Aliases for MAX Gene
Aliases for MAX Gene
External Ids for MAX Gene
- HGNC: 6913
- Entrez Gene: 4149
- Ensembl: ENSG00000125952
- OMIM: 154950
- UniProtKB: P61244
Previous GeneCards Identifiers for MAX Gene
- GC14M062799
- GC14M059335
- GC14M063462
- GC14M063531
- GC14M064542
- GC14M065472
- GC14M045642
Summaries for MAX Gene
-
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for MAX Gene
MAX (MYC Associated Factor X) is a Protein Coding gene. Diseases associated with MAX include Hereditary Paraganglioma-Pheochromocytoma Syndromes and Pheochromocytoma. Among its related pathways are Validated targets of C-MYC transcriptional repression and Validated targets of C-MYC transcriptional activation. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding.
UniProtKB/Swiss-Prot for MAX Gene
-
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5-CAC[GA]TG-3. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 Lys-9 histone methyltransferase activity.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAX Gene
Genomics for MAX Gene
Regulatory Elements for MAX Gene
Enhancers for MAX Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MAX on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MAX gene promoter:
Regulatory Element Products
Genomic Location for MAX Gene
- Chromosome:
- 14
- Start:
- 65,006,101 bp from pter
- End:
- 65,102,695 bp from pter
- Size:
- 96,595 bases
- Orientation:
- Minus strand
Genomic View for MAX Gene
Genes around MAX on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q23.3 by Ensembl
- 14q23.3 by Entrez Gene
- 14q23.3 by HGNC
MAX Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAX Gene
Proteins for MAX Gene
-
Protein details for MAX Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P61244-MAX_HUMAN
- Recommended name:
- Protein max
- Protein Accession:
- P61244
- A6NH73
- A8K265
- A8K4G4
- A8K824
- P25912
- P52163
- Q14803
- Q96CY8
Protein attributes for MAX Gene
- Size:
- 160 amino acids
- Molecular mass:
- 18275 Da
- Quaternary structure:
-
- Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with SPAG9. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity.
Three dimensional structures from OCA and Proteopedia for MAX Gene
Alternative splice isoforms for MAX Gene
- UniProtKB/Swiss-Prot:
Protein Expression for MAX Gene
Post-translational modifications for MAX Gene
- Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes.
- Ubiquitination at posLast=6666
- Modification sites at PhosphoSitePlus
Other Protein References for MAX Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for MAX (Max)
- Cell Signaling Technology (CST) Antibodies for MAX (MAX)
-
Custom Antibody ServicesOriGene Antibodies for MAX
- Novus Biologicals Antibodies for MAX
-
Abcam antibodies for MAX
-
Cloud-Clone Corp. Antibodies for MAX
- Invitrogen Antibodies for MAX
- antibodies-online Antibodies for MAX: See all 100
- GeneTex MAX antibody for MAX
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAX
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for MAX
- Origene Custom Protein Services for MAX
- Sino Biological Recombinant Proteins for MAX
- Sino Biological Cell Lysates for MAX
- ProSpec Recombinant Proteins for MAX
-
Cloud-Clone Corp. Proteins for MAX
- antibodies-online Proteins for MAX: See all 27
- Search antibodies-online for peptides
- Search GeneTex for Proteins for MAX
-
ProSci Proteins for MAX
-
Abcam proteins for MAX
No data available for DME Specific Peptides for MAX Gene
Domains & Families for MAX Gene
Gene Families for MAX Gene
Suggested Antigen Peptide Sequences for MAX Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P61244- Family:
-
- Belongs to the MAX family.
