,with high affinity for the DNA-binding site of MYC,binds to MAD and MNT
Phenotypes From GWAS Catalog for MAX Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | contributes_to RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 8425219 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001227 | contributes_to DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA | 8521822 |
| GO:0003677 | DNA binding | IDA | 9399572 |
Phenotypes for MAX Gene
- MGI mutant phenotypes for MAX:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MAX:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV) infection
- Decreased Salmonella enterica Typhimurium invasion
- Decreased Salmonella-containing vacuole maturation
- Decreased Salmonella enterica Typhimurium binding
- Decreased Salmonella enterica Typhimurium effector injection
- Decreased Salmonella enterica Typhimurium ruffling
- Decreased Salmonella enterica Typhimurium membrane closure
- shRNA abundance <= 25%
- Increased Nanog expression
- Decreased cell number
- Decreased IL-8 secretion
- Decreased HPV16-GFP infection
- Decreased viability in colon lineage
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased epidermal growth factor (EGF) endocytosis, increased transferrin (TF) endocytosis
Animal Models for MAX Gene
- MGI Knock Outs for MAX:
-
- Max Max<tm1Rdp>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAX - Select products 50% OFF >
- * MAX CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MAX
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAX
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAX
miRNA for MAX Gene
- miRTarBase miRNAs that target MAX
-
- mmu-miR-34b-5p (MIRT012834)
- hsa-miR-193b-3p (MIRT016436)
- hsa-miR-22-3p (MIRT030633)
- mmu-miR-22-3p (MIRT053176)
- hsa-miR-365a-3p (MIRT438021)
- hsa-miR-6855-5p (MIRT473512)
- hsa-miR-5572 (MIRT473513)
- hsa-miR-3170 (MIRT473514)
- hsa-miR-6819-5p (MIRT473515)
- hsa-miR-6812-5p (MIRT473516)
- hsa-miR-6737-5p (MIRT473517)
- hsa-miR-609 (MIRT473518)
- hsa-miR-6747-5p (MIRT473519)
- hsa-miR-608 (MIRT473520)
- hsa-miR-4651 (MIRT473521)
- hsa-miR-4480 (MIRT473522)
- hsa-miR-4259 (MIRT473523)
- hsa-miR-140-3p (MIRT473524)
- hsa-miR-4429 (MIRT473525)
- hsa-miR-320d (MIRT473526)
- hsa-miR-320c (MIRT473527)
- hsa-miR-320b (MIRT473528)
- hsa-miR-320a (MIRT473529)
- hsa-miR-3912-5p (MIRT473530)
- hsa-miR-2110 (MIRT473531)
- hsa-miR-1185-2-3p (MIRT473532)
- hsa-miR-1185-1-3p (MIRT473533)
- hsa-let-7f-2-3p (MIRT473534)
- hsa-miR-6755-3p (MIRT473535)
- hsa-miR-6780b-5p (MIRT473536)
- hsa-miR-4725-3p (MIRT473537)
- hsa-miR-4271 (MIRT473538)
- hsa-miR-4533 (MIRT473539)
- hsa-miR-5093 (MIRT473540)
- hsa-miR-4428 (MIRT473541)
- hsa-miR-4668-5p (MIRT623287)
- hsa-miR-3148 (MIRT623288)
- hsa-miR-651-3p (MIRT623289)
- hsa-miR-548as-3p (MIRT623290)
- hsa-miR-548z (MIRT623291)
- hsa-miR-548h-3p (MIRT623292)
- hsa-miR-548d-3p (MIRT623293)
- hsa-miR-548bb-3p (MIRT623294)
- hsa-miR-548ac (MIRT623295)
Transcription Factor Targets for MAX Gene
Targeted motifs for MAX Gene
HOMER Transcription Factor Regulatory Elements motif MAX
- Consensus sequence: ACCACGTGGTCN Submotif: canonical Cell Type: K562 GEO ID: GSE31477
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAX
- Browse OriGene Inhibitory RNA Products For MAX
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAX
Clone Products
- Applied Biological Materials (abm): Clones for MAX - Select products 50% OFF >
- * MAX as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG223868
- MG224686
- MR223868
- MR223868L3
- MR223868L4
- MR224686
- MR224686L3
- MR224686L4
- RC203944
- RC203944L3
- RC203944L4
- RC206294
- RC206294L3
- RC206294L4
- RC206812
- RC206812L1
- RC206812L2
- RC206812L3
- RC206812L4
- RC213128
- RC213128L1
- RC213128L2
- RC213128L3
- RC213128L4
- RC213886
- RC213886L3
- RC213886L4
- RC220343
- RC220343L3
- RC220343L4
- RC231595
- RC235467
- RG203944
- RG206294
- RG206812
- RG213128
- RG213886
- RG220343
- RG231595
- RR209605
- RR209605L3
- RR209605L4
- MR223868L3V
- MR223868L4V
- MR224686L3V
- MR224686L4V
- RC203944L3V
- RC203944L4V
- RC206294L3V
- RC206294L4V
- RC206812L1V
- RC206812L2V
- RC206812L3V
- RC206812L4V
- RC213128L1V
- RC213128L2V
- RC213128L3V
- RC213128L4V
- RC213886L3V
- RC213886L4V
- RC220343L3V
- RC220343L4V
- RR209605L3V
- RR209605L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAX
- Addgene plasmids for MAX
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAX
No data available for Enzyme Numbers (IUBMB) for MAX Gene
Localization for MAX Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAX Gene
- Nucleus. Cell projection, dendrite.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| extracellular | 2 |
| mitochondrion | 2 |
| golgi apparatus | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Nucleoplasm (3)
- Golgi apparatus (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IDA,ISA | -- |
| GO:0005634 | nucleus | IBA,IDA | 15358760 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0016605 | PML body | IEA | -- |
Pathways & Interactions for MAX Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.78
|
|
| 2 | MAPK signaling pathway | ||
| 3 | P38 MAPK Signaling Pathway (sino) | ||
| 4 | ERK Signaling |
ERK Signaling
.61
|
Molecular Mechanisms of Cancer
.51
|
| 5 | Cell Cycle, Mitotic |
.83
|
|
Pathways by source for MAX Gene
1 Sino Biological pathway for MAX Gene
11 BioSystems pathways for MAX Gene
7 Reactome pathways for MAX Gene
4 KEGG pathways for MAX Gene
2 R&D Systems pathways for MAX Gene
3 Qiagen pathways for MAX Gene
- ERK Signaling
- Molecular Mechanisms of Cancer
- p38 Signaling
1 Cell Signaling Technology pathway for MAX Gene
Interacting Proteins for MAX Gene
Selected Interacting proteins:
P61244-MAX_HUMAN
ENSP00000351490
for MAX Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MAX
SIGNOR curated interactions for MAX Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | -- |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 8521822 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | TAS | 8425218 |
Drugs & Compounds for MAX Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| 10058-F4 | Pharma | C-Myc-Max dimerization inhibitor | 0 |
(1) ApexBio Compounds for MAX Gene
| Compound | Action | Cas Number |
|---|---|---|
| 10058-F4 | C-Myc-Max dimerization inhibitor | 403811-55-2 |
Transcripts for MAX Gene
mRNA/cDNA for MAX Gene
- 9 REFSEQ mRNAs :
- 28 NCBI additional mRNA sequence :
- 20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000246163 897 nts (view in UCSC)
- ENST00000284165 3155 nts (view in UCSC)
- ENST00000341653 330 nts (view in UCSC)
- ENST00000358402 1973 nts (view in UCSC)
- ENST00000358664 2010 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MAX - Select products 50% OFF >
- * MAX CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MAX
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAX
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAX
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MAX
- Browse OriGene Inhibitory RNA Products For MAX
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAX
Clone Products
- Applied Biological Materials (abm): Clones for MAX - Select products 50% OFF >
- * MAX as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG223868
- MG224686
- MR223868
- MR223868L3
- MR223868L4
- MR224686
- MR224686L3
- MR224686L4
- RC203944
- RC203944L3
- RC203944L4
- RC206294
- RC206294L3
- RC206294L4
- RC206812
- RC206812L1
- RC206812L2
- RC206812L3
- RC206812L4
- RC213128
- RC213128L1
- RC213128L2
- RC213128L3
- RC213128L4
- RC213886
- RC213886L3
- RC213886L4
- RC220343
- RC220343L3
- RC220343L4
- RC231595
- RC235467
- RG203944
- RG206294
- RG206812
- RG213128
- RG213886
- RG220343
- RG231595
- RR209605
- RR209605L3
- RR209605L4
- MR223868L3V
- MR223868L4V
- MR224686L3V
- MR224686L4V
- RC203944L3V
- RC203944L4V
- RC206294L3V
- RC206294L4V
- RC206812L1V
- RC206812L2V
- RC206812L3V
- RC206812L4V
- RC213128L1V
- RC213128L2V
- RC213128L3V
- RC213128L4V
- RC213886L3V
- RC213886L4V
- RC220343L3V
- RC220343L4V
- RR209605L3V
- RR209605L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAX
- Addgene plasmids for MAX
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAX
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||
| SP4: | - | ||||||||||||||||||||
| SP5: |
Relevant External Links for MAX Gene
- GeneLoc Exon Structure for
- MAX
Expression for MAX Gene
This gene is overexpressed in Peripheral blood mononuclear cells (20.0), CD4 Tcells (13.0), and Monocytes (9.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAX Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MAX
SOURCE GeneReport for Unigene cluster for MAX Gene:
Hs.285354mRNA Expression by UniProt/SwissProt for MAX Gene:
P61244-MAX_HUMAN
Tissue specificity:
High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
Evidence on tissue expression from TISSUES for MAX Gene
- Nervous system(4.8)
- Lung(4.6)
- Intestine(3)