Function for MAX Gene
Molecular function for MAX Gene
- GENATLAS Biochemistry:
- Max protein,heterodimerizing with MYC,with high affinity for the DNA-binding site of MYC,binds to MAD and MNT
- UniProtKB/Swiss-Prot Function:
- Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5-CAC[GA]TG-3. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 Lys-9 histone methyltransferase activity.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IEA | -- |
| GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific | IEA | -- |
| GO:0003677 | DNA binding | IMP,IEA | 9399572 |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | TAS | 2006410 |
| GO:0003712 | transcription cofactor activity | TAS | 8425218 |
Phenotypes for MAX Gene
- MGI mutant phenotypes for MAX:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MAX:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased transferrin (TF) endocytosis
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Decreased IL-8 secretion
- Decreased Salmonella enterica Typhimurium ruffling
- Decreased Salmonella enterica Typhimurium invasion
- Decreased Salmonella enterica Typhimurium effector injection
- Increased HPV16-GFP infection
- Increased Nanog expression
- Decreased cell number
- Decreased Salmonella-containing vacuole maturation
- Decreased Salmonella enterica Typhimurium binding
- Decreased Salmonella enterica Typhimurium membrane closure
Animal Models for MAX Gene
- MGI Knock Outs for MAX:
-
- Max tm1Rdp
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAX
-
- Search ViGene Biosciences for MAX
CRISPR Products
-
OriGene CRISPR knockouts for MAX
-
Applied Biological Materials CRISPR for MAX
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAX
- GenScript: Design CRISPR guide RNA sequences for MAX
miRNA for MAX Gene
- miRTarBase miRNAs that target MAX
-
- hsa-mir-193b-3p (MIRT016436)
- hsa-mir-22-3p (MIRT030633)
- hsa-mir-365a-3p (MIRT438021)
- hsa-mir-6855-5p (MIRT473512)
- hsa-mir-5572 (MIRT473513)
- hsa-mir-3170 (MIRT473514)
- hsa-mir-6819-5p (MIRT473515)
- hsa-mir-6812-5p (MIRT473516)
- hsa-mir-6737-5p (MIRT473517)
- hsa-mir-609 (MIRT473518)
- hsa-mir-6747-5p (MIRT473519)
- hsa-mir-608 (MIRT473520)
- hsa-mir-4651 (MIRT473521)
- hsa-mir-4480 (MIRT473522)
- hsa-mir-4259 (MIRT473523)
- hsa-mir-140-3p (MIRT473524)
- hsa-mir-4429 (MIRT473525)
- hsa-mir-320d (MIRT473526)
- hsa-mir-320c (MIRT473527)
- hsa-mir-320b (MIRT473528)
- hsa-mir-320a (MIRT473529)
- hsa-mir-3912-5p (MIRT473530)
- hsa-mir-2110 (MIRT473531)
- hsa-mir-1185-2-3p (MIRT473532)
- hsa-mir-1185-1-3p (MIRT473533)
- hsa-let-7f-2-3p (MIRT473534)
- hsa-mir-6755-3p (MIRT473535)
- hsa-mir-6780b-5p (MIRT473536)
- hsa-mir-4725-3p (MIRT473537)
- hsa-mir-4271 (MIRT473538)
- hsa-mir-4533 (MIRT473539)
- hsa-mir-5093 (MIRT473540)
- hsa-mir-4428 (MIRT473541)
- hsa-mir-4668-5p (MIRT623287)
- hsa-mir-3148 (MIRT623288)
- hsa-mir-651-3p (MIRT623289)
- hsa-mir-548as-3p (MIRT623290)
- hsa-mir-548z (MIRT623291)
- hsa-mir-548h-3p (MIRT623292)
- hsa-mir-548d-3p (MIRT623293)
- hsa-mir-548bb-3p (MIRT623294)
- hsa-mir-548ac (MIRT623295)
Transcription Factor Targets for MAX Gene
Targeted motifs for MAX Gene
HOMER Transcription Factor Regulatory Elements motif MAX
- Consensus sequence: ACCACGTGGTCN Submotif: canonical Cell Type: K562 GEO ID: GSE31477
miRNA Products
- Search ViGene Biosciences for MAX
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for MAX
- Browse OriGene Inhibitory RNA Products For MAX
Clone Products
-
OriGene ORF clones in human for MAX
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAX
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MAX
- VectorBuilder custom plasmid, inducible vectors for MAX
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAX
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for MAX Gene
Localization for MAX Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAX Gene
- Nucleus. Cell projection, dendrite.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| golgi apparatus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 15358760 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0016605 | PML body | IEA | -- |
| GO:0030425 | dendrite | IEA | -- |
Pathways & Interactions for MAX Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.78
|
|
| 2 | MAPK signaling pathway | ||
| 3 | ERK Signaling |
.61
|
|
| 4 | Cell Cycle, Mitotic |
.83
|
|
| 5 | Mitotic G1-G1/S phases |
.83
|
|
Pathways by source for MAX Gene
1 Sino Biological pathway for MAX Gene
1 Cell Signaling Technology pathway for MAX Gene
11 BioSystems pathways for MAX Gene
7 Reactome pathways for MAX Gene
4 KEGG pathways for MAX Gene
2 R&D Systems pathways for MAX Gene
3 Qiagen pathways for MAX Gene
Interacting Proteins for MAX Gene
Selected Interacting proteins:
ENSP00000351490
P61244-MAX_HUMAN
for MAX Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | 8425218 |
Drugs & Compounds for MAX Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| 10058-F4 | Pharma | C-Myc-Max dimerization inhibitor | 0 |
(1) ApexBio Compounds for MAX Gene
| Compound | Action | Cas Number |
|---|---|---|
| 10058-F4 | C-Myc-Max dimerization inhibitor | 403811-55-2 |
Transcripts for MAX Gene
mRNA/cDNA for MAX Gene
- (12) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (306) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for MAX
-
Applied Biological Materials CRISPR for MAX
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAX
- GenScript: Design CRISPR guide RNA sequences for MAX
miRNA Products
- Search ViGene Biosciences for MAX
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for MAX
- Browse OriGene Inhibitory RNA Products For MAX
Clone Products
-
OriGene ORF clones in human for MAX
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MAX
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MAX
- VectorBuilder custom plasmid, inducible vectors for MAX
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAX
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||
| SP4: | - | ||||||||||||||||||||
| SP5: |
Expression for MAX Gene
This gene is overexpressed in Peripheral blood mononuclear cells (20.0), CD4 Tcells (13.0), and Monocytes (9.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAX Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MAX Gene:
MAXSOURCE GeneReport for Unigene cluster for MAX Gene:
Hs.285354mRNA Expression by UniProt/SwissProt for MAX Gene:
P61244-MAX_HUMAN
Tissue specificity:
High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
Evidence on tissue expression from TISSUES for MAX Gene
- Nervous system(4.8)
- Lung(4.5)
- Blood(2.1)
- Intestine(2.1)
- Adrenal gland(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MAX Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- endocrine
- immune
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
- urinary
Organs:
Head and neck:
- brain
- cranial nerve
- ear
- eye
- head
- larynx
- meninges
- middle ear
- mouth
- neck
- nose
- outer ear
- thyroid
- tongue
- vocal cord
Thorax:
- heart
- heart valve
- lung
- trachea
Abdomen:
- adrenal gland
- kidney
Pelvis:
- urinary bladder
General:
- blood
- blood vessel
- coagulation system
- peripheral nerve
- peripheral nervous system
- skin
- sweat gland
Primer Products
-
OriGene qPCR primer pairs for MAX
-
OriGene qPCR primer pairs and template standards for MAX
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAX Gene
Orthologs for MAX Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MAX 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MAX 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MAX 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | MAX 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MAX 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Max 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Max 34 |
|
||
| chicken (Gallus gallus) |
Aves | MAX 34 35 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | max 34 |
|
||
| Str.4058 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | max-A 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | max 34 35 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11119 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Max 35 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | mxl-1 35 |
|
OneToMany | |
| mxl-3 35 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2903 35 |
|
OneToOne |
- Species where no ortholog for MAX was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MAX Gene
(11) SIMAP similar genes for MAX Gene using alignment to 10 proteins:
Pseudogenes.org Pseudogenes for MAX Gene
No data available for Paralogs for MAX Gene
Variants for MAX Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs387906650 | Pathogenic | 65,077,985(-) | ATATG(C/T)GAAGG | intron-variant, nc-transcript-variant, reference, stop-gained, utr-variant-5-prime | |
| rs587781931 | Pathogenic | 65,077,974(-) | AAAAA(-/A)CCACA | intron-variant, nc-transcript-variant, reference, frameshift-variant, utr-variant-5-prime | |
| rs786203385 | Pathogenic | 65,077,912(-) | GCAAG(A/G)TGAGC | intron-variant, splice-donor-variant | |
| rs876660073 | Pathogenic | 65,076,639(-) | GAGGT(A/C)AAGTG | intron-variant, nc-transcript-variant, reference, utr-variant-3-prime, stop-gained | |
| rs786203009 | Likely pathogenic | 65,093,706(-) | GAAGG(A/T)GAGTT | nc-transcript-variant, splice-donor-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2506970 | CNV | deletion | 19546169 |