- Blood(2.8)
- Skin(2.8)
- Adrenal gland(2.7)
- Muscle(2.6)
- Liver(2.6)
- Lymph node(2.5)
- Bone marrow(2.5)
- Kidney(2.5)
- Heart(2.5)
- Spleen(2.3)
- Thyroid gland(2.3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MAX Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- endocrine
- immune
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cranial nerve
- ear
- eye
- head
- larynx
- meninges
- middle ear
- mouth
- neck
- nose
- outer ear
- thyroid
- tongue
- vocal cord
Thorax:
- heart
- heart valve
- lung
- trachea
Abdomen:
- adrenal gland
- kidney
Pelvis:
- urinary bladder
General:
- blood
- blood vessel
- coagulation system
- peripheral nerve
- peripheral nervous system
- skin
- sweat gland
Primer Products
-
OriGene qPCR primer pairs for MAX
-
OriGene qPCR primer pairs and template standards for MAX
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAX Gene
Orthologs for MAX Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MAX 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MAX 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MAX 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MAX 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MAX 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Max 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Max 30 |
|
||
| Chicken (Gallus gallus) |
Aves | MAX 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | max 30 |
|
||
| Str.4058 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | max-A 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | max 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11119 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Max 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | mxl-1 31 |
|
OneToMany | |
| mxl-3 31 |
|
OneToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2903 31 |
|
OneToOne |
- Species where no ortholog for MAX was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MAX Gene
- ENSEMBL:
- Gene Tree for MAX (if available)
- TreeFam:
- Gene Tree for MAX (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MAX: view image
Paralogs for MAX Gene
(11) SIMAP similar genes for MAX Gene using alignment to 10 proteins:
- MAX_HUMAN
- G3V2N4_HUMAN
- G3V2R5_HUMAN
- G3V302_HUMAN
- G3V563_HUMAN
- G3V570_HUMAN
- G3V5L1_HUMAN
- Q6V3B1_HUMAN
- Q8IYC6_HUMAN
- Q8TAX8_HUMAN
Pseudogenes.org Pseudogenes for MAX Gene
No data available for Paralogs for MAX Gene
Variants for MAX Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MAX Gene
| SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 647774 | Uncertain Significance: Hereditary cancer-predisposing syndrome; Hereditary Paraganglioma-Pheochromocytoma Syndromes | 65,076,493(-) | G/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
| 652863 | Pathogenic: Hereditary Paraganglioma-Pheochromocytoma Syndromes | 65,093,758(-) | CT/C | FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 654236 | Uncertain Significance: Hereditary cancer-predisposing syndrome; Hereditary Paraganglioma-Pheochromocytoma Syndromes | 65,076,660(-) | C/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
| 654688 | Uncertain Significance: Hereditary Paraganglioma-Pheochromocytoma Syndromes | 65,093,741(-) | C/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 658608 | Pathogenic/Likely Pathogenic: Hereditary cancer-predisposing syndrome; Hereditary Paraganglioma-Pheochromocytoma Syndromes | 65,077,919(-) | G/A | NONSENSE,NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2506970 | CNV | deletion | 19546169 |
| esv2665422 | CNV | deletion | 23128226 |
| esv2673460 | CNV | deletion | 23128226 |
| esv2748779 | CNV | deletion | 23290073 |
| esv2748787 | CNV | deletion | 23290073 |
| esv2748788 | CNV | deletion | 23290073 |
| esv2748789 | CNV | deletion | 23290073 |
| esv3551663 | CNV | deletion | 23714750 |
| esv3634761 | CNV | loss | 21293372 |
| esv3634762 | CNV | loss | 21293372 |
| nsv1070225 | CNV | deletion | 25765185 |
| nsv1108903 | CNV | deletion | 24896259 |
| nsv832816 | CNV | gain | 17160897 |
| nsv952855 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.25;
5.54% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MAX Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAX Gene
Disorders for MAX Gene
(15) MalaCards diseases for MAX Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pheochromocytoma |
|
|
| hereditary paraganglioma-pheochromocytoma syndromes |
|
|
| inherited cancer-predisposing syndrome |
|
|
| paraganglioma |