| esv2665422 | CNV | deletion | 23128226 |
| esv2673460 | CNV | deletion | 23128226 |
| esv2748779 | CNV | deletion | 23290073 |
| esv2748787 | CNV | deletion | 23290073 |
| esv2748788 | CNV | deletion | 23290073 |
| esv2748789 | CNV | deletion | 23290073 |
| esv3551663 | CNV | deletion | 23714750 |
| esv3634761 | CNV | loss | 21293372 |
| esv3634762 | CNV | loss | 21293372 |
| nsv1070225 | CNV | deletion | 25765185 |
| nsv1108903 | CNV | deletion | 24896259 |
| nsv832816 | CNV | gain | 17160897 |
| nsv952855 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.25;
5.54% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MAX Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAX Gene
Disorders for MAX Gene
(6) MalaCards diseases for MAX Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hereditary paraganglioma-pheochromocytoma syndromes |
|
|
| pheochromocytoma |
|
|
| max-related hereditary paraganglioma-pheochromocytoma syndrome |
|
|
| max-related susceptibility to pheochromocytoma |
|
|
| renal oncocytoma |
|
|
Search MAX in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MAX_HUMAN- Pheochromocytoma (PCC) [MIM:171300]: A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent. {ECO:0000269 PubMed:21685915}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Relevant External Links for MAX
No data available for Genatlas for MAX Gene
Publications for MAX Gene
- Max is acetylated by p300 at several nuclear localization residues. (PMID: 17217336) Faiola F. … Martinez E. (Biochem. J. 2007) 3 4 22 64
- The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control. (PMID: 9115440) Brownlie P. … Suck D. (Structure 1997) 3 4 22 64
- Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. (PMID: 2006410) Blackwood E.M. … Eisenman R.N. (Science 1991) 3 4 22 64
- Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma. (PMID: 21685915) Comino-MAcndez I. … CascA^n A. (Nat. Genet. 2011) 3 4 64
- Genome-wide association study of anthropometric traits in Korcula Island, Croatia. (PMID: 19260139) Polasek O. … Rudan I. (Croat. Med. J. 2009) 3 46 64
Products for MAX Gene
- R&D Systems Antibodies for MAX (Max)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for MAX
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for MAX
- Origene Custom Protein Services for MAX
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for MAX
- Browse OriGene Inhibitory RNA Products For MAX
- OriGene qPCR primer pairs and template standards for MAX
- OriGene qPCR primer pairs for MAX
- OriGene CRISPR knockouts for MAX
- OriGene ORF clones in human for MAX
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MAX
- GenScript: Next-day shipping of latest version cDNA ORF clones for MAX in any vector
- GenScript Custom Purified and Recombinant Proteins Services for MAX
- GenScript Custom Assay Services for MAX
- GenScript Custom overexpressing Cell Line Services for MAX
- GenScript: Design CRISPR guide RNA sequences for MAX
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MAX
- Cell Signaling Technology (CST) Antibodies for MAX (MAX)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for MAX
- Sino Biological Recombinant Proteins for MAX
- Sino Biological Cell Lysates for MAX
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for MAX
- Novus Biologicals proteins and lysates for MAX
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for MAX
- Abcam proteins for MAX
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- ProSpec Recombinant Proteins for MAX
- Cloud-Clone Corp. Antibodies for MAX
- Cloud-Clone Corp. Proteins for MAX
- Cloud-Clone Corp. Assay Kits for MAX
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for MAX
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for MAX
- Addgene plasmids for MAX
- antibodies-online Antibodies for MAX: See all 100
- antibodies-online Kits for MAX: See all 6
- antibodies-online Proteins for MAX: See all 27
- Search antibodies-online for peptides
- GeneTex MAX antibody for MAX
- Search GeneTex for Proteins for MAX
- Search ViGene Biosciences for MAX
- Santa Cruz Biotechnology (SCBT) Antibodies for MAX
- Search Santa Cruz Biotechnology (SCBT) for MAX siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MAX
- Search for MAX Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for MAX
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAX
- VectorBuilder custom plasmid, inducible vectors for MAX
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAX
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MAX Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer
- (156) abm
- (157) CrownBio