|
|
| malignant pheochromocytoma |
|
|
Search MAX in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MAX_HUMAN- Pheochromocytoma (PCC) [MIM:171300]: A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent. {ECO:0000269 PubMed:21685915, ECO:0000269 PubMed:22452945, ECO:0000269 PubMed:26070438}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Additional Disease Information for MAX
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for MAX Gene
Publications for MAX Gene
- Max is acetylated by p300 at several nuclear localization residues. (PMID: 17217336) Faiola F … Martinez E (The Biochemical journal 2007) 3 4 23
- The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control. (PMID: 9115440) Brownlie P … Suck D (Structure (London, England : 1993) 1997) 3 4 23
- Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. (PMID: 2006410) Blackwood EM … Eisenman RN (Science (New York, N.Y.) 1991) 3 4 23
- Functional and in silico assessment of MAX variants of unknown significance. (PMID: 26070438) Comino-Méndez I … Cascón A (Journal of molecular medicine (Berlin, Germany) 2015) 3 4
- MAX mutations cause hereditary and sporadic pheochromocytoma and paraganglioma. (PMID: 22452945) Burnichon N … Robledo M (Clinical cancer research : an official journal of the American Association for Cancer Research 2012) 3 4
ExternalLinks
Products for MAX Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Browse OriGene Inhibitory RNA Products For MAX
- OriGene qPCR primer pairs for MAX
- OriGene qPCR primer pairs and template standards for MAX
- OriGene CRISPR knockouts for MAX
- MG223868
- MG224686
- MR223868
- MR223868L3
- MR223868L4
- MR224686
- MR224686L3
- MR224686L4
- RC203944
- RC203944L3
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- RC206294
- RC206294L3
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- RC206812
- RC206812L1
- RC206812L2
- RC206812L3
- RC206812L4
- RC213128
- RC213128L1
- RC213128L2
- RC213128L3
- RC213128L4
- RC213886
- RC213886L3
- RC213886L4
- RC220343
- RC220343L3
- RC220343L4
- RC231595
- RC235467
- RG203944
- RG206294
- RG206812
- RG213128
- RG213886
- RG220343
- RG231595
- RR209605
- RR209605L3
- RR209605L4
- MR223868L3V
- MR223868L4V
- MR224686L3V
- MR224686L4V
- RC203944L3V
- RC203944L4V
- RC206294L3V
- RC206294L4V
- RC206812L1V
- RC206812L2V
- RC206812L3V
- RC206812L4V
- RC213128L1V
- RC213128L2V
- RC213128L3V
- RC213128L4V
- RC213886L3V
- RC213886L4V
- RC220343L3V
- RC220343L4V
- RR209605L3V
- RR209605L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MAX
- Sino Biological Human cDNA Clone for MAX
- Sino Biological Recombinant Proteins for MAX
- Sino Biological Cell Lysates for MAX
- Sino Biological Antibodies for MAX
- Browse Sino Biological Assays
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals proteins and lysates for MAX
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam proteins for MAX
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- ApexBio compounds for MAX
- VectorBuilder Custom and pre-made DNA vectors for MAX (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MAX (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MAX (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MAX CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MAX
- Addgene plasmids for MAX
- antibodies-online: Show 163 available MAX Antibodies ranked by validation data
- Compare Top MAX Antibodies
- Recommended
- 49 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 99 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 DB Antibody (anti-human)
- 47 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 5 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Show 15 available MAX Elisa Kits ranked by validation data
- Compare Top MAX Elisa Kits
- antibodies-online: Show 21 available MAX Proteins ranked by validation data
- Compare Top MAX Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for MAX
- Search Santa Cruz Biotechnology (SCBT) for MAX siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MAX
- Search for MAX Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for MAX
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MAX
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MAX
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MAX
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MAX
- Boster Bio Antibodies for MAX
- Browse Boster Bio ELISA Kits
Sources for MAX Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